Quantitative Fundamentals Of Molecular And Cellular Bioengineering

Author : K. Dane Wittrup,Bruce Tidor,Benjamin J. Hackel,Casim A. Sarkar
Publisher : MIT Press
Page : 593 pages
File Size : 47,5 Mb
Release : 2020-01-07
Category : Science
ISBN : 9780262042659

Get Book

Quantitative Fundamentals of Molecular and Cellular Bioengineering by K. Dane Wittrup,Bruce Tidor,Benjamin J. Hackel,Casim A. Sarkar Pdf

A comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena. This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering. The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After introducing the motivations for formulation of mathematical rate process models in biology, the text goes on to cover such topics as noncovalent binding interactions; quantitative descriptions of the transient, steady state, and equilibrium interactions of proteins and their ligands; enzyme kinetics; gene expression and protein trafficking; network dynamics; quantitative descriptions of growth dynamics; coupled transport and reaction; and discrete stochastic processes. The textbook is intended for advanced undergraduate and graduate courses in chemical engineering and bioengineering, and has been developed by the authors for classes they teach at MIT and the University of Minnesota.

Author : Michael E. Wall
Publisher : CRC Press
Page : 392 pages
File Size : 42,5 Mb
Release : 2012-08-25
Category : Science
ISBN : 9781439827239

Get Book

Quantitative Biology by Michael E. Wall Pdf

Quantitative methods are revolutionizing modern molecular and cellular biology. Groundbreaking technical advances are fueling the rapid expansion in our ability to observe, as seen in multidisciplinary studies that integrate theory, computation, experimental assays, and the control of microenvironments. Integrating new experimental and theoretical

Author : Shu Q. Liu
Publisher : John Wiley & Sons
Page : 1106 pages
File Size : 47,6 Mb
Release : 2007-04-06
Category : Science
ISBN : 9780470116852

Get Book

Bioregenerative Engineering by Shu Q. Liu Pdf

A unique, comprehensive reference that integrates the molecular, cellular, physiological, pathological, and engineering aspects of regenerative processes Bioregenerative engineering is an emerging discipline based on applying engineering principles and technologies to regenerative medicine. It induces, modulates, enhances, and/or controls regenerative processes by using engineering approaches to improve the restoration of the structure and function of disordered or lost molecules, cells, tissues, and organs. This reference systematically summarizes bioregenerative engineering principles, technologies, and current research to help scientists understand biological regeneration and design new therapeutic strategies. Succinct and well-organized with a detailed table of contents to help readers pinpoint information, this reference: * Provides the fundamental theory and principles of molecular, cellular, and tissue regenerative engineering concurrently with experimental approaches * Presents the foundations of bioregenerative engineering, encompassing the molecular basis, the regulatory mechanism of regeneration, and the developmental aspects * Combines molecular and cell biology with potential applications * Addresses experimental design, methods, and modeling at the molecular/cellular/tissue levels * Covers the general mechanisms and technologies of bioregenerative engineering, as well as its application to the treatment of human disorders * Discusses the engineering tests and therapies for major organ systems Presenting an in-depth introduction to the biological and engineering aspects of the field and an up-to-date overview of current research, this is a one-of-a-kind resource for scientific researchers and medical practitioners, as well as for graduate and undergraduate students in biomedical engineering, bioengineering, chemical engineering, molecular biology, and cell biology.

Author : Daniel A. Beard,Hong Qian
Publisher : Cambridge University Press
Page : 0 pages
File Size : 44,6 Mb
Release : 2010-11-25
Category : Technology & Engineering
ISBN : 0521158249

Get Book

Chemical Biophysics by Daniel A. Beard,Hong Qian Pdf

Chemical Biophysics provides an engineering-based approach to biochemical system analysis for graduate-level courses on systems biology, computational bioengineering and molecular biophysics. It is the first textbook to apply rigorous physical chemistry principles to mathematical and computational modeling of biochemical systems for an interdisciplinary audience. The book is structured to show the student the basic biophysical concepts before applying this theory to computational modeling and analysis, building up to advanced topics and research. Topics explored include the kinetics of nonequilibrium open biological systems, enzyme mediated reactions, metabolic networks, biological transport processes, large-scale biochemical networks and stochastic processes in biochemical systems. End-of-chapter exercises range from confidence-building calculations to computational simulation projects.

Author : Joseph D. Bronzino,Donald R. Peterson
Publisher : CRC Press
Page : 1891 pages
File Size : 52,9 Mb
Release : 2018-10-08
Category : Medical
ISBN : 9781439825310

Get Book

Molecular, Cellular, and Tissue Engineering by Joseph D. Bronzino,Donald R. Peterson Pdf

Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering. Molecular, Cellular, and Tissue Engineering, the fourth volume of the handbook, presents material from respected scientists with diverse backgrounds in molecular biology, transport phenomena, physiological modeling, tissue engineering, stem cells, drug delivery systems, artificial organs, and personalized medicine. More than three dozen specific topics are examined, including DNA vaccines, biomimetic systems, cardiovascular dynamics, biomaterial scaffolds, cell mechanobiology, synthetic biomaterials, pluripotent stem cells, hematopoietic stem cells, mesenchymal stem cells, nanobiomaterials for tissue engineering, biomedical imaging of engineered tissues, gene therapy, noninvasive targeted protein and peptide drug delivery, cardiac valve prostheses, blood substitutes, artificial skin, molecular diagnostics in personalized medicine, and bioethics.

Author : Heinments F.
Publisher : Unknown
Page : 128 pages
File Size : 45,8 Mb
Release : 1974
Category : Electronic
ISBN : OCLC:769809926

Get Book

Quantitative Cellular Biology by Heinments F. Pdf

Author : Gabi Nindl Waite,Lee Waite
Publisher : McGraw Hill Professional
Page : 326 pages
File Size : 41,7 Mb
Release : 2007-04-05
Category : Technology & Engineering
ISBN : 0071509526

Get Book

Applied Cell and Molecular Biology for Engineers by Gabi Nindl Waite,Lee Waite Pdf

A Guide to the Fundamentals and Latest Concepts of Molecular and Cell Biology Bridging the gap between biology and engineering, Applied Cell and Molecular Biology for Engineers uses clear, straightforward language to introduce you to the cutting-edge concepts of molecular and cell biology. Written by an international team of engineers and life scientists, this vital tool contains “clinical focus boxes” and “applications boxes” in each chapter to link biology and engineering in today's world. To help grasp complex material quickly and easily, a glossary is provided. Applied Cell and Molecular Biology for Engineers features: Clear descriptions of cell structures and functions Detailed coverage of cellular communication In-depth information on cellular energy conversion Concise facts on information flow across generations A succinct guide to the evolution of cells to organisms Inside This Biomedical Engineering Guide Biomolecules: • Energetics • Components of the cell • Cell Morphology: • Cell membranes • Cell organelles • Enzyme Kinetics: • Steady-state kinetics • Enzyme inhibition • Cellular Signal Transduction: • Receptor binding • Apoptosis • Energy Conversion: • Cell metabolism • Cell respiration • Cellular Communication: • Direct • Local • Long distance • Cellular Genetics: • DNA and RNA synthesis and repair • Cell Division and Growth: • Cell cycle • Mitosis • Stem cells • Cellular Development: • Germ cells and fertilization • Limb development • From Cells to Organisms: • Cell differentiation • Systems biology

Author : Wallace F. Marshall
Publisher : Unknown
Page : 50 pages
File Size : 44,6 Mb
Release : 2017-07-20
Category : Electronic
ISBN : 1615047700

Get Book

Introduction to Quantitative Cell Biology by Wallace F. Marshall Pdf

For the past decade or more, much of cell biology research has been focused on determining the key molecules involved in different cellular processes, an analytical problem that has been amenable to biochemical and genetic approaches. Now, we face an integrative problem of understanding how all of these molecules work together to produce living cells, a challenge that requires using quantitative approaches to model the complex interactions within a cell, and testing those models with careful quantitative measurements. This book is an introductory overview of the various approaches, methods, techniques, and models employed in quantitative cell biology, which are reviewed in greater detail in the other volumes in this e-book series. Particular emphasis is placed on the goals and purpose of quantitative analysis and modeling, and the special challenges that cell biology holds for understanding life at the physical level.

Author : Angelo Carpi
Publisher : IntechOpen
Page : 662 pages
File Size : 44,9 Mb
Release : 2011-08-01
Category : Science
ISBN : 9533072687

Get Book

Progress in Molecular and Environmental Bioengineering by Angelo Carpi Pdf

This book provides an example of the successful and rapid expansion of bioengineering within the world of the science. It includes a core of studies on bioengineering technology applications so important that their progress is expected to improve both human health and ecosystem. These studies provide an important update on technology and achievements in molecular and cellular engineering as well as in the relatively new field of environmental bioengineering. The book will hopefully attract the interest of not only the bioengineers, researchers or professionals, but also of everyone who appreciates life and environmental sciences.

Author : James M. Bower,Hamid Bolouri
Publisher : MIT Press
Page : 386 pages
File Size : 52,7 Mb
Release : 2001
Category : Computers
ISBN : 0262524236

Get Book

Computational Modeling of Genetic and Biochemical Networks by James M. Bower,Hamid Bolouri Pdf

How new modeling techniques can be used to explore functionally relevant molecular and cellular relationships.

Author : Daniel Johnston,Samuel Miao-Sin Wu
Publisher : MIT Press
Page : 709 pages
File Size : 42,5 Mb
Release : 1994-11-02
Category : Medical
ISBN : 9780262293495

Get Book

Foundations of Cellular Neurophysiology by Daniel Johnston,Samuel Miao-Sin Wu Pdf

with simulations and illustrations by Richard Gray Problem solving is an indispensable part of learning a quantitative science such as neurophysiology. This text for graduate and advanced undergraduate students in neuroscience, physiology, biophysics, and computational neuroscience provides comprehensive, mathematically sophisticated descriptions of modern principles of cellular neurophysiology. It is the only neurophysiology text that gives detailed derivations of equations, worked examples, and homework problem sets (with complete answers). Developed from notes for the course that the authors have taught since 1983, Foundations of Cellular Neurophysiology covers cellular neurophysiology (also some material at the molecular and systems levels) from its physical and mathematical foundations in a way that is far more rigorous than other commonly used texts in this area.

Author : K. E. Bett,J. S. Rowlinson,G. Saville
Publisher : MIT Press (MA)
Page : 518 pages
File Size : 43,5 Mb
Release : 2003-02-01
Category : Technology & Engineering
ISBN : 0262523981

Get Book

Thermodynamics for Chemical Engineers by K. E. Bett,J. S. Rowlinson,G. Saville Pdf

This textbook covers the thermodynamics needed by chemical engineers both in their engineering and in their chemistry; it is intended for use in all undergraduate and some graduate-level courses. The authors emphasize a rigorous yet concise presentation of the fundamental chemical concepts governing the behavior of single and multicomponent mixtures, including phase and chemical equilibria. In the application of these concepts, consideration is given to the presentation of experimentally measured thermodynamic properties, and to their prediction for real fluids and their mixtures using methods founded on statistical mechanics. Several applications involving the transfer of heat and work that are of special importance to chemical engineers are studied in detail to show the use of thermodynamics in improving performance. The book is written in SI units and contains worked examples, exercises, and problems.

Author : Thomas K. Uchida,Scott L Delp
Publisher : MIT Press
Page : 396 pages
File Size : 45,7 Mb
Release : 2021-01-12
Category : Technology & Engineering
ISBN : 9780262359191

Get Book

Biomechanics of Movement by Thomas K. Uchida,Scott L Delp Pdf

An engaging introduction to human and animal movement seen through the lens of mechanics. How do Olympic sprinters run so fast? Why do astronauts adopt a bounding gait on the moon? How do running shoes improve performance while preventing injuries? This engaging and generously illustrated book answers these questions by examining human and animal movement through the lens of mechanics. The authors present simple conceptual models to study walking and running and apply mechanical principles to a range of interesting examples. They explore the biology of how movement is produced, examining the structure of a muscle down to its microscopic force-generating motors. Drawing on their deep expertise, the authors describe how to create simulations that provide insight into muscle coordination during walking and running, suggest treatments to improve function following injury, and help design devices that enhance human performance.

Author : Brian P. Ingalls
Publisher : MIT Press
Page : 423 pages
File Size : 48,7 Mb
Release : 2022-06-07
Category : Science
ISBN : 9780262545822

Get Book

Mathematical Modeling in Systems Biology by Brian P. Ingalls Pdf

An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology. Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels. The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3–8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.

Author : Cornell University
Publisher : Unknown
Page : 712 pages
File Size : 45,5 Mb
Release : 2006
Category : Universities and colleges
ISBN : CORNELL:31924101553729

Get Book

Cornell University Courses of Study by Cornell University Pdf