Selective Heat Sensitivity Of Cancer Cells

Author : A. Rossi-Fanelli,R. Cavaliere,B. Mondovi,G. Moricca
Publisher : Springer Science & Business Media
Page : 334 pages
File Size : 40,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642810800

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Selective Heat Sensitivity of Cancer Cells by A. Rossi-Fanelli,R. Cavaliere,B. Mondovi,G. Moricca Pdf

Since the first observations of Busch in 1866, the possible use of heat as a therapeutic agent in the cure of cancer has been repeatedly subject to bursts of interest, almost invariably followed by periods of neglect and skepticism. In 1963-1964, this problem was again attacked by us both from the biochemical and from the clinical points of view. The first results of this joint effort were positive beyond expectation, and generated a new revial of studies aimed at the identification of the nature of the bio chemical lesion as well as at the optimization of technique and of the therapeutic schedules connected with clinical use. Although the number of mammalian tumors which have been proved to be heat-sensitive is now relatively large, and although in some cases a correlation has been demonstrated between tumorigenicity and heat-sensitivity of in vitro cultured cell lines, the question of a direct and constant relationship between neoplastic character and higher sensitivity to hyperthermic exposure is still open to continuing investigation and reappraisal. Several studies deal in fact with the determination of the conditions under which, in vitro and or in vivo, different tumors are efficiently damaged by elevated temperatures.

Author : Gian F. Baronzio,E. Dieter Hager
Publisher : Springer Science & Business Media
Page : 382 pages
File Size : 44,6 Mb
Release : 2008-05-08
Category : Medical
ISBN : 9780387334417

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Hyperthermia In Cancer Treatment: A Primer by Gian F. Baronzio,E. Dieter Hager Pdf

Following an introductory overview, Hyperthermia In Cancer Treatment: A Primer comprehensively describes the biological reasons for associating hyperthermia with radiation and chemotherapy and the biological and clinical effects of hyperthermia on cancerous and normal tissues. The volume’s 20 chapters are arranged in three principal parts: physical and methodological studies, biologic principles, and clinical studies.

Author : Anonim
Publisher : Unknown
Page : 124 pages
File Size : 46,5 Mb
Release : 1984
Category : Cancer
ISBN : MINN:30000010688970

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Cancer Treatment Reports by Anonim Pdf

Author : Joseph C. Bottino,Franco M. Muggia,Richard W. Opfell
Publisher : Springer Science & Business Media
Page : 387 pages
File Size : 47,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461325932

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Liver Cancer by Joseph C. Bottino,Franco M. Muggia,Richard W. Opfell Pdf

Neoplastic disease confined to the liver is an important worldwide problem. In the industrialized nations, metastatic disease of the most common cancers involves the liver in upwards of 50% of cases. Primary hepatic tumors are virtually epidemic in most third world countries and certainly constitute one of the ten most common causes of cancer deaths on a worldwide scale. Amazingly, little specific attention has been devoted to therapeutic approaches of liver and biliary tumors until recently. We attribute this apparent lack of interest to the uniformly poor progno sis of patients so afflicted, and attribute the renewed interest to the exciting new developments in diagnostic and therapeutic technology as well as in tumor biology. The purpose of this book is to collect in one volume an integrated selection of articles that would provide the therapist with a comprehensive, yet practical, overview of liver cancer. We believe the contributors to the book are superbly qualified experts on the various subjects and provide in-depth information on respective fields. The edit ing process for us was not only educational but thrilling as the high quality and complementary nature of the chapters became evident as we received them. Be cause many areas in the field of liver cancer are controversial, the reader will notice that contradictory opinions are presented by some of the authors.

Author : H.M. Pinedo,J. Verweij
Publisher : Springer Science & Business Media
Page : 154 pages
File Size : 48,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461323198

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Clinical Management of Soft Tissue Sarcomas by H.M. Pinedo,J. Verweij Pdf

Although soft tissue sarcomas are rare tumors, representing only ± 1 % of all malignant tumors in adults, they remain a challenge to all disciplines in medical treatment and research. Apart from research in all fields of treatment, soft tissue sarcomas are also encountered in several forms of combined modality treatment. Since the appearance of the first volume on soft tissue sarcomas in this series (Soft Tissue Sarcomas, Laurence H. Baker, ed., Martinus Nijhoff Publishers, 1983), a large amount of data has emerged from preclinical as well as clinical in vestigations. The present volume provides an up-to-date review of the state of the art without duplicating the contents of the earlier volume. In the chapter on pathology it is again indicated that malignant fibrocytic hys tiocytoma is at present the most frequently diagnosed type of soft tissue sarcoma. Nevertheless, sub-typing is less important for the prognosis than grade. Recently, grading has been defined better, permitting a more common use of this prognostic factor. However, the experience of the pathologist is most important for adequate grading. The pathologist will need an adequate biopsy to perform his investiga tions. Cytology is not sufficient for diagnosis. However, for confirmation of metastatic lesions, cytology may provide enough information. Some new tools have been added to the equipment of the pathologist.

Author : Anonim
Publisher : Unknown
Page : 572 pages
File Size : 48,8 Mb
Release : 1973
Category : Cancer
ISBN : CUB:U183029147625

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Cancer Chemotherapy Reports by Anonim Pdf

Author : Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca
Publisher : Springer Science & Business Media
Page : 399 pages
File Size : 48,7 Mb
Release : 2007-09-09
Category : Medical
ISBN : 9781402064012

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Heat Shock Proteins in Cancer by Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca Pdf

Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

Author : Riadh Habash
Publisher : CRC Press
Page : 506 pages
File Size : 54,6 Mb
Release : 2020-05-04
Category : Medical
ISBN : 9781498779043

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BioElectroMagnetics by Riadh Habash Pdf

This book is an educational resource of evolving scientific knowledge in the area of bioelectromagnetics that may serve the interests of students and decision-makers, as well as society as a whole. It is distinguished by extensive descriptions of fundamental biophysical concepts and their relevance to human health. Reflecting the transdisciplinary approach from several different intellectual streams including physics, biology, epidemiology, medicine, environment, risk science, and engineering, the book is quite a venture into the battling studies to assess the latest research on health effects and biomedical applications of EM energy. This new edition of the book particularly looks at the potential threats from the emerging 5G wireless networks, which will deploy large numbers of low-powered smartphones, notebooks, tablets, radio access networks, and other transmitters. Features Introduces necessary biophysical principles of EM fields in the context of their interaction with living systems. Strengthens understanding of cutting-edge research on several major areas in the broad area of bioelectromagnetics. Presents safety standards and guidelines for human exposure to EM fields. Discusses techniques that have been developed to ensure adequate EM-thermal dosimetry required for both health effects and biomedical applications. Provides insight into the determinants of EM health risk assessment and public concerns. Includes extensive reference list at the end of each chapter to enhance further study. Riadh Habash is a special appointment professor and McLaughlin Research Chair in Electromagnetic Fields and Health at the University of Ottawa, Canada. He has been the recipient of many awards, including the National Wighton Fellowship Award, and has authored or co-authored over 90 research articles, six books, and five book chapters. His most recent books are Green Engineering in 2017 and Professional Practice in 2019 (CRC Press), with the remaining previous books targeting the area of bioelectromagnetics.

Author : George M. Hahn
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 40,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468441932

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Hyperthermia and Cancer by George M. Hahn Pdf

Hyperthermia as a tool for the treatment of malignant disease is rapidly becoming a clinical reality. In this book I am attempting to summarize the known biological and physical underpinnings that have led to this development. I also present a compilation of existing clinical results, limited as these are. My aim is to provide oncologists and other physicians with up-to-date information on this modality, which is both new and old, as well as to make available to biologists, physicists and engineers sum maries of currently available information on specific areas of hyperthermic research. Many people have helped me with this book. Specifically, thanks are due to Drs. William Dewey, Jean Dutreix, Peter Fessenden, Gloria Li, and Jane Marmor. Their suggestions have been invaluable. I hope that not too many errors and omissions have crept into the volume, but in any case, for these I have only myself to blame. I also wish to express my appreciation to David Betten and Marie Graham for their help. Most of this material was written while I was on sabbatical leave on the shores of Lake Atitlan in Guatemala. There I enjoyed the hospitality of a gracious, friendly, and proud people who deserve better than fate seems to have in store for them.

Author : Ashley M. Ford
Publisher : Nova Publishers
Page : 218 pages
File Size : 46,6 Mb
Release : 2006
Category : Diabetes
ISBN : 1594547963

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Trends in Diabetes Research by Ashley M. Ford Pdf

Diabetes mellitus is a chronic disease of absolute or relative insulin deficiency or resistance characterised by disturbances in carbohydrate, protein and fat metabolism. It is estimated that between 5-10 per cent of the population suffer from this disease. This syndrome is a contributing factor in a large percentage of deaths from heart attacks and strokes as well as renal failure and vascular disease. About 90 per cent of the cases of diabetes mellitus fall into Type 2 where obesity plays a major role. Research in the field is wide-spread ranging from causes to treatment. This book brings together leading research from throughout the world.

Author : Tadayoshi Matsuda
Publisher : Taylor & Francis
Page : 420 pages
File Size : 43,7 Mb
Release : 1993
Category : Cancer
ISBN : 0850668379

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Cancer Treatment by Hyperthermia, Radiation and Drugs by Tadayoshi Matsuda Pdf

This work describes the ways in which the techniques of hyperthermia have been used in a project in Japanese oncology clinics since 1984. The physical, biological and clinical aspects of hyperthermic oncology are detailed.

Author : K. Schwemmle,K. Aigner
Publisher : Springer Science & Business Media
Page : 381 pages
File Size : 48,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642820250

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Vascular Perfusion in Cancer Therapy by K. Schwemmle,K. Aigner Pdf

Substantial relief of discomfort may be anticipated by most patients suffering from pelvic and lower-extremity pain who are treated by arterial infusion of nitrogen mustard. Seventy-three patients with intractable pain secondary to malignancy arising in the pelvis received 83 percutaneous pelvic arterial infusions of this drug. Sixty infusions (72%) resulted in marked relief from pain for periods averaging 6-8 weeks. Advantages of the procedure are low toxicity, relative simplicity and availability of technique, and an acceptable rate of complications with minimal morbidity. Patients experiencing satisfactory results may expect significant relief from a second infusion for recurrent pain. The most rewarding result is the freedom from the cyclic return of pain characterized by oral and intramuscular analgesic therapy. Little or no relief can be expected in patients with pain caused by compression fractures of the vertebrae, or where the tumor burden is so great that adequate perfusion of the involved nerves is not possible. One should consider this procedure for controlling pain before resorting to the more dangerous and potentially disabling techniques of spinal cordotomy or intrathecal alcohol injection. References Bateman JR, Hazen JG, Stolinsky DC, Steinfeld JL (1966) Advanced carcinoma of the cervix treated by intra-arterial methotrexate. Am J Obstet Gynecol 96: 181-187 Calabresi P, Parks RW Jr (1970) Alkylating agents, antimetabolites, hormones. and other antiproliferative agents. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics, 4th edn.

Author : Haim I. Bicher,John R. McLaren,Giuseppe M. Pigliucci
Publisher : Springer Science & Business Media
Page : 545 pages
File Size : 55,8 Mb
Release : 2013-03-08
Category : Medical
ISBN : 9781468457667

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Consensus on Hyperthermia for the 1990s by Haim I. Bicher,John R. McLaren,Giuseppe M. Pigliucci Pdf

Hyperthermia as a safe and effective cancer treatment modality is rapidly evolving propelled by widespread research and clinical efforts worldwide. Presentations on Hyperthermia experience are now commonplace at Oncology meetings, as are congresses dedicated entirely to the intertwined interactions between basic sciences and patient treatment that together are forming the structure of a new medical specialty. Such was the XII International Symposium on Clinical Hyperthermia held in Rome, Italy, April 27 - 29, 1989. Papers presented therein constitute the backbone of this book. Biology research has provided data describing mechanisms of action for the cancer cell killing and physiological effects of Hyperthermia. Physics research has led to the development of equipment enabling treatment of many areas of the human body, as well as explained the limitations that still constrain our ability to treat, especially in the areas of deep seated tumor heating and non-invasive thermometry. The main question that will decide the future of this modality is that of its clinical use. To put it succinctly, what do we do with this potentially useful tool in an everyday clinical oncological practice . •• ? This is the main question addressed in this book as "Consensus on Hyperthermia for the 1990s. " The book in cludes 28 presented papers and 25 invited chapters from some of the leading experts in the field. Their basic mechanisms of action were physics principles, treatment quality assurance and especially, clinical indications.

Author : M. Urano,Evan B. Douple
Publisher : CRC Press
Page : 221 pages
File Size : 52,7 Mb
Release : 2023-01-06
Category : Medical
ISBN : 9781466563773

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Thermal Effects on Cells and Tissues by M. Urano,Evan B. Douple Pdf

Volume 1 of Thermal Effects on Cells and Tissues covers Hyperthermia and Oncology. This is a collection of eight essays.

Author : Leopold J. Anghileri,Jacques Robert
Publisher : CRC Press
Page : 345 pages
File Size : 50,9 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9781000012675

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Hyperthermia In Cancer Treatment by Leopold J. Anghileri,Jacques Robert Pdf

First published in 1986, Hyperthermia in Cancer Treatment is a most useful guide to the relationship between Hyperthermia, and the ways in which it is used for the control and treatment of cancer cells. Well-structured and comprehensive, this book is a must-read for any students of Oncology or professionals in their respective fields.