Rna Delivery Function For Anticancer Therapeutics

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RNA Delivery Function for Anticancer Therapeutics

Loutfy H. Madkour
RNA Delivery Function for Anticancer Therapeutics Book PDF

Author : Loutfy H. Madkour
Publisher : CRC Press
Page : 860 pages
File Size : 40,5 Mb
Release : 2022-01-26
Category : Science
ISBN : 9781000532241

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RNA Delivery Function for Anticancer Therapeutics by Loutfy H. Madkour Pdf

This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies. Key Features Provides insight into the current advances and hurdles of RNAi therapeutics. Accelerates RNAi, miRNAs, and siRNA drug development for cancer therapy from bench to bedside. Addresses various modifications and novel delivery strategies for miRNAs, piRNAs and siRNA delivery in anticancer therapeutics. Explores the need for the interaction of hematologists,cell biologists, immunologists, and material scientists in the development of novel cancer therapies. Describes the current status of clinical trials related to miRNA and siRNA-based cancer therapy Presents remaining issues that need to be overcome to establish successful therapies.

Advanced Delivery and Therapeutic Applications of RNAi

Kun Cheng,Ram I. Mahato
Advanced Delivery and Therapeutic Applications of RNAi Book PDF

Author : Kun Cheng,Ram I. Mahato
Publisher : John Wiley & Sons
Page : 660 pages
File Size : 55,6 Mb
Release : 2013-04-19
Category : Science
ISBN : 9781118610732

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Advanced Delivery and Therapeutic Applications of RNAi by Kun Cheng,Ram I. Mahato Pdf

Commonly used by researchers to develop technologies for modifying and studying genetic process, RNA interference (RNAi) has many potential uses in medicine, biotechnology, and functional genomics. This book covers all essential aspects involved in the development of RNAi therapeutics, providing detailed guidance on the challenges and opportunities of bringing RNAi technologies from bench to clinic. It explores the design and mechanism of RNAi molecules, delivery strategies, and therapeutic applications in various diseases. Preclinical, regulatory, market, and intellectual aspects of RNAi technologies are also covered.

RNA Therapeutics

Paloma H. Giangrande,Vittorio de Franciscis,John J. Rossi
RNA Therapeutics Book PDF

Author : Paloma H. Giangrande,Vittorio de Franciscis,John J. Rossi
Publisher : Academic Press
Page : 474 pages
File Size : 43,6 Mb
Release : 2022-04-10
Category : Science
ISBN : 9780128217399

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RNA Therapeutics by Paloma H. Giangrande,Vittorio de Franciscis,John J. Rossi Pdf

RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with an emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies. Later sections discuss delivery technologies, remaining hurdles in research and translation, the therapy development process from the lab to the clinic, and novel RNA-based therapies currently in development. Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies Provides a detailed examination of approved RNA therapies and lessons learned from failed therapeutics Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing and regulatory aspects

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Loutfy H. Madkour
Nucleic Acids as Gene Anticancer Drug Delivery Therapy Book PDF

Author : Loutfy H. Madkour
Publisher : Academic Press
Page : 650 pages
File Size : 41,6 Mb
Release : 2019-08-27
Category : Business & Economics
ISBN : 9780128197783

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Nucleic Acids as Gene Anticancer Drug Delivery Therapy by Loutfy H. Madkour Pdf

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

RNA Therapeutics

Mouldy Sioud
RNA Therapeutics Book PDF

Author : Mouldy Sioud
Publisher : Humana
Page : 526 pages
File Size : 55,9 Mb
Release : 2016-08-23
Category : Science
ISBN : 1493961519

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RNA Therapeutics by Mouldy Sioud Pdf

Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular BiologyTM series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.

RNA Delivery Function for Anticancer Therapeutics

Loutfy H. Madkour
RNA Delivery Function for Anticancer Therapeutics Book PDF

Author : Loutfy H. Madkour
Publisher : CRC Press
Page : 424 pages
File Size : 43,6 Mb
Release : 2022-01-26
Category : Science
ISBN : 9781000532234

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RNA Delivery Function for Anticancer Therapeutics by Loutfy H. Madkour Pdf

This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies. Key Features Provides insight into the current advances and hurdles of RNAi therapeutics. Accelerates RNAi, miRNAs, and siRNA drug development for cancer therapy from bench to bedside. Addresses various modifications and novel delivery strategies for miRNAs, piRNAs and siRNA delivery in anticancer therapeutics. Explores the need for the interaction of hematologists,cell biologists, immunologists, and material scientists in the development of novel cancer therapies. Describes the current status of clinical trials related to miRNA and siRNA-based cancer therapy Presents remaining issues that need to be overcome to establish successful therapies.

Advanced Drug Delivery Systems in the Management of Cancer

Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Advanced Drug Delivery Systems in the Management of Cancer Book PDF

Author : Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Publisher : Elsevier
Page : 572 pages
File Size : 40,8 Mb
Release : 2021-06-24
Category : Business & Economics
ISBN : 9780323900799

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Advanced Drug Delivery Systems in the Management of Cancer by Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone Pdf

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Nano Drug Delivery Strategies for the Treatment of Cancers

Awesh K. Yadav,Umesh Gupta,Rajeev Sharma
Nano Drug Delivery Strategies for the Treatment of Cancers Book PDF

Author : Awesh K. Yadav,Umesh Gupta,Rajeev Sharma
Publisher : Academic Press
Page : 374 pages
File Size : 54,9 Mb
Release : 2020-09-03
Category : Science
ISBN : 9780128197943

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Nano Drug Delivery Strategies for the Treatment of Cancers by Awesh K. Yadav,Umesh Gupta,Rajeev Sharma Pdf

Nano Drug Delivery Strategies for the Treatment of Cancers discusses several current and promising approaches for the diagnosis and treatment of cancer by using the most recent developments in nanomedical technologies. The book presents introductory information about the biology of different types of cancer in order to provide the reader with knowledge on their specificities. In addition, it discusses various novel drug delivery systems, detailing their functionalities, expected outcomes and future developments in the field, focusing on brain, mouth and throat, breast, lung, liver, pancreas, stomach, colon, bool, skin and prostate cancers. The book is a valuable source for cancer researchers, oncologists, pharmacologists and nanotechnologists who are interested in novel drug delivery systems and devices for treatment of various types of cancer that take advantage of recent advances in this exciting field. Discusses a wide range of promising approaches for the diagnosis and treatment of cancer using the latest advancement in cutting-edge nanomedical technologies Provides foundational information on different types of cancer and their biology to help the reader choose the best nano drug delivery system for patients Presents novel drug delivery systems based on nanoparticles, microparticles, liposomes, self-assembling Micelles and block copolymer micelles

Nanoparticle-Based Drug Delivery in Cancer Treatment

Loutfy H. Madkour
Nanoparticle Based Drug Delivery in Cancer Treatment Book PDF

Author : Loutfy H. Madkour
Publisher : CRC Press
Page : 558 pages
File Size : 49,9 Mb
Release : 2022-03-03
Category : Science
ISBN : 9781000532166

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Nanoparticle-Based Drug Delivery in Cancer Treatment by Loutfy H. Madkour Pdf

The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.

Molecular Regulation of Endocytosis

Brian Ceresa
Molecular Regulation of Endocytosis Book PDF

Author : Brian Ceresa
Publisher : BoD – Books on Demand
Page : 470 pages
File Size : 52,6 Mb
Release : 2012-07-06
Category : Science
ISBN : 9789535106623

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Molecular Regulation of Endocytosis by Brian Ceresa Pdf

Molecular Regulation of Endocytosis is a compilation of scientific "short stories" about the entry of external substances into cells. As one can see from the chapters, endocytosis regulates diverse processes such as homeostasis of the cell, signal transduction, entry of pathogens and viruses. In addition to the experimental techniques embedded in each chapter, entire chapters are dedicated to experimental approaches that will be useful to all scientists and their model systems. For those more clinically oriented, the final chapters look to the future and ways of utilizing endocytic pathways for therapeutic purposes.

RNA Nanotechnology

Bin Wang
RNA Nanotechnology Book PDF

Author : Bin Wang
Publisher : CRC Press
Page : 452 pages
File Size : 54,9 Mb
Release : 2014-04-02
Category : Medical
ISBN : 9789814411653

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RNA Nanotechnology by Bin Wang Pdf

In the past few decades there has been incredible growth in "bionano"-related research, which has been accompanied by numerous publications in this field. Although various compilations address topics related to deoxyribonucleic acid (DNA) and protein, there are few books that focus on determining the structure of ribonucleic acid (RNA) and using RN

siRNA and miRNA Gene Silencing

Mouldy Sioud
siRNA and miRNA Gene Silencing Book PDF

Author : Mouldy Sioud
Publisher : Humana Press
Page : 472 pages
File Size : 46,8 Mb
Release : 2008-11-26
Category : Science
ISBN : 1603275460

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siRNA and miRNA Gene Silencing by Mouldy Sioud Pdf

RNA interference has become a key method in the suppression of gene expression and the development of therapeutic agents, yet there is still the problem of delivery, stability, and the danger of off-target effects such as the silencing of unwanted genes and activation of innate immunity. In siRNA and miRNA Gene Silencing: From Bench to Bedside, expert researchers explore the most recent advances in siRNA design, expression, delivery, in vivo imaging, and methods to minimize siRNA’s unwanted effects and promote successful use in patients. As part of the highly successful Methods in Molecular BiologyTM series, the chapters focus on their respective subjects with easy-to-use, up-to-date information, including several step-by-step laboratory protocols on topics such as new delivery formulations and strategies with promising applications in vitro and in vivo, validated therapeutic target genes, and components of miRNA function, biogenesis, and interference with virus infection. Comprehensive and cutting-edge, siRNA and miRNA Gene Silencing: From Bench to Bedside offers an excellent collection of chapters to aid all those with an interest in RNAi, gene regulation, and new therapies.

Bioresponsive Polymers

Deepa H. Patel
Bioresponsive Polymers Book PDF

Author : Deepa H. Patel
Publisher : CRC Press
Page : 228 pages
File Size : 49,6 Mb
Release : 2020-10-08
Category : Science
ISBN : 9781000517590

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Bioresponsive Polymers by Deepa H. Patel Pdf

This volume, Bioresponsive Polymers: Design and Application in Drug Delivery, focuses on recent advancements in bioresponsive polymers and their design, characterization, and applications in varied fields, such as drug delivery and gene delivery. It looks at several carriers for drug delivery and biological molecules using different bioresponsive polymers. To address the many difficulties in existing dosage forms, this book provides information on recent developments to overcome drawbacks of conventional forms of the drug delivery. The chapters cover most areas of bioresponsive polymers, starting with a basic introduction to bioresponsive polymers, followed by chapters on design, characterization, and mechanism of bioresponsive polymers; and applications of drug and gene delivery using bioresponsive polymers via oral, topical, nasal, ocular, and parenteral methods. The book also reviews recent advancements in bioresponsive polymers and advanced applications, such as engineering particulate moieties, biomedical applications, hydrogels as emerging therapy, and electrochemical responses, bioresponsive nanoparticles, and bioresponsive hydrogels.

Therapeutic Oligonucleotides

Jens Kurreck
Therapeutic Oligonucleotides Book PDF

Author : Jens Kurreck
Publisher : Royal Society of Chemistry
Page : 362 pages
File Size : 44,7 Mb
Release : 2008
Category : Medical
ISBN : 9780854041169

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Therapeutic Oligonucleotides by Jens Kurreck Pdf

This book provides a compelling overall update on current status of RNA interference

Viral Nanoparticles

Nicole F. Steinmetz,Marianne Manchester
Viral Nanoparticles Book PDF

Author : Nicole F. Steinmetz,Marianne Manchester
Publisher : CRC Press
Page : 281 pages
File Size : 42,8 Mb
Release : 2019-08-21
Category : Technology & Engineering
ISBN : 9789814267946

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Viral Nanoparticles by Nicole F. Steinmetz,Marianne Manchester Pdf

This book overviews the applications of viral nanoparticles (VNPs) in areas ranging from materials science to biomedicine. It summarizes the many different VNP building blocks and describes chemistries that allow one to attach, entrap, or display functionalities on VNPs. The book outlines the strategies for the construction of 1-, 2-, and 3-D arrays, highlights the achievements in utilizing VNPs as tools for novel biosensors and nanoelectronic devices, and describes efforts in designing VNPs for biomedical applications, including their use as gene delivery vectors, novel vaccines, imaging modalities, and applications in targeted therapeutics.