Reproductive And Developmental Toxicology

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Reproductive and Developmental Toxicology

Ramesh C. Gupta
Reproductive and Developmental Toxicology Book PDF

Author : Ramesh C. Gupta
Publisher : Academic Press
Page : 1220 pages
File Size : 44,9 Mb
Release : 2011-04-04
Category : Medical
ISBN : 0123820332

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Reproductive and Developmental Toxicology by Ramesh C. Gupta Pdf

Reproductive toxicology is a complex subject dealing with three components—parent, placenta, and fetus—and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife. Provides a complete, integrated source of information on the key risk stages during reproduction and development Includes coverage of emerging science such as stem cell application, toxicoproteomics, metabolomics, phthalates, infertility, teratogenicity, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis

Developmental and Reproductive Toxicology

Ronald D. Hood,Ronald D Hood
Developmental and Reproductive Toxicology Book PDF

Author : Ronald D. Hood,Ronald D Hood
Publisher : CRC Press
Page : 1168 pages
File Size : 55,5 Mb
Release : 2005-08-30
Category : Medical
ISBN : 9781420040548

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Developmental and Reproductive Toxicology by Ronald D. Hood,Ronald D Hood Pdf

Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers evaluating and interpreting data. Originally titled Handbook of Developmental Toxicology, the second edition's new name reflects significant changes in its content and scope. New coverage in the Second Edition: Genomics and proteomics Tests for endocrine disruptors Testing for male and female reproductive toxicity Extensive treatment of the significance, reliability, and interpretation of developmental and reproductive toxicity data Toxicity testing in neonatal and juvenile animals Postnatal developmental milestones FDA perspective on risk assessment Extensive glossaries of developmental defect terminology Previous books on this subject have largely been academically oriented and not intended to guide the practicing developmental or reproductive toxicologist. Useful and informative, this book blends the theoretical foundation with insights gained from hands-on experience. It includes tables of comparative developmental milestones - both pre- and postnatal, glossaries of descriptive terms used in developmental toxicity evaluation, and both US and international regulatory guidelines. Bridging the gap between theory and application, this is a handy single-source of essential information to use in planning, conducting, and interpreting studies.

Computational Methods for Reproductive and Developmental Toxicology

Donald R. Mattison
Computational Methods for Reproductive and Developmental Toxicology Book PDF

Author : Donald R. Mattison
Publisher : CRC Press
Page : 330 pages
File Size : 48,6 Mb
Release : 2015-12-02
Category : Medical
ISBN : 9781439861080

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Computational Methods for Reproductive and Developmental Toxicology by Donald R. Mattison Pdf

Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology. The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next one reviews the biological processes and endpoints involved in reproduction and development. The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods. The book takes a cross-disciplinary approach bringing together developmental, reproductive and systems biology, chemistry, toxicology, pharmacology, biostatistics, information sciences, bioinformatics, and computational approaches. This valuable resource provides those in the field with the necessary knowledge to evaluate both classic and recent approaches to characterize toxicity.

Reproductive and Developmental Toxicology

Ramesh C. Gupta
Reproductive and Developmental Toxicology Book PDF

Author : Ramesh C. Gupta
Publisher : Academic Press
Page : 1460 pages
File Size : 49,5 Mb
Release : 2017-03-24
Category : Medical
ISBN : 9780128042403

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Reproductive and Developmental Toxicology by Ramesh C. Gupta Pdf

Reproductive and Developmental Toxicology, Second Edition, is a comprehensive and authoritative resource that provides the latest literature on this complex subject with a primary focus on three core components—parent, placenta, and fetus—and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics, including nanoparticles and radiation, gases and solvents, smoking, alcohol and drug abuse, and metals, amongst others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, also including discussions on reproductive and developmental toxicity in domestic animals, fish, and wildlife. Completely revised and updated to include the most recent developments in the field, the book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Includes new chapters covering significant developments, such as dose-response assessment for developmental toxicity, juvenile toxicity, and neural tube defects, as well as emerging science, such as stem cell application, toxicoproteomics, metabolomics, endocrine disruption, surveillance and regulatory considerations, and risk assessment Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis

Reproductive and Developmental Toxicology

Kenneth S . Korach
Reproductive and Developmental Toxicology Book PDF

Author : Kenneth S . Korach
Publisher : CRC Press
Page : 748 pages
File Size : 50,5 Mb
Release : 1998-03-27
Category : Medical
ISBN : 1420002899

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Reproductive and Developmental Toxicology by Kenneth S . Korach Pdf

This timely resource offers extensive discussions on the pharmacological, environmental,endocrinological, and natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of reproduction. Describing biological actions common to both genders as well as gender-specific processes, Reproducti

Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test

OECD
Test No 422 Combined Repeated Dose Toxicity Study with the Reproduction Developmental Toxicity Screening Test Book PDF

Author : OECD
Publisher : OECD Publishing
Page : 14 pages
File Size : 55,7 Mb
Release : 1996-03-22
Category : Electronic
ISBN : 9789264070981

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Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test by OECD Pdf

The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks; females should be dosed throughout the study (approximately 54 days). Normally, matings “one male to one ...

Oligonucleotide-Based Drugs and Therapeutics

Nicolay Ferrari,Rosanne Seguin
Oligonucleotide Based Drugs and Therapeutics Book PDF

Author : Nicolay Ferrari,Rosanne Seguin
Publisher : John Wiley & Sons
Page : 576 pages
File Size : 46,5 Mb
Release : 2018-07-31
Category : Medical
ISBN : 9781118537336

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Oligonucleotide-Based Drugs and Therapeutics by Nicolay Ferrari,Rosanne Seguin Pdf

A comprehensive review of contemporary antisense oligonucleotides drugs and therapeutic principles, methods, applications, and research Oligonucleotide-based drugs, in particular antisense oligonucleotides, are part of a growing number of pharmaceutical and biotech programs progressing to treat a wide range of indications including cancer, cardiovascular, neurodegenerative, neuromuscular, and respiratory diseases, as well as other severe and rare diseases. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide covering all key aspects of this increasingly popular area of pharmacology and biotech and pharma research, from the basic science behind antisense oligonucleotides chemistry, toxicology, manufacturing, to safety assessments, the design of therapeutic protocols, to clinical experience. Antisense oligonucleotides are single strands of DNA or RNA that are complementary to a chosen sequence. While the idea of antisense oligonucleotides to target single genes dates back to the 1970's, most advances have taken place in recent years. The increasing number of antisense oligonucleotide programs in clinical development is a testament to the progress and understanding of pharmacologic, pharmacokinetic, and toxicologic properties as well as improvement in the delivery of oligonucleotides. This valuable book reviews the fundamentals of oligonucleotides, with a focus on antisense oligonucleotide drugs, and reports on the latest research underway worldwide. • Helps readers understand antisense molecules and their targets, biochemistry, and toxicity mechanisms, roles in disease, and applications for safety and therapeutics • Examines the principles, practices, and tools for scientists in both pre-clinical and clinical settings and how to apply them to antisense oligonucleotides • Provides guidelines for scientists in drug design and discovery to help improve efficiency, assessment, and the success of drug candidates • Includes interdisciplinary perspectives, from academia, industry, regulatory and from the fields of pharmacology, toxicology, biology, and medicinal chemistry Oligonucleotide-Based Drugs and Therapeutics belongs on the reference shelves of chemists, pharmaceutical scientists, chemical biologists, toxicologists and other scientists working in the pharmaceutical and biotechnology industries. It will also be a valuable resource for regulatory specialists and safety assessment professionals and an important reference for academic researchers and post-graduates interested in therapeutics, antisense therapy, and oligonucleotides.

Biologic Markers in Reproductive Toxicology

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Reproductive and Neurodevelopmental Toxicology
Biologic Markers in Reproductive Toxicology Book PDF

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Reproductive and Neurodevelopmental Toxicology
Publisher : National Academies Press
Page : 424 pages
File Size : 50,8 Mb
Release : 1989-02-01
Category : Social Science
ISBN : 0309039797

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Biologic Markers in Reproductive Toxicology by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Reproductive and Neurodevelopmental Toxicology Pdf

Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markersâ€"indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive abilityâ€"are a promising tool for research aimed at answering that important question. Biologic Markers in Reproductive Toxicology examines the potential of these markers in environmental health studies; clarifies definitions, underlying concepts, and possible applications; and shows the benefits to be gained from their use in reproductive and neurodevelopmental research.

Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity

National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Reproductive and Developmental Toxicology
Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity Book PDF

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Reproductive and Developmental Toxicology
Publisher : National Academies Press
Page : 261 pages
File Size : 41,8 Mb
Release : 2001-04-13
Category : Nature
ISBN : 9780309073165

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Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Reproductive and Developmental Toxicology Pdf

The United States Navy has been concerned for some time with protecting its military and civilian personnel from reproductive and developmental hazards in the workplace. As part of its efforts to reduce or eliminate exposure of Naval personnel and their families to reproductive and developmental toxicants, the Navy requested that the National Research Council (NRC) recommend an approach that can be used to evaluate chemicals and physical agents for their potential to cause reproductive and developmental toxicity. The NRC assigned this project to the Committee on Toxicology, which convened the Subcommittee on Reproductive and Developmental Toxicology, to prepare this report. In this report, the subcommittee recommends an approach for evaluating agents for potential reproductive and developmental toxicity and demonstrates how that approach can be used by the Navy. This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the NRC's Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report: James Chen (National Center for Toxicological Research), George Daston (Procter and Gamble Company), Jerry Heindel (National Institute of Environmental Health Sciences), Grace Lemasters (University of Cincinnati), and John Young (National Center for Toxicological Research).

Reproductive Toxicology, Third Edition

Robert W. Kapp,Rochelle W. Tyl
Reproductive Toxicology Third Edition Book PDF

Author : Robert W. Kapp,Rochelle W. Tyl
Publisher : CRC Press
Page : 512 pages
File Size : 40,9 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420073447

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Reproductive Toxicology, Third Edition by Robert W. Kapp,Rochelle W. Tyl Pdf

Thoroughly examining the popular and expanding field of reproductive toxicology, this newly revised and expanded third edition provides the latest, cutting-edge scientific developments in this constantly evolving discipline. Reproductive Toxicology’s contributors are experienced regulatory agency and Clinical Research Organization representatives who currently utilize the new techniques discussed in the text and continue to revolutionize reproductive toxicology research. This ground-breaking resource includes: New and important critical mechanistic topics such as epigenetics and omics The first significant compilation of epigenetic mechanisms An in-depth analysis of the role of genomics, proteomics, and metabolomicsin human reproduction New guidelines with respect to the latest research applications in the field

Male-Mediated Developmental Toxicity

Andrew F. Olshan,Donald R. Mattison
Male Mediated Developmental Toxicity Book PDF

Author : Andrew F. Olshan,Donald R. Mattison
Publisher : Springer Science & Business Media
Page : 401 pages
File Size : 41,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461518778

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Male-Mediated Developmental Toxicity by Andrew F. Olshan,Donald R. Mattison Pdf

The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events.

Scientific Frontiers in Developmental Toxicology and Risk Assessment

National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
Scientific Frontiers in Developmental Toxicology and Risk Assessment Book PDF

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology
Publisher : National Academies Press
Page : 348 pages
File Size : 51,8 Mb
Release : 2000-12-21
Category : Nature
ISBN : 9780309070867

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Scientific Frontiers in Developmental Toxicology and Risk Assessment by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Developmental Toxicology Pdf

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Reproductive and Developmental Toxicants

Eleanor Chelimsky
Reproductive and Developmental Toxicants Book PDF

Author : Eleanor Chelimsky
Publisher : DIANE Publishing
Page : 118 pages
File Size : 43,7 Mb
Release : 2000
Category : Electronic
ISBN : 0788186264

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Reproductive and Developmental Toxicants by Eleanor Chelimsky Pdf

Evaluates federal regulatory actions on environmental chemicals known to cause adverse reproductive and developmental outcomes. Identifies 30 environmental chemicals found to be of high concern because of the widespread acknowledgment of their reproductive and developmental consequences as toxicants. Determines the extent to which these chemicals are regulated by the federal government. Assesses the degree to which these regulatory actions are based on reproductive and developmental toxicity. Evaluates whether the regulatory protection currently provided to the public against reproductive and developmental disease is sufficient.

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

Ali S. Faqi
A Comprehensive Guide to Toxicology in Nonclinical Drug Development Book PDF

Author : Ali S. Faqi
Publisher : Elsevier
Page : 1074 pages
File Size : 44,5 Mb
Release : 2024-02-11
Category : Medical
ISBN : 9780323984621

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A Comprehensive Guide to Toxicology in Nonclinical Drug Development by Ali S. Faqi Pdf

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapy Includes the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology

Developmental and Reproductive Toxicology

Ali S. Faqi
Developmental and Reproductive Toxicology Book PDF

Author : Ali S. Faqi
Publisher : Humana
Page : 314 pages
File Size : 49,6 Mb
Release : 2018-06-15
Category : Medical
ISBN : 1493984160

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Developmental and Reproductive Toxicology by Ali S. Faqi Pdf

This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab. Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resource for researchers working in this vital field of study./div