Red Blood Cell Aging

Author : Antonio De Flora,Mauro Magnani
Publisher : Springer Science & Business Media
Page : 365 pages
File Size : 48,7 Mb
Release : 2013-03-08
Category : Medical
ISBN : 9781468459852

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Red Blood Cell Aging by Antonio De Flora,Mauro Magnani Pdf

The mammalian erythrocyte is a very suitable model for the study of aging at the cellular and molecular level. It is not only a matter of apparent simplicity in terms of biochemistry, biophysics and physiology but more likely this cell offers a great possibility for elucidating some basic problems in the process of aging. In fact, nowadays, it is possible to follow individual cells all along their life span in circulation, it is possible to obtain these cells when young, middle aged or old and it is possible to obtain cells from individuals of defined ages and transfuse them into compatible recipients to investigate the role of the environment where the cell lives, and finally it is possible to easily manipulate the red cell content in terms of enzymatic activities and/or metabolic properties to investigate the possible effect of these manipulations on cell survival. This book, Red Blood Cell Aging, is based on a symposium held in Urbino, Italy, at the end of 1990 and examines the impact of age on the membrane, metabolism, structural and enzymatic proteins of mammalian erythrocytes. The various contributions to this symposium not only described those processes of aging which affect the cell but also provided a nearly complete picture of the event{s} and mechanism{s} that every day permits to recognize among 25 trillion circulating red cells {in an average adult} that 1 percent that have reached the end of their 120 day life span in circulation.

Author : Oguz Baskurt,Björn Neu,Herbert J. Meiselman
Publisher : CRC Press
Page : 326 pages
File Size : 41,7 Mb
Release : 2011-09-28
Category : Medical
ISBN : 9781439841808

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Red Blood Cell Aggregation by Oguz Baskurt,Björn Neu,Herbert J. Meiselman Pdf

Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate students; and clinicians interested in mammalian red blood cells.

Author : Lars Kaestner,Anna Bogdanova
Publisher : Frontiers E-books
Page : 118 pages
File Size : 54,8 Mb
Release : 2014-12-03
Category : Biology (General)
ISBN : 9782889193486

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Regulation of red cell life-span, erythropoiesis, senescence and clearance by Lars Kaestner,Anna Bogdanova Pdf

Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives.

Author : Dieter Platt
Publisher : Springer
Page : 242 pages
File Size : 54,5 Mb
Release : 1988
Category : Medical
ISBN : UOM:39015012557347

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Blood Cells, Rheology and Aging by Dieter Platt Pdf

In the third Erlangen-Nuremberg symposium on experimental geronto logy we discussed the effect of aging on blood cells and rheology. Most studies with red cells have been performed on humans, rats, and rabbits. All these erythrocytes have no nucleus; the cells are therefore a model in which new synthesis of proteins is impossible. All the processes are age dependent except for exchange with the plasma. Investigations of red cells have attracted attention because of the latter's availability in large quantities from biochemists, physiologists, immunologists, and micro scopists. We now have a relative abundance of data on the biochemical and immunologic composition as well as on the ultrastructure of the cells. The second topic under discussion at the symposium was the immune system and cell receptors. One of the most apparent features of aging of the organism is progressive dysregulation of the immune system. As a result, the incidence of infection, cancer, and autoimmune and immune complex diseases increases. While we have a lot of new data on the function and differentiation of lymphoid cells, we have little informa tion on lymphocyte receptors during the aging process. Rheologic studies reflect changes in red cell deformability and blood coagulation. The erythrocyte deformability influences blood flow in all parts of the circulation. The fluidity of the red cell membranes controls whole blood viscosity. During aging, there are significant alterations in blood coagulation and hemostasis. One of the best known modifications of blood co agulation is a typical thrombophilic tendency with aging.

Author : D. Danon
Publisher : Unknown
Page : 24 pages
File Size : 50,6 Mb
Release : 1967
Category : Electronic
ISBN : IND:30000090441373

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Influence of Oxygen Toxicity on the Rate of Red Cell Aging by D. Danon Pdf

Author : Charles Anderson Sondhaus
Publisher : Unknown
Page : 84 pages
File Size : 43,8 Mb
Release : 1958
Category : Erythrocytes
ISBN : UOM:39015077593849

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The Hemoglobin Content of Single Erythrocytes in Cell Aging and Hemopoietic Disturbance by Charles Anderson Sondhaus Pdf

Author : Lodovico Balducci,William B. Ershler,John M. Bennett
Publisher : Springer Science & Business Media
Page : 148 pages
File Size : 53,7 Mb
Release : 2007-09-10
Category : Medical
ISBN : 9780387495057

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Anemia in the Elderly by Lodovico Balducci,William B. Ershler,John M. Bennett Pdf

Anemia in the elderly, known as the silent epidemic, afflicts 3 million people in the U.S. ages 65 or older. This reference, complete with the most recent findings, answers all the crucial questions regarding anemia in the elderly.

Author : Surajit Pathak,Antara Banerjee
Publisher : Academic Press
Page : 322 pages
File Size : 46,7 Mb
Release : 2021-03-17
Category : Science
ISBN : 9780128204139

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Stem Cells and Aging by Surajit Pathak,Antara Banerjee Pdf

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Author : Franck Mauvais-Jarvis
Publisher : Springer
Page : 627 pages
File Size : 47,8 Mb
Release : 2017-12-08
Category : Medical
ISBN : 9783319701783

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Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity by Franck Mauvais-Jarvis Pdf

The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.

Author : Ingolf Bernhardt,J. Clive Ellory
Publisher : Springer Science & Business Media
Page : 761 pages
File Size : 53,7 Mb
Release : 2013-04-17
Category : Science
ISBN : 9783662051818

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Red Cell Membrane Transport in Health and Disease by Ingolf Bernhardt,J. Clive Ellory Pdf

51 worldwide leading experts in the field of erythrocyte research contributed to this first book on transport processes in red blood cells. It explains the latest findings on the basis of well-established principles, in an accessibly structured and carefully organized compilation.

Author : Ivan Bernat
Publisher : Springer Science & Business Media
Page : 399 pages
File Size : 41,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461573081

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Iron Metabolism by Ivan Bernat Pdf

Author : Lars Kaestner,Anna Bogdanova
Publisher : Frontiers Media SA
Page : 238 pages
File Size : 41,5 Mb
Release : 2019-02-05
Category : Electronic
ISBN : 9782889457021

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The Red Cell Life-Cycle From Erythropoiesis to Clearance by Lars Kaestner,Anna Bogdanova Pdf

The eBook ‘The red cell life-cycle from erythropoiesis to clearance’ continues the discussion of questions like: What are the changes associated with red blood cell maturation, adulthood and senescence? What are the determinants of red blood cell life span and clearance? What are the mechanisms in control of red blood cell mass in healthy humans and patients with various forms of anaemia? Can red blood cells be 'trained' to provide the body with more oxygen during endurance exercises? What are the markers of circulating red blood cell senescence and in cells during storage and transfusion? And what can be learned from various species that developed advanced adaptations to maintain oxygen delivery under stress conditions such as exercising to the limit, diving or living in anaerobic aquatic habitats or at high altitude? Within the approximately 120 days (or 40 in a mouse, or 150-170 in a horse) life span of 'healthy' red blood cells, many cellular properties change leading to aged mixed cell populations in the circulation. Red blood cells seem to be genetically terminated by the time they become red blood cells and the contributions of this eBook increase the understanding of this process. There are surprisingly versatile remodeling processes happening during the red blood cell life span. Numerous disorders are associated with the premature onset of the 'ageing process' of red blood cells. Furthermore, in vitro ageing and/or modifications as well as the slowing down of the modifications is an important issue in transfusion medicine. Many of the molecular mechanisms behind such effects are elucidated in this eBook.

Author : Toby L. Simon,Jeffrey McCullough,Edward L. Snyder,Bjarte G. Solheim,Ronald G. Strauss
Publisher : John Wiley & Sons
Page : 754 pages
File Size : 47,5 Mb
Release : 2016-05-23
Category : Medical
ISBN : 9781119012993

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Rossi's Principles of Transfusion Medicine by Toby L. Simon,Jeffrey McCullough,Edward L. Snyder,Bjarte G. Solheim,Ronald G. Strauss Pdf

Rossi's Principles of Transfusion Medicine is the most comprehensive and practical reference on transfusion science and medicine available Led by a world class Editor team, including two past-presidents of AABB, a past- President of the American Board of Pathology and members of the FDA Blood Products Advisory Committee , and international contributor team Comprehensive reference resource, considered the gold standard in transfusion Covers current hot topics such as donor care – including the frequency of donation and management of iron deficiency/status), patient blood management, hemovigilance, cstem cell therapies, and global aspects of the organization of transfusion and transplant services New material on molecular immunohematology Companion website includes figures, full text and references

Author : Dieter Platt
Publisher : Unknown
Page : 236 pages
File Size : 40,6 Mb
Release : 1987-12-11
Category : Electronic
ISBN : 3642717918

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Blood Cells, Rheology, and Aging by Dieter Platt Pdf

This volume on experimental gerontology deals with the effects of aging on blood cells and rheology. Since gerontology is an interdisciplinary science, numerous experts engaged in various disciplines present their up-to-date results related to aging. The detailed accounts compiled in this book will augment the knowledge of red cells, immunology, receptors, blood coagulation, and rheology. The volume provides a valuable basis for future scientific work in gerontological research.

Author : O.K. Baskurt,M.R. Hardeman,M.W. Rampling
Publisher : IOS Press
Page : 468 pages
File Size : 50,8 Mb
Release : 2007-10-03
Category : Medical
ISBN : 9781607502630

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Handbook of Hemorheology and Hemodynamics by O.K. Baskurt,M.R. Hardeman,M.W. Rampling Pdf

This publication primarily focuses on the macro- and micro-rheological behavior of blood and its formed elements, on interactions between the formed elements and blood vessel walls, and on the microvascular aspects of hemodynamics. Since many aspects of hemorheology and hemodynamics are affected by disease or clinical states, these effects are discussed as are hyperviscosity syndromes, therapy for disturbed blood rheology, and methods in hemorheology and hemodynamics. Sections of the Handbook include History of Hemorheology; Hemorheology, covering basic aspects, blood composition, blood rheology, cell mechanics, pathophysiology, methods and comparative studies; Hemodynamics, covering basic principles, microcirculation, in vivo effects, endothelium and methods; and Clinical Aspects of Hemorheology, covering hyperviscosity, clinical significance and treatment. The goal is to foster greater interchange between workers in the fields so as to promote collaborative efforts and, hopefully, improved health. In selecting topics for this handbook the editors have attempted to provide a general overview of both basic science and clinical hemorheology and hemodynamics. Hemorheology and hemodynamics are closely related, the former dealing with all aspects of the flow and interactions of the individual blood cells mostly studied in vitro, the latter with the in vivo relationships among vessel architecture, driving pressure, flow rate and shear stress. The linkage between the in vitro and in vivo research described in the book will be of interest to both basic science and clinical investigators. The editors of the handbook have each been active in the fields of bio- and hemorheology for many years, and have published extensively. They have successfully achieved their objective to publish a well-written and well-edited handbook that will be valuable for researchers and students in the field.