Review Of Epa S 2022 Draft Formaldehyde Assessment

Author : National Academies of Sciences Engineering and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Review of Epa's 2022 Draft Formaldehyde Assessment
Publisher : Unknown
Page : 0 pages
File Size : 44,7 Mb
Release : 2024-05-09
Category : Electronic
ISBN : 0309706556

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Review of Epa's 2022 Draft Formaldehyde Assessment by National Academies of Sciences Engineering and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Review of Epa's 2022 Draft Formaldehyde Assessment Pdf

Formaldehyde is widely present in the environment and is one of the highest production chemicals by volume, used in manufactured goods including wood products, permanent press fabrics, and household products. It is also formed by combustion sources and is present in smoke from cigarettes and other tobacco products, and in emissions from gas stoves and open fireplaces. In carrying out its mission to protect human health, the U.S. Environmental Protection Agency (EPA) identifies and characterizes the health hazards of chemicals found in the environment through its Integrated Risk Information System (IRIS) Program, which has reviewed the human health hazards resulting from formaldehyde exposure in several assessments. This report is a continuation of guidance from the National Academies on draft IRIS assessments of formaldehyde and other aspects of the IRIS program. This report reviews the 2022 Draft Assessment with regard to its adequacy and transparency in evaluating the scientific literature, use of appropriate methods to synthesize the current state-of-the science, and presentations of conclusions that are supported by the scientific evidence. The report concludes that the 2022 Draft Assessment follows the advice of prior National Academies reports and that its findings on hazard and quantitative risk are supported by the evidence identified. However, revisions are needed to ensure that users can find and follow the methods used in each step of the assessment for each health outcome.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 49,8 Mb
Release : 2023
Category : Electronic
ISBN : 0309706564

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Review of EPA's 2022 Draft Formaldehyde Assessment by Anonim Pdf

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review EPA's Draft IRIS Assessment of Formaldehyde
Publisher : National Academies Press
Page : 204 pages
File Size : 48,5 Mb
Release : 2011-05-31
Category : Science
ISBN : 9780309211963

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Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review EPA's Draft IRIS Assessment of Formaldehyde Pdf

Formaldehyde is ubiquitous in indoor and outdoor air, and everyone is exposed to formaldehyde at some concentration daily. Formaldehyde is used to produce a wide array of products, particularly building materials; it is emitted from many sources, including power plants, cars, gas and wood stoves, and cigarettes; it is a natural product in come foods; and it is naturally present in the human body as a metabolic intermediate. Much research has been conducted on the health effects of exposure to formaldehyde, including effects on the upper airway, where formaldehyde is deposited when inhaled, and effects on tissues distant from the site of initial contact. The U.S. Environmental Protection Agency (EPA) released noncancer and cancer assessments of formaldehyde for its Intergated Risk Information System (IRIS) in 1990 and 1991, respectively. The agency began reassessing formaldehyde in 1998 and released a draft IRIS assessment in June 2010. Given the complexity of the issues and the knowledge that the assessment will be used as the basis of regulatory decisions, EPA asked the National Research Council (NRC) to conduct an independent scientific review of the draft IRIS assessment. In this report, the Committee to Review EPA's Draft IRIS Assessment of Formaldehyde first addresses some general issues associated with the draft IRIS assessment. The committee next focuses on questions concerning specific aspects of the draft assessment, including derivation of the reference concentrations and the cancer unit risk estimates for formaldehyde. The committee closes with recommendations for improving the IRIS assessment of formaldehyde and provides some general comments on the IRIS development process.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review the IRIS Process
Publisher : National Academies Press
Page : 170 pages
File Size : 47,5 Mb
Release : 2014-06-25
Category : Political Science
ISBN : 9780309304177

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Review of EPA's Integrated Risk Information System (IRIS) Process by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Review the IRIS Process Pdf

The Integrated Risk Information System (IRIS) is a program within the US Environmental Protection Agency (EPA) that is responsible for developing toxicologic assessments of environmental contaminants. An IRIS assessment contains hazard identifications and dose-response assessments of various chemicals related to cancer and noncancer outcomes. Although the program was created to increase consistency among toxicologic assessments within the agency, federal, state, and international agencies and other organizations have come to rely on IRIS assessments for setting regulatory standards, establishing exposure guidelines, and estimating risks to exposed populations. Over the last decade, the National Research Council (NRC) has been asked to review some of the more complex and challenging IRIS assessments, including those of formaldehyde, dioxin, and tetrachloroethylene. In 2011, an NRC committee released its review of the IRIS formaldehyde assessment. Like other NRC committees that had reviewed IRIS assessments, the formaldehyde committee identified deficiencies in the specific assessment and more broadly in some of EPA's general approaches and specific methods. Although the committee focused on evaluating the IRIS formaldehyde assessment, it provided suggestions for improving the IRIS process and a roadmap for its revision in case EPA decided to move forward with changes to the process. Congress directed EPA to implement the report's recommendations and then asked the National Research Council to review the changes that EPA was making (or proposing to make) in response to the recommendations. Review of EPA's Integrated Risk Information System (IRIS) Process provides an overview of some general issues associated with IRIS assessments. This report then addresses evidence identification and evaluation for IRIS assessments and discusses evidence integration for hazard evaluation and methods for calculating reference values and unit risks. The report makes recommendations and considerations for future directions. Overall, Review of EPA's Integrated Risk Information System Process finds that substantial improvements in the IRIS process have been made, and it is clear that EPA has embraced and is acting on the recommendations in the NRC formaldehyde report. The recommendations of this report should be seen as building on the progress that EPA has already made.

Author : United States. Congress. House. Committee on Science and Technology. Subcommittee on Investigations and Oversight
Publisher : Unknown
Page : 808 pages
File Size : 48,5 Mb
Release : 1983
Category : Carcinogenicity testing
ISBN : STANFORD:36105045594954

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Formaldehyde--review of Scientific Basis of EPA's Carcinogenic Risk Assessment by United States. Congress. House. Committee on Science and Technology. Subcommittee on Investigations and Oversight Pdf

Author : National Research Council,Board on Environmental Studies and Toxicology
Publisher : Unknown
Page : 0 pages
File Size : 46,7 Mb
Release : 2014
Category : Medical
ISBN : 0309312272

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Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens by National Research Council,Board on Environmental Studies and Toxicology Pdf

Review of: Report on carcinogens. 12th ed. 2011.

Author : United States Environmental Protection Agency (EPA)
Publisher : Createspace Independent Publishing Platform
Page : 82 pages
File Size : 49,8 Mb
Release : 2018-07-06
Category : Electronic
ISBN : 1722277297

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Review of Epa's Draft Framework for Inorganic Metals Risk Assessment by United States Environmental Protection Agency (EPA) Pdf

Review of EPA's Draft Framework for Inorganic Metals Risk Assessment : Internal Deliberative Draft

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on the Health Risks of Phthalates
Publisher : National Academies Press
Page : 208 pages
File Size : 53,8 Mb
Release : 2009-01-19
Category : Nature
ISBN : 9780309128414

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Phthalates and Cumulative Risk Assessment by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on the Health Risks of Phthalates Pdf

People are exposed to a variety of chemicals throughout their daily lives. To protect public health, regulators use risk assessments to examine the effects of chemical exposures. This book provides guidance for assessing the risk of phthalates, chemicals found in many consumer products that have been shown to affect the development of the male reproductive system of laboratory animals. Because people are exposed to multiple phthalates and other chemicals that affect male reproductive development, a cumulative risk assessment should be conducted that evaluates the combined effects of exposure to all these chemicals. The book suggests an approach for cumulative risk assessment that can serve as a model for evaluating the health risks of other types of chemicals.

Author : Anonim
Publisher : Unknown
Page : 232 pages
File Size : 47,6 Mb
Release : 2014
Category : Electronic books
ISBN : 0309312248

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Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens by Anonim Pdf

"Many people in the United States are exposed to formaldehyde. Exposure can occur from environmental sources (for example, combustion processes, building materials, and tobacco smoke) or in occupational settings (for example, the furniture, textile, and construction industries). Formaldehyde exposure also has endogenous sources--it is produced intracellularly as a component of the one carbon pool intermediary metabolism pathway. Scientists have studied formaldehyde for decades to determine whether exogenous formaldehyde exposure may be associated with cancer in humans. In 1981, The National Toxicology Program (NTP) first listed formaldehyde in the 2nd Report on Carcinogens as "reasonably anticipated to be a human carcinogen". In 2011, NTP upgraded the listing of formaldehyde to "known to be a human carcinogen". Following the new listing, Congress directed the Department of Health and Human Services to arrange for the National Academy of Sciences to independently review formaldehyde's substance profile and listing. This report presents the findings and conclusions of the committee formed in response to the congressional request. Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens concurs with NTP that there is sufficient evidence in studies that had adequate characterization of relevant exposure metrics to enable a strong conclusion about the association between formaldehyde exposure and cancer in humans. Additionally, the authoring committee independently reviewed the scientific evidence from studies in humans, experimental animals, and other studies relevant to the mechanisms of carcinogenesis and made level-of-evidence conclusions. This report finds clear and convincing epidemiologic evidence of an association between formaldehyde exposure and nasopharyngeal and sinonasal cancers in humans."--Publisher's description.

Author : Stephen M. Roberts,Robert C. James,Phillip L. Williams
Publisher : John Wiley & Sons
Page : 596 pages
File Size : 52,9 Mb
Release : 2022-04-26
Category : Science
ISBN : 9781119635178

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Principles of Toxicology by Stephen M. Roberts,Robert C. James,Phillip L. Williams Pdf

Principles of Toxicology concisely and efficiently presents the scientific basis for toxicology as it applies to the workplace and the environment, covering diverse chemical hazards encountered in modern workplaces and natural environments and providing a practical understanding of these hazards for those concerned with protecting the health of humans and ecosystems. The work presents not only theory, but also practical information regarding chemical hazards to give the student and new professional a working knowledge of the practice of toxicology and the ability to solve problems in environmental and industrial settings. Case histories and examples from industrial and environmental exposures to chemicals are included to demonstrate the application of toxicological principles. To allow for seamless reader comprehension and further exploration of covered topics, the work is supplemented with numerous illustrations to clarify and summarize key points, as well as annotated bibliographies. In the 4th edition, all chapters and references have been updated to account for the latest scientific thinking, and new color figures have been added. New topics covered in 4th Edition of Principles of Toxicology include: Regulatory toxicology, including the key regulatory framework in which much of the field of toxicology operates Alternative methods in toxicology, including cutting-edge approaches to developing new information on the toxicity of drugs and chemicals The dilemma of selecting safe exposure limits, guiding readers through practical considerations and pitfalls in developing and using safe exposure limits Ecological risk assessment, with detailed discussion of methods and considerations when evaluating the effects of contaminants on plants and animals. Providing information on the principles of toxicology and the application of those principles to solve problems in environmental and industrial settings, Principles of Toxicology serves as an excellent textbook resource for advanced undergraduate, graduate, and professional students in a range of environmental and health fields. It is also valuable to health professionals who need toxicological information and assistance beyond what is found in an introductory text to general toxicology.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human and Environmental Exposure Science in the 21st Century
Publisher : National Academies Press
Page : 210 pages
File Size : 40,7 Mb
Release : 2012-10-28
Category : Nature
ISBN : 9780309264686

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Exposure Science in the 21st Century by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human and Environmental Exposure Science in the 21st Century Pdf

From the use of personal products to our consumption of food, water, and air, people are exposed to a wide array of agents each day-many with the potential to affect health. Exposure Science in the 21st Century: A Vision and A Strategy investigates the contact of humans or other organisms with those agents (that is, chemical, physical, and biologic stressors) and their fate in living systems. The concept of exposure science has been instrumental in helping us understand how stressors affect human and ecosystem health, and in efforts to prevent or reduce contact with harmful stressors. In this way exposure science has played an integral role in many areas of environmental health, and can help meet growing needs in environmental regulation, urban and ecosystem planning, and disaster management. Exposure Science in the 21st Century: A Vision and A Strategy explains that there are increasing demands for exposure science information, for example to meet needs for data on the thousands of chemicals introduced into the market each year, and to better understand the health effects of prolonged low-level exposure to stressors. Recent advances in tools and technologies-including sensor systems, analytic methods, molecular technologies, computational tools, and bioinformatics-have provided the potential for more accurate and comprehensive exposure science data than ever before. This report also provides a roadmap to take advantage of the technologic innovations and strategic collaborations to move exposure science into the future.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Assess the Health Implications of Perchlorate Ingestion
Publisher : National Academies Press
Page : 276 pages
File Size : 42,7 Mb
Release : 2005-05-18
Category : Science
ISBN : 9780309095686

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Health Implications of Perchlorate Ingestion by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee to Assess the Health Implications of Perchlorate Ingestion Pdf

Perchlorateâ€"a powerful oxidant used in solid rocket fuels by the military and aerospace industryâ€"has been detected in public drinking water supplies of over 11 million people at concentrations of at least 4 parts per billion (ppb). High doses of perchlorate can decrease thyroid hormone production by inhibiting the uptake of iodide by the thyroid. Thyroid hormones are critical for normal growth and development of the central nervous system of fetuses and infants. This report evaluates the potential health effects of perchlorate and the scientific underpinnings of the 2002 draft risk assessment issued by the U.S. Environmental Protection Agency (EPA). The report finds that the body can compensate for iodide deficiency, and that iodide uptake would likely have to be reduced by at least 75% for months or longer for adverse health effects, such as hypothryroidism, to occur. The report recommends using clinical studies of iodide uptake in humans as the basis for determining a reference dose rather than using studies of adverse health effects in rats that serve as EPA's basis. The report suggests that daily ingestion of 0.0007 milligrams of perchlorate per kilograms of body weightâ€"an amount more than 20 times the reference dose proposed by EPAâ€"should not threaten the health of even the most sensitive populations.

Author : Jim Morris
Publisher : Beacon Press
Page : 266 pages
File Size : 45,5 Mb
Release : 2024-01-23
Category : Social Science
ISBN : 9780807059142

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The Cancer Factory by Jim Morris Pdf

“No journalist knows more about toxic chemicals in the workplace than Jim Morris. The Cancer Factory is the crowning achievement of his estimable career spent walking fence lines, factory floors, and doctor’s offices.” —Dan Fagin, author of the Pulitzer Prize–winning Toms River “The Cancer Factory could not come at a better time, as we reckon with how our bodies pay the price for our nation’s toxic history and as today’s workers fight not for only their rights but for their very lives.… A powerful and essential read.” —Anna Clark, author of The Poisoned City The story of a group of Goodyear Tire and Rubber workers fatally exposed to toxic chemicals, the lawyer who sought justice on their behalf, and the shameful lack of protection our society affords all workers Working at the Goodyear Tire and Rubber Company chemical plant in Niagara Falls, New York, was considered a good job. It was the kind of industrial manufacturing job that allowed blue-collar workers to thrive in the latter half of the 20th century—that allowed them to buy their own home, and maybe a small boat for the lake. But it was also the kind of job that exposed you to toxic chemicals and offered little to no protection from them, either in the way of protective gear or adequate ventilation. Eventually, it was a job that gave you bladder cancer. The Cancer Factory tells the story of the workers who experienced one of the nation’s worst, and best-documented, outbreaks of work-related cancer, and the lawyer who has represented the bladder-cancer victims at the plant for more than 30 years. Goodyear, and its chemical supplier, DuPont, knew that two of the chemicals used in the plant had been shown to cause cancer, but made little effort to protect the plant’s workers until the cluster of cancer cases—and deaths—was undeniable. In doing so it tells a broader story of corporate malfeasance and governmental neglect. Workers have only weak protections from exposure to toxic substances in America, and regulatory breaches contribute to an estimated 95,000 deaths from occupational illness each year. Based on 4 decades of reporting and delving deeply into the scientific literature about toxic substances and health risks, the arcana of worker regulations, and reality of loose enforcement, The Cancer Factory exposes the terrible health risks too many workers face.

Author : Jerome F. Strauss,Robert L. Barbieri,Anuja Dokras,Carmen J Williams,S. Zev Williams
Publisher : Elsevier Health Sciences
Page : 1393 pages
File Size : 45,6 Mb
Release : 2023-03-24
Category : Medical
ISBN : 9780323810081

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Yen & Jaffe's Reproductive Endocrinology - E-Book by Jerome F. Strauss,Robert L. Barbieri,Anuja Dokras,Carmen J Williams,S. Zev Williams Pdf

For over 40 years, Yen & Jaffe's Reproductive Endocrinology has been the gold standard text of both basic science and clinical practice of the full range of female and male reproductive disorders. The fully revised 9th Edition continues this tradition of excellence with complete coverage, including up-to-date information on impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, contraception, and more. An outstanding editorial board and other global experts in the field share their knowledge and expertise to keep you abreast of current science and practice in endocrinology. Includes new chapters on Meiosis, Fertilization and Embryo Development; Recurrent Pregnancy Loss; Uterus Transplantation; Mitochondrial Transplantation and Gene Editing; and Germs Cells Developed In Vitro. Provides extensively revised information on contemporary practices in assisted reproduction, fertility preservation, and ovulation induction. Provides an online video library that highlights surgical procedures, diagnostic imaging, and functional ultrasound imaging. Adds three new members to the exceptional editorial team: Drs. Anuja Dokras, Carmen J. Williams, and Zev Williams. Features full-color, high-quality illustrations that clearly depict basic anatomic structures, endocrine processes, and cell function and dysfunction. Includes bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section. Lists Top References at the end of each chapter that distill the most important references for research underpinnings, to complement the complete online reference list.

Author : National Academies of Sciences, Engineering, and Medicine,National Academy of Engineering,Division on Engineering and Physical Sciences,Division on Earth and Life Studies,Water Science and Technology Board,Ocean Studies Board,NAE Office of Programs,Board on Life Sciences,Board on Environmental Studies and Toxicology,Board on Earth Sciences and Resources,Board on Energy and Environmental Systems,Board on Chemical Sciences and Technology,Board on Atmospheric Sciences and Climate,Board on Agriculture and Natural Resources,Committee on the Grand Challenges and Opportunites in Environmental Engineering for the Twenty-First Century
Publisher : National Academies Press
Page : 125 pages
File Size : 50,6 Mb
Release : 2019-03-08
Category : Technology & Engineering
ISBN : 9780309476553

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Environmental Engineering for the 21st Century by National Academies of Sciences, Engineering, and Medicine,National Academy of Engineering,Division on Engineering and Physical Sciences,Division on Earth and Life Studies,Water Science and Technology Board,Ocean Studies Board,NAE Office of Programs,Board on Life Sciences,Board on Environmental Studies and Toxicology,Board on Earth Sciences and Resources,Board on Energy and Environmental Systems,Board on Chemical Sciences and Technology,Board on Atmospheric Sciences and Climate,Board on Agriculture and Natural Resources,Committee on the Grand Challenges and Opportunites in Environmental Engineering for the Twenty-First Century Pdf

Environmental engineers support the well-being of people and the planet in areas where the two intersect. Over the decades the field has improved countless lives through innovative systems for delivering water, treating waste, and preventing and remediating pollution in air, water, and soil. These achievements are a testament to the multidisciplinary, pragmatic, systems-oriented approach that characterizes environmental engineering. Environmental Engineering for the 21st Century: Addressing Grand Challenges outlines the crucial role for environmental engineers in this period of dramatic growth and change. The report identifies five pressing challenges of the 21st century that environmental engineers are uniquely poised to help advance: sustainably supply food, water, and energy; curb climate change and adapt to its impacts; design a future without pollution and waste; create efficient, healthy, resilient cities; and foster informed decisions and actions.