Novel Biomarkers Of Gastrointestinal Cancer

Author : Takaya Shimura
Publisher : Mdpi AG
Page : 0 pages
File Size : 41,8 Mb
Release : 2022-08-12
Category : Electronic
ISBN : 3036549315

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Novel Biomarkers of Gastrointestinal Cancer by Takaya Shimura Pdf

Gastrointestinal (GI) cancer is a major cause of morbidity and mortality in the world. Since early diagnosis and optimal treatment selection are crucial to improving the prognosis of these diseases, the discovery of useful biomarkers has the potential to greatly reduce their burden. Recent technical and mechanical developments have allowed for the detection of tiny differences in various factors modified in physical conditions, which could contribute to the discovery of novel biomarkers for some diseases. In this Special Issue, we aim to focus on novel biomarkers for GI cancers, including esophageal cancer, gastric cancer, colorectal cancer, liver cancer, pancreatic cancer and biliary cancer. In addition, any samples (tissue, blood, urine and feces) are useful as biomarker sources, although body-fluid-based biomarkers are promising as diagnostic biomarkers due to their noninvasiveness. This Special Issue aims to collect novel insights clarifying the current situation and future perspective in this field.

Author : Pallaval Veera Bramhachari,Nageswara Rao Reddy Neelapu
Publisher : Springer Nature
Page : 238 pages
File Size : 47,8 Mb
Release : 2020-07-21
Category : Medical
ISBN : 9789811544316

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Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers by Pallaval Veera Bramhachari,Nageswara Rao Reddy Neelapu Pdf

This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.

Author : Zequn Li,Kui Zhang,Qun Zhang,Huashan Shi,Dongshi Chen
Publisher : Frontiers Media SA
Page : 467 pages
File Size : 44,7 Mb
Release : 2023-11-17
Category : Medical
ISBN : 9782832538982

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Biomarkers, Functional Mechanisms, and Therapeutic Potentials in Gastrointestinal Cancers by Zequn Li,Kui Zhang,Qun Zhang,Huashan Shi,Dongshi Chen Pdf

Significant changes in diet, environment, and population increase gastrointestinal cancer morbidity. A growing number of novel biomarkers and underlying mechanisms are being elucidated, some of which may even conflict with assumptions of past decades. Therefore, collecting recent findings on novel diagnostic/prognostic factors, biomarkers, and/or risk factors in gastrointestinal cancers is a prerequisite for a better understanding of the disease. Despite remarkable progressions in surgical treatments and chemotherapies, the prognosis of gastrointestinal cancer is far from satisfactory due to the high occurrence of drug resistance. Based on the identification of novel biomarkers as well as their underlying mechanisms, targeted drug development will provide significant complementary therapeutic effects to conventional chemoradiotherapies. High-throughput methods such as next-generation sequencing on RNA level and mass spectrometry on protein/lipid/metabolite level serve as efficient strategies for biomarker identification and drug development. This Research Topic aims at presenting recent advances on gastrointestinal cancer biomarkers and their underlying functional mechanisms, providing a better understanding of carcinogenesis, tumor progression, tumor relapse, as well as drug resistance. This will subsequently contribute to the development of novel therapeutic interventions targeting gastrointestinal cancers, thus improving patients' outcomes.

Author : Kenneth K. W. To
Publisher : Frontiers Media SA
Page : 188 pages
File Size : 45,8 Mb
Release : 2022-04-11
Category : Medical
ISBN : 9782889748594

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The Evolving Landscape, Clinical Implications and Future Perspective of Biomarkers in Gastrointestinal Cancers by Kenneth K. W. To Pdf

Author : Ganji Purnachandra Nagaraju,Sujatha Peela
Publisher : Springer Nature
Page : 259 pages
File Size : 45,7 Mb
Release : 2020-10-01
Category : Medical
ISBN : 9789811554711

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Novel therapeutic approaches for gastrointestinal malignancies by Ganji Purnachandra Nagaraju,Sujatha Peela Pdf

This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.

Author : Ashok Palaniappan
Publisher : Unknown
Page : 128 pages
File Size : 53,9 Mb
Release : 2017
Category : Electronic
ISBN : 3330866128

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Computational Determination of Novel Biomarkers of Colon Cancer by Ashok Palaniappan Pdf

Author : Sudhir Srivastava
Publisher : John Wiley & Sons
Page : 320 pages
File Size : 49,8 Mb
Release : 2017-06-07
Category : Medical
ISBN : 9781118468821

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Biomarkers in Cancer Screening and Early Detection by Sudhir Srivastava Pdf

Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment. Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers Provides immediately actionable information – and hopefully also inspiration – to move discovery and clinical application forward Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers

Author : Mikhael Kular
Publisher : American Medical Publishers
Page : 0 pages
File Size : 54,7 Mb
Release : 2023-09-19
Category : Health & Fitness
ISBN : 9798887404196

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Recent Advancements in Biomarkers and Detection of Gastrointestinal Cancers by Mikhael Kular Pdf

A biomarker is a biological molecule present in the blood, other body fluids or tissues, that indicates normal or abnormal process, condition or a disease. It can act as an alternative tool and is helpful in selecting accurate treatment in various diseases. Gastrointestinal cancer is a malignant condition affecting gastrointestinal tract and organs of the digestive system including the stomach, pancreas, esophagus, small and large intestine, biliary system, rectum and anus. In the case of esophageal cancer, methylation of DNA can be used as a biomarker for early detection because methylation patterns appear in the initial stages. Protein biomarkers are utilized as markers for gastric tumor for effective diagnosis, prognosis and checking for recurrence of cancer after treatment. Various biomarkers that are utilized in case of stomach cancer include antigens like CA12-5 and CA72-4 as well as alpha-fetoprotein. This book provides comprehensive insights on biomarkers. The topics covered herein deal with the core aspects of the detection of gastrointestinal cancers through biomarkers. This book will serve as a reference to a broad spectrum of readers.

Author : Dhananjay Shukla,Naveen Kumar Vishvakarma,Ganji Purnachandra Nagaraju
Publisher : Springer
Page : 460 pages
File Size : 43,5 Mb
Release : 2022-02-15
Category : Medical
ISBN : 3030727017

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Colon Cancer Diagnosis and Therapy Vol. 3 by Dhananjay Shukla,Naveen Kumar Vishvakarma,Ganji Purnachandra Nagaraju Pdf

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the third of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Author : Naveen Kumar Vishvakarma,Ganji Purnachandra Nagaraju,Dhananjay Shukla
Publisher : Springer
Page : 453 pages
File Size : 45,5 Mb
Release : 2021-06-05
Category : Medical
ISBN : 303064667X

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Colon Cancer Diagnosis and Therapy by Naveen Kumar Vishvakarma,Ganji Purnachandra Nagaraju,Dhananjay Shukla Pdf

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the second of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Author : Ganji Purnachandra Nagaraju,Dhananjay Shukla,Naveen Kumar Vishvakarma
Publisher : Springer
Page : 369 pages
File Size : 46,5 Mb
Release : 2021-07-14
Category : Medical
ISBN : 3030633683

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Colon Cancer Diagnosis and Therapy by Ganji Purnachandra Nagaraju,Dhananjay Shukla,Naveen Kumar Vishvakarma Pdf

Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Author : Mu Wang,Frank Witzmann
Publisher : BoD – Books on Demand
Page : 262 pages
File Size : 51,9 Mb
Release : 2016-08-17
Category : Medical
ISBN : 9789535125051

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Role of Biomarkers in Medicine by Mu Wang,Frank Witzmann Pdf

The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management.

Author : Joseph Anderson, MD,Charles Kahi, MD
Publisher : Springer Science & Business Media
Page : 205 pages
File Size : 49,5 Mb
Release : 2011-04-23
Category : Medical
ISBN : 9781607613985

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Colorectal Cancer Screening by Joseph Anderson, MD,Charles Kahi, MD Pdf

Colorectal Cancer Screening provides a complete overview of colorectal cancer screening, from epidemiology and molecular abnormalities, to the latest screening techniques such as stool DNA and FIT, Computerized Tomography (CT) Colonography, High Definition Colonoscopes and Narrow Band Imaging. As the text is devoted entirely to CRC screening, it features many facts, principles, guidelines and figures related to screening in an easy access format. This volume provides a complete guide to colorectal cancer screening which will be informative to the subspecialist as well as the primary care practitioner. It represents the only text that provides this up to date information about a subject that is continually changing. For the primary practitioner, information on the guidelines for screening as well as increasing patient participation is presentedd. For the subspecialist, information regarding the latest imaging techniques as well as flat adenomas and chromoendoscopy are covered. The section on the molecular changes in CRC will appeal to both groups. The text includes up to date information about colorectal screening that encompasses the entire spectrum of the topic and features photographs of polyps as well as diagrams of the morphology of polyps as well as photographs of CT colonography images. Algorithms are presented for all the suggested guidelines. Chapters are devoted to patient participation in screening and risk factors as well as new imaging technology. This useful volume explains the rationale behind screening for CRC. In addition, it covers the different screening options as well as the performance characteristics, when available in the literature, for each test. This volume will be used by the sub specialists who perform screening tests as well as primary care practitioners who refer patients to be screened for colorectal cancer.

Author : Kecheng Zhang,Seungwan Ryu,Fenglin Liu
Publisher : Frontiers Media SA
Page : 407 pages
File Size : 47,7 Mb
Release : 2022-11-23
Category : Medical
ISBN : 9782889768219

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Molecular Biomarkers for Gastric Cancer by Kecheng Zhang,Seungwan Ryu,Fenglin Liu Pdf

Author : Institute of Medicine,Food and Nutrition Board,Board on Health Sciences Policy,Board on Health Care Services,Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease
Publisher : National Academies Press
Page : 335 pages
File Size : 54,5 Mb
Release : 2010-06-25
Category : Medical
ISBN : 9780309157278

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Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease by Institute of Medicine,Food and Nutrition Board,Board on Health Sciences Policy,Board on Health Care Services,Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease Pdf

Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process.