Recombinant Protein Drugs

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Recombinant Protein Drugs

P. Buckel
Recombinant Protein Drugs Book PDF

Author : P. Buckel
Publisher : Birkhäuser
Page : 207 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783034883467

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Recombinant Protein Drugs by P. Buckel Pdf

Recombinant protein drugs are intimately associated with the impressive success story of the Biotech Industry during the past thirty years, some of them belonging to the most successful pharmaceutical products. More than thirty different proteins are available for a variety of clinical applications, over 300 proteins are presently being evaluated in clinical trials. In this new volume of the MDT series, historical, technical and clinical aspects of recombinant protein drug discovery and development are presented, covering past, present and future highlights. Leading scientists and co-founders of early Biotech companies describe technical breakthroughs and the fascinating story of pioneering discoveries, as well as the long way of translating them into products and business. Therefore, this book represents an exciting documentation of the beginning of a new era in the pharmaceutical industry. In addition, scientists from basic research, clinic and industry actively involved in new developments discuss...

Therapeutic Proteins

C. Mark Smales,David C. James
Therapeutic Proteins Book PDF

Author : C. Mark Smales,David C. James
Publisher : Springer Science & Business Media
Page : 481 pages
File Size : 43,7 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781592599226

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Therapeutic Proteins by C. Mark Smales,David C. James Pdf

With the recent completion of the sequencing of the human genome, it is widely anticipated that the number of potential new protein drugs and targets will escalate at an even greater rate than that observed in recent years. However, identification of a potential target is only part of the process in developing these new next generation protein-based “drugs” that are increasingly being used to treat human disease. Once a potential protein drug has been identified, the next rate-limiting step on the road to development is the production of sufficient authentic material for testing, charact- ization, clinical trials, and so on. If a protein drug does actually make it through this lengthy and costly process, methodology that allows the production of the protein on a scale large enough to meet demand must be implemented. Furthermore, large-scale production must not compromise the authenticity of the final product. It is also nec- sary to have robust methods for the purification, characterization, viral inactivation and continued testing of the authenticity of the final protein product and to be able to formulate it in a manner that retains both its biological activity and lends itself to easy administration. Therapeutic Proteins: Methods and Protocols covers all aspects of protein drug production downstream of the discovery stage. This volume contains contributions from leaders in the field of therapeutic protein expression, purification, characterization, f- mulation, and viral inactivation.

Interferon: The Dawn of Recombinant Protein Drugs

J. Lindenmann,W.-D. Schleuning
Interferon The Dawn of Recombinant Protein Drugs Book PDF

Author : J. Lindenmann,W.-D. Schleuning
Publisher : Springer Science & Business Media
Page : 149 pages
File Size : 46,7 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783662037874

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Interferon: The Dawn of Recombinant Protein Drugs by J. Lindenmann,W.-D. Schleuning Pdf

Forty years of Interferon I wish to dedicate this short introduction to the memory of Alick Isaacs (1921-1967), and to that of Sir Christopher Andrewes (1896-1988). Let us go back more than 40 years. In 1956 Isaacs was in charge of the Wodd Influenza Centre. Andrewes was head of the division of bac teriology and virology, and deputy director of the National Institute for Medical Research in London. When researchers are faced with a seemingly new phenomenon, ex planations are easy to come by. These explanations fall into two broad categories: the phenomenon in question is either due to something or to the lack of something. I apologize for the primitive way in which I ex press this, but I am going to give three examples, scattered over 100 years, of what I mean. First example: in 1880 the great French microbiologist Louis Pas teur was involved in work on chicken cholera. He was struck by the following observation: if a suitable chicken broth was inoculated with the bacterium, the organism grew profusely and the liquid became tur bid. If he now freed the fluid, by sedimentation or filtration, from the bulk of the organisms and re-inoculated it with the same bacterium, no growth occurred.

Protein Therapeutics, 2 Volume Set

Tristan Vaughan,Jane Osbourn,Bahija Jallal
Protein Therapeutics 2 Volume Set Book PDF

Author : Tristan Vaughan,Jane Osbourn,Bahija Jallal
Publisher : John Wiley & Sons
Page : 762 pages
File Size : 47,9 Mb
Release : 2017-12-04
Category : Medical
ISBN : 9783527340866

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Protein Therapeutics, 2 Volume Set by Tristan Vaughan,Jane Osbourn,Bahija Jallal Pdf

In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.

Protein Therapeutics

Zuben E. Sauna,Chava Kimchi-Sarfaty
Protein Therapeutics Book PDF

Author : Zuben E. Sauna,Chava Kimchi-Sarfaty
Publisher : Springer
Page : 0 pages
File Size : 48,8 Mb
Release : 2018-07-28
Category : Science
ISBN : 3319824376

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Protein Therapeutics by Zuben E. Sauna,Chava Kimchi-Sarfaty Pdf

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors

Therapeutic Peptides and Proteins

Ajay K. Banga
Therapeutic Peptides and Proteins Book PDF

Author : Ajay K. Banga
Publisher : CRC Press
Page : 336 pages
File Size : 55,6 Mb
Release : 1997-07-01
Category : Medical
ISBN : 1566763290

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Therapeutic Peptides and Proteins by Ajay K. Banga Pdf

From the Preface At the time of this writing, the American biotechnology and pharmaceutical industry has more than two dozen biotechnology-derived therapeutic proteins on the market, while several hundred are in various stages of human clinical trials or at the FDA for review. Today, more than a thousand companies are involved in biotechnology research, with a total revenue of $7.7 billion for 1993. Therapeutic peptides and proteins are expected to mitigate suffering in coming years as anticancer agents, hormones, growth factors, analgesics, anti-hypertensives, and thrombolytics, among others. However, the clinical application of these therapeutic peptides and proteins is limited by several problems, such as lack of physical and chemical stability or the lack of desirable attributes for adequate absorption or distribution. Thus, as these therapeutic peptides and proteins are made available, it will be essential to formulate these drugs into safe, stable and efficacious delivery systems. The pharmaceutical scientist involved in this effort needs to call upon the knowledge of several disciplines, such as pharmaceutics, medicinal chemistry, biochemistry, and microbiology, and needs to keep abreast with the latest research in the published literature. This book presents these principles in a simple, interesting and practically useful manner for the benefit of scientists working in this area and to further research in this area. This book will also provide useful information for students and academic researchers and add to their interest in this area. The book should also be useful in a hospital setting to understand potential physicochemical stability problems that may result during reconstitution or administration of the new recombinant proteins. Since this field is relatively new and rapidly evolving, efforts were made to include very recent literature in the book. As a result, over 40% of the literature citations in the book are for the work published in the last two years.

Formulation, Characterization, and Stability of Protein Drugs

Rodney Pearlman,Y. John Wang
Formulation Characterization and Stability of Protein Drugs Book PDF

Author : Rodney Pearlman,Y. John Wang
Publisher : Springer Science & Business Media
Page : 432 pages
File Size : 52,9 Mb
Release : 2006-04-11
Category : Medical
ISBN : 9780306474521

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Formulation, Characterization, and Stability of Protein Drugs by Rodney Pearlman,Y. John Wang Pdf

Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are described from the perspective of their formulation, characterization, and stability. This ready reference also features recent data and an abundance of previously unpublished information. The in-depth coverage includes a highly useful compendium of degradation sites occurring in over 70 proteins. An invaluable aid in the rapid identification of potential `hot spots' in proteins, this accessible compilation allows for inspection of the protein's primary structure and preparation of a hydroflex plot.

Biotechnology and Biopharmaceuticals

Anonim
Biotechnology and Biopharmaceuticals Book PDF

Author : Anonim
Publisher : John Wiley & Sons
Page : 744 pages
File Size : 50,9 Mb
Release : 2013-12-16
Category : Science
ISBN : 9781118179796

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Biotechnology and Biopharmaceuticals by Anonim Pdf

Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics and cost-effectiveness considerations. The new edition also provides an update on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development including cancer vaccines, stem cell therapeutics, and cell-based therapies.

Biotechnology and Biopharmaceuticals

Anonim
Biotechnology and Biopharmaceuticals Book PDF

Author : Anonim
Publisher : John Wiley & Sons
Page : 744 pages
File Size : 47,7 Mb
Release : 2013-09-19
Category : Science
ISBN : 9781118659984

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Biotechnology and Biopharmaceuticals by Anonim Pdf

Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics and cost-effectiveness considerations. The new edition also provides an update on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development including cancer vaccines, stem cell therapeutics, and cell-based therapies.

Pharmaceutical Biotechnology

Oliver Kayser,Heribert Warzecha
Pharmaceutical Biotechnology Book PDF

Author : Oliver Kayser,Heribert Warzecha
Publisher : John Wiley & Sons
Page : 677 pages
File Size : 41,7 Mb
Release : 2012-05-21
Category : Science
ISBN : 9783527329946

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Pharmaceutical Biotechnology by Oliver Kayser,Heribert Warzecha Pdf

This second edition of a very successful book is thoroughly updated with existing chapters completely rewritten while the content has more than doubled from 16 to 36 chapters. As with the first edition, the focus is on industrial pharmaceutical research, written by a team of industry experts from around the world, while quality and safety management, drug approval and regulation, patenting issues, and biotechnology fundamentals are also covered. In addition, this new edition now not only includes biotech drug development but also the use of biopharmaceuticals in diagnostics and vaccinations. With a foreword by Robert Langer, Kenneth J Germeshausen Professor of Chemical and Biomedical Engineering at MIT and member of the National Academy of Engineering and the National Academy of Sciences.

Analytical Characterization of Biotherapeutics

Jennie R. Lill,Wendy Sandoval
Analytical Characterization of Biotherapeutics Book PDF

Author : Jennie R. Lill,Wendy Sandoval
Publisher : John Wiley & Sons
Page : 378 pages
File Size : 51,5 Mb
Release : 2017-08-14
Category : Science
ISBN : 9781119053101

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Analytical Characterization of Biotherapeutics by Jennie R. Lill,Wendy Sandoval Pdf

The definitive guide to the myriad analytical techniques available to scientists involved in biotherapeutics research Analytical Characterization of Biotherapeutics covers all current and emerging analytical tools and techniques used for the characterization of therapeutic proteins and antigen reagents. From basic recombinant antigen and antibody characterization, to complex analyses for increasingly complex molecular designs, the book explores the history of the analysis techniques and offers valuable insights into the most important emerging analytical solutions. In addition, it frames critical questions warranting attention in the design and delivery of a therapeutic protein, exposes analytical challenges that may occur when characterizing these molecules, and presents a number of tested solutions. The first single-volume guide of its kind, Analytical Characterization of Biotherapeutics brings together contributions from scientists at the leading edge of biotherapeutics research and manufacturing. Key topics covered in-depth include the structural characterization of recombinant proteins and antibodies, antibody de novo sequencing, characterization of antibody drug conjugates, characterization of bi-specific or other hybrid molecules, characterization of manufacturing host-cell contaminant proteins, analytical tools for biologics molecular assessment, and more. Each chapter is written by a recognized expert or experts in their field who discuss current and cutting edge approaches to fully characterizing biotherapeutic proteins and antigen reagents Covers the full range of characterization strategies for large molecule based therapeutics Provides an up-to-date account of the latest approaches used for large molecule characterization Chapters cover the background needed to understand the challenges at hand, solutions to characterize these large molecules, and a summary of emerging options for analytical characterization Analytical Characterization of Biotherapeutics is an up-to-date resource for analytical scientists, biologists, and mass spectrometrists involved in the analysis of biomolecules, as well as scientists employed in the pharmaceuticals and biotechnology industries. Graduate students in biology and analytical science, and their instructors will find it to be fascinating and instructive supplementary reading.

Protein Therapeutics

Zuben E. Sauna,Chava Kimchi-Sarfaty
Protein Therapeutics Book PDF

Author : Zuben E. Sauna,Chava Kimchi-Sarfaty
Publisher : Springer
Page : 182 pages
File Size : 47,5 Mb
Release : 2017-07-19
Category : Science
ISBN : 9783319418186

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Protein Therapeutics by Zuben E. Sauna,Chava Kimchi-Sarfaty Pdf

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors

Fusion Protein Technologies for Biopharmaceuticals

Stefan R. Schmidt
Fusion Protein Technologies for Biopharmaceuticals Book PDF

Author : Stefan R. Schmidt
Publisher : John Wiley & Sons
Page : 995 pages
File Size : 41,7 Mb
Release : 2013-01-28
Category : Medical
ISBN : 9781118354582

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Fusion Protein Technologies for Biopharmaceuticals by Stefan R. Schmidt Pdf

The state of the art in biopharmaceutical FUSION PROTEIN DESIGN Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched. Fusion Protein Technologies for Biopharmaceuticals examines the state of the art in developing fusion proteins for biopharmaceuticals, shedding light on the immense potential inherent in fusion protein design and functionality. A wide pantheon of international scientists and researchers deliver a comprehensive and complete overview of therapeutic fusion proteins, combining the success stories of marketed drugs with the dynamic preclinical and clinical research into novel drugs designed for as yet unmet medical needs. The book covers the major types of fusion proteins—receptor-traps, immunotoxins, Fc-fusions and peptibodies—while also detailing the approaches for developing, delivering, and improving the stability of fusion proteins. The main body of the book contains three large sections that address issues key to this specialty: strategies for extending the plasma half life, the design of toxic proteins, and utilizing fusion proteins for ultra specific targeting. The book concludes with novel concepts in this field, including examples of highly relevant multifunctional antibodies. Detailing the innovative science, commercial realities, and brilliant potential of fusion protein therapeutics, Fusion Protein Technologies for Biopharmaceuticals is a must for pharmaceutical scientists, biochemists, medicinal chemists, molecular biologists, pharmacologists, and genetic engineers interested in determining the shape of innovation in the world of biopharmaceuticals.

Therapeutic Peptides and Proteins

Ajay K. Banga
Therapeutic Peptides and Proteins Book PDF

Author : Ajay K. Banga
Publisher : CRC Press
Page : 376 pages
File Size : 54,5 Mb
Release : 2005-09-14
Category : Medical
ISBN : 0849316308

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Therapeutic Peptides and Proteins by Ajay K. Banga Pdf

Upon publication of the first edition of Therapeutic Peptides and Proteins ten years ago there were only 19 biotechology medicines on the market. Currently there are more than 100, with at least 400 more in various stages of development. That alone would be grounds for a new edition. Add to that the fact that it is still difficult to find up-to-date, relevant information on protein formulation and/or delivery systems and the need for a new edition is self-evident. This second edition continues the tradition of providing a ready-to-use reference of accurate information, tables, and illustrations. The book begins with the basics of the origin of recombinant proteins, explores structural and analytical aspects, and moves on to discuss the stability of proteins and peptides. Against this background, the author addresses preformulation and formulation considerations and provides detailed information on important topics such as lyophilization. He goes on to discuss various delivery systems, including controlled release delivery systems and products currently on the market. The book also contains newly added regulatory information and thoroughly investigates therapeutic drugs made from proteins as well as protein-based vaccines. A new chapter on recombinant protein subunit vaccines and their delivery systems has been added. The work of a single author, the book provides complex information in a simple, elegant, and cohesive style. The author minimizes overlap between coverage and includes extensive cross-referencing that links related topics. Completely revised and updated, packed with cutting-edge information, the second edition once again fills the need for a reference that pulls all the relevant information together into one resource.

Basic and Applied Aspects of Biotechnology

Varsha Gupta,Manjistha Sengupta,Jaya Prakash,Baishnab Charan Tripathy
Basic and Applied Aspects of Biotechnology Book PDF

Author : Varsha Gupta,Manjistha Sengupta,Jaya Prakash,Baishnab Charan Tripathy
Publisher : Springer
Page : 527 pages
File Size : 45,5 Mb
Release : 2016-10-22
Category : Technology & Engineering
ISBN : 9789811008757

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Basic and Applied Aspects of Biotechnology by Varsha Gupta,Manjistha Sengupta,Jaya Prakash,Baishnab Charan Tripathy Pdf

This book explores the journey of biotechnology, searching for new avenues and noting the impressive accomplishments to date. It has harmonious blend of facts, applications and new ideas. Fast-paced biotechnologies are broadly applied and are being continuously explored in areas like the environmental, industrial, agricultural and medical sciences. The sequencing of the human genome has opened new therapeutic opportunities and enriched the field of medical biotechnology while analysis of biomolecules using proteomics and microarray technologies along with the simultaneous discovery and development of new modes of detection are paving the way for ever-faster and more reliable diagnostic methods. Life-saving bio-pharmaceuticals are being churned out at an amazing rate, and the unraveling of biological processes has facilitated drug designing and discovery processes. Advances in regenerative medical technologies (stem cell therapy, tissue engineering, and gene therapy) look extremely promising, transcending the limitations of all existing fields and opening new dimensions for characterizing and combating diseases.