Recognition And Alleviation Of Pain And Distress In Laboratory Animals

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Recognition and Alleviation of Pain in Laboratory Animals
Publisher : National Academies Press
Page : 198 pages
File Size : 53,5 Mb
Release : 2010-01-14
Category : Science
ISBN : 9780309128346

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Recognition and Alleviation of Pain in Laboratory Animals by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Recognition and Alleviation of Pain in Laboratory Animals Pdf

The use of animals in research adheres to scientific and ethical principles that promote humane care and practice. Scientific advances in our understanding of animal physiology and behavior often require theories to be revised and standards of practice to be updated to improve laboratory animal welfare. Recognition and Alleviation of Pain in Laboratory Animals, the second of two reports revising the 1992 publication Recognition and Alleviation of Pain and Distress in Laboratory Animals from the Institute for Laboratory Animal Research (ILAR), focuses on pain experienced by animals used in research. This book aims to educate laboratory animal veterinarians; students, researchers and investigators; Institutional Animal Care and Use Committee members; and animal care staff and animal welfare officers on the current scientific and ethical issues associated with pain in laboratory animals. It evaluates pertinent scientific literature to generate practical and pragmatic guidelines for recognizing and alleviating pain in laboratory animals, focusing specifically on the following areas: physiology of pain in commonly used laboratory species; pharmacologic and non-pharmacologic principles to control pain; identification of humane endpoints; and principles for minimizing pain associated with experimental procedures. Finally, the report identifies areas in which further scientific investigation is needed to improve laboratory animal welfare.

Author : National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Pain and Distress in Laboratory Animals
Publisher : National Academies Press
Page : 161 pages
File Size : 52,9 Mb
Release : 1992-01-01
Category : Science
ISBN : 9780309042758

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Recognition and Alleviation of Pain and Distress in Laboratory Animals by National Research Council,Commission on Life Sciences,Institute for Laboratory Animal Research,Committee on Pain and Distress in Laboratory Animals Pdf

Clear guidelines on the proper care and use of laboratory animals are being sought by researchers and members of the many committees formed to oversee animal care at universities as well as the general public. This book provides a comprehensive overview of what we know about behavior, pain, and distress in laboratory animals. The volume explores: Stressors in the laboratory and the animal behaviors they cause, including in-depth discussions of the physiology of pain and distress and the animal's ecological relationship to the laboratory as an environment. A review of euthanasia of lab animals-exploring the decision, the methods, and the emotional effects on technicians. Also included is a highly practical, extensive listing, by species, of dosages and side effects of anesthetics, analgesics, and tranquilizers.

Author : National Research Council,Institute for Laboratory Animal Research,Committee on Regulatory Issues in Animal Care and Use
Publisher : National Academies Press
Page : 131 pages
File Size : 42,6 Mb
Release : 2001-01-26
Category : Science
ISBN : 9780309072915

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Definition of Pain and Distress and Reporting Requirements for Laboratory Animals by National Research Council,Institute for Laboratory Animal Research,Committee on Regulatory Issues in Animal Care and Use Pdf

In this first in a proposed series of workshops on regulatory issues in animal care and use, the Institute for Laboratory Animal Research (ILAR) has addressed the existing and proposed requirements for reporting pain and distress in laboratory animals. The Animal Welfare Act, administered by the Animal and Plant Health Inspection Service of the United States Department of Agriculture (USDA), mandates that pain and distress in laboratory animals be minimized. USDA is considering two policy changes with regard to this specific mandate. Firstly, since there has been no functional definition of "distress," USDA has prepared such a definition and requested feedback from the scientific community on its usefulness for regulatory and reporting requirements. The second issue concerns the pain and distress categorization scheme for reporting to USDA. Various groups and individuals have questioned the efficacy of the current categories, and specific changes have been proposed by the Humane Society of the United States. USDA is considering these and other potential changes to the existing scheme. Thus, given these potential changes to animal welfare policy, the aim of the ILAR/NIH joint workshop was to provide feedback to the USDA. The speakers were asked to address these two issues as well as to comment upon whether the information contained in the 1992 ILAR report Recognition and Alleviation of Pain and Distress in Laboratory Animals is still useful to investigators in assisting them to comply with regulations. The speakers provided perspectives based on their individual expertise in the areas of science of pain and distress, animal welfare policy, protocol review, and/or as representatives of relevant organizations or institutions. The following proceedings are an edited transcript of their presentations.

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Recognition and Alleviation of Distress in Laboratory Animals
Publisher : National Academies Press
Page : 137 pages
File Size : 40,5 Mb
Release : 2008-04-10
Category : Science
ISBN : 9780309108171

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Recognition and Alleviation of Distress in Laboratory Animals by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Recognition and Alleviation of Distress in Laboratory Animals Pdf

Scientific advances in our understanding of animal physiology and behavior often require theories to be revised and standards of practice to be updated to improve laboratory animal welfare. This new book from the Institute for Laboratory Animal Research (ILAR) at the National Research Council, Recognition and Alleviation of Distress in Laboratory Animals, focuses on the stress and distress which is experienced by animals when used in laboratory research. This book aims to educate laboratory animal veterinarians; students, researchers, and investigators; animal care staff, as well as animal welfare officers on the current scientific and ethical issues associated with stress and distress in laboratory animals. It evaluates pertinent scientific literature to generate practical and pragmatic guidelines. Recognition and Alleviation of Distress in Laboratory Animals focuses specifically on the scientific understanding of the causes and the functions of stress and distress, the transformation of stress to distress, and the identification of principles for the recognition and alleviation of distress. This book discusses the role of humane endpoints in situations of distress and principles for the minimization of distress in laboratory animals. It also identifies areas in which further scientific investigation is needed to improve laboratory animal welfare in order to adhere to scientific and ethical principles that promote humane care and practice.

Author : Gianni Dal Negro,Silvia Sabbioni
Publisher : Academic Press
Page : 348 pages
File Size : 50,6 Mb
Release : 2021-11-18
Category : Science
ISBN : 9780128212523

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Practical Handbook on the 3Rs in the Context of the Directive 2010/63/EU by Gianni Dal Negro,Silvia Sabbioni Pdf

Practical Handbook on the 3Rs in the Context of the Directive 2010/63/EU provides updated information on the EU Directive 2010/63/EU, which is the European Union legislation that protects animals being used in research. EU Directive 2010/63/EU is the European Union (EU) legislation 'on the protection of animals used for scientific purposes' and is one of the most stringent ethical and welfare standards worldwide. Closes a gap in scientific literature by addressing the need for clear guidance in walking through the multifaced universe of 3Rs Offers a useful starting point for readers and scientist who approach the 3Rs for the first-time Gives insights into the harmonization of the animal research legislation across countries

Author : Committee on Pain and Distress in Laboratory Animals,Institute for Laboratory Animal Research,Commission on Life Sciences,National Research Council
Publisher : National Academies Press
Page : 130 pages
File Size : 54,7 Mb
Release : 1992-01-15
Category : Science
ISBN : 0309075254

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Recognition and Alleviation of Pain and Distress in Laboratory Animals by Committee on Pain and Distress in Laboratory Animals,Institute for Laboratory Animal Research,Commission on Life Sciences,National Research Council Pdf

Clear guidelines on the proper care and use of laboratory animals are being sought by researchers and members of the many committees formed to oversee animal care at universities as well as the general public. This book provides a comprehensive overview of what we know about behavior, pain, and distress in laboratory animals. The volume explores: Stressors in the laboratory and the animal behaviors they cause, including in-depth discussions of the physiology of pain and distress and the animal's ecological relationship to the laboratory as an environment. A review of euthanasia of lab animals--exploring the decision, the methods, and the emotional effects on technicians. Also included is a highly practical, extensive listing, by species, of dosages and side effects of anesthetics, analgesics, and tranquilizers.

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research
Publisher : National Academies Press
Page : 223 pages
File Size : 50,6 Mb
Release : 2003-08-22
Category : Science
ISBN : 9780309167857

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Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research Pdf

Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Author : Kathryn Bayne,Patricia V. Turner
Publisher : Academic Press
Page : 336 pages
File Size : 43,5 Mb
Release : 2013-09-02
Category : Science
ISBN : 9780123851048

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Laboratory Animal Welfare by Kathryn Bayne,Patricia V. Turner Pdf

Laboratory Animal Welfare provides a comprehensive, up-to-date look into the new science of animal welfare within laboratory research. Animals specifically considered include rodents, cats and dogs, nonhuman primates, agricultural animals, avian animals and aquatic animals. The book examines the impact of experiment design and environment on animal welfare, as well as emergency situations and euthanasia practices. Readers will benefit from a review of regulations and policy guidelines concerning lab animal use, as well as information on assessing animal welfare. With discussions of the history and ethics of animals in research, and a debate on contemporary and international issues, this book is a go-to resource for laboratory animal welfare.

Author : Paul Flecknell
Publisher : Academic Press
Page : 304 pages
File Size : 46,8 Mb
Release : 2009-04-09
Category : Medical
ISBN : 0080918999

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Laboratory Animal Anaesthesia by Paul Flecknell Pdf

Laboratory Animal Anesthesia looks at recent significant developments in anesthetic practices in laboratory experiments involving animals. It also provides information about basic standards for proper use of anesthesia. In addition, it examines the equipment and different anesthetic agents that are used in performing an experiment on animals. The book also discusses the profound effects of anesthesia on the physiological aspect of the animals’ body systems, such as hypothermia and respiratory depression. The book addresses the proper management and care that should be provided for the animals that undergo anesthesia. Furthermore, it covers different anesthetic procedures that should be used on various kinds of small animals intended for laboratory experiments. The main goal of this book is to provide information about the different anesthetic agents used in experiments, and the proper standards to follow when using anesthetics on lab animals. • New edition provides new information on anesthesia and analgesia, and has an extensively revised and updated bibliography • Provides a balanced consideration of the needs of scientific research and the welfare of laboratory animals • Written by a veterinary anesthetist and scientist with over 30 years' experience in the field, and who is actively engaged in research in this area • Provides rapid, easily accessed information using tabulated summaries • Provides those with limited experience of anesthesia with the information they need to carry our procedures effectively, safely, and humanely • Provides sufficient depth for the more experienced anesthetist moving to this field

Author : Anonim
Publisher : Unknown
Page : 208 pages
File Size : 53,6 Mb
Release : 1980
Category : Animal experimentation
ISBN : 0919087108

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Guide to the Care and Use of Experimental Animals by Anonim Pdf

Author : John P. Gluck,Tony DiPasquale,F. Barbara Orlans
Publisher : Purdue University Press
Page : 216 pages
File Size : 46,5 Mb
Release : 2002
Category : Medical
ISBN : 1557531366

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Applied Ethics in Animal Research by John P. Gluck,Tony DiPasquale,F. Barbara Orlans Pdf

This volume is a collection of chapters all contributed by individuals who have presented their ideas at conferences and who take moderate stands with the use of animals in research. Specifically the chapters bear of the issues of: notions of the moral standings of animals, history of the methods of argumentation, knowledge of the animal mind, nature and value of regulatory structures, how respect for animals can be converted from theory to action in the laboratory. The chapters have been tempered by open discussion with individuals with different opinions and not audiences of true believers. It is the hope of all, that careful consideration of the positions in these chapters will leave reader with a deepened understanding--not necessarily a hardened position.

Author : Eila Kaliste
Publisher : Springer Science & Business Media
Page : 351 pages
File Size : 47,7 Mb
Release : 2007-04-18
Category : Science
ISBN : 9781402022715

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The Welfare of Laboratory Animals by Eila Kaliste Pdf

This book examines the general principles of laboratory animal maintenance and experimental use as well as factors that have to be taken into account when good research is done with animals. In addition, it provides species specific coverage, concentrating on the species most used as laboratory animals. The book gives a comprehensive description of the welfare questions considered to be important for each species under laboratory conditions.

Author : Animal Welfare Institute
Publisher : Unknown
Page : 106 pages
File Size : 54,5 Mb
Release : 1956*
Category : Animal welfare
ISBN : OCLC:4854072

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Comfortable Quarters for Laboratory Animals by Animal Welfare Institute Pdf

Author : Committee on Regulatory Issues in Animal Care and Use,Institute for Laboratory Animal Research,National Research Council
Publisher : National Academies Press
Page : 118 pages
File Size : 49,9 Mb
Release : 2001-01-09
Category : Science
ISBN : 0309076986

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Definition of Pain and Distress and Reporting Requirements for Laboratory Animals by Committee on Regulatory Issues in Animal Care and Use,Institute for Laboratory Animal Research,National Research Council Pdf

In this first in a proposed series of workshops on regulatory issues in animal care and use, the Institute for Laboratory Animal Research (ILAR) has addressed the existing and proposed requirements for reporting pain and distress in laboratory animals. The Animal Welfare Act, administered by the Animal and Plant Health Inspection Service of the United States Department of Agriculture (USDA), mandates that pain and distress in laboratory animals be minimized. USDA is considering two policy changes with regard to this specific mandate. Firstly, since there has been no functional definition of "distress," USDA has prepared such a definition and requested feedback from the scientific community on its usefulness for regulatory and reporting requirements. The second issue concerns the pain and distress categorization scheme for reporting to USDA. Various groups and individuals have questioned the efficacy of the current categories, and specific changes have been proposed by the Humane Society of the United States. USDA is considering these and other potential changes to the existing scheme. Thus, given these potential changes to animal welfare policy, the aim of the ILAR/NIH joint workshop was to provide feedback to the USDA. The speakers were asked to address these two issues as well as to comment upon whether the information contained in the 1992 ILAR report Recognition and Alleviation of Pain and Distress in Laboratory Animals is still useful to investigators in assisting them to comply with regulations. The speakers provided perspectives based on their individual expertise in the areas of science of pain and distress, animal welfare policy, protocol review, and/or as representatives of relevant organizations or institutions. The following proceedings are an edited transcript of their presentations.

Author : Jerald Silverman,Mark A. Suckow,Sreekant Murthy
Publisher : CRC Press
Page : 832 pages
File Size : 44,7 Mb
Release : 2014-05-20
Category : Medical
ISBN : 9781466555648

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The IACUC Handbook, Third Edition by Jerald Silverman,Mark A. Suckow,Sreekant Murthy Pdf

Ever since its establishment by USDA regulation in the mid-1980s, the Institutional Animal Care and Use Committee (IACUC) has evolved as the premier instrument of animal welfare oversight within research institutions in the United States. As biomedical research continuously grows, the role and impact of the IACUC has increased in scope and complexity. The IACUC Handbook has become "the Bible" for individuals when the time comes for them to serve on their institution’s IACUC. It provides a foundation for understanding and implementing the many and varied responsibilities of this committee. This Third Edition comprehensively addresses the significant changes in the pertinent regulatory environment and interpretation of applicable federal laws, regulations, and policies. It provides multiple references and commentary on the new edition of the Guide for the Care and Use of Laboratory Animals, the new AVMA Guidelines for the Euthanasia of Animals: 2013 Edition, and the Office of Laboratory Animal Welfare’s Frequently Asked Questions. The Third Edition also features an updated survey of IACUC practices from institutions around the United States, offering wisdom gained from their experience. In addition, it includes a chapter that provides an international perspective on how animal welfare reviews can function in other countries.