Radiation Damage In Biomolecular Systems

Author : Gustavo García Gómez-Tejedor,Martina Christina Fuss
Publisher : Springer Science & Business Media
Page : 508 pages
File Size : 41,9 Mb
Release : 2012-01-04
Category : Science
ISBN : 9789400725645

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Radiation Damage in Biomolecular Systems by Gustavo García Gómez-Tejedor,Martina Christina Fuss Pdf

Since the discovery of X-rays and radioactivity, ionizing radiations have been widely applied in medicine both for diagnostic and therapeutic purposes. The risks associated with radiation exposure and handling led to the parallel development of the field of radiation protection. Pioneering experiments done by Sanche and co-workers in 2000 showed that low-energy secondary electrons, which are abundantly generated along radiation tracks, are primarily responsible for radiation damage through successive interactions with the molecular constituents of the medium. Apart from ionizing processes, which are usually related to radiation damage, below the ionization level low-energy electrons can induce molecular fragmentation via dissociative processes such as internal excitation and electron attachment. This prompted collaborative projects between different research groups from European countries together with other specialists from Canada, the USA and Australia. This book summarizes the advances achieved by these research groups after more than ten years of studies on radiation damage in biomolecular systems. An extensive Part I deals with recent experimental and theoretical findings on radiation induced damage at the molecular level. It includes many contributions on electron and positron collisions with biologically relevant molecules. X-ray and ion interactions are also covered. Part II addresses different approaches to radiation damage modelling. In Part III biomedical aspects of radiation effects are treated on different scales. After the physics-oriented focus of the previous parts, there is a gradual transition to biology and medicine with the increasing size of the object studied. Finally, Part IV is dedicated to current trends and novel techniques in radiation reserach and the applications hence arising. It includes new developments in radiotherapy and related cancer therapies, as well as technical optimizations of accelerators and totally new equipment designs, giving a glimpse of the near future of radiation-based medical treatments.

Author : Gustavo García Gómez-Tejedor,Martina Christina Fuss
Publisher : Springer
Page : 510 pages
File Size : 53,9 Mb
Release : 2012-01-26
Category : Science
ISBN : 9400725655

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Radiation Damage in Biomolecular Systems by Gustavo García Gómez-Tejedor,Martina Christina Fuss Pdf

Since the discovery of X-rays and radioactivity, ionizing radiations have been widely applied in medicine both for diagnostic and therapeutic purposes. The risks associated with radiation exposure and handling led to the parallel development of the field of radiation protection. Pioneering experiments done by Sanche and co-workers in 2000 showed that low-energy secondary electrons, which are abundantly generated along radiation tracks, are primarily responsible for radiation damage through successive interactions with the molecular constituents of the medium. Apart from ionizing processes, which are usually related to radiation damage, below the ionization level low-energy electrons can induce molecular fragmentation via dissociative processes such as internal excitation and electron attachment. This prompted collaborative projects between different research groups from European countries together with other specialists from Canada, the USA and Australia. This book summarizes the advances achieved by these research groups after more than ten years of studies on radiation damage in biomolecular systems. An extensive Part I deals with recent experimental and theoretical findings on radiation induced damage at the molecular level. It includes many contributions on electron and positron collisions with biologically relevant molecules. X-ray and ion interactions are also covered. Part II addresses different approaches to radiation damage modelling. In Part III biomedical aspects of radiation effects are treated on different scales. After the physics-oriented focus of the previous parts, there is a gradual transition to biology and medicine with the increasing size of the object studied. Finally, Part IV is dedicated to current trends and novel techniques in radiation reserach and the applications hence arising. It includes new developments in radiotherapy and related cancer therapies, as well as technical optimizations of accelerators and totally new equipment designs, giving a glimpse of the near future of radiation-based medical treatments.

Author : Károly Tokési,Béla Sulik
Publisher : AIP Conference Proceedings (Nu
Page : 242 pages
File Size : 49,6 Mb
Release : 2008-12-11
Category : Medical
ISBN : UCSD:31822036967719

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Radiation Damage in Biomolecular Systems by Károly Tokési,Béla Sulik Pdf

The objective of the meeting was to review our progress in obtaining a detailed understanding of the fundamental interaction processes initiated by the deposition of various types of radiation within biological material. The program represents a strong interdisciplinary approach, covering the range from photon-, electron- and ion-molecule interactions, to the clinical applications.

Author : Anonim
Publisher : Unknown
Page : 220 pages
File Size : 55,9 Mb
Release : 2008
Category : Electronic
ISBN : OCLC:1132171896

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Radiation Damage in Biomolecular Systems by Anonim Pdf

Author : Institute of Physics Publishing (Iop)
Publisher : Unknown
Page : 165 pages
File Size : 40,7 Mb
Release : 2009-06-16
Category : Science
ISBN : 1605602426

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Radiation Damage in Biomolecular Systems 2007 by Institute of Physics Publishing (Iop) Pdf

Author : Gustavo García Gómez-Tejedor,Martina Christina Fuss
Publisher : Springer Science & Business Media
Page : 508 pages
File Size : 40,6 Mb
Release : 2012-01-05
Category : Science
ISBN : 9789400725638

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Radiation Damage in Biomolecular Systems by Gustavo García Gómez-Tejedor,Martina Christina Fuss Pdf

Since the discovery of X-rays and radioactivity, ionizing radiations have been widely applied in medicine both for diagnostic and therapeutic purposes. The risks associated with radiation exposure and handling led to the parallel development of the field of radiation protection. Pioneering experiments done by Sanche and co-workers in 2000 showed that low-energy secondary electrons, which are abundantly generated along radiation tracks, are primarily responsible for radiation damage through successive interactions with the molecular constituents of the medium. Apart from ionizing processes, which are usually related to radiation damage, below the ionization level low-energy electrons can induce molecular fragmentation via dissociative processes such as internal excitation and electron attachment. This prompted collaborative projects between different research groups from European countries together with other specialists from Canada, the USA and Australia. This book summarizes the advances achieved by these research groups after more than ten years of studies on radiation damage in biomolecular systems. An extensive Part I deals with recent experimental and theoretical findings on radiation induced damage at the molecular level. It includes many contributions on electron and positron collisions with biologically relevant molecules. X-ray and ion interactions are also covered. Part II addresses different approaches to radiation damage modelling. In Part III biomedical aspects of radiation effects are treated on different scales. After the physics-oriented focus of the previous parts, there is a gradual transition to biology and medicine with the increasing size of the object studied. Finally, Part IV is dedicated to current trends and novel techniques in radiation reserach and the applications hence arising. It includes new developments in radiotherapy and related cancer therapies, as well as technical optimizations of accelerators and totally new equipment designs, giving a glimpse of the near future of radiation-based medical treatments.

Author : Shirley Lehnert
Publisher : CRC Press
Page : 560 pages
File Size : 49,9 Mb
Release : 2007-10-24
Category : Science
ISBN : 9781420011920

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Biomolecular Action of Ionizing Radiation by Shirley Lehnert Pdf

Embracing the transformation of radiation sciences by the recent surge of developments in molecular biology, this progressive text offers an up-to-date analysis of in vitro and in vivo molecular responses in the body induced by ionizing radiation. With a unique emphasis on medical physics applications, Biomolecular Action of Ionizing Radiation also presents a much needed, in-depth perspective on clinical applications for the treatment of cancer and radiation injuries. Based on a popular course given by the author at McGill University,the bookplaces the traditional tenets of radiation biology in the context of contemporary cell and molecular biology. Using terms that non-experts in molecular biology can understand, it clarifies the underlying mechanisms of radiation effects on molecular interactions including signal transduction pathways, modes of cell killing, and non-targeted effects. The author subsequently associates key principles and advances with potential applications, including the use of ionizing radiation as a cytotoxic and cytostatic agent, and radiosensitization by targeting molecular intermediates or signaling molecules involved in radiation-induced processes. Raising the standard for radiation biology texts that are currently available, Biomolecular Action of Ionizing Radiation is an outstanding resource for advanced undergraduate and graduate students in medical physics, radiation oncology, radiation biology, and those who have an interest in the radiation sciences and in cancer treatment.

Author : Arnold Hicks Sparrow,Benjamin Arnold Rubin
Publisher : Unknown
Page : 62 pages
File Size : 45,9 Mb
Release : 1955
Category : Radiation
ISBN : UOM:39015086579516

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Effects of Radiation on Biological Systems by Arnold Hicks Sparrow,Benjamin Arnold Rubin Pdf

Author : William A. Glass,Matesh N. Varma
Publisher : Springer Science & Business Media
Page : 512 pages
File Size : 48,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468476279

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Physical and Chemical Mechanisms in Molecular Radiation Biology by William A. Glass,Matesh N. Varma Pdf

The fundamental understanding of the production of biological effects by ionizing radiation may well be one of the most important scientific objectives of mankind; such understanding could lead to the effective and safe utilization of the nuclear energy option. In addition, this knowledge will be of immense value in such diverse fields as radiation therapy and diagnosis and in the space program. To achieve the above stated objective, the U. S. Department of Energy (DOE) and its predecessors embarked upon a fundamental interdisciplinary research program some 35 years ago. A critical component of this program is the Radiological and Chemical Physics Program (RCPP). When the RCPP was established, there was very little basic knowledge in the fields of physics, chemistry, and biology that could be directly applied to understanding the effects of radiation on biological systems. Progress of the RCPP program in its first 15 years was documented in the proceedings of a conference held at Airlie, Virginia, in 1972. At this conference, it was clear that considerable progr:ess had been made in research on the physical and chemical processes in well-characterized systems that could be used to understand biological effects. During this period of time, most physical knowledge was obtained for the gas phase because the technology and instru mentation had not progressed to the point that measurements could be made in liquids more characteristic of biological materials.

Author : Waldemar Alfredo Monteiro
Publisher : BoD – Books on Demand
Page : 464 pages
File Size : 45,8 Mb
Release : 2016-07-20
Category : Science
ISBN : 9789535124177

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Radiation Effects in Materials by Waldemar Alfredo Monteiro Pdf

The study of radiation effects has developed as a major field of materials science from the beginning, approximately 70 years ago. Its rapid development has been driven by two strong influences. The properties of the crystal defects and the materials containing them may then be studied. The types of radiation that can alter structural materials consist of neutrons, ions, electrons, gamma rays or other electromagnetic waves with different wavelengths. All of these forms of radiation have the capability to displace atoms/molecules from their lattice sites, which is the fundamental process that drives the changes in all materials. The effect of irradiation on materials is fixed in the initial event in which an energetic projectile strikes a target. The book is distributed in four sections: Ionic Materials; Biomaterials; Polymeric Materials and Metallic Materials.

Author : J. E. Coggle
Publisher : Taylor & Francis Group
Page : 268 pages
File Size : 41,5 Mb
Release : 1983
Category : Radiation
ISBN : UOM:39015006688876

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Biological Effects of Radiation by J. E. Coggle Pdf

Author : Ilia A. Solov'yov,Alexey V. Verkhovtsev,Andrei V. Korol,Andrey V. Solov'yov
Publisher : Springer Nature
Page : 554 pages
File Size : 40,7 Mb
Release : 2022-06-03
Category : Science
ISBN : 9783030992910

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Dynamics of Systems on the Nanoscale by Ilia A. Solov'yov,Alexey V. Verkhovtsev,Andrei V. Korol,Andrey V. Solov'yov Pdf

This book presents the structure formation and dynamics of animate and inanimate matter on the nanometre scale. This is a new interdisciplinary field known as Meso-Bio-Nano (MBN) science that lies at the intersection of physics, chemistry, biology and material science. Special attention in the book is devoted to investigations of the structure, properties and dynamics of complex MBN systems by means of photonic, electronic, heavy particle and atomic collisions. This includes problems of fusion and fission, fragmentation, surfaces and interfaces, reactivity, nanoscale phase and morphological transitions, irradiation-driven transformations of complex molecular systems, collective electron excitations, radiation damage and biodamage, channeling phenomena and many more. Emphasis in the book is placed on the theoretical and computational physics research advances in these areas and related state-of-the-art experiments. Particular attention in the book is devoted to the utilization of advanced computational techniques and high-performance computing in studies of the dynamics of systems.

Author : Andrey V. Solov’yov
Publisher : Springer
Page : 498 pages
File Size : 47,7 Mb
Release : 2016-12-07
Category : Science
ISBN : 9783319430300

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Nanoscale Insights into Ion-Beam Cancer Therapy by Andrey V. Solov’yov Pdf

This book provides a unique and comprehensive overview of state-of-the-art understanding of the molecular and nano-scale processes that play significant roles in ion-beam cancer therapy. It covers experimental design and methodology, and reviews the theoretical understanding of the processes involved. It offers the reader an opportunity to learn from a coherent approach about the physics, chemistry and biology relevant to ion-beam cancer therapy, a growing field of important medical application worldwide. The book describes phenomena occurring on different time and energy scales relevant to the radiation damage of biological targets and ion-beam cancer therapy from the molecular (nano) scale up to the macroscopic level. It illustrates how ion-beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue whilst maximizing cell-killing within the tumour, offering a significant development in cancer therapy. The full potential of such therapy can only be realized by better understanding the physical, chemical and biological mechanisms, on a range of time and space scales that lead to cell death under ion irradiation. This book describes how, using a multiscale approach, experimental and theoretical expertise available can lead to greater insight at the nanoscopic and molecular level into radiation damage of biological targets induced by ion impact. The book is intended for advanced students and specialists in the areas of physics, chemistry, biology and medicine related to ion-beam therapy, radiation protection, biophysics, radiation nanophysics and chemistry, atomic and molecular physics, condensed matter physics, and the physics of interaction of charged particles with matter. One of the most important features of the book is the inclusive multiscale approach to the understanding of complex and highly interdisciplinary processes behind ion-beam cancer therapy, which stretches from the atomistic level up to the biological scale and is demonstrated to be in excellent agreement with experimental observations.

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V)
Publisher : National Academies
Page : 436 pages
File Size : 55,8 Mb
Release : 1990-02-01
Category : Science
ISBN : 9780309039956

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Health Effects of Exposure to Low Levels of Ionizing Radiation by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V) Pdf

This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.

Author : Oddur Ingólfsson
Publisher : CRC Press
Page : 274 pages
File Size : 42,5 Mb
Release : 2019-04-23
Category : Science
ISBN : 9780429602764

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Low-Energy Electrons by Oddur Ingólfsson Pdf

Low-energy electrons are ubiquitous in nature and play an important role in natural phenomena as well as many potential and current industrial processes. Authored by 16 active researchers, this book describes the fundamental characteristics of low-energy electron–molecule interactions and their role in different fields of science and technology, including plasma processing, nanotechnology, and health care, as well as astro- and atmospheric physics and chemistry. The book is packed with illustrative examples, from both fundamental and application sides, features about 130 figures, and lists over 800 references. It may serve as an advanced graduate-level study course material where selected chapters can be used either individually or in combination as a basis to highlight and study specific aspects of low-energy electron–molecule interactions. It is also directed at researchers in the fields of plasma physics, nanotechnology, and radiation damage to biologically relevant material (such as in cancer therapy), especially those with an interest in high-energy-radiation-induced processes, from both an experimental and a theoretical point of view.