Therapy Of Autoimmune Diseases

Author : Noel R. Rose,Ian R. Mackay
Publisher : Unknown
Page : 928 pages
File Size : 55,6 Mb
Release : 1998
Category : Medical
ISBN : UOM:39015045615823

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The Autoimmune Diseases by Noel R. Rose,Ian R. Mackay Pdf

The Autoimmune Diseases comprehensively describes the clinical expressions of all known autoimmune diseases, as well as the experimental bases of autoimmunity and failure of tolerance. The scientific chapters include mechanisms of natural tolerance, the genetic basis of autoimmunity, the significance of apoptosis, the influence of cytokines, environmental influences, and experimental models. The clinical chapters cover autoimmune endocrine deficiencies, insulin-dependent diabetes, rheumatic disorders, neurological diseases, and diseases of the blood, skin, eye, kidney, and liver.

Author : Richard K. Burt
Publisher : CRC Press
Page : 512 pages
File Size : 48,6 Mb
Release : 2019-11-11
Category : Medical
ISBN : 9781000716856

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Stem Cell Therapy for Autoimmune Disease by Richard K. Burt Pdf

Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.

Author : Wanzhu Hou,Guangpi Xu,Hanjie Wang
Publisher : Unknown
Page : 303 pages
File Size : 42,8 Mb
Release : 2011
Category : Medical
ISBN : 0443069743

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Treating Autoimmune Disease with Chinese Medicine by Wanzhu Hou,Guangpi Xu,Hanjie Wang Pdf

This book clearly describes how Chinese medicine can treat autoimmune diseases. Recommendations are given for acupuncture and herbal treatments for patients with a variety of different symptoms, blood results, and medical histories.

Author : C. Garrison Fathman
Publisher : Karger Medical and Scientific Publishers
Page : 229 pages
File Size : 43,7 Mb
Release : 2000-01-01
Category : Medical
ISBN : 9783805569491

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Biologic and Gene Therapy of Autoimmune Disease by C. Garrison Fathman Pdf

The clinical management of autoimmune diseases has proven to be extremely difficult. Current therapies focus on trying to alleviate symptoms, but fail to correct the fundamental immune defects that lead to pathology. To achieve this goal, it is necessary to understand much of the biology of antigen presentation, lymphocyte activation and the effects of cytokines. The articles in this book provide an up-to-date review of current innovative therapies using both biologic and gene therapy for the treatment of selected autoimmune diseases. Therapeutical approaches discussed include oral tolerance, the use of anti-CD4 monoclonal antibodies, IL-10 and anti-TNFa antibodies, DNA vaccination, and gene therapy applied to organ-specific autoimmune disease. Although some of these techniques are still in their infancy, their potential efficacy has been demonstrated in several animal models of autoimmune disease, holding great promise for the future development of treatments. Written by recognized experts in the field, the chapters in this book illustrate the concept of technology transfer from bench to bedside and provide a valuable update for clinicians and scientists in clinical immunology.

Author : Julius M. Cruse,Robert Edwin Lewis
Publisher : Unknown
Page : 232 pages
File Size : 41,9 Mb
Release : 1989
Category : Medical
ISBN : UOM:39015018825185

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Therapy of Autoimmune Diseases by Julius M. Cruse,Robert Edwin Lewis Pdf

Author : C. Pozzilli,P. Pozzilli,J.-F. Kapp
Publisher : Springer Science & Business Media
Page : 139 pages
File Size : 43,5 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783662044506

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New Concepts in Pathology and Treatment of Autoimmune Disorders by C. Pozzilli,P. Pozzilli,J.-F. Kapp Pdf

Autoimmunity, characterized by autoreactive lymphocytes and autoantibodies, is the consequence of a failure to discriminate between self and non-self, and autoimmune diseases are an increasing threat to people living in the industrialized countries. Autoimmune disorders are treatable, but not curable, and patients can face disability at later stages of the disease. Thus, there is a medical and economic need for new concepts and treatments in autoimmune disorders. New concepts and treatments can only be achieved by an interdisciplinary approach bringing together expertise, technologies, and clinical experience. The workshop focused on multiple sclerosis, rheumatoid arthritis and type I diabetes, and discussed conventional drug therapies, gene therapy, cell and tissue transplantation therapies, and first treatments using blood stem cells for reprogramming the patients' immune system.

Author : Katerina Chatzidionysiou
Publisher : BoD – Books on Demand
Page : 212 pages
File Size : 46,9 Mb
Release : 2015-06-17
Category : Medical
ISBN : 9789535121343

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Autoimmunity by Katerina Chatzidionysiou Pdf

Autoimmunity is defined as an immune response against a self-antigen. This abnormal immune response can lead to tissue damage and to the development of autoimmune disease. From organ-specific autoimmune diseases, such as myasthenia gravis, to non-organ-specific, such as systemic lupus erythematosus, autoimmune diseases represent a heterogeneous group of disorders which affect approximately 6% of the population. The pathogenesis of many autoimmune diseases is complex and remains not completely understood. The aim of this book is to present current knowledge regarding pathogenic mechanisms of autoimmune diseases, clinical aspects of specific autoimmune diseases, like vitiligo, celiac disease and autoimmune liver disease, as well as insights regarding specific therapies.

Author : Gerald J. Prud'homme
Publisher : Springer Science & Business Media
Page : 148 pages
File Size : 49,5 Mb
Release : 2007-02-26
Category : Medical
ISBN : 9780387286709

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Gene Therapy of Autoimmune Disease by Gerald J. Prud'homme Pdf

Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.

Author : Vibeke Strand,David L. Scot,Lee S. Simon
Publisher : CRC Press
Page : 341 pages
File Size : 51,5 Mb
Release : 1996-09-19
Category : Medical
ISBN : 9781482273533

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Novel Therapeutic Agents for the Treatment of Autoimmune Diseases by Vibeke Strand,David L. Scot,Lee S. Simon Pdf

Provides a detailed survey of therapies for autoimmune diseases, exploring the rationale for their use and clinical data regarding their potential benefit.

Author : Rita Baron-Faust,Jill P. Buyon
Publisher : McGraw Hill Professional
Page : 427 pages
File Size : 46,9 Mb
Release : 2003-04-22
Category : Health & Fitness
ISBN : 9780071425513

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The Autoimmune Connection by Rita Baron-Faust,Jill P. Buyon Pdf

Empowers women to make informed decisions about autoimmune disorders More than 50 million Americans, most of them women, suffer from a constellation of mysterious, often misdiagnosed diseases that can result in disability, disfigurement, and death. Called "autoimmune diseases," they arise when the immune system attacks healthy tissues in almost any area of the body, and include lupus rheumatoid arthritis, Crohn's disease, scleroderma, and Graves' disease. Now Jill Buyon, a doctor working on the cutting edge of research into these diseases, and Rita Baron-Faust, an award-winning medical journalist, arm women with the knowledge they need to obtain accurate diagnoses and the best possible treatments. In The Autoimmune Connection readers learn about the recent groundbreaking discovery of the links between the different autoimmune diseases and why women are more likely to develop them. The authors offer the most up-to-date information on diagnosis, treatments, and risks for women with one or more autoimmune disease.

Author : Mary Patterson
Publisher : Createspace Independent Publishing Platform
Page : 0 pages
File Size : 41,6 Mb
Release : 2016-03-13
Category : Autoimmune diseases
ISBN : 1530457351

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Autoimmune Disease by Mary Patterson Pdf

Gain Vitality, Energy and Happiness With Increased Autoimmune Health! Do you have an autoimmune disorder? Does a family member have this condition? How can you know if one of these diseases is affecting your life? If so, Autoimmune Disease: Discover The Symptoms & Treatment of Chronic Pain & Genetic Disease is the book for you! Mary Patterson explains the scientific background and root causes of autoimmune diseases so you know exactly what you're dealing with. You'll understand the basic processes underlying autoimmunity - and which symptoms you should look for in yourself and your loved ones! Discover The Details of A Number of Autoimmune Diseases: Thyroid Gland Disorders Rheumatoid Arthritis Systemic Lupus Erythematosus Multiple Sclerosis Type 1 Diabetes Mellitus and even Celiac Disease! With natural nutrition, a belief in healing and the functional treatments in this book, you can combat autoimmune diseases and feel great - TODAY!

Author : W.B. Harrison,B.A.C. Dijkmans
Publisher : Springer Science & Business Media
Page : 209 pages
File Size : 55,9 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9783662047590

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Combination Treatment in Autoimmune Diseases by W.B. Harrison,B.A.C. Dijkmans Pdf

W. B. Harrison, B. A. C. Dijkmans During the last decade intervention has been instituted for all kinds of disease- even in a premorbid state, as early as possible, to control the activity of the disease, to avoid further damage and to maintain quality of life. Apart from the principle 'Treat now, not later", emphasis is laid on aggressive initial therapy. These adagia have influenced in recent times all fields of medicine, from oncology to infectious diseases and also - the topic of the present edition - the "autoimmune diseases". As an example of the latter, rheumatoid arthritis (RA) demonstrates how the attitude of physicians has been changed. From an expectant point of view in the eighties (primum nil nocere) the attitude has been changed, as we approached and entered the new millennium, to initial ag gressive therapy especially in patients with a poor prognosis. Despite the advance of instituting monotherapy with a single optimised disease-modifying anti-rheumatic drug (DMARD) - with methotrexate as prototype agent in RA - adequate disease re mission is not often achieved, and adverse events may well prevent the use of higher dosages of the single agent in question. Therefore, the next step was to combine two or more DMARDs. The choice of combining DMARDs can be purely practical and based upon the anti-rheumatics most used in daily practice, for instance methotrexate and sulphasalazine. The choice of combining drugs can be influenced by different toxicity patterns to avoid cumulative toxicity.

Author : Gerald J. Prud'homme
Publisher : Springer
Page : 149 pages
File Size : 46,8 Mb
Release : 2005-07-13
Category : Medical
ISBN : 0306479915

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Gene Therapy of Autoimmune Disease by Gerald J. Prud'homme Pdf

Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.

Author : Mourad Aribi
Publisher : BoD – Books on Demand
Page : 184 pages
File Size : 50,7 Mb
Release : 2017-03-22
Category : Medical
ISBN : 9789535130215

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Immunopathogenesis and Immune-based Therapy for Selected Autoimmune Disorders by Mourad Aribi Pdf

The book Immunopathogenesis and Immune-Based Therapy for Selected Autoimmune Disorders is a synthesis work that discusses two main aspects of autoimmunity: Immunopathogenesis and therapeutic approaches essentially based on the immunotherapies. This book deals with different topics on a number of autoimmune disorders, including type 1 diabetes, autoimmune cardiomyopathy, autoimmunity of gastrointestinal tract, systemic sclerosis, and myasthenia gravis. This book will be useful to clinicians, biologists, researchers, teachers, and students who are interested in immunology and immunopathology.

Author : Michael Sticherling,Enno Christophers
Publisher : Springer Science & Business Media
Page : 184 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783709160169

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Treatment of Autoimmune Disorders by Michael Sticherling,Enno Christophers Pdf

Progress in basic and clinical immunology within the last two decades has provided profound insight into the immune system and its role in preventing endogenous and exogenous damage. In contrast, disbalances within this system can result in autoimmune disorders which may affect diverse organs and result in distinct clinical pictures. In many of these, however, the individual etiopathogenetic mechanisms are poorly understood and even more their clinical symptoms are hard to treat. The book offers insight into basic mechanisms of autoimmune disorders. It includes neurological, gastrointestinal, ophthalmological and skin diseases as well as current and future therapeutic options including immunomodulatory drugs and different vaccination strategies. By addressing diverse organ systems, both singular and shared features are elaborated. Thus an exchange of ideas is intended across research on single organ systems within a truly interdisciplinary setting.