Crispr Cas Based Genome Editing For Treating Human Diseases Part A

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CRISPR-Cas-Based Genome Editing for Treating Human Diseases-Part A

Anonim
CRISPR Cas Based Genome Editing for Treating Human Diseases Part A Book PDF

Author : Anonim
Publisher : Academic Press
Page : 0 pages
File Size : 54,9 Mb
Release : 2024-10-01
Category : Science
ISBN : 0443315884

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CRISPR-Cas-Based Genome Editing for Treating Human Diseases-Part A by Anonim Pdf

CRISPR-Cas-based genome editing for treating human diseases part A represents CRISPR-Cas systems for genome editing. Currently, CRISPR-Cas systems are proven a key technology for targeted genome editing which is acting as a simple, rapid, and cost-effective solution. CRISPR-Cas9 system is being used in microbial genome editing, mammalian genome editing, disease models, and many. It has shown potential in human disease treatment. However, it is not easy to find CRISPR-Cas systems genome editing in a single source. This volume offers CRISPR-Cas systems for human diseases, bacterial disease, gut microbiome editing, viral disease, protozoan disease, fungal disease, stem cell therapy, CRISPR in epigenetics, CRISPR in cancer, autoimmune and blood disorders. This volume highlights a number of aspects of the CRISPR-Cas sytems that can help the basic understanding of students, researchers, clinicians, entrepreneurs, and stakeholders to perform their research with great interest.

CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases

Luis María Vaschetto
CRISPR Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases Book PDF

Author : Luis María Vaschetto
Publisher : CRC Press
Page : 268 pages
File Size : 53,8 Mb
Release : 2022-01-31
Category : Mathematics
ISBN : 9781000540819

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CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases by Luis María Vaschetto Pdf

The CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of applications of CRISPR/Cas9 genetic scissors. Some topics included in this book are: the role of the CRISPR/Cas9 system in neuroscience, gene therapy, epigenome editing, genome mapping, cancer, virus infection control strategies, regulatory challenges and bioethical considerations.

CRISPR-Cas-Based Genome Editing for Treating Human Diseases - Part B

Anonim
CRISPR Cas Based Genome Editing for Treating Human Diseases Part B Book PDF

Author : Anonim
Publisher : Academic Press
Page : 0 pages
File Size : 54,5 Mb
Release : 2025-01-01
Category : Science
ISBN : 044322420X

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CRISPR-Cas-Based Genome Editing for Treating Human Diseases - Part B by Anonim Pdf

CRISPR-Cas-based genome editing for treating human diseases part B represents CRISPR-Cas systems for genome editing. Currently, CRISPR-Cas systems are proven a key technology for targeted genome editing which is acting as a simple, rapid, and cost-effective solution. CRISPR-Cas9 system is being used in microbial genome editing, mammalian genome editing, disease models, and many. It has shown potential in human disease treatment. However, it is not easy to find CRISPR-Cas systems genome editing in a single source. This volume offers CRISPR-Cas systems for metabolic disorders, retinal disease cataract and blindness, muscular dystrophy, cardiac disease, diabetes, liver disease, lung disease, kidney diseases, rare disease, heredity disease, neurological disorders and CRISPR challenges in clinical developments. This volume highlights a number of aspects of the CRISPR-Cas sytems that can help the basic understanding of students, researchers, clinicians, entrepreneurs, and stakeholders to perform their research with great interest.

Heritable Human Genome Editing

The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Heritable Human Genome Editing Book PDF

Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publisher : National Academies Press
Page : 239 pages
File Size : 52,6 Mb
Release : 2021-01-16
Category : Medical
ISBN : 9780309671132

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Heritable Human Genome Editing by The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing Pdf

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

CRISPR-Cas Systems

Rodolphe Barrangou,John van der Oost
CRISPR Cas Systems Book PDF

Author : Rodolphe Barrangou,John van der Oost
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 46,9 Mb
Release : 2012-12-13
Category : Science
ISBN : 9783642346576

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CRISPR-Cas Systems by Rodolphe Barrangou,John van der Oost Pdf

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Human Genome Editing

National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Human Genome Editing Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publisher : National Academies Press
Page : 329 pages
File Size : 52,9 Mb
Release : 2017-08-13
Category : Medical
ISBN : 9780309452885

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Human Genome Editing by National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations Pdf

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Anticipatory Ethics and The Use of CRISPR in Humans

Michael W. Nestor,Richard L. Wilson
Anticipatory Ethics and The Use of CRISPR in Humans Book PDF

Author : Michael W. Nestor,Richard L. Wilson
Publisher : Springer Nature
Page : 156 pages
File Size : 47,5 Mb
Release : 2022-05-20
Category : Medical
ISBN : 9783030983680

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Anticipatory Ethics and The Use of CRISPR in Humans by Michael W. Nestor,Richard L. Wilson Pdf

The future of gene editing in humans will involve the use of CRISPR. How we think about the combination of the scientific, ethical, and moral aspects of this technology is paramount to the success or failure of CRISPR in humans. Unfortunately, the current scientific discussion around CRISPR in humans has left ethics trailing behind due to the rapid pace of innovation. New modes of ethics and stakeholder participation are needed to keep pace with rapid scientific advances and provide the necessary policy and ethical frameworks necessary to help CRISPR flourish as an important health care tool to treat human disease. This requires intense interdisciplinary collaboration and discussion between scientists and philosophers, policymakers and legal scholars, and the public. Dr. Michael W. Nestor (a neuroscientist who actively uses CRISPR in pre-clinical research) and Professor Richard Wilson (a philosopher who focuses on anticipatory ethics) set out to develop a new ethical approach considering the use of CRISPR in human targeted therapies. The field of anticipatory ethics is uniquely poised to tackle questions in fast-evolving technical areas where the pace of innovation outstrips traditional philosophical approaches. Furthermore, because of its “anticipatory” nature, this type of analysis provides the opportunity to look ahead and into the future concerning potential uses of CRISPR in humans, uses that are not currently possible. Nestor and Wilson collaborate both scientifically and philosophically in this book to forecast potential outcomes as the scientific and medical community goes beyond using CRISPR to correct genes that underlie diseases where a single gene is involved. Instead, Nestor and Wilson envision CRISPR in complex, multigenic disorders with a specific focus on the use of CRISPR to edit genes involved in mental traits like IQ or other cognitive characteristics. They argue that the use of CRISPR to modify genes that are potentially important for mental traits represents a particular category for special consideration from scientists, policymakers, the public, and other stakeholders. Nestor and Wilson explain why using CRISPR to alter mental states is very different from treating a disease like cancer by combining the latest scientific advancements with anticipatory ethics and philosophical phenomenology. Their analysis considers the role that mental states play in personhood and the lived experience-as genes that can change mental/cognitive attributes like IQ have wide-ranging effects on the lived experience in ways that are categorically different from other attributes. This book was written to set a non-exhaustive framework for shared understanding and discussion across disciplines and appeal to scientists and non-scientists alike. This appeal is made inclusively, inviting all stakeholders to engage in active dialogue about the appropriate context for using CRISPR and other gene-editing technologies in humans. It provides policy analysis and recommendations for assuring the most inclusive, equitable, and ethically sound use of CRISPR in humans, concerning its positive potential to treat mental conditions like depression, schizophrenia, Alzheimer’s disease, autism, and the potential to induce other cognitive enhancements.

Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy

Vijai Singh
Reprogramming the Genome CRISPR Cas based Human Disease Therapy Book PDF

Author : Vijai Singh
Publisher : Elsevier
Page : 392 pages
File Size : 49,7 Mb
Release : 2021-06-15
Category : Science
ISBN : 9780323853231

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Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy by Vijai Singh Pdf

Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy, presents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 is a key technology for targeted genome editing and regulation in a number of organisms including mammalian cells. It is a rapid, simple, and cost-effective solution. CRISPR-Cas system has recently gained much scientific and public attention. This volume covers CRISPR-Cas9 based mammalian genome editing, creating disease models, cancer therapy, neurological, heredity, blood disorders, defective gene correction, stem cells therapy, epigenetic modifications, patents, ethics, biosafety and regulatory issues challenges and opportunities. This book is a key source of information on mammalian genome editing available in a single volume. This book will be useful for beginners in mammalian genome editing and also students, researchers, scientists, policymakers, clinicians and stakeholders interested in genome editing in several areas. Offers basic understanding and a clear picture of mammalian genome editing through CRISPR-Cas systems Discusses how to create mammalian disease models, stem cell modification, epigenetic modifications, correction of defective gene in blood disorders, heredity, neurological disorders and many more Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, molecular biology, translational sciences, neurobiology, neurology, cancer, stem cells, and many more

How Genome Editing is Revolutionizing Medicine

Gunnar Keller
How Genome Editing is Revolutionizing Medicine Book PDF

Author : Gunnar Keller
Publisher : GRIN Verlag
Page : 62 pages
File Size : 47,5 Mb
Release : 2021-12-20
Category : Science
ISBN : 9783346558978

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How Genome Editing is Revolutionizing Medicine by Gunnar Keller Pdf

Bachelor Thesis from the year 2020 in the subject Biology - Genetics / Gene Technology, grade: 1,1, Management Center Innsbruck, course: Biotechnology, language: English, abstract: CRISPR continues to drive the world of gene editing. About seven years ago, scientists reported that CRISPR technology can enable precise and efficient genome editing in living eukaryotic cells. Since then, interest in the method has spread extensively across the globe. Not long after its sudden headstart in 2013, already thousands of laboratories started taking up the technique and investors began funding startups to harness its potential. This ultimately resulted in major improvements being made in incredibly short periods of time. Simultaneously, this also initiated and continues to drive an increasing gap between new innovative applications in the field of gene editing and the overall awareness of the general public. Ethical concerns have remained a steady companion of this rise. With myriads of research papers about CRISPR related topics being published every year, trying to stay on top of developments can be a cumbersome task. The goal of this paper is to summarize current practice and research areas that are part of modern gene editing. Following a brief summary of CRISPR basics, used endonucleases and techniques, its impact on the treatment of hereditary diseases, viral infections and cancer is illustrated based on recent examples. Effects of gene editing on cell line engineering efforts are described using studies focusing on glycosylation, impurities, cultivation and production efficiency issues of CHO cell lines. Besides discussing CRISPR applications for rapid SARS-CoV-2 diagnosis, current challenges for clinical use including off-targets, immune responses and lacking drug delivery efficiencies as well as promising developments are being reviewed. This paper is supposed to support quick elucidation of future potential of the rapidly evolving world of CRISPR Cas genome editing and facilitate retrieval of further literature.

CRISPR Genome Surgery in Stem Cells and Disease Tissues

Stephen H. Tsang
CRISPR Genome Surgery in Stem Cells and Disease Tissues Book PDF

Author : Stephen H. Tsang
Publisher : Academic Press
Page : 138 pages
File Size : 53,6 Mb
Release : 2021-10-20
Category : Science
ISBN : 9780128178775

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CRISPR Genome Surgery in Stem Cells and Disease Tissues by Stephen H. Tsang Pdf

CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The book's target audience includes researchers, students, clinicians and the general public. This space that is not currently served by any existing resource, so this publication fills a gap in current literature. Provides a thorough review of CRISPR-Cas9, from discovery to therapy Covers the latest advances in gene editing and its translational applications to various diseases Written by global leaders in the fields of gene editing and stem cell therapy

Genome Editing in Neurosciences

Rudolf Jaenisch,Feng Zhang,Fred Gage
Genome Editing in Neurosciences Book PDF

Author : Rudolf Jaenisch,Feng Zhang,Fred Gage
Publisher : Springer
Page : 0 pages
File Size : 46,5 Mb
Release : 2018-08-11
Category : Medical
ISBN : 3319868012

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Genome Editing in Neurosciences by Rudolf Jaenisch,Feng Zhang,Fred Gage Pdf

This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

Genome Editing in Neurosciences

Rudolf Jaenisch,Feng Zhang,Fred Gage
Genome Editing in Neurosciences Book PDF

Author : Rudolf Jaenisch,Feng Zhang,Fred Gage
Publisher : Springer
Page : 123 pages
File Size : 40,5 Mb
Release : 2017-09-14
Category : Medical
ISBN : 9783319601922

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Genome Editing in Neurosciences by Rudolf Jaenisch,Feng Zhang,Fred Gage Pdf

This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

Gene Editing in Plants

Anonim
Gene Editing in Plants Book PDF

Author : Anonim
Publisher : Academic Press
Page : 264 pages
File Size : 42,7 Mb
Release : 2017-08-31
Category : Science
ISBN : 9780128117446

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Gene Editing in Plants by Anonim Pdf

Gene Editing in Plants, Volume 149 aims to provide the reader with an up-to-date survey of cutting-edge research with gene editing tools and an overview of the implications of this research on the nutritional quality of fruits, vegetables and grains. New chapters in the updated volume include topics relating to Genome Engineering and Agriculture: Opportunities and Challenges, the Use of CRISPR/Cas9 for Crop Improvement in Maize and Soybean, the Use of Zinc-Finger Nucleases for Crop Improvement, Gene Editing in Polyploid Crops: Wheat, Camelina, Canola, Potato, Cotton, Peanut, Sugar Cane, and Citrus, and Gene Editing With TALEN and CRISPR/Cas in Rice. This ongoing serial contain contributions from leading scientists and researchers in the field of gene editing in plants who describe the results of their own research in this rapidly expanding area of science. Shows the importance of revolutionary gene editing technology on plant biology research and its application to agricultural production Provides insight into what may lie ahead in this rapidly expanding area of plant research and development Contains contributions from major leaders in the field of plant gene editing

CRISPR-Cas System Based Diagnosis of Infectious Diseases

Roohi Bansal
CRISPR Cas System Based Diagnosis of Infectious Diseases Book PDF

Author : Roohi Bansal
Publisher : Unknown
Page : 214 pages
File Size : 47,8 Mb
Release : 2021-03-08
Category : Electronic
ISBN : 9354458300

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CRISPR-Cas System Based Diagnosis of Infectious Diseases by Roohi Bansal Pdf

Since its discovery as a part of the bacterial defense mechanism, the Nobel Prize-winning technology CRISPR-Cas system has revolutionized the fields of genome editing and genetic engineering. Beyond gene-editing ability, scientists have leveraged its potential in the diagnosis of infectious diseases including COVID-19. This book provides a detailed understanding of CRISPR-based rapid and point-of-care diagnostic kits like SHERLOCK, DETECTR, FELUDA, AIOD CRISPR-Cas12a, etc. for the diagnosis of infectious diseases including COVID-19; the importance of isothermal nucleic acid amplification processes like RPA and LAMP; and how the results of the CRISPR-based tests can be interpreted using paper-based lateral flow strips. Because of the ease of performing the test and simple interpretation of the test results, CRISPR-based tests can be used at airports, ports, clinics, schools, etc., for better disease diagnosis, monitoring, management, and containment of infectious diseases like COVID-19. Additionally, this book discusses Monoclonal Antibodies, which have revolutionized the treatment for cancer, arthritis, autoimmune diseases, etc. This book also talks about various strategies to isolate monoclonal antibodies from the COVID-19 recovered people and different ways to engineer these antibodies using hybridoma technology.

Ethics Dumping

Doris Schroeder,Julie Cook,François Hirsch,Solveig Fenet,Vasantha Muthuswamy
Ethics Dumping Book PDF

Author : Doris Schroeder,Julie Cook,François Hirsch,Solveig Fenet,Vasantha Muthuswamy
Publisher : Springer
Page : 134 pages
File Size : 44,7 Mb
Release : 2017-12-04
Category : Philosophy
ISBN : 9783319647319

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Ethics Dumping by Doris Schroeder,Julie Cook,François Hirsch,Solveig Fenet,Vasantha Muthuswamy Pdf

This open access book provides original, up-to-date case studies of “ethics dumping” that were largely facilitated by loopholes in the ethics governance of low and middle-income countries. It is instructive even to experienced researchers since it provides a voice to vulnerable populations from the fore mentioned countries. Ensuring the ethical conduct of North-South collaborations in research is a process fraught with difficulties. The background conditions under which such collaborations take place include extreme differentials in available income and power, as well as a past history of colonialism, while differences in culture can add a new layer of complications. In this context, up-to-date case studies of unethical conduct are essential for research ethics training.