Recent Advances In Psychiatry From Psycho Neuro Immunology Research Autoimmunencephalitis Autoimmune Encephalopathy Mild Encephalitis

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Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis

Author : Karl Bechter,David Brown,Souhel Najjar
Publisher : Frontiers Media SA
Page : 189 pages
File Size : 46,5 Mb
Release : 2019-08-12
Category : Electronic
ISBN : 9782889459506

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Recent Advances in Psychiatry from Psycho-Neuro-Immunology Research: Autoimmunencephalitis, Autoimmune-Encephalopathy, Mild Encephalitis by Karl Bechter,David Brown,Souhel Najjar Pdf

Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms may contribute to a subset of patients currently diagnosed as having treatment-resistant SMDs such as schizophrenia and major depressive disorder. Additionally, mounting data indicate that various infections can serve as an immunological trigger of aberrant immune responses, presumably by causing release of excess neural antigen, thereby giving rise to NSAs or aberrant immune cellular responses to give rise to primary or secondary psychiatric disorders such as schizophrenia and those associated with AE, respectively. Collectively, these findings support the “mild encephalitis” hypothesis of SMD. The significant overlap among AE-associated psychosis, systemic autoimmune disorder-associated psychosis, and psychotic disorders associated with pathological processes involving inflammation and immune dysregulation has also prompted some authors to adopt the term “autoimmune psychosis” (AP). This term reflects that this psychosis subtype is mechanistically linked to complex neuroimmune and inflammatory signalling abnormalities that can be responsive to early immunomodulatory treatment. It also suggests that a subset of AP might represent an incomplete or “forme fruste” subtype of AE presenting with dominant or pure psychiatric symptoms mimicking primary psychiatric illnesses. Because data indicate that delayed diagnosis and treatment may lead to permanent sequelae, early recognition of AP utilizing neurodiagnostic workup (e.g., CSF analysis, neuroimaging, and EEG) and its early treatment with appropriate immunotherapy are paramount to a meaningful recovery. This eBook will provide an overview of the current knowledge and research areas from epidemiology, risk factors and diagnosis to the management of these conditions, in this rapidly emerging field, helping to bridge the gaps in knowledge that currently exist in the disciplines of Psychiatry, Neurology, and Neuroimmunology.

Autoimmune Neurology

Author : Anonim
Publisher : Elsevier
Page : 568 pages
File Size : 45,9 Mb
Release : 2016-03-11
Category : Science
ISBN : 9780444634467

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Autoimmune Neurology by Anonim Pdf

Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

Neuroimmune Diseases

Author : Hiroshi Mitoma,Mario Manto
Publisher : Springer
Page : 822 pages
File Size : 47,6 Mb
Release : 2019-08-13
Category : Medical
ISBN : 9783030195151

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Neuroimmune Diseases by Hiroshi Mitoma,Mario Manto Pdf

A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases

Encephalitis

Author : Roy McClen
Publisher : Unknown
Page : 0 pages
File Size : 44,9 Mb
Release : 2015
Category : Medical
ISBN : 1632411180

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Encephalitis by Roy McClen Pdf

Detailed account on the pathogenesis of encephalitis is provided in this book. Several infectious agents including bacteria, parasites, and viruses, can cause inflammation of the central nervous system (CNS). Encephalitis is an inflammation of the brain p

Monoclonals and DNA Probes in Diagnostic and Preventive Medicine

Author : Robert C. Gallo,Giuseppe Della Porta,Alberto Albertini
Publisher : Unknown
Page : 264 pages
File Size : 40,8 Mb
Release : 1987
Category : DNA
ISBN : UOM:39015011749770

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Monoclonals and DNA Probes in Diagnostic and Preventive Medicine by Robert C. Gallo,Giuseppe Della Porta,Alberto Albertini Pdf

Autoantibodies and Autoimmunity

Author : Kenneth Michael Pollard
Publisher : John Wiley & Sons
Page : 633 pages
File Size : 55,5 Mb
Release : 2006-05-12
Category : Medical
ISBN : 9783527607228

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Autoantibodies and Autoimmunity by Kenneth Michael Pollard Pdf

This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology. The editor, currently professor at the W.M. Keck Autoimmune Disease Center of The Scripps Research Institute, has assembled an all-star team of authors to report on the latest research, technologies, and applications. Following an introductory chapter, the book goes on to cover such topics as cellular mechanisms of autoantibody production, clinical and diagnostic usefulness in human disease, and animal models used to study the elicitation of autoantibodies. The whole is rounded off with a look at future perspectives. With its comprehensive coverage, this volume will appeal not only to immunologists and clinicians but also to cell and molecular biologists.

Therapy of Autoimmune Diseases

Author : Julius M. Cruse,Robert Edwin Lewis
Publisher : Unknown
Page : 232 pages
File Size : 41,8 Mb
Release : 1989
Category : Medical
ISBN : UOM:39015018825185

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Therapy of Autoimmune Diseases by Julius M. Cruse,Robert Edwin Lewis Pdf

Autoimmune Blistering Diseases

Author : Cezary Kowalewski,Takashi Hashimoto,Pascal Joly
Publisher : Unknown
Page : 0 pages
File Size : 55,5 Mb
Release : 2020
Category : Electronic
ISBN : OCLC:1368435017

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Autoimmune Blistering Diseases by Cezary Kowalewski,Takashi Hashimoto,Pascal Joly Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.