Radical And Radical Ion Reactivity In Nucleic Acid Chemistry

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Radical and Radical Ion Reactivity in Nucleic Acid Chemistry

Michael D. Greenberg
Radical and Radical Ion Reactivity in Nucleic Acid Chemistry Book PDF

Author : Michael D. Greenberg
Publisher : John Wiley & Sons
Page : 400 pages
File Size : 43,8 Mb
Release : 2009-09-22
Category : Science
ISBN : 9780470526262

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Radical and Radical Ion Reactivity in Nucleic Acid Chemistry by Michael D. Greenberg Pdf

Comprehensive coverage of radical reactive intermediates in nucleic acid chemistry and biochemistry The Wiley Series on Reactive Intermediates in Chemistry and Biology investigates reactive intermediates from the broadest possible range of disciplines. The contributions in each volume offer readers fresh insights into the latest findings, emerging applications, and ongoing research in the field from a diverse perspective. The chemistry and biochemistry of reactive intermediates is central to organic chemistry and biochemistry, and underlies a significant portion of modern synthetic chemistry. Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides the only comprehensive review of the chemistry and biochemistry of nucleic acid radical intermediates. With contributions by world leaders in the field, the text covers a broad range of topics, including: A discussion of the relevant theory Ionization of DNA Nucleic acid sugar radicals Halopyrimidines Oxidative, reductive, and low energy electron transfer Electron affinity sensitizers Photochemical generative of reactive oxygen species Reactive nitrogen species Enediyne rearrangements Phenoxyl radicals A unique compilation on the cutting edge of our understanding, Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides an unparalleled resource to student and professional researchers in such fields as organic chemistry, biochemistry, molecular biology, and physical chemistry, as well as the industries associated with these disciplines.

Applications of EPR in Radiation Research

Anders Lund,Masaru Shiotani
Applications of EPR in Radiation Research Book PDF

Author : Anders Lund,Masaru Shiotani
Publisher : Springer
Page : 773 pages
File Size : 48,9 Mb
Release : 2014-10-20
Category : Science
ISBN : 9783319092164

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Applications of EPR in Radiation Research by Anders Lund,Masaru Shiotani Pdf

Applications of EPR in Radiation Research is a multi-author contributed volume presented in eight themes: I. Elementary radiation processes (in situ and low temperature radiolysis, quantum solids); II: Solid state radiation chemistry (crystalline, amorphous and heterogeneous systems); III: Biochemistry, biophysics and biology applications (radicals in biomaterials, spin trapping, free-radical-induced DNA damage); IV: Materials science (polymeric and electronic materials, materials for treatment of nuclear waste, irradiated food); V: Radiation metrology (EPR-dosimetry, retrospective and medical applications); VI: Geological dating; VII: Advanced techniques (PELDOR, ESE and ENDOR spectroscopy, matrix isolation); VIII: Theoretical tools (density-functional calculations, spectrum simulations).

Encyclopedia of Astrobiology

Muriel Gargaud,Ricardo Amils
Encyclopedia of Astrobiology Book PDF

Author : Muriel Gargaud,Ricardo Amils
Publisher : Springer Science & Business Media
Page : 1890 pages
File Size : 50,7 Mb
Release : 2011-05-26
Category : Body, Mind & Spirit
ISBN : 9783642112713

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Encyclopedia of Astrobiology by Muriel Gargaud,Ricardo Amils Pdf

Astrobiology is a remarkably interdisciplinary field. This reference serves as a key to understanding technical terms from the different subfields of astrobiology, including astronomy, biology, chemistry, the geosciences and the space sciences.

DNA Damage, DNA Repair and Disease

Miral Dizdaroglu,R Stephen Lloyd
DNA Damage DNA Repair and Disease Book PDF

Author : Miral Dizdaroglu,R Stephen Lloyd
Publisher : Royal Society of Chemistry
Page : 509 pages
File Size : 48,5 Mb
Release : 2020-11-11
Category : Science
ISBN : 9781839162565

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DNA Damage, DNA Repair and Disease by Miral Dizdaroglu,R Stephen Lloyd Pdf

The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.

Practical Aspects of Computational Chemistry III

Jerzy Leszczynski,Manoj K. Shukla
Practical Aspects of Computational Chemistry III Book PDF

Author : Jerzy Leszczynski,Manoj K. Shukla
Publisher : Springer Science & Business
Page : 436 pages
File Size : 44,5 Mb
Release : 2014-04-23
Category : Science
ISBN : 9781489974457

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Practical Aspects of Computational Chemistry III by Jerzy Leszczynski,Manoj K. Shukla Pdf

Theoretical and Computational Chemistry research has made unparalleled advancements in understanding every expanding area of science and technology. This volume presents the state-of-the-art research and progress made by eminent researchers in the area of theoretical computational chemistry and physics. The title mirrors the name of the annual international conference “Conference on Current Trends on Computational Chemistry” (CCTCC) which has become a popular discussion ground for eminent Theoretical and Computational Chemists and has been honored by the presence of several Nobel Laureates. Practical Aspects of Computational Chemistry III is aimed at theoretical and computational chemists, physical chemists, material scientists and those who are eager to apply computational chemistry methods to problems of chemical and physical importance. The book is a valuable resource for undergraduate, graduate and PhD students as well as established researchers.

Handbook of Computational Chemistry

Jerzy Leszczynski
Handbook of Computational Chemistry Book PDF

Author : Jerzy Leszczynski
Publisher : Springer Science & Business Media
Page : 1451 pages
File Size : 45,7 Mb
Release : 2012-01-13
Category : Science
ISBN : 9789400707115

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Handbook of Computational Chemistry by Jerzy Leszczynski Pdf

The role the Handbook of Computational Chemistry is threefold. It is primarily intended to be used as a guide that navigates the user through the plethora of computational methods currently in use; it explains their limitations and advantages; and it provides various examples of their important and varied applications. This reference work is presented in three volumes. Volume I introduces the different methods used in computational chemistry. Basic assumptions common to the majority of computational methods based on molecular, quantum, or statistical mechanics are outlined and special attention is paid to the limits of their applicability. Volume II portrays the applications of computational methods to model systems and discusses in detail molecular structures, the modelling of various properties of molecules and chemical reactions. Both ground and excited states properties are covered in the gas phase as well as in solution. This volume also describes Nanomaterials and covers topics such as clusters, periodic, and nano systems. Special emphasis is placed on the environmental effects of nanostructures. Volume III is devoted to the important class of Biomolecules. Useful models of biological systems considered by computational chemists are provided and RNA, DNA and proteins are discussed in detail. This volume presents examples of calcualtions of their properties and interactions and reveals the role of solvents in biologically important reactions as well as the structure function relationship of various classes of Biomolecules.

Reviews in Computational Chemistry

Abby L. Parrill,Kenny B. Lipkowitz
Reviews in Computational Chemistry Book PDF

Author : Abby L. Parrill,Kenny B. Lipkowitz
Publisher : John Wiley & Sons
Page : 560 pages
File Size : 49,8 Mb
Release : 2015-04-29
Category : Science
ISBN : 9781118889930

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Reviews in Computational Chemistry by Abby L. Parrill,Kenny B. Lipkowitz Pdf

The Reviews in Computational Chemistry series brings together leading authorities in the field to teach the newcomer and update the expert on topics centered around molecular modeling, such as computer-assisted molecular design (CAMD), quantum chemistry, molecular mechanics and dynamics, and quantitative structure-activity relationships (QSAR). This volume, like those prior to it, features chapters by experts in various fields of computational chemistry. Topics in Volume 28 include: Free-energy Calculations with Metadynamics Polarizable Force Fields for Biomolecular Modeling Modeling Protein Folding Pathways Assessing Structural Predictions of Protein-Protein Recognition Kinetic Monte Carlo Simulation of Electrochemical Systems Reactivity and Dynamics at Liquid Interfaces

Low-Energy Electron Scattering from Molecules, Biomolecules and Surfaces

Petr Carsky,Roman Curik
Low Energy Electron Scattering from Molecules Biomolecules and Surfaces Book PDF

Author : Petr Carsky,Roman Curik
Publisher : CRC Press
Page : 296 pages
File Size : 40,7 Mb
Release : 2016-04-19
Category : Science
ISBN : 9781439839119

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Low-Energy Electron Scattering from Molecules, Biomolecules and Surfaces by Petr Carsky,Roman Curik Pdf

Since the turn of the 21st century, the field of electron molecule collisions has undergone a renaissance. The importance of such collisions in applications from radiation chemistry to astrochemistry has flowered, and their role in industrial processes such as plasma technology and lighting are vital to the advancement of next generation devices. Furthermore, the development of the scanning tunneling microscope highlights the role of such collisions in the condensed phase, in surface processing, and in the development of nanotechnology. Low-Energy Electron Scattering from Molecules, Biomolecules and Surfaces highlights recent progress in the theory and experiment of electron-molecule collisions, providing a detailed review of the current state of knowledge of electron molecule scattering—theoretical and experimental—for the general physicist and chemist interested in solving practical problems. In few other branches of science is the collaboration between theorists and experimentalists so topical. Covering advancements in practical problems, such as those met in plasma physics, microelectronics, nanolithography, DNA research, atmospheric chemistry, and astrochemistry, this book describes the formal general scattering theory and description of the experimental setup at a level the interested non-expert can appreciate.

Contemporary Carbene Chemistry

Robert A. Moss,Michael P. Doyle
Contemporary Carbene Chemistry Book PDF

Author : Robert A. Moss,Michael P. Doyle
Publisher : John Wiley & Sons
Page : 506 pages
File Size : 49,8 Mb
Release : 2013-10-17
Category : Science
ISBN : 9781118730263

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Contemporary Carbene Chemistry by Robert A. Moss,Michael P. Doyle Pdf

Presents the most innovative results in carbene chemistry, setting the foundation for new discoveries and applications The discovery of stable carbenes has reinvigorated carbene chemistry research, with investigators seeking to develop carbenes into new useful catalysts and ligands. Presenting the most innovative and promising areas of carbene research over the past decade, this book explores newly discovered structural, catalytic, and organometallic aspects of carbene chemistry, with an emphasis on new and emerging synthetic applications. Contemporary Carbene Chemistry features contributions from an international team of pioneering carbene chemistry researchers. Collectively, these authors have highlighted the most interesting and promising areas of investigation in the field. The book is divided into two parts: Part 1, Properties and Reactions of Carbenes, explores new findings on carbene stability, acid-base behavior, and catalysis. Carbenic structure and reactivity are examined in chapters dedicated to stable carbenes, carbodicarbenes, carbenes as guests in supramolecular hosts, tunneling in carbene and oxacarbene reactions, and ultrafast kinetics of carbenes and their excited state precursors. Theoretical concerns are addressed in chapters on computational methods and dynamics applied to carbene reactions. Part 2, Metal Carbenes, is dedicated to the synthetic dimensions of carbenes, particularly the reactions and catalytic properties of metal carbenes. The authors discuss lithium, rhodium, ruthenium, chromium, molybdenum, tungsten, cobalt, and gold. All the chapters conclude with a summary of the current situation, new challenges on the horizon, and promising new research directions. A list of key reviews and suggestions for further reading also accompanies every chapter. Each volume of the Wiley Series on Reactive Intermediates in Chemistry and Biology focuses on a specific reactive intermediate, offering a broad range of perspectives from leading experts that sets the stage for new applications and further discoveries.

Oxidation of Amino Acids, Peptides, and Proteins

Virender K. Sharma,Steven E. Rokita
Oxidation of Amino Acids Peptides and Proteins Book PDF

Author : Virender K. Sharma,Steven E. Rokita
Publisher : John Wiley & Sons
Page : 349 pages
File Size : 49,5 Mb
Release : 2012-11-06
Category : Science
ISBN : 9781118482452

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Oxidation of Amino Acids, Peptides, and Proteins by Virender K. Sharma,Steven E. Rokita Pdf

Explains the role of reactive intermediates in biological systems as well as in environmental remediation With its clear and systematic approach, this book examined the broad range of reactive intermediate that can be generated in biological environments, detailing the fundamental properties of each reactive intermediate. Readers gain a contemporary understanding of how these intermediates react with different compounds, with an emphasis on amino acids, peptides, and proteins. The author not only sets forth the basic chemistry and nature of reactive intermediates, he also demonstrates how the properties of the intermediates presented in the book compare with each other. Oxidation of Amino Acids, Peptides, and Proteins begins with a discussion of radical and non-radical reactive species as well as an exploration of the significance of reactive species in the atmosphere, disinfection processes, and environmental remediation. Next, the book covers such topics as: Thermodynamics of amino acids and reactive species and the effect of metal-ligand binding in oxidation chemistry Kinetics and mechanisms of reactive halogen, oxygen, nitrogen, carbon, sulfur and phosphate species as well as reactive high-valent Cr, Mn, and Fe species Reactivity of the species with molecules of biological and environmental importance Generation of reactive species in the laboratory for kinetics studies Oxidation of amino acids, peptides, and proteins by permanganate, ferryl, and ferrate species Application of reactive species in purifying water and treating wastewater With this book as their guide, readers will be able to assess the overall effects of reactive intermediates in biological environments. Moreover, they’ll learn how to apply this knowledge for successful water purification and wastewater treatment.

Copper-Oxygen Chemistry

Kenneth D. Karlin,Shinobu Itoh,Steven Rokita
Copper Oxygen Chemistry Book PDF

Author : Kenneth D. Karlin,Shinobu Itoh,Steven Rokita
Publisher : John Wiley & Sons
Page : 417 pages
File Size : 51,8 Mb
Release : 2011-08-24
Category : Science
ISBN : 9781118094358

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Copper-Oxygen Chemistry by Kenneth D. Karlin,Shinobu Itoh,Steven Rokita Pdf

Covers the vastly expanding subject of oxidative processes mediated by copper ions within biological systems Copper-mediated biological oxidations offer a broad range of fundamentally important and potentially practical chemical processes that cross many chemical and pharmaceutical disciplines. This newest volume in the Wiley Series on Reactive Intermediates in Chemistry and Biology is divided into three logical areas within the topic of copper/oxygen chemistry— biological systems, theory, and bioinorganic models and applications—to explore the biosphere for its highly evolved and thus efficient oxidative transformations in the discovery of new types of interactions between molecular oxygen and copper ion. Featuring a diverse collection of subject matter unified in one complete and comprehensive resource, Copper-Oxygen Chemistry probes the fundamental aspects of copper coordination chemistry, synthetic organic chemistry, and biological chemistry to reveal both the biological and chemical aspects driving the current exciting research efforts behind copper-oxygen chemistry. In addition, Copper-Oxygen Chemistry: Addresses the significantly increasing literature on oxygen-atom insertion and carbon-carbon bond-forming reactions as well as enantioselective oxidation chemistries Progresses from biological systems to spectroscopy and theory, and onward to bioinorganic models and applications Covers a wide array of reaction types such as insertion and dehydrogenation reactions that utilize the cheap, abundant, and energy-containing O2 molecule With thorough coverage by prominent authors and researchers shaping innovations in this growing field, this valuable reference is essential reading for bioinorganic chemists, as well as organic, synthetic, and pharmaceutical chemists in academia and industry.

Molecular Basis of Oxidative Stress

Frederick A. Villamena
Molecular Basis of Oxidative Stress Book PDF

Author : Frederick A. Villamena
Publisher : John Wiley & Sons
Page : 730 pages
File Size : 51,8 Mb
Release : 2013-06-06
Category : Science
ISBN : 9781118355879

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Molecular Basis of Oxidative Stress by Frederick A. Villamena Pdf

Sets the stage for the development of better diagnostic techniques and therapeutics Featuring contributions from an international team of leading clinicians and biomedical researchers, Molecular Basis of Oxidative Stress reviews the molecular and chemical bases of oxidative stress, describing how oxidative stress can lead to the development of cancer and cardiovascular and neurodegenerative diseases. Moreover, it explains the potential role of free radicals in both the diagnosis and the development of therapeutics to treat disease. Molecular Basis of Oxidative Stress is logically organized, beginning with a comprehensive discussion of the fundamental chemistry of reactive species. Next, the book: Presents new mechanistic insights into how oxidative damage of biomolecules occurs Examines how these oxidative events effect cellular metabolism Investigates the role of oxidative stress in the pathogenesis of cancer, neurodegenerative disease, cardiovascular disease, and cystic fibrosis Explores opportunities to improve the diagnosis of disease and the design of new therapeutic agents Readers will find much novel information, including new radical chemistries and the latest discoveries of how free radicals react with biomolecules. The contributors also present recent findings that help us better understand the initiation of oxidative stress and the mechanisms leading to the pathogenesis of various diseases. Throughout the book, the use of molecular structures helps readers better understand redox chemistry. In addition, plenty of detailed figures illustrate the mechanisms of oxidative stress and disease pathogenesis. Examining everything from the basic chemistry of oxidative stress to the pathogenesis of disease, Molecular Basis of Oxidative Stress will help readers continue to explore the nature of oxidative stress and then use that knowledge to develop new approaches to prevent, detect, and treat a broad range of disease conditions.

Radiation in Bioanalysis

Alice S. Pereira,Pedro Tavares,Paulo Limão-Vieira
Radiation in Bioanalysis Book PDF

Author : Alice S. Pereira,Pedro Tavares,Paulo Limão-Vieira
Publisher : Springer Nature
Page : 397 pages
File Size : 43,8 Mb
Release : 2019-09-21
Category : Science
ISBN : 9783030282479

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Radiation in Bioanalysis by Alice S. Pereira,Pedro Tavares,Paulo Limão-Vieira Pdf

This book describes the state of the art across the broad range of spectroscopic techniques used in the study of biological systems. It reviews some of the latest advances achieved in the application of these techniques in the analysis and characterization of small and large biological compounds, covering topics such as VUV/UV and UV-visible spectroscopies, fluorescence spectroscopy, IR and Raman techniques, dynamic light scattering (DLS), circular dichroism (CD/SR-CD), pulsed electron paramagnetic resonance techniques, Mössbauer spectroscopy, nuclear magnetic resonance, X-ray methods and electron and ion impact spectroscopies. The second part of the book focuses on modelling methods and illustrates how these tools have been used and integrated with other experimental and theoretical techniques including also electron transfer processes and fast kinetics methods. The book will benefit students, researchers and professionals working with these techniques to understand the fundamental mechanisms of biological systems.

Metal Ions in Biological Systems

Astrid Sigel,Helmut Sigel
Metal Ions in Biological Systems Book PDF

Author : Astrid Sigel,Helmut Sigel
Publisher : CRC Press
Page : 736 pages
File Size : 43,7 Mb
Release : 1996-02-29
Category : Science
ISBN : 0824796888

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Metal Ions in Biological Systems by Astrid Sigel,Helmut Sigel Pdf

"Volume 33 focuses on the vibrant research area of probing nucleic acids--the carriers of the genetic code--by metal ion complexes of small molecules providing an authoritative, timely account of this fascinating topic by over 50 distinguished experts."

Environmental Toxicology

Edward A. Laws
Environmental Toxicology Book PDF

Author : Edward A. Laws
Publisher : Springer Science & Business Media
Page : 737 pages
File Size : 44,9 Mb
Release : 2012-12-12
Category : Science
ISBN : 9781461457640

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Environmental Toxicology by Edward A. Laws Pdf

Environmental Toxicology provides a detailed, comprehensive introduction to this key area of sustainability and public health research. The broad coverage includes sections on ecological risk assessment, monitoring, mechanisms, fate and transport, prevention, and correctives, as well as treatment of the health effects of solar radiation and toxicology in the ocean. The 23 state-of-the-art chapters provide a multi-disciplinary perspective on this vital area, which encompasses environmental science, biology, chemistry, and public health.