Protein Therapeutics

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Protein Therapeutics, 2 Volume Set

Tristan Vaughan,Jane Osbourn,Bahija Jallal
Protein Therapeutics 2 Volume Set Book PDF

Author : Tristan Vaughan,Jane Osbourn,Bahija Jallal
Publisher : John Wiley & Sons
Page : 762 pages
File Size : 55,8 Mb
Release : 2017-12-04
Category : Medical
ISBN : 9783527340866

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Protein Therapeutics, 2 Volume Set by Tristan Vaughan,Jane Osbourn,Bahija Jallal Pdf

In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.

Protein Therapeutics

Zuben E. Sauna,Chava Kimchi-Sarfaty
Protein Therapeutics Book PDF

Author : Zuben E. Sauna,Chava Kimchi-Sarfaty
Publisher : Springer
Page : 0 pages
File Size : 46,8 Mb
Release : 2018-07-28
Category : Science
ISBN : 3319824376

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Protein Therapeutics by Zuben E. Sauna,Chava Kimchi-Sarfaty Pdf

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors

Characterization of Protein Therapeutics using Mass Spectrometry

Guodong Chen
Characterization of Protein Therapeutics using Mass Spectrometry Book PDF

Author : Guodong Chen
Publisher : Springer Science & Business Media
Page : 408 pages
File Size : 41,8 Mb
Release : 2014-07-08
Category : Science
ISBN : 9781441978622

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Characterization of Protein Therapeutics using Mass Spectrometry by Guodong Chen Pdf

This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.

Therapeutic Proteins

C. Mark Smales,David C. James
Therapeutic Proteins Book PDF

Author : C. Mark Smales,David C. James
Publisher : Springer Science & Business Media
Page : 481 pages
File Size : 47,7 Mb
Release : 2008-02-04
Category : Science
ISBN : 9781592599226

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Therapeutic Proteins by C. Mark Smales,David C. James Pdf

With the recent completion of the sequencing of the human genome, it is widely anticipated that the number of potential new protein drugs and targets will escalate at an even greater rate than that observed in recent years. However, identification of a potential target is only part of the process in developing these new next generation protein-based “drugs” that are increasingly being used to treat human disease. Once a potential protein drug has been identified, the next rate-limiting step on the road to development is the production of sufficient authentic material for testing, charact- ization, clinical trials, and so on. If a protein drug does actually make it through this lengthy and costly process, methodology that allows the production of the protein on a scale large enough to meet demand must be implemented. Furthermore, large-scale production must not compromise the authenticity of the final product. It is also nec- sary to have robust methods for the purification, characterization, viral inactivation and continued testing of the authenticity of the final protein product and to be able to formulate it in a manner that retains both its biological activity and lends itself to easy administration. Therapeutic Proteins: Methods and Protocols covers all aspects of protein drug production downstream of the discovery stage. This volume contains contributions from leaders in the field of therapeutic protein expression, purification, characterization, f- mulation, and viral inactivation.

Protein Therapeutics

Tristan Vaughan,Jane Osbourn,Bahija Jallal
Protein Therapeutics Book PDF

Author : Tristan Vaughan,Jane Osbourn,Bahija Jallal
Publisher : John Wiley & Sons
Page : 480 pages
File Size : 41,5 Mb
Release : 2017-07-28
Category : Medical
ISBN : 9783527699131

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Protein Therapeutics by Tristan Vaughan,Jane Osbourn,Bahija Jallal Pdf

In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.

Recombinant Protein Drugs

P. Buckel
Recombinant Protein Drugs Book PDF

Author : P. Buckel
Publisher : Springer Science & Business Media
Page : 226 pages
File Size : 54,9 Mb
Release : 2001-08-01
Category : Medical
ISBN : 3764359048

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Recombinant Protein Drugs by P. Buckel Pdf

Recombinant protein drugs are intimately associated with the impressive success story of the Biotech Industry during the past thirty years, some of them belonging to the most successful pharmaceutical products. More than thirty different proteins are available for a variety of clinical applications, over 300 proteins are presently being evaluated in clinical trials. In this new volume of the MDT series, historical, technical and clinical aspects of recombinant protein drug discovery and development are presented, covering past, present and future highlights. Leading scientists and co-founders of early Biotech companies describe technical breakthroughs and the fascinating story of pioneering discoveries, as well as the long way of translating them into products and business. Therefore, this book represents an exciting documentation of the beginning of a new era in the pharmaceutical industry. In addition, scientists from basic research, clinic and industry actively involved in new developments discuss...

Production of Plasma Proteins for Therapeutic Use

Joseph Bertolini,Neil Goss,John Curling
Production of Plasma Proteins for Therapeutic Use Book PDF

Author : Joseph Bertolini,Neil Goss,John Curling
Publisher : John Wiley & Sons
Page : 518 pages
File Size : 52,6 Mb
Release : 2012-12-26
Category : Medical
ISBN : 9780470924310

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Production of Plasma Proteins for Therapeutic Use by Joseph Bertolini,Neil Goss,John Curling Pdf

Sets forth the state of the science and technology in plasma protein production With contributions from an international team of eighty leading experts and pioneers in the field, Production of Plasma Proteins for Therapeutic Use presents a comprehensive overview of the current state of knowledge about the function, use, and production of blood plasma proteins. In addition to details of the operational requirements for the production of plasma derivatives, the book describes the biology, development, research, manufacture, and clinical indications of essentially all plasma proteins with established clinical use or therapeutic potential. Production of Plasma Proteins for Therapeutic Use covers the key aspects of the plasma fractionation industry in five sections: Section 1: Introduction to Plasma Fractionation initially describes the history of transfusion and then covers the emergence of plasma collection and fractionation from its earliest days to the present time, with the commercial and not-for-profit sectors developing into a multi-billion dollar industry. Section 2: Plasma Proteins for Therapeutic Use contains 24 chapters dedicated to specific plasma proteins, including coagulation factors, albumin, immunoglobulin, and a comprehensive range of other plasma-derived proteins with therapeutic indications. Each chapter discusses the physiology, biochemistry, mechanism of action, and manufacture of each plasma protein including viral safety issues and clinical uses. Section 3: Pathogen Safety of Plasma Products examines issues and procedures for enhancing viral safety and reducing the risk of transmissible spongiform encephalopathy transmission. Section 4: The Pharmaceutical Environment Applied to Plasma Fractionation details the requirements and activities associated with plasma collection, quality assurance, compliance with regulatory requirements, provision of medical affairs support, and the manufacture of plasma products. Section 5: The Market for Plasma Products and the Economics of Fractionation reviews the commercial environment and economics of the plasma fractionation industry including future trends, highlighting regions such as Asia, which have the potential to exert a major influence on the plasma fractionation industry in the twenty-first century.

Therapeutic Proteins

Vladimir Voynov,Justin A. Caravella
Therapeutic Proteins Book PDF

Author : Vladimir Voynov,Justin A. Caravella
Publisher : Humana Press
Page : 516 pages
File Size : 53,5 Mb
Release : 2016-05-01
Category : Medical
ISBN : 1493959492

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Therapeutic Proteins by Vladimir Voynov,Justin A. Caravella Pdf

Emphasizing the newest developments in the field, this volume presents detailed methodswith added emphasison therapeutic protein discovery. It features key tips and valuable implementation advice to ensure successful results."

PEGylated Protein Drugs: Basic Science and Clinical Applications

Francesco M. Veronese
PEGylated Protein Drugs Basic Science and Clinical Applications Book PDF

Author : Francesco M. Veronese
Publisher : Springer Science & Business Media
Page : 289 pages
File Size : 52,9 Mb
Release : 2009-12-30
Category : Medical
ISBN : 9783764386795

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PEGylated Protein Drugs: Basic Science and Clinical Applications by Francesco M. Veronese Pdf

PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.

Formulation, Characterization, and Stability of Protein Drugs

Rodney Pearlman,Y. John Wang
Formulation Characterization and Stability of Protein Drugs Book PDF

Author : Rodney Pearlman,Y. John Wang
Publisher : Springer Science & Business Media
Page : 432 pages
File Size : 43,8 Mb
Release : 2006-04-11
Category : Medical
ISBN : 9780306474521

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Formulation, Characterization, and Stability of Protein Drugs by Rodney Pearlman,Y. John Wang Pdf

Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are described from the perspective of their formulation, characterization, and stability. This ready reference also features recent data and an abundance of previously unpublished information. The in-depth coverage includes a highly useful compendium of degradation sites occurring in over 70 proteins. An invaluable aid in the rapid identification of potential `hot spots' in proteins, this accessible compilation allows for inspection of the protein's primary structure and preparation of a hydroflex plot.

Therapeutic Peptides and Proteins

Ajay K. Banga
Therapeutic Peptides and Proteins Book PDF

Author : Ajay K. Banga
Publisher : CRC Press
Page : 400 pages
File Size : 42,7 Mb
Release : 2015-04-23
Category : Medical
ISBN : 9781466566071

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Therapeutic Peptides and Proteins by Ajay K. Banga Pdf

There are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis. The clinical application of these therapeutic peptides and proteins is limited by several problems, such as lack of physical and chemical stability or the lack of desirable attributes for adequate absorption or distribution. Thus, as these therapeutic peptides and proteins are made available, it will be essential to formulate these drugs into safe, stable, and efficacious delivery systems. The pharmaceutical scientist involved in this effort needs to call upon the knowledge of several disciplines, such as pharmaceutics, medicinal chemistry, biochemistry, microbiology, and chemical engineering and needs to keep abreast with the latest research in the published literature. Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Third Edition provides a comprehensive overview of the field for scientists in industry and academia and for students, while also providing practical information on the challenges facing the formulation and delivery aspects of these unique macromolecules. In particular, the book: Explains how recombinant DNA techniques now allow us to produce therapeutic proteins in a commercially viable form Discusses the physical and chemical pathways of peptide and protein degradation Includes a detailed discussion of protein formulation and lyophilization Overviews the pharmacokinetic aspects of therapeutic peptides and proteins and discusses controlled delivery systems for parenteral administration, including microsphere formulations Discusses research progress on oral, transdermal, mucosal, and topical delivery systems discusses transdermal and topical delivery

Therapeutic Proteins Against Human Diseases

Fahmida Khatoon Zahid Balouch
Therapeutic Proteins Against Human Diseases Book PDF

Author : Fahmida Khatoon Zahid Balouch
Publisher : Springer Nature
Page : 178 pages
File Size : 40,9 Mb
Release : 2022-09-28
Category : Psychology
ISBN : 9789811678974

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Therapeutic Proteins Against Human Diseases by Fahmida Khatoon Zahid Balouch Pdf

This book compiles updated research about the implications of therapeutic proteins in various human diseases. The initial chapters of the book provide basic information on the therapeutic proteins and discuss techniques for their formulation, production, and analytic approaches for their characterization. The subsequent chapters shed light on therapies based on therapeutic proteins against metabolic disorders, neurological disorders, cancer, autoimmune disorders, and infectious diseases. Importantly, it presents the factors influencing the immunogenicity of therapeutic proteins, including, genetic factors, disease type, and origin of therapeutic protein, dose frequency, administration route, and treatment duration. The book also reviews the strategies for reducing immunogenicity associated with therapeutic proteins, including PEGylation, site specific mutagenesis, exon shuffling, and humanizing of monoclonal antibodies. Further, it presents strategies for improving the typical drawback associated with protein therapeutics including instability and limited penetration through biological barriers. This book covers various computational methods that are commonly used for designing therapeutic proteins and in silico method for predicting and improving in vivo efficacy of the therapeutic molecules. Lastly, the book highlights the recent advances in developing nanosized delivery systems to improve safety and efficacy of protein therapeutics. This book caters to students and researchers of medicinal chemistry, pharmaceutical sciences and therapeutics. It is also useful to clinicians working with therapeutic proteins.

Proteins and Peptides

Randall J. Mrsny,Ann Daugherty
Proteins and Peptides Book PDF

Author : Randall J. Mrsny,Ann Daugherty
Publisher : CRC Press
Page : 288 pages
File Size : 55,5 Mb
Release : 2009-10-19
Category : Medical
ISBN : 9781420078077

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Proteins and Peptides by Randall J. Mrsny,Ann Daugherty Pdf

Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is

Therapeutic Protein Drug Products

Brian K Meyer
Therapeutic Protein Drug Products Book PDF

Author : Brian K Meyer
Publisher : Elsevier
Page : 205 pages
File Size : 54,8 Mb
Release : 2012-01-02
Category : Medical
ISBN : 9781908818102

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Therapeutic Protein Drug Products by Brian K Meyer Pdf

Therapeutic protein drug products provides a comprehensive overview of therapeutic protein drug products, with an emphasis on formulation beginning in the laboratory, followed by manufacturing and administration in the clinic. A list of many commercial therapeutic drug products are described and include the product name, dosages, active concentration, buffer, excipients, Ph, container type and route of administration. The laboratory formulation sections focus on the most common buffers, excipients, and Ph ranges that are commonly tested in addition to systematic approaches. A brief section on biophysical and analytical analysis is also provided. Properties of therapeutic protein formulations are described and include opalescence, phase separation, color, and subvisible particles. An emphasis is placed on material and process testing to ensure success during manufacturing. The drug product manufacturing process, which includes the process of compounding to filling, is also covered. Methods of delivery in the clinic are addressed, as well as delivery strategies. Finally, a perspective on the regulatory requirements for therapeutic protein formulations is discussed. Provides a list and description of commercially available therapeutic drug products and their formulations A comprehensive and practical overview of protein formulation in the laboratory, manufacturing, and the clinic Discusses recent topics including high protein concentration, phase separation, opalescence, and subvisible particles

Recombinant Protein Drugs

P. Buckel
Recombinant Protein Drugs Book PDF

Author : P. Buckel
Publisher : Birkhäuser
Page : 207 pages
File Size : 49,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783034883467

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Recombinant Protein Drugs by P. Buckel Pdf

Recombinant protein drugs are intimately associated with the impressive success story of the Biotech Industry during the past thirty years, some of them belonging to the most successful pharmaceutical products. More than thirty different proteins are available for a variety of clinical applications, over 300 proteins are presently being evaluated in clinical trials. In this new volume of the MDT series, historical, technical and clinical aspects of recombinant protein drug discovery and development are presented, covering past, present and future highlights. Leading scientists and co-founders of early Biotech companies describe technical breakthroughs and the fascinating story of pioneering discoveries, as well as the long way of translating them into products and business. Therefore, this book represents an exciting documentation of the beginning of a new era in the pharmaceutical industry. In addition, scientists from basic research, clinic and industry actively involved in new developments discuss...