Safety Of Biologics Therapy

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Safety of Biologics Therapy

Brian A. Baldo
Safety of Biologics Therapy Book PDF

Author : Brian A. Baldo
Publisher : Springer
Page : 610 pages
File Size : 40,6 Mb
Release : 2016-08-12
Category : Medical
ISBN : 9783319304724

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Safety of Biologics Therapy by Brian A. Baldo Pdf

This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences.

Adverse Reactions to Biologics

L. Puig,W. Gulliver
Adverse Reactions to Biologics Book PDF

Author : L. Puig,W. Gulliver
Publisher : Karger Medical and Scientific Publishers
Page : 120 pages
File Size : 49,7 Mb
Release : 2017-11-07
Category : Medical
ISBN : 9783318061017

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Adverse Reactions to Biologics by L. Puig,W. Gulliver Pdf

In many areas of medicine physicians still face the great challenge of finding therapies that will meet the patients’ needs. In dermatology the challenge has arisen on multiple fronts through advances in the understanding of the immunopathogenesis of many inflammatory and malignant cutaneous disorders. Breakthroughs, combined with significant developments in targeted immunotherapy, have resulted in improved outcomes as these newer therapies are being used for both approved indications and as off-label therapies for various chronic inflammatory skin disorders and many forms of skin cancer. In the expectation that by truly understanding the safety profile of these targeted therapies patients’ outcomes will be significantly improved, this book offers insights into topics such as adverse reactions, infectious complications and the perioperative use of biologics in psoriasis, immunogenicity of biologic therapies, paradoxical reactions, safety of biologics used to treat autoimmune bullous diseases and primary cutaneous lymphomas, adverse reactions and skin manifestations of therapies targeting melanoma and non-melanoma skin cancer and other neoplastic diseases. Eminent researchers with extensive clinical experience have contributed to this publication, providing an in-depth overview of the latest knowledge in this field.

Safe and Effective Medicines for Children

Institute of Medicine,Board on Health Sciences Policy,Committee on Pediatric Studies Conducted Under the Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA)
Safe and Effective Medicines for Children Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Pediatric Studies Conducted Under the Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA)
Publisher : National Academies Press
Page : 432 pages
File Size : 46,8 Mb
Release : 2012-10-13
Category : Medical
ISBN : 9780309225496

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Safe and Effective Medicines for Children by Institute of Medicine,Board on Health Sciences Policy,Committee on Pediatric Studies Conducted Under the Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) Pdf

The Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) were designed to encourage more pediatric studies of drugs used for children. The FDA asked the IOM to review aspects of pediatric studies and changes in product labeling that resulted from BPCA and PREA and their predecessor policies, as well as assess the incentives for pediatric studies of biologics and the extent to which biologics have been studied in children. The IOM committee concludes that these policies have helped provide clinicians who care for children with better information about the efficacy, safety, and appropriate prescribing of drugs. The IOM suggests that more can be done to increase knowledge about drugs used by children and thereby improve the clinical care, health, and well-being of the nation's children.

Rare Diseases and Orphan Products

Institute of Medicine,Board on Health Sciences Policy,Committee on Accelerating Rare Diseases Research and Orphan Product Development
Rare Diseases and Orphan Products Book PDF

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Accelerating Rare Diseases Research and Orphan Product Development
Publisher : National Academies Press
Page : 442 pages
File Size : 44,8 Mb
Release : 2011-04-03
Category : Medical
ISBN : 9780309158060

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Rare Diseases and Orphan Products by Institute of Medicine,Board on Health Sciences Policy,Committee on Accelerating Rare Diseases Research and Orphan Product Development Pdf

Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.

Treatment of Inflammatory Bowel Disease with Biologics

Adam S. Cheifetz,Joseph D. Feuerstein
Treatment of Inflammatory Bowel Disease with Biologics Book PDF

Author : Adam S. Cheifetz,Joseph D. Feuerstein
Publisher : Springer
Page : 0 pages
File Size : 46,6 Mb
Release : 2017-11-22
Category : Medical
ISBN : 3319602756

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Treatment of Inflammatory Bowel Disease with Biologics by Adam S. Cheifetz,Joseph D. Feuerstein Pdf

This book is a concise yet comprehensive overview of the use of biologics for the treatment of Crohn’s disease and ulcerative colitis. The volume details how best to utilize these medications in order to optimize their efficacy and safety, as well as how to understand, recognize, and treat complications that may arise from using biologics to treat IBD. The text also focuses on new data, novel biologics, and biosimilars of this rapidly expanding field. Written by experts in the field, Treatment of Inflammatory Bowel Disease with Biologics is a valuable resource for gastroenterologists, allied health professionals, fellows, and trainees who treat patients with inflammatory bowel disease.

Biologic Therapy for Psoriasis

Nicholas Brownstone,Tina Bhutani,Wilson Liao
Biologic Therapy for Psoriasis Book PDF

Author : Nicholas Brownstone,Tina Bhutani,Wilson Liao
Publisher : Springer Nature
Page : 153 pages
File Size : 46,7 Mb
Release : 2022-02-17
Category : Medical
ISBN : 9783030929381

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Biologic Therapy for Psoriasis by Nicholas Brownstone,Tina Bhutani,Wilson Liao Pdf

Biologic therapy is a treatment that strives to modulate a patient's immune system to fight a given disease. In psoriasis, a skin disorder that is partly caused by a dysregulated immune system resulting in well-demarcated red areas of the skin with white scales, biologic therapy has the potential to vastly improve upon patient outcomes by minimizing the symptoms of this disease while maximizing the safety profile of the therapy. This book offers an up-to-date and comprehensive review on biologic therapy for the treatment of psoriasis. With over 10 FDA approved biologic agents for psoriasis (with more in the pipeline), confusion exists among providers regarding which agent is best for a particular patient. Chapters cover all FDA approved psoriasis biologic agents (including pipeline agents) for use in pediatric, adult, and geriatric patients. This book is unique in that it will not only cover cutting edge treatment principles based on the latest research, it will also be one of the most comprehensive reviews of psoriasis biologics in the COVID-19 era. Biologic Therapy for Psoriasis is a must-have resource for board certified dermatologists and rheumatologists, dermatology and rheumatology residents and fellows, dermatology physician assistants, nurse practitioners and medical students. The ultimate goal of this book is to improve patient care by making the busy practicing dermatology provider more adept with these particular therapies.

Biologics in General Medicine

W.-H. Boehncke,H.H. Radeke
Biologics in General Medicine Book PDF

Author : W.-H. Boehncke,H.H. Radeke
Publisher : Springer Science & Business Media
Page : 202 pages
File Size : 47,9 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9783540290179

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Biologics in General Medicine by W.-H. Boehncke,H.H. Radeke Pdf

This is the first book to cover every angle in the clinical application of biologics. Readers will not only find that all of the biologics currently approved for clinical use are delineated in a standardized way, but also the "differential therapy" with biologics in fields including dermatology and neurology is described in detail and summarized in treatment algorithms. Shorter sections on biologic biotechnology as well as safety and regulatory issues complement the more clinically-oriented central chapters.

Biologics in Inflammatory Bowel Disease

Scott Plevy Associate Professor of Medicine Division of Gastroenterology
Biologics in Inflammatory Bowel Disease Book PDF

Author : Scott Plevy Associate Professor of Medicine Division of Gastroenterology
Publisher : Oxford University Press, USA
Page : 64 pages
File Size : 42,5 Mb
Release : 2010
Category : Medical
ISBN : 9780199749188

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Biologics in Inflammatory Bowel Disease by Scott Plevy Associate Professor of Medicine Division of Gastroenterology Pdf

SERIES OVERVIEW: The Oxford American Pocket Notes are a series of ultra-concise, small-format books for healthcare professionals on topics related to the diagnosis, treatment and management of various medical conditions. Each title typically features an outline of key points, guidelines and tools such as patient assessments and treatment algorithms, for a specific area of medical diagnosis and/or management. Highly practical in format, content and style, the Pocket Notes serve as a quick, easily accessible point-of-care reference for busy practitioners. In effect, they are miniature versions of the Oxford American Medical Library and Oxford American Handbooks in Medicine, capturing the key essentials needed for appropriate assessment and treatment. Inflammatory bowel disease (IBD) is a gastrointestinal condition which causes inflammation of the lining of the digestive tract. This disease affects an estimated one million Americans, usually in the forms of ulcerative colitis (UC) and Crohn's disease (CD). These two diseases have similar symptoms and are often confused for one another. Crohn's disease can occur anywhere in the digestive tract, often spreading deep into the layers of affected tissues, but ulcerative colitis usually affects only the innermost lining (mucosa) of the large intestine and rectum. IBD patients suffer from severe diarrhea and abdominal pain, and may experience other complications, such as arthritis and kidney stones, that affect the body beyond the intestinal tract. The Oxford American Pocket Notes: Biologics in Inflammatory Bowel Disease is a practical guide to the safe administration of biological agents to treat inflammatory gastrointestinal illnesses. This ultra-concise and practical volume focuses on tumor necrosis factor (TNF) blocking therapy (TNF blocker), an important new class of biologic therapy indicated for the treatment of several rheumatic and other auto-immune disorders, including Crohn's disease and ulcerative colitis. This uniquely compact and affordable book features evidence-based discussion and guidelines on the mechanism of action, dosing, administration and safety considerations for the biologic agents approved to treat CD and UC, thus providing practicing physicians with easily accessible tools and insights on the use of these drugs in a daily practice setting. Culled from the pages of Handbook of Biological Therapy, this portable guide is a valuable resource for gastroenterologists, primary care physicians and other healthcare providers involved in the management of these chronic but treatable diseases.

Drug Safety: Managing Innovation in Rheumatology, An Issue of Rheumatic Disease Clinics

Jack Cush,Kathryn H. Dao
Drug Safety Managing Innovation in Rheumatology An Issue of Rheumatic Disease Clinics Book PDF

Author : Jack Cush,Kathryn H. Dao
Publisher : Elsevier Health Sciences
Page : 240 pages
File Size : 41,5 Mb
Release : 2012-11-15
Category : Medical
ISBN : 9781455750597

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Drug Safety: Managing Innovation in Rheumatology, An Issue of Rheumatic Disease Clinics by Jack Cush,Kathryn H. Dao Pdf

Edited by Drs. Jack Cush and Kathryn Dao, this issue of Rheumatic Disease Clinics of North America addresses one of the most significant issues facing the rheumatologist today––drug safety in a changing world where rheumatoid arthritis (RA) severity is less, patients are being identified and treated at a very early stage, and prevention is on the horizon. Topics covered include: communicating the risk of side effects, urate-lowering therapies, biphosphonates, biologics, malignancy risks, and administering therapies to patients with co-morbidities.

Treatment of Inflammatory Bowel Disease with Biologics

Adam S. Cheifetz,Joseph D. Feuerstein
Treatment of Inflammatory Bowel Disease with Biologics Book PDF

Author : Adam S. Cheifetz,Joseph D. Feuerstein
Publisher : Springer
Page : 335 pages
File Size : 52,6 Mb
Release : 2017-11-09
Category : Medical
ISBN : 9783319602769

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Treatment of Inflammatory Bowel Disease with Biologics by Adam S. Cheifetz,Joseph D. Feuerstein Pdf

This book is a concise yet comprehensive overview of the use of biologics for the treatment of Crohn’s disease and ulcerative colitis. The volume details how best to utilize these medications in order to optimize their efficacy and safety, as well as how to understand, recognize, and treat complications that may arise from using biologics to treat IBD. The text also focuses on new data, novel biologics, and biosimilars of this rapidly expanding field. Written by experts in the field, Treatment of Inflammatory Bowel Disease with Biologics is a valuable resource for gastroenterologists, allied health professionals, fellows, and trainees who treat patients with inflammatory bowel disease.

The Handbook of Biological Therapy

Bruce Kirkham,Arthur Kavanaugh,Scott Eric Plevy,Jonathan Barker
The Handbook of Biological Therapy Book PDF

Author : Bruce Kirkham,Arthur Kavanaugh,Scott Eric Plevy,Jonathan Barker
Publisher : OUP Oxford
Page : 176 pages
File Size : 49,7 Mb
Release : 2008-11-27
Category : Medical
ISBN : 9780191548970

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The Handbook of Biological Therapy by Bruce Kirkham,Arthur Kavanaugh,Scott Eric Plevy,Jonathan Barker Pdf

Drugs produced by molecular biological techniques, called the 'biologics', differ from the usual chemical medications. Their optimum use, and the detection and managemenet of adverse events, pose a significant challenge to the clinician. Licences for new biologics continue to be granted for the likes of rituximab, abatacept and certocizumals pegol. Intensive research is also defining new areas in which these drugs will be used in the future, increasing the number of practitioners using biologics. As the use of these drugs increases around the world, so the level of information needed by primary care practitioners and specialist prescribers needs to be expanded The Handbook of Biological Therapy provides the practising clinician with a practica guide to the use of Tumour Necrosis Factor Blocking Therapy (TNF-blockers), and important new class of biologic therapy for rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, psoriasis, and psoriatic arthritis. It is a comprehensive distillation of the authors' clinical experience with these drugs, combined with data from diverse databases offering practical advice on their uses, specific indications, supporting clinical trial data and safety issues, with the aim of making the use of these drugs easier for the busy clinician. All of the authors have been involved from the beginnings of the clinical trial programmes with these drugs and continue to use them in daily practice.

Drug Efficacy, Safety, and Biologics Discovery

Sean Ekins,Jinghai J. Xu
Drug Efficacy Safety and Biologics Discovery Book PDF

Author : Sean Ekins,Jinghai J. Xu
Publisher : John Wiley & Sons
Page : 442 pages
File Size : 41,9 Mb
Release : 2009-01-28
Category : Medical
ISBN : 9780470431801

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Drug Efficacy, Safety, and Biologics Discovery by Sean Ekins,Jinghai J. Xu Pdf

Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.

Pharmacoepidemiology

Brian L. Strom,Stephen E. Kimmel,Sean Hennessy
Pharmacoepidemiology Book PDF

Author : Brian L. Strom,Stephen E. Kimmel,Sean Hennessy
Publisher : John Wiley & Sons
Page : 1220 pages
File Size : 48,8 Mb
Release : 2019-12-16
Category : Medical
ISBN : 9781119413417

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Pharmacoepidemiology by Brian L. Strom,Stephen E. Kimmel,Sean Hennessy Pdf

This classic, field-defining textbook, now in its sixth edition, provides the most comprehensive guidance available for anyone needing up-to-date information in pharmacoepidemiology. This edition has been fully revised and updated throughout and continues to provide a rounded view on all perspectives from academia, industry and regulatory bodies, addressing data sources, applications and methodologies with great clarity.

Biologics in Inflammatory Bowel Disease, An issue of Gastroenterology Clinics of North America,

Edward V. Loftus, Jr
Biologics in Inflammatory Bowel Disease An issue of Gastroenterology Clinics of North America Book PDF

Author : Edward V. Loftus, Jr
Publisher : Elsevier Health Sciences
Page : 257 pages
File Size : 49,7 Mb
Release : 2014-08-21
Category : Medical
ISBN : 9780323323260

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Biologics in Inflammatory Bowel Disease, An issue of Gastroenterology Clinics of North America, by Edward V. Loftus, Jr Pdf

By the time this issue of Gastroenterology Clinics of North America is released, it will have been 16 years since infliximab was approved by the US Food and Drug Administration for the treatment of moderate to severe Crohn disease. Not only have we come a long way in understanding the efficacy and safety of infliximab, we are beginning to understand how and when to use the drug. Furthermore, as of this writing, we have five other biologic agents approved for either Crohn disease or ulcerative colitis, and there are many more molecules currently in drug development for these indications. In this issue,the Editors have assembled a collection of experts to provide the most cutting-edge information on the status of biologic therapy for inflammatory bowel disease.

Biologics for the Treatment of Rheumatoid Arthritis

Ronald van Vollenhoven
Biologics for the Treatment of Rheumatoid Arthritis Book PDF

Author : Ronald van Vollenhoven
Publisher : Adis
Page : 0 pages
File Size : 51,9 Mb
Release : 2016-01-06
Category : Medical
ISBN : 3319131079

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Biologics for the Treatment of Rheumatoid Arthritis by Ronald van Vollenhoven Pdf

This book provides a comprehensive overview of the available biologic therapies whilst comparing them to standard disease modifying anti-rheumatic drugs, and discusses how best to determine which therapy is most appropriate for an individual patient in the framework of current guidelines. Biologics for the Treatment of Rheumatoid Arthritis is an up-to-date and concise practical guide to the latest therapeutic developments in this field. This book is an invaluable source of topical information for all rheumatologists and health care professionals treating patients with rheumatoid arthritis.