Reprogramming The Genome Crispr Cas Based Human Disease Therapy

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Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy

Anonim
Reprogramming the Genome CRISPR Cas based Human Disease Therapy Book PDF

Author : Anonim
Publisher : Academic Press
Page : 394 pages
File Size : 53,5 Mb
Release : 2021-06-12
Category : Science
ISBN : 9780323853248

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Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy by Anonim Pdf

Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy, presents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 is a key technology for targeted genome editing and regulation in a number of organisms including mammalian cells. It is a rapid, simple, and cost-effective solution. CRISPR-Cas system has recently gained much scientific and public attention. This volume covers CRISPR-Cas9 based mammalian genome editing, creating disease models, cancer therapy, neurological, heredity, blood disorders, defective gene correction, stem cells therapy, epigenetic modifications, patents, ethics, biosafety and regulatory issues challenges and opportunities. This book is a key source of information on mammalian genome editing available in a single volume. This book will be useful for beginners in mammalian genome editing and also students, researchers, scientists, policymakers, clinicians and stakeholders interested in genome editing in several areas. Offers basic understanding and a clear picture of mammalian genome editing through CRISPR-Cas systems Discusses how to create mammalian disease models, stem cell modification, epigenetic modifications, correction of defective gene in blood disorders, heredity, neurological disorders and many more Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, molecular biology, translational sciences, neurobiology, neurology, cancer, stem cells, and many more

CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases

Luis María Vaschetto
CRISPR Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases Book PDF

Author : Luis María Vaschetto
Publisher : CRC Press
Page : 268 pages
File Size : 45,7 Mb
Release : 2022-01-31
Category : Mathematics
ISBN : 9781000540819

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CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases by Luis María Vaschetto Pdf

The CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of applications of CRISPR/Cas9 genetic scissors. Some topics included in this book are: the role of the CRISPR/Cas9 system in neuroscience, gene therapy, epigenome editing, genome mapping, cancer, virus infection control strategies, regulatory challenges and bioethical considerations.

Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part A

Anonim
Reprogramming the Genome Applications of CRISPR Cas in non mammalian systems part A Book PDF

Author : Anonim
Publisher : Academic Press
Page : 244 pages
File Size : 40,5 Mb
Release : 2021-03-28
Category : Science
ISBN : 9780323853224

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Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part A by Anonim Pdf

Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems, Part A presents a collation of chapters written by global, eminent scientists. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. Chapters in this release include An Introduction and applications of CRISPR-Cas Systems, History, evolution and classification of CRISPR-Cas associated systems, CRISPR based bacterial genome editing and removal of pathogens, CRISPR based genome editing and removal of human viruses, CRISPR based development of RNA editing and diagnostic platform, and much more. Additional sections cover Genome engineering in insects for control of vector borne diseases, Development of insect cell line using CRISPR technology, CRISPRing protozoan parasites to better understand the biology of diseases, CRISPR based genome editing of Caenorhabditis elegans, and a variety of other important topics. Offers a basic understanding and clear picture of genome editing CRISPR-Cas systems in different organisms Explains how to create an animal model for disease diagnosis/research and reprogram CRISPR for removal of virus, bacteria, fungi, protozoan, and many more Discusses the advances, patents, applications, challenges and opportunities in CRISPR-Cas9 systems in basic sciences, biomedicine, virology, bacteriology, molecular biology, and many more

Curing Genetic Diseases through Genome Reprogramming

Anonim
Curing Genetic Diseases through Genome Reprogramming Book PDF

Author : Anonim
Publisher : Academic Press
Page : 560 pages
File Size : 49,6 Mb
Release : 2021-06-24
Category : Science
ISBN : 9780323853026

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Curing Genetic Diseases through Genome Reprogramming by Anonim Pdf

Curing Genetic Diseases through Genome Reprogramming, Volume 182 captures an historic moment in the field of gene therapy—the dawn of a new age in which the dream of curing genetic diseases has become realizable. The volume presents the most clinically advanced gene therapy and genome editing approaches for the treatment of genetic diseases in specific organs, including difficult therapeutic targets, futuristic ideas of genetic interventions, and large scale human genome repair. An initial chapter addresses the complex ethical aspects involved in the very idea of modifying the human genome. Provides a comprehensive view of gene therapy and genome editing technologies, including epigenetic editing Describes the state-of-the-art and future directions for the treatment of genetic diseases, also considering economical aspects Presents chapters that each give a thorough review of a specific disease, target organ or visionary approach, including ethical considerations

Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part B

Anonim
Reprogramming the Genome Applications of CRISPR Cas in non mammalian systems part B Book PDF

Author : Anonim
Publisher : Academic Press
Page : 200 pages
File Size : 44,8 Mb
Release : 2021-04-29
Category : Science
ISBN : 9780323852982

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Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part B by Anonim Pdf

Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems Part B, represents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. It is a simple, rapid, precise, and cost-effective tool for genome editing and regulation of a wide range of organisms. It has gained scientific and public attention worldwide. This volume mainly covers insect cell line, protozoans, zebrafish, drosophila, CRISPRi, patents as well as technology transfer, and many more. This book is a key source of information available in a single volume. This book will be useful for not only beginners in genome engineering, but also students, researchers, scientists, policymakers, and stakeholders interested in harnessing the potential of reprogramming of the genomes in several areas. Offers basic understanding and a clear picture of genome editing CRISPR-Cas systems in different organisms Explains how to create an animal model for disease diagnosis/research and reprogram CRISPR for insect cell line, protozoans, zebrafish, drosophila, and many more Discusses the advances, patents, applications, challenges and opportunities in CRISPR-Cas9 systems in basic sciences, biomedicine, molecular biology and many more

Heritable Human Genome Editing

The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Heritable Human Genome Editing Book PDF

Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publisher : National Academies Press
Page : 239 pages
File Size : 49,7 Mb
Release : 2021-01-16
Category : Medical
ISBN : 9780309671132

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Heritable Human Genome Editing by The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing Pdf

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

CRISPR Genome Surgery in Stem Cells and Disease Tissues

Stephen H. Tsang
CRISPR Genome Surgery in Stem Cells and Disease Tissues Book PDF

Author : Stephen H. Tsang
Publisher : Academic Press
Page : 138 pages
File Size : 55,8 Mb
Release : 2021-10-20
Category : Science
ISBN : 9780128178775

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CRISPR Genome Surgery in Stem Cells and Disease Tissues by Stephen H. Tsang Pdf

CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The book's target audience includes researchers, students, clinicians and the general public. This space that is not currently served by any existing resource, so this publication fills a gap in current literature. Provides a thorough review of CRISPR-Cas9, from discovery to therapy Covers the latest advances in gene editing and its translational applications to various diseases Written by global leaders in the fields of gene editing and stem cell therapy

Gene Editing in Plants

Anonim
Gene Editing in Plants Book PDF

Author : Anonim
Publisher : Academic Press
Page : 264 pages
File Size : 54,9 Mb
Release : 2017-08-31
Category : Science
ISBN : 9780128117446

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Gene Editing in Plants by Anonim Pdf

Gene Editing in Plants, Volume 149 aims to provide the reader with an up-to-date survey of cutting-edge research with gene editing tools and an overview of the implications of this research on the nutritional quality of fruits, vegetables and grains. New chapters in the updated volume include topics relating to Genome Engineering and Agriculture: Opportunities and Challenges, the Use of CRISPR/Cas9 for Crop Improvement in Maize and Soybean, the Use of Zinc-Finger Nucleases for Crop Improvement, Gene Editing in Polyploid Crops: Wheat, Camelina, Canola, Potato, Cotton, Peanut, Sugar Cane, and Citrus, and Gene Editing With TALEN and CRISPR/Cas in Rice. This ongoing serial contain contributions from leading scientists and researchers in the field of gene editing in plants who describe the results of their own research in this rapidly expanding area of science. Shows the importance of revolutionary gene editing technology on plant biology research and its application to agricultural production Provides insight into what may lie ahead in this rapidly expanding area of plant research and development Contains contributions from major leaders in the field of plant gene editing

CRISPR-Cas Systems

Rodolphe Barrangou,John van der Oost
CRISPR Cas Systems Book PDF

Author : Rodolphe Barrangou,John van der Oost
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 45,8 Mb
Release : 2012-12-13
Category : Science
ISBN : 9783642346576

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CRISPR-Cas Systems by Rodolphe Barrangou,John van der Oost Pdf

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

CRISPR-Cas-Based Genome Editing for Treating Human Diseases-Part A

Anonim
CRISPR Cas Based Genome Editing for Treating Human Diseases Part A Book PDF

Author : Anonim
Publisher : Academic Press
Page : 0 pages
File Size : 40,5 Mb
Release : 2024-10-01
Category : Science
ISBN : 0443315884

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CRISPR-Cas-Based Genome Editing for Treating Human Diseases-Part A by Anonim Pdf

CRISPR-Cas-based genome editing for treating human diseases part A represents CRISPR-Cas systems for genome editing. Currently, CRISPR-Cas systems are proven a key technology for targeted genome editing which is acting as a simple, rapid, and cost-effective solution. CRISPR-Cas9 system is being used in microbial genome editing, mammalian genome editing, disease models, and many. It has shown potential in human disease treatment. However, it is not easy to find CRISPR-Cas systems genome editing in a single source. This volume offers CRISPR-Cas systems for human diseases, bacterial disease, gut microbiome editing, viral disease, protozoan disease, fungal disease, stem cell therapy, CRISPR in epigenetics, CRISPR in cancer, autoimmune and blood disorders. This volume highlights a number of aspects of the CRISPR-Cas sytems that can help the basic understanding of students, researchers, clinicians, entrepreneurs, and stakeholders to perform their research with great interest.

Genome Editing

Toni Cathomen,Matthew Hirsch,Matthew Porteus
Genome Editing Book PDF

Author : Toni Cathomen,Matthew Hirsch,Matthew Porteus
Publisher : Springer
Page : 263 pages
File Size : 43,9 Mb
Release : 2016-03-04
Category : Medical
ISBN : 9781493935093

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Genome Editing by Toni Cathomen,Matthew Hirsch,Matthew Porteus Pdf

This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genome editing for neuromuscular diseases, phase integrases, triplex forming oligonucleotides and peptide nucleic acids, aptamer-guided gene targeting, AAV gene editing via DSB repair, engineered nucleases and trinucleotide repeat diseases, and creation of HIV-resistant cells. The expertly authored chapters contextualize current developments within the history of genome editing while also discussing the current and potential safety concerns of this rapidly growing field. Genome Editing: The Next Step in Gene Therapy, the latest volume in the American Society of Gene and Cell Therapy series, deftly illuminates the potential of genetic engineering technology to eradicate today’s deadliest and most prolific diseases. It is ideal reading for clinicians and researchers in genetics and immunology.

Precision Medicine, CRISPR, and Genome Engineering

Stephen H. Tsang
Precision Medicine CRISPR and Genome Engineering Book PDF

Author : Stephen H. Tsang
Publisher : Springer
Page : 178 pages
File Size : 42,9 Mb
Release : 2017-11-11
Category : Science
ISBN : 9783319639048

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Precision Medicine, CRISPR, and Genome Engineering by Stephen H. Tsang Pdf

This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine. Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians.

CRISPR-Cas-Based Genome Editing for Treating Human Diseases - Part B

Anonim
CRISPR Cas Based Genome Editing for Treating Human Diseases Part B Book PDF

Author : Anonim
Publisher : Academic Press
Page : 0 pages
File Size : 55,9 Mb
Release : 2025-01-01
Category : Science
ISBN : 044322420X

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CRISPR-Cas-Based Genome Editing for Treating Human Diseases - Part B by Anonim Pdf

CRISPR-Cas-based genome editing for treating human diseases part B represents CRISPR-Cas systems for genome editing. Currently, CRISPR-Cas systems are proven a key technology for targeted genome editing which is acting as a simple, rapid, and cost-effective solution. CRISPR-Cas9 system is being used in microbial genome editing, mammalian genome editing, disease models, and many. It has shown potential in human disease treatment. However, it is not easy to find CRISPR-Cas systems genome editing in a single source. This volume offers CRISPR-Cas systems for metabolic disorders, retinal disease cataract and blindness, muscular dystrophy, cardiac disease, diabetes, liver disease, lung disease, kidney diseases, rare disease, heredity disease, neurological disorders and CRISPR challenges in clinical developments. This volume highlights a number of aspects of the CRISPR-Cas sytems that can help the basic understanding of students, researchers, clinicians, entrepreneurs, and stakeholders to perform their research with great interest.

CRISPR Gene Editing

Yonglun Luo
CRISPR Gene Editing Book PDF

Author : Yonglun Luo
Publisher : Unknown
Page : 362 pages
File Size : 44,9 Mb
Release : 2019
Category : CRISPR-associated protein 9
ISBN : 1493991701

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CRISPR Gene Editing by Yonglun Luo Pdf

This detailed volume guides readers through strategic planning and user-friendly guidelines in order to select the most suitable CRISPR-Cas system and target sites with high activity and specificity. Methods covering CRISPR gRNA design, CRISPR delivery, CRISPR activity quantification (indel quantification), and examples of applying CRISPR gene editing in human pluripotent stem cells, primary cells, gene therapy, and genetic screening are included. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and invaluable, CRISPR Gene Editing: Methods and Protocols will assist undergraduates, graduates, and researchers with detailed guidelines and methods for the vitally important CRISPR gene editing field. Chapter 3 is available open access under a CC BY 4.0 license via link.springer.com.

CRISPR-Cas Enzymes

Anonim
CRISPR Cas Enzymes Book PDF

Author : Anonim
Publisher : Academic Press
Page : 451 pages
File Size : 40,7 Mb
Release : 2019-01-25
Category : Science
ISBN : 9780128167618

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CRISPR-Cas Enzymes by Anonim Pdf

CRISPR-Cas Enzymes, Volume 616, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Topics covered in this release include CRISPR bioinformatics, A method for one-step assembly of Class 2 CRISPR arrays, Biochemical reconstitution and structural analysis of ribonucleoprotein complexes in Type I-E CRISPR-Cas systems, Mechanistic dissection of the CRISPR interference pathway in Type I-E CRISPR-Cas system, Site-specific fluorescent labeling of individual proteins within CRISPR complexes, Fluorescence-based methods for measuring target interference by CRISPR-Cas systems, Native State Structural Characterization of CRISRP Associated Complexes using Mass Spectrometry, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Updated release includes the latest information on the CRISPR-Cas Enzymes