Rna Interference Research Progress

Author : Roger T. Lyland,Irving B. Browning
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 45,9 Mb
Release : 2008
Category : MicroRNA.
ISBN : 1604564466

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RNA Interference Research Progress by Roger T. Lyland,Irving B. Browning Pdf

RNA interference (RNAi) is a mechanism that inhibits gene expression by causing the degradation of specific RNA molecules or hindering the transcription of specific genes. RNAi targets include RNA from viruses and transposons (probably as a form of innate immune response), and also plays a role in regulating development and genome maintenance. Small interfering RNA strands (siRNA) are key to the RNAi process, and have complementary nucleotide sequences to the targeted RNA strand. Specific RNAi pathway proteins are guided by the siRNA to the targeted messenger RNA (mRNA), where they "cleave" the target, breaking it down into smaller portions that can no longer be translated into protein. A type of RNA transcribed from the genome itself, microRNA (miRNA), and works in the same way. This book presents the latest research in the field from around the globe.

Author : Miao-Kun Sun
Publisher : Nova Publishers
Page : 492 pages
File Size : 42,9 Mb
Release : 2007
Category : Alzheimer's disease
ISBN : 1594549494

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Research Progress in Alzheimer's Disease and Dementia by Miao-Kun Sun Pdf

Alzheimer's disease (AD) is the most common type of neurodegenerative disorder in the ageing population, with dementia as a common consequence. AD is defined pathologically by the appearance of extracellular senile plaques and intracellular neurofibrillary tangles, as described by Alois Alzheimer about a century ago. The causes for AD include genetic predisposition in a small population, ageing and environmental stresses in majority cases. The underlying pathogenic cascades, increases in expression of amyloid precursor protein and accumulation of Aß and reactive oxidant activity and inflammation, have the features of both adaptive, at least initially, and harmful when becoming excessive. Dementia, on the other hand, is a clinical diagnosis and is defined as globally, persistently impaired cognitive skills including memory. Alzheimer dementia refers to clinical dementia in patients who also have Alzheimer neuropathology. Alzheimer dementia is what brings the patients to seek medical treatments. An extraordinary inability to form new memory, especially of those episodic type, and executive dysfunction are among the earliest symptoms in AD patients. In end-stage AD, cognitive degeneration extends far beyond memory loss. The underlying causes include decreases in impaired brain metabolism, which results in impaired synaptic functions and capacities, thus impaired information processing, and eventually leads to neuronal injury and death. This book presents leading-edge research in this dynamic field.

Author : R. K. Gaur,Yedidya Gafni,P. Sharma,V. K. Gupta
Publisher : CRC Press
Page : 380 pages
File Size : 47,8 Mb
Release : 2016-04-19
Category : Science
ISBN : 9781439873250

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RNAi Technology by R. K. Gaur,Yedidya Gafni,P. Sharma,V. K. Gupta Pdf

RNAi technology is used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Introducing new technology in the study of RNA

Author : Calvin V. Burnside
Publisher : Nova Publishers
Page : 348 pages
File Size : 46,7 Mb
Release : 2008
Category : Medical
ISBN : 1604560665

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Cell Apoptosis Research Progress by Calvin V. Burnside Pdf

Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This title looks at research into this programmed cell death.

Author : Ibrokhim Y. Abdurakhmonov
Publisher : BoD – Books on Demand
Page : 460 pages
File Size : 44,7 Mb
Release : 2016-04-06
Category : Medical
ISBN : 9789535122722

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RNA Interference by Ibrokhim Y. Abdurakhmonov Pdf

RNA interference (RNAi), a hallmark of all biological sciences of twenty-first century, is an evolutionarily conserved and double-stranded RNA-dependent eukaryotic cell defense process. Opportunity to utilize an organisms own gene and to systematically induce and trigger RNAi for any desired sequence made RNAi an efficient approach for functional genomics, providing a solution for conventional longstanding obstacles in life sciences. RNAi research and application have significantly advanced during past two decades. This book RNA interference provides an updated knowledge and progress on RNAi in various organisms, explaining basic principles, types, and property of inducers, structural modifications, delivery systems/methodologies, and various successful bench-to-field or clinic applications and disease therapies with some aspects of limitations, alternative tools, safety, and risk assessment.

Author : Paul I. Quinn
Publisher : Nova Publishers
Page : 178 pages
File Size : 48,5 Mb
Release : 2008
Category : Medical
ISBN : 1604561645

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Aspirin and Health Research Progress by Paul I. Quinn Pdf

Aspirin serves as one of the leading agents for cardiovascular treatment in women. However, many patients have experienced negative side effects of internal bleeding and lining damage due to strong amounts of acid in the drug. This book presents medical and biological research.

Author : Aditi Singh,Mohammad W. Khan
Publisher : BoD – Books on Demand
Page : 136 pages
File Size : 42,9 Mb
Release : 2019-05-29
Category : Medical
ISBN : 9781838806965

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Modulating Gene Expression by Aditi Singh,Mohammad W. Khan Pdf

RNA interference (RNAi) is a widely used technology for gene silencing and has become a key tool in a myriad of research and lead discoveries. In recent years, the mechanism of RNAi agents has been well investigated, and the technique has been optimized for better effectiveness and safety. On the other hand, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9/gRNA system is a recent, novel, targeted genome-editing technique derived from the bacterial immune system. Recent advances in gene-editing research and technologies have enabled the CRISPR Cas9 system to become a popular tool for sequence-specific gene editing to correct and modify eukaryotic systems. In this book, we will focus on the mechanisms, applications, regulations (their pros and cons), and various ways in which RNAi-based methods and CRIPSR-Cas9 technology have stimulated the modulation of gene expression, thereby making them a promising therapeutic tool to treat and prevent complex diseases and disorders.

Author : Kamel A Abd-Elsalam,Ki-Taek Lim
Publisher : Elsevier
Page : 842 pages
File Size : 54,6 Mb
Release : 2021-02-27
Category : Technology & Engineering
ISBN : 9780128219119

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CRISPR and RNAi Systems by Kamel A Abd-Elsalam,Ki-Taek Lim Pdf

Plants are vulnerable to pathogens including fungi, bacteria, and viruses, which cause critical problems and deficits. Crop protection by plant breeding delivers a promising solution with no obvious effect on human health or the local ecosystem. Crop improvement has been the most powerful approach for producing unique crop cultivars since domestication occurred, making possible the main innovations in feeding the globe and community development. Genome editing is one of the genetic devices that can be implemented, and disease resistance is frequently cited as the most encouraging application of CRISPR/Cas9 technology in agriculture. Nanobiotechnology has harnessed the power of genome editing to develop agricultural crops. Nanosized DNA or RNA nanotechnology approaches could contribute to raising the stability and performance of CRISPR guide RNAs. This book brings together the latest research in these areas. CRISPR and RNAi Systems: Nanobiotechnology Approaches to Plant Breeding and Protection presents a complete understanding of the RNAi and CRISPR/Cas9 techniques for controlling mycotoxins, fighting plant nematodes, and detecting plant pathogens. CRISPR/Cas genome editing enables efficient targeted modification in most crops, thus promising to accelerate crop improvement. CRISPR/Cas9 can be used for management of plant insects, and various plant pathogens. The book is an important reference source for both plant scientists and environmental scientists who want to understand how nano biotechnologically based approaches are being used to create more efficient plant protection and plant breeding systems. Shows how nanotechnology is being used as the basis for new solutions for more efficient plant breeding and plant protection Outlines the major techniques and applications of both CRISPR and RNAi technologies Assesses the major challenges of escalating these technologies on a mass scale

Author : Naeem Sarwar,Atique-ur-Rehman,Shakeel Ahmad,Mirza Hasanuzzaman
Publisher : Springer Nature
Page : 856 pages
File Size : 41,8 Mb
Release : 2022-04-09
Category : Technology & Engineering
ISBN : 9789811649554

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Modern Techniques of Rice Crop Production by Naeem Sarwar,Atique-ur-Rehman,Shakeel Ahmad,Mirza Hasanuzzaman Pdf

This book collects all the latest technologies with their implications on the global rice cultivation. It discusses all aspects of rice production and puts together the latest trends and best practices in the rice production. Rice is produced and consumed worldwide and especially an important crop for Asia. It is a staple food in majority of population living is this continent which distinguishes this from rest of the world. Climatic fluctuations, elevated concentrations of carbon dioxide, enhanced temperature have created extreme weather conditions for rice cultivation. Also, increasing pest attacks make situation complicated for the farmers. Therefore, rice production technology also has to be adjusted accordingly. This book is of interest to teachers, researchers, plant biotechnologists, pathologists, agronomists, soil scientists, food technologists from different part of the globe. Also, the book serves as additional reading material for students of agriculture, soil science, and environmental sciences. National and international agricultural scientists, policy makers will also find this to be a useful read

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 55,6 Mb
Release : 19??
Category : Electronic
ISBN : 9535138685

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Gene Expression and Regulation in Mammalian Cells - Transcription Toward the Establishment of Novel Therapeutics by Anonim Pdf

Author : Qiang Wang
Publisher : CABI
Page : 224 pages
File Size : 53,7 Mb
Release : 2023-12-13
Category : Science
ISBN : 9781800621930

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Algal Biotechnology by Qiang Wang Pdf

Algae are sunlight-driven cell factories, and can efficiently absorb CO2 and convert light energy to chemical energy such as lipid, starch and other carbohydrates and release O2. Algal feedstock is a promising resource for bioproduct production, given its high photosynthetic efficiency for producing biomass compared to conventional crops. Microalgae can be used for flue-gas and wastewater bioremediation. This book highlights recent breakthroughs in the multidisciplinary areas of algal biotechnology and the chapters feature recent developments from cyanobacteria to eukaryotic algae, from theoretical biology to applied biology. It also includes the latest advancements in algal-based synthetic biology, including metabolic engineering, artificial biological system construction and green chemicals production. With contributions by leading authorities in algal biotechnology research, it is a valuable resource for graduate students and researchers in the field, and those involved in the study of photosynthesis and green-cell factories.

Author : Kivie Moldave
Publisher : Elsevier
Page : 488 pages
File Size : 54,7 Mb
Release : 2004-09-08
Category : Science
ISBN : 0080522718

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Progress in Nucleic Acid Research and Molecular Biology by Kivie Moldave Pdf

Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.

Author : Stella Pelengaris,Michael Khan
Publisher : John Wiley & Sons
Page : 544 pages
File Size : 44,6 Mb
Release : 2009-03-12
Category : Science
ISBN : 9781444309089

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The Molecular Biology of Cancer by Stella Pelengaris,Michael Khan Pdf

This comprehensive text provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. Written by an international panel of researchers, specialists and practitioners in the field, the text discusses all aspects of cancer biology from the causes, development and diagnosis through to the treatment of cancer. Written by an international panel of researchers, specialists and practitioners in the field Covers both traditional areas of study and areas of controversy and emerging importance, highlighting future directions for research Features up-to-date coverage of recent studies and discoveries, as well as a solid grounding in the key concepts in the field Each chapter includes key points, chapter summaries, text boxes, and topical references for added comprehension and review Supported by a dedicated website at www.blackwellpublishing.com/pelengaris An excellent text for upper-level courses in the biology of cancer, for medical students and qualified practitioners preparing for higher exams, and for researchers and teachers in the field

Author : Charles E. Carraher Jr.
Publisher : CRC Press
Page : 589 pages
File Size : 53,6 Mb
Release : 2017-01-06
Category : Science
ISBN : 9781498737852

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Introduction to Polymer Chemistry by Charles E. Carraher Jr. Pdf

Introduction to Polymer Chemistry provides undergraduate students with a much-needed, well-rounded presentation of the principles and applications of natural, synthetic, inorganic, and organic polymers. With an emphasis on the environment and green chemistry and materials, this fourth edition continues to provide detailed coverage of natural and synthetic giant molecules, inorganic and organic polymers, elastomers, adhesives, coatings, fibers, plastics, blends, caulks, composites, and ceramics. Building on undergraduate work in foundational courses, the text fulfills the American Chemical Society Committee on Professional Training (ACS CPT) in-depth course requirement

Author : Charles E. Carraher Jr.
Publisher : CRC Press
Page : 794 pages
File Size : 50,6 Mb
Release : 2017-10-12
Category : Science
ISBN : 9781498737456

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Carraher's Polymer Chemistry by Charles E. Carraher Jr. Pdf

Carraher's Polymer Chemistry, Tenth Edition integrates the core areas of polymer science. Along with updating of each chapter, newly added content reflects the growing applications in Biochemistry, Biomaterials, and Sustainable Industries. Providing a user-friendly approach to the world of polymeric materials, the book allows students to integrate their chemical knowledge and establish a connection between fundamental and applied chemical information. It contains all of the elements of an introductory text with synthesis, property, application, and characterization. Special sections in each chapter contain definitions, learning objectives, questions, case studies and additional reading.