Recent Applications Of Selected Name Reactions In The Total Synthesis Of Alkaloids

Author : Majid M. Heravi,Vahideh Zadsirjan
Publisher : Elsevier
Page : 404 pages
File Size : 55,5 Mb
Release : 2021-06-12
Category : Science
ISBN : 9780128242582

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Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids by Majid M. Heravi,Vahideh Zadsirjan Pdf

Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids includes comprehensive coverage of name reactions in the synthesis of alkaloids. This book highlights the synthesis of various alkaloids using special name reactions including the Diels-Alder, Friedel-Crafts, Heck, Mannich, Pauson-Khand, Pictet-Spengler, Sonogashira and Suzuki reactions. In this book, some selected name reactions in the total synthesis of alkaloids are covered, as they can be used as the key step/steps in the synthesis of different alkaloids exhibiting various biological activities. All chapters include an introduction, history and mechanism of the name reaction, and present the origin of the natural product and its known biological activities. The pathway to total synthesis is visually illustrated, and the focus is on the step in which a name reaction is applied. Chemists working in the area of synthetic organic chemistry will find this reference useful, as well as those working to develop novel methodologies for the synthesis of natural products in both academia and industry. This book is also beneficial to biologists, pharmacists and botanists. Includes an introduction of alkaloids, their origins and biological properties Features the applications of special name reactions as the key step in the total synthesis of featured alkaloids Covers the pathway for the synthesis of alkaloids from commercially available or easily accessible starting materials by using at least one name reaction to achieve the desired target products

Author : Atta-ur Rahman
Publisher : Elsevier
Page : 546 pages
File Size : 55,9 Mb
Release : 2023-09-13
Category : Science
ISBN : 9780323912556

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Studies in Natural Products Chemistry by Atta-ur Rahman Pdf

Studies in Natural Products Chemistry, Volume 78 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

Author : Majid M. Heravi,Fatemeh F. Bamoharram
Publisher : Elsevier
Page : 390 pages
File Size : 46,5 Mb
Release : 2022-01-19
Category : Science
ISBN : 9780323906586

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Heteropolyacids as Highly Efficient and Green Catalysts Applied in Organic Transformations by Majid M. Heravi,Fatemeh F. Bamoharram Pdf

Heteropolyacids as Highly Efficient and Green Catalysts Applied in Organic Transformations introduces heteropolyacids (HPAs) as promising candidates for use as green catalysts. This book initially presents an overview of chemistry of HPAs, including the history of their discovery and applications, systematic classifications, solubility, coordination and binding chemistry, isomerization, stability, redox activity, acidic properties, basicity, skeleton structure, structure types, self-assemblage, surface area, electrochemical behavior, methods of investigation, and characterization. Other sections present and compare the applications of HPAs as homogeneous and heterogeneous catalysts. The book provides readers with a basic-to-advanced range of knowledge on how useful and green HPAs can be used for use as catalysts in organic transformations and even the synthesis of complex organic molecules. Focuses on applications of HPAs as catalysts, but also includes basic information on HPAs to make it useful to those researchers and scientists whose activities are focused on biochemical analysis, electrochemistry, electrochemical devices, protection of corrosion, medicine and photo-catalyzed reactions Includes a subdivision devoted to HPA-catalyzed multicomponent reactions for the synthesis of some biologically active compounds via a double-green strategy Illustrates reactions with approximately 100 chemical reaction schemes to aid understanding

Author : Ana Escribano Cuesta
Publisher : Springer Science & Business Media
Page : 202 pages
File Size : 43,7 Mb
Release : 2013-08-13
Category : Science
ISBN : 9783319007021

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New Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids by Ana Escribano Cuesta Pdf

Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.

Author : Hans-Joachim Knoelker
Publisher : Springer Science & Business Media
Page : 268 pages
File Size : 41,5 Mb
Release : 2012-01-13
Category : Science
ISBN : 9783642255281

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Alkaloid Synthesis by Hans-Joachim Knoelker Pdf

Lycopodium Alkaloids: Isolation and Asymmetric Synthesis, by Mariko Kitajima and Hiromitsu Takayama.- Synthesis of Morphine Alkaloids and Derivatives, by Uwe Rinner and Tomas Hudlicky.- Indole Prenylation in Alkaloid Synthesis, by Thomas Lindel, Nils Marsch and Santosh Kumar Adla.- Marine Pyrroloiminoquinone Alkaloids, by Yasuyuki Kita and Hiromichi Fujioka.- Synthetic Studies on Amaryllidaceae and Other Terrestrially Derived Alkaloids, by Martin G. Banwell, Nadia Yuqian Gao, Brett D. Schwartz and Lorenzo V. White.- Synthesis of Pyrrole and Carbazole Alkaloids, by Ingmar Bauer and Hans-Joachim Knölker.-

Author : Ramon Rios Torres
Publisher : John Wiley & Sons
Page : 422 pages
File Size : 50,6 Mb
Release : 2012-03-01
Category : Science
ISBN : 9781118308639

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The Pauson-Khand Reaction by Ramon Rios Torres Pdf

The Pauson-Khand reaction is an important reaction in the field of organic chemistry. It involves the transition-metal catalysed cycloaddition of an alkyne, an alkene and carbon monoxide, to produce cyclopentenones. The importance of this reaction originates from its high value in transforming simple components into the synthetically useful cyclopentenone unit, in which a high degree of molecular complexity can be achieved in a single step, with impressive stereochemical and regiochemical control. The Pauson-Khand Reaction investigates the nature and many variations of this reaction. Topics covered include: the mechanisms of Pauson‐Khand-type reactions non chiral intramolecular and intermolecular versions of Pauson‐Khand reactions asymmetric Pauson‐Khand reaction using chiral auxiliaries the enantioselective Pauson‐Khand reaction Pauson‐Khand reactions catalysed by metals other than cobalt unconventional Pauson‐Khand reactions the Pauson‐Khand reaction in total synthesis Presenting a comprehensive overview of this fundamental reaction, The Pauson-Khand Reaction will find a place on the bookshelves of any organic or organometallic chemist.

Author : Jie Jack Li,E.J. Corey
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 44,5 Mb
Release : 2013-03-14
Category : Science
ISBN : 9783642340659

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Total Synthesis of Natural Products by Jie Jack Li,E.J. Corey Pdf

'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.

Author : Joanna Kurek
Publisher : BoD – Books on Demand
Page : 102 pages
File Size : 45,6 Mb
Release : 2019-11-13
Category : Medical
ISBN : 9781789845761

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Alkaloids by Joanna Kurek Pdf

"Alkaloids" is intended for by chemistry, biochemistry, pharmacy, and other medical students, biologists, chemists, biochemists, and other professionals involved in the field of alkaloids. All chapters in this book are written by professionals in the areas of alkaloid chemistry, biology, pharmacy, and other interesting applications. The chapters cover interesting and less obvious information about different groups of alkaloids.

Author : Anonim
Publisher : Unknown
Page : 834 pages
File Size : 40,8 Mb
Release : 1987
Category : Medicine
ISBN : UOM:39015011769695

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Research Awards Index by Anonim Pdf

Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher : Unknown
Page : 1212 pages
File Size : 42,9 Mb
Release : 1975
Category : Medicine
ISBN : UOM:39015072175394

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Research Grants Index by National Institutes of Health (U.S.). Division of Research Grants Pdf

Author : Majid M. Heravi,Vahideh Zadsirjan
Publisher : Elsevier
Page : 438 pages
File Size : 55,7 Mb
Release : 2020-05-29
Category : Science
ISBN : 9780128196953

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Recent Advances in Applications of Name Reactions in Multicomponent Reactions by Majid M. Heravi,Vahideh Zadsirjan Pdf

Recent Advances in Applications of Name Reactions in Multicomponent Reactions is an ideal reference for researchers and postgraduate students studying organic chemistry, as well as synthetic organic chemists working on the development of novel methodologies for the synthesis of various heterocyclic systems, especially drug design and discovery, in both academia and industry. The book reviews recent applications of name reactions in multicomponents for the synthesis of heterocycles and examines recent advances in applications of significant name reactions, such as Ugi and Passirini, Click, Knoevenagel, Michael, Diels-Alder, Aldol, Mannich, Heck, Huisgen, and Suzuki in MCRs. These reactions can be used in the synthesis of a wide variety of novel heterocycles with different sizes and heteroatoms, as well as in the total synthesis of natural products in order to decrease the number of synthetic steps. Since chiral inductions are necessary for most of these sequential name reactions, their asymmetric catalyzed reactions are also described. Includes the synthesis of many heterocycles, which is ideal for synthetic organic chemists engaged in the synthesis of heterocyclic systems Covers the recent advances of asymmetric synthesis of a wide range of heterocycles in satisfactory enantioselectivities (ees) or distereoselectivities (des) Reviews the synthesis of a wide variety of interesting heterocycles by using a combination of different and versatile name reactions via MCRs

Author : Martin Oestreich
Publisher : John Wiley & Sons
Page : 608 pages
File Size : 53,6 Mb
Release : 2009-02-11
Category : Science
ISBN : 0470716061

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The Mizoroki-Heck Reaction by Martin Oestreich Pdf

Exploring the importance of Richard F. Heck’s carbon coupling reaction, this book highlights the subject of the 2010 Nobel Prize in Chemistry for palladium-catalyzed cross couplings in organic synthesis, and includes a foreword from Nobel Prize winner Richard F. Heck. The Mizoroki-Heck reaction is a palladium-catalyzed carbon–carbon bond forming process which is widely used in organic and organometallic synthesis. It has seen increasing use in the past decade as chemists look for strategies enabling the controlled construction of complex carbon skeletons. The Mizoroki-Heck Reaction is the first dedicated volume on this important reaction, including topics on: mechanisms of the Mizoroki-Heck reaction intermolecular Mizoroki-Heck reactions focus on regioselectivity and product outcome in organic synthesis waste-minimized Mizoroki-Heck reactions intramolecular Mizoroki-Heck reactions formation of heterocycles chelation-controlled Mizoroki-Heck reactions the Mizoroki-Heck reaction in domino processes oxidative heck-type reactions (Fujiwara-Moritani reactions) Mizoroki-Heck reactions with metals other than palladium ligand design for intermolecular asymmetric Mizoroki-Heck reactions intramolecular enantioselective Mizoroki-Heck reactions desymmetrizing Mizoroki-Heck reactions applications in combinatorial and solid phase syntheses, and the development of modern solvent systems and reaction techniques the asymmetric intramolecular Mizoroki-Heck reaction in natural product total synthesis Several chapters are devoted to asymmetric Heck reactions with particular focus on the construction of otherwise difficult-to-obtain sterically congested tertiary and quaternary carbons. Industrial and academic applications are highlighted in the final section. The Mizoroki-Heck Reaction will find a place on the bookshelves of any organic or organometallic chemist. “I am convinced that this book will rapidly become the most important reference text for research chemists in academia and industry who seek orientation in the rapidly growing and – for the layman – confusing field described as the “’Mizoroki–Heck reaction’.” (Synthesis, March 2010)

Author : Gordon W. Gribble
Publisher : John Wiley & Sons
Page : 704 pages
File Size : 50,7 Mb
Release : 2016-08-08
Category : Science
ISBN : 9780470512180

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Indole Ring Synthesis by Gordon W. Gribble Pdf

Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade — highlighted by the power of transition metal catalysis — this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. Following presentation of the classic indole ring syntheses and many newer methods, coverage continues with indole ring syntheses via pyrroles, indolines, oxindoles, isatins, radical and photochemical reactions, aryne cycloadditions. This extensive volume concludes with the modern transition metal–catalyzed indole ring syntheses that utilize copper, palladium, rhodium, gold, ruthenium, platinum, and other metals to fashion the indole ring Indole Ring Synthesis is a comprehensive, authoritative and up-to-date guide to the synthesis of this important heterocycle for organic chemists, pharmaceutical researchers and those interested in the chemistry of natural products.

Author : Dipakranjan Mal
Publisher : Elsevier
Page : 464 pages
File Size : 40,9 Mb
Release : 2018-10-25
Category : Science
ISBN : 9780128138014

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Anionic Annulations in Organic Synthesis by Dipakranjan Mal Pdf

Anionic Annulations in Organic Synthesis: A Versatile and Prolific Class of Ring-Forming Reactions is a comprehensive review of the best annulations for the construction of cyclic structures and their applications in the total synthesis of functional molecules. The reactions described in the work are particularly useful for the synthesis of polyoxygenated polycyclic compounds, including tetracyclines, angucyclines, uncialamycins, and lignans, among other compounds. Included in detail are the Hauser, Robinson, Sammes and Meyers annulations, all of which can be effectively used to construct substrates with complex molecular structures. This work provides the tools to master anionic organic chemistry, ortho-lithiation, lateral lithaition/metalation and organic selectivity issues, like chemoselectivity, regioselectivity and stereoselectivity. This book is a valuable resource for organic chemists, researchers and students seeking a complete and detailed understanding of anionic annulations. Provides a comprehensive review of anionic cyclization for chemical construction of a variety of cyclic scaffolds involved in many kinds of biologically active natural products and pharmaceutical drugs Serves as a useful tool to academic and industrial researchers working on the synthesis of cyclic compounds as their targets Includes many examples of anionic annulations and practical information on how to use them in research and industry Features anionic annulations that are particularly useful for the synthesis of polyoxygenated polycyclic compounds, including tetracyclines, angucyclines, uncialamycins and lignans

Author : Alfred Hassner,C Stumer
Publisher : Elsevier
Page : 462 pages
File Size : 52,8 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483287348

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Organic Syntheses Based on Name Reactions and Unnamed Reactions by Alfred Hassner,C Stumer Pdf

Synthetically useful organic reactions or reagents are often referred to by the name of the discoverer(s) or developer(s). Older name reactions are described in text books, but more recently developed synthetically useful reactions that may have been associated occasionally with a name are not always well known. For neither of the above are experimental procedures or references easy to find. In this monograph approximately 500 name reactions are included, of which over 200 represent newer name reactions and modern reagents. Each of these reactions are extremely useful for the contemporary organic chemistry researcher in industry or academic institutions. This book provides the information in an easily accessible form. In addition to seminal references and reviews, one or more examples for each name reaction are provided and a complete typical experimental procedure is included, to enable the student or researcher to immediately evaluate reaction conditions. Besides an alphabetical listing of reactions and reagents, cross references permit the organic practitioner to find those name reactions or reagents that enable specific transformations, such as, conversion of amines to nitriles, stereoselective reduction, fluoroalkylation, phenol alkynylation, asymmetric syntheses, allylic alkylation, nucleoside synthesis, cyclopentanation, hydrozirconation, to name a few. Emphasis has been placed on stereoselective and regioselective transformations as well as on enantioselective processes. The listing of reactions and reagents is supported by four indexes.