Recent Advancements In Biomarkers And Detection Of Gastrointestinal Cancers

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Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers

Pallaval Veera Bramhachari,Nageswara Rao Reddy Neelapu
Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers Book PDF

Author : Pallaval Veera Bramhachari,Nageswara Rao Reddy Neelapu
Publisher : Springer Nature
Page : 238 pages
File Size : 43,7 Mb
Release : 2020-07-21
Category : Medical
ISBN : 9789811544316

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Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers by Pallaval Veera Bramhachari,Nageswara Rao Reddy Neelapu Pdf

This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.

Recent Advancements in Biomarkers and Detection of Gastrointestinal Cancers

Mikhael Kular
Recent Advancements in Biomarkers and Detection of Gastrointestinal Cancers Book PDF

Author : Mikhael Kular
Publisher : American Medical Publishers
Page : 0 pages
File Size : 47,9 Mb
Release : 2023-09-19
Category : Health & Fitness
ISBN : 9798887404196

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Recent Advancements in Biomarkers and Detection of Gastrointestinal Cancers by Mikhael Kular Pdf

A biomarker is a biological molecule present in the blood, other body fluids or tissues, that indicates normal or abnormal process, condition or a disease. It can act as an alternative tool and is helpful in selecting accurate treatment in various diseases. Gastrointestinal cancer is a malignant condition affecting gastrointestinal tract and organs of the digestive system including the stomach, pancreas, esophagus, small and large intestine, biliary system, rectum and anus. In the case of esophageal cancer, methylation of DNA can be used as a biomarker for early detection because methylation patterns appear in the initial stages. Protein biomarkers are utilized as markers for gastric tumor for effective diagnosis, prognosis and checking for recurrence of cancer after treatment. Various biomarkers that are utilized in case of stomach cancer include antigens like CA12-5 and CA72-4 as well as alpha-fetoprotein. This book provides comprehensive insights on biomarkers. The topics covered herein deal with the core aspects of the detection of gastrointestinal cancers through biomarkers. This book will serve as a reference to a broad spectrum of readers.

Biomarkers, Functional Mechanisms, and Therapeutic Potentials in Gastrointestinal Cancers

Zequn Li,Kui Zhang,Qun Zhang,Huashan Shi,Dongshi Chen
Biomarkers Functional Mechanisms and Therapeutic Potentials in Gastrointestinal Cancers Book PDF

Author : Zequn Li,Kui Zhang,Qun Zhang,Huashan Shi,Dongshi Chen
Publisher : Frontiers Media SA
Page : 467 pages
File Size : 42,9 Mb
Release : 2023-11-17
Category : Medical
ISBN : 9782832538982

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Biomarkers, Functional Mechanisms, and Therapeutic Potentials in Gastrointestinal Cancers by Zequn Li,Kui Zhang,Qun Zhang,Huashan Shi,Dongshi Chen Pdf

Significant changes in diet, environment, and population increase gastrointestinal cancer morbidity. A growing number of novel biomarkers and underlying mechanisms are being elucidated, some of which may even conflict with assumptions of past decades. Therefore, collecting recent findings on novel diagnostic/prognostic factors, biomarkers, and/or risk factors in gastrointestinal cancers is a prerequisite for a better understanding of the disease. Despite remarkable progressions in surgical treatments and chemotherapies, the prognosis of gastrointestinal cancer is far from satisfactory due to the high occurrence of drug resistance. Based on the identification of novel biomarkers as well as their underlying mechanisms, targeted drug development will provide significant complementary therapeutic effects to conventional chemoradiotherapies. High-throughput methods such as next-generation sequencing on RNA level and mass spectrometry on protein/lipid/metabolite level serve as efficient strategies for biomarker identification and drug development. This Research Topic aims at presenting recent advances on gastrointestinal cancer biomarkers and their underlying functional mechanisms, providing a better understanding of carcinogenesis, tumor progression, tumor relapse, as well as drug resistance. This will subsequently contribute to the development of novel therapeutic interventions targeting gastrointestinal cancers, thus improving patients' outcomes.

Novel Biomarkers of Gastrointestinal Cancer

Takaya Shimura
Novel Biomarkers of Gastrointestinal Cancer Book PDF

Author : Takaya Shimura
Publisher : Unknown
Page : 0 pages
File Size : 44,5 Mb
Release : 2022
Category : Electronic
ISBN : 3036549323

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Novel Biomarkers of Gastrointestinal Cancer by Takaya Shimura Pdf

Gastrointestinal (GI) cancer is a major cause of morbidity and mortality in the world. Since early diagnosis and optimal treatment selection are crucial to improving the prognosis of these diseases, the discovery of useful biomarkers has the potential to greatly reduce their burden. Recent technical and mechanical developments have allowed for the detection of tiny differences in various factors modified in physical conditions, which could contribute to the discovery of novel biomarkers for some diseases.In this Special Issue, we aim to focus on novel biomarkers for GI cancers, including esophageal cancer, gastric cancer, colorectal cancer, liver cancer, pancreatic cancer and biliary cancer. In addition, any samples (tissue, blood, urine and feces) are useful as biomarker sources, although body-fluid-based biomarkers are promising as diagnostic biomarkers due to their noninvasiveness. This Special Issue aims to collect novel insights clarifying the current situation and future perspective in this field.

Gastrointestinal Cancers: An Interdisciplinary Approach

Nima Rezaei
Gastrointestinal Cancers An Interdisciplinary Approach Book PDF

Author : Nima Rezaei
Publisher : Springer Nature
Page : 405 pages
File Size : 49,6 Mb
Release : 2024-01-01
Category : Medical
ISBN : 9783031483714

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Gastrointestinal Cancers: An Interdisciplinary Approach by Nima Rezaei Pdf

Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.

Novel therapeutic approaches for gastrointestinal malignancies

Ganji Purnachandra Nagaraju,Sujatha Peela
Novel therapeutic approaches for gastrointestinal malignancies Book PDF

Author : Ganji Purnachandra Nagaraju,Sujatha Peela
Publisher : Springer Nature
Page : 259 pages
File Size : 46,7 Mb
Release : 2020-10-01
Category : Medical
ISBN : 9789811554711

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Novel therapeutic approaches for gastrointestinal malignancies by Ganji Purnachandra Nagaraju,Sujatha Peela Pdf

This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.

Molecular Pathogenesis of Colorectal Cancer

Kevin M. Haigis, Ph.D.
Molecular Pathogenesis of Colorectal Cancer Book PDF

Author : Kevin M. Haigis, Ph.D.
Publisher : Springer Science & Business Media
Page : 319 pages
File Size : 44,8 Mb
Release : 2013-10-02
Category : Medical
ISBN : 9781461484127

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Molecular Pathogenesis of Colorectal Cancer by Kevin M. Haigis, Ph.D. Pdf

Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.

Role of Biomarkers in Medicine

Mu Wang,Frank Witzmann
Role of Biomarkers in Medicine Book PDF

Author : Mu Wang,Frank Witzmann
Publisher : BoD – Books on Demand
Page : 262 pages
File Size : 43,9 Mb
Release : 2016-08-17
Category : Medical
ISBN : 9789535125051

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Role of Biomarkers in Medicine by Mu Wang,Frank Witzmann Pdf

The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management.

Oncogenic Viruses Volume 2

Moulay Mustapha Ennaji
Oncogenic Viruses Volume 2 Book PDF

Author : Moulay Mustapha Ennaji
Publisher : Academic Press
Page : 417 pages
File Size : 54,7 Mb
Release : 2022-09-14
Category : Science
ISBN : 9780323859165

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Oncogenic Viruses Volume 2 by Moulay Mustapha Ennaji Pdf

Oncogenic Viruses: Medical Applications of Viral Oncology Research, Volume Two builds on the introductory overview of Volume One, Oncogenic Viruses: Fundamentals of Oncogenic Viruses. It looks at recent advances and medical application of research studies on oncoviruses, including examining oncoviruses on a molecular level, covers diagnostic and prognostic viral biomarkers and identifying biomarkers in specific human cancers, and delves into prevention, treatment and the future of cancer therapy of oncoviruses, antiviral activities and vaccination strategies. Advanced topics and the future direction of oncovirology round out the book. This book is a comprehensive reference for researchers and practitioners engaged in learning more about the role of oncogenic viruses in the pathogenesis of human cancers and how that information can be applied to identify strategies for prevention and treatment. Explores the biology of oncoviruses and mechanisms of action on a cellular level Examines recent advances in oncoviruses prevention and curative treatments Discusses the use of modeling and bioinformatics in research studies on oncoviruses

Advances in Cancer Biomarkers

Roberto Scatena
Advances in Cancer Biomarkers Book PDF

Author : Roberto Scatena
Publisher : Springer
Page : 372 pages
File Size : 48,6 Mb
Release : 2015-11-03
Category : Medical
ISBN : 9789401772150

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Advances in Cancer Biomarkers by Roberto Scatena Pdf

At present there are a growing number of biomolecules under investigation to understand their potential role as cancer biomarker for diagnostic, prognostic and therapeutic purposes. Intriguingly, the state of art on cancer biomarkers research shows interesting and promising results together to clamorous failures. Also from a clinical point of view, there are contradictory results on routine clinical use of the present cancer biomarkers. Some patients may be simply monitored in their course by a periodic blood sample, but sometimes this monitoring shows dramatic limits. A lot of patients show serious and extensive relapses without significant change in serum concentrations of biomarkers tested. Often the physician who should utilize these biomarker does not entirely know their limits and the total potential applications as well and sometimes this knowledge is influenced by economical and marketing strategies. This limited and “polluted” knowledge may have dramatic consequences for patient. The aim of this book is to diffuse all aspects of cancer biomarkers, from their biochemical peculiarities to all clinical implications by passing through their physiology and pathophysiology. This critical approach towards old and new cancer biomarkers should foster a deepened and useful understanding of the diagnostic and prognostic index of these fundamental parameters of laboratory medicine and in the same time facilitating the research of new and more sensitive-specific signals of the cancer cell proliferation.

Early Detection of Breast Cancer

S. Brünner,B. Langfeldt,P. E. Andersen
Early Detection of Breast Cancer Book PDF

Author : S. Brünner,B. Langfeldt,P. E. Andersen
Publisher : Springer Science & Business Media
Page : 253 pages
File Size : 44,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642820311

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Early Detection of Breast Cancer by S. Brünner,B. Langfeldt,P. E. Andersen Pdf

The enormous expansion seen over the last decade in the mammo graphic detection of breast cancer lesions, especially the use of screen ing procedures for the early detection of clinically unsuspected tumors, has made it necessary to summarize the experience made by various centers in the world. The 2nd International Copenhagen Symposium on Detection of Breast Cancer afforded an opportunity of gathering scientists from all over the world to discuss the various problems of early breast cancer detection with special reference to screening procedures. This book forms a synthesis of the information presented by leading scientists from many of the world's mammo graphic centers, particularly those in Sweden and the USA. Hence, the reader will have the opportunity to study the outstanding work carried out by various institutes and centers of breast cancer screening. It is our sincere hope that a study of this volume will encourage other scientists to join in the work on screening procedures. S. Brunner B. Langfeldt P. E. Andersen Contents S. A. Feig: 1 Hypothetical Breast Cancer Risk from Mammography S. A. Feig: Benefits and Risks of Mammography 11 R. L. Egan and M. B. McSweeney: Multicentric Breast Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . 28 M. B. McSweeney and R. L. Egan: Breast Cancer in the Younger Patient: A Preliminary Report 36 M. B. McSweeney and R. L. Egan: Bilateral Breast Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . ' 41 N. Bjurstam: The Radiographic Appearance of Normal and Metastatic Axillary Lymph Nodes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 M. Moskowitz, S. A. Feig, C. Cole-Beuglet, S. H.

Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease

Institute of Medicine,Food and Nutrition Board,Board on Health Sciences Policy,Board on Health Care Services,Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease
Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease Book PDF

Author : Institute of Medicine,Food and Nutrition Board,Board on Health Sciences Policy,Board on Health Care Services,Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease
Publisher : National Academies Press
Page : 335 pages
File Size : 49,7 Mb
Release : 2010-06-25
Category : Medical
ISBN : 9780309157278

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Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease by Institute of Medicine,Food and Nutrition Board,Board on Health Sciences Policy,Board on Health Care Services,Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease Pdf

Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.

Cytoskeletal Proteins: Advances in Research and Application: 2011 Edition

Anonim
Cytoskeletal Proteins Advances in Research and Application 2011 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 82 pages
File Size : 45,7 Mb
Release : 2012-01-09
Category : Science
ISBN : 9781464932878

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Cytoskeletal Proteins: Advances in Research and Application: 2011 Edition by Anonim Pdf

Cytoskeletal Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Cytoskeletal Proteins in a concise format. The editors have built Cytoskeletal Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cytoskeletal Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cytoskeletal Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Immunotherapy for Gastrointestinal Malignancies

Ramakrishna Vadde,Ganji Purnachandra Nagaraju
Immunotherapy for Gastrointestinal Malignancies Book PDF

Author : Ramakrishna Vadde,Ganji Purnachandra Nagaraju
Publisher : Springer Nature
Page : 257 pages
File Size : 44,6 Mb
Release : 2021-01-31
Category : Medical
ISBN : 9789811564871

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Immunotherapy for Gastrointestinal Malignancies by Ramakrishna Vadde,Ganji Purnachandra Nagaraju Pdf

This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies.

Liver Regeneration and Carcinogenesis

Gerard Meurant
Liver Regeneration and Carcinogenesis Book PDF

Author : Gerard Meurant
Publisher : Elsevier
Page : 402 pages
File Size : 49,8 Mb
Release : 1995-09-27
Category : Science
ISBN : 0080535542

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Liver Regeneration and Carcinogenesis by Gerard Meurant Pdf

Because of its marked capacity to regenerate and the ability of chemical carcinogens and viruses to ready transform hepatocytes, the liver has been used extensively as a model for investigating the molecular mechanisms of cellular proliferation and carcinogenesis. Recently, striking advances have occured in the understanding of hepatocyte growth regulation and the manner in which chemical agents and viruses alter these normal growth regulatory pathways in liver carcinogenesis. This explosion of information has occured in a multitude of researh disciplines. This book brings together current findings in a coherent manner, from a molecular point of view. Three sections cover in detail the areas of liver regeneration, liver carcinogenesis, and liver tumor therapy. The contributors are pioneers and leaders in this field. * Logical organization of material in three detailed and comprehensive sections: liver regeneration, liver carcinogenesis, and liver tumor treatment * Contributors are pioneers and leaders in the field * There are currently no books on this subject on the market * Research focus is at the molecular level