Signal Transduction And Human Disease

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Signal Transduction and Human Disease

Toren Finkel,J. Silvio Gutkind
Signal Transduction and Human Disease Book PDF

Author : Toren Finkel,J. Silvio Gutkind
Publisher : John Wiley & Sons
Page : 490 pages
File Size : 41,7 Mb
Release : 2003-07-18
Category : Science
ISBN : 9780471448372

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Signal Transduction and Human Disease by Toren Finkel,J. Silvio Gutkind Pdf

This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.

Signal Transduction: Pathways, Mechanisms and Diseases

Ari Sitaramayya
Signal Transduction Pathways Mechanisms and Diseases Book PDF

Author : Ari Sitaramayya
Publisher : Springer Science & Business Media
Page : 429 pages
File Size : 50,7 Mb
Release : 2009-12-02
Category : Science
ISBN : 9783642021121

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Signal Transduction: Pathways, Mechanisms and Diseases by Ari Sitaramayya Pdf

Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.

Signal Transduction

Lorenzo F. Greco,Alessandro L. Martino
Signal Transduction Book PDF

Author : Lorenzo F. Greco,Alessandro L. Martino
Publisher : Unknown
Page : 0 pages
File Size : 54,8 Mb
Release : 2008
Category : Cellular signal transduction
ISBN : 1604563389

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Signal Transduction by Lorenzo F. Greco,Alessandro L. Martino Pdf

Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, auto-immune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms. This book presents the latest research in the field.

Regulation of Signal Transduction in Human Cell Research

Nariyoshi Shinomiya,Hiroaki Kataoka,Qian Xie
Regulation of Signal Transduction in Human Cell Research Book PDF

Author : Nariyoshi Shinomiya,Hiroaki Kataoka,Qian Xie
Publisher : Springer
Page : 218 pages
File Size : 49,5 Mb
Release : 2018-02-15
Category : Medical
ISBN : 9789811072963

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Regulation of Signal Transduction in Human Cell Research by Nariyoshi Shinomiya,Hiroaki Kataoka,Qian Xie Pdf

This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders. Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on. This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area. This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases.

Focus on Signal Transduction Research

Gavin McAlpine
Focus on Signal Transduction Research Book PDF

Author : Gavin McAlpine
Publisher : Nova Publishers
Page : 256 pages
File Size : 48,8 Mb
Release : 2007
Category : Cell division
ISBN : 1600213766

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Focus on Signal Transduction Research by Gavin McAlpine Pdf

Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.

Trends in Signal Transduction Research

Jennifer N. Meyers
Trends in Signal Transduction Research Book PDF

Author : Jennifer N. Meyers
Publisher : Nova Publishers
Page : 270 pages
File Size : 40,7 Mb
Release : 2007
Category : Cell interaction
ISBN : 1600213758

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Trends in Signal Transduction Research by Jennifer N. Meyers Pdf

Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.

Mitogen Activated Protein Kinases

Ritva Tikkanen,David Nikolic-Paterson
Mitogen Activated Protein Kinases Book PDF

Author : Ritva Tikkanen,David Nikolic-Paterson
Publisher : MDPI
Page : 276 pages
File Size : 54,5 Mb
Release : 2020-06-18
Category : Science
ISBN : 9783039280704

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Mitogen Activated Protein Kinases by Ritva Tikkanen,David Nikolic-Paterson Pdf

Mitogen-activated protein kinases (MAPK) are a large family of enzymes that function as signal transducers to regulate a diverse range of physiological responses. However, signaling via extracellular signal-regulated kinase (ERK), c-Jun amino terminal kinase (JNK), and p38 MAPK also underpin many disease processes. This Special Issue provides new insights into how MAPK signaling contributes to specific pathological processes across a range of conditions, including disorders of lung development, type 2 diabetes, proliferative skin diseases, cardiovascular diseases, and neurological diseases.

Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease

Edward Bittar
Caveolae and Lipid Rafts Roles in Signal Transduction and the Pathogenesis of Human Disease Book PDF

Author : Edward Bittar
Publisher : Elsevier
Page : 264 pages
File Size : 52,8 Mb
Release : 2005-10-07
Category : Science
ISBN : 0080458602

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Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease by Edward Bittar Pdf

Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.

Signal Transduction Research Trends

Nickolas O. Grachevsky
Signal Transduction Research Trends Book PDF

Author : Nickolas O. Grachevsky
Publisher : Nova Publishers
Page : 330 pages
File Size : 54,7 Mb
Release : 2007
Category : Medical
ISBN : 1600214878

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Signal Transduction Research Trends by Nickolas O. Grachevsky Pdf

Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.

Cellular Signal Transduction in Toxicology and Pharmacology

Jonathan W. Boyd,Richard R. Neubig
Cellular Signal Transduction in Toxicology and Pharmacology Book PDF

Author : Jonathan W. Boyd,Richard R. Neubig
Publisher : John Wiley & Sons
Page : 336 pages
File Size : 45,6 Mb
Release : 2019-04-16
Category : Science
ISBN : 9781119060260

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Cellular Signal Transduction in Toxicology and Pharmacology by Jonathan W. Boyd,Richard R. Neubig Pdf

Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology

Salvatore V. Pizzo
Cell Surface GRP78 a New Paradigm in Signal Transduction Biology Book PDF

Author : Salvatore V. Pizzo
Publisher : Academic Press
Page : 144 pages
File Size : 40,8 Mb
Release : 2018-03-20
Category : Science
ISBN : 9780128123522

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Cell Surface GRP78, a New Paradigm in Signal Transduction Biology by Salvatore V. Pizzo Pdf

Cell Surface GRP78, a New Paradigm in Signal Transduction Biology presents a new paradigm that has emerged in the past decade with the discovery that various intracellular proteins may acquire new functions as cell surface receptors. Two very prominent examples are ATP synthase and GRP78. While the role of cell surface ATP synthase has been reviewed in various books, this book directs its attention to the story of cell surface GRP78. Edited by the researcher who identified cell surface expression of the molecular chaperone GRP78 as a major factor in prostate cancer and other malignancies Presents an in-depth treatment of the biological underpinnings of GRP78 and its connection to disease Provides four-color illustrations that facilitate the narrative

Tissue-Specific Cell Signaling

Joana Vieira Silva,Maria João Freitas,Margarida Fardilha
Tissue Specific Cell Signaling Book PDF

Author : Joana Vieira Silva,Maria João Freitas,Margarida Fardilha
Publisher : Springer Nature
Page : 444 pages
File Size : 43,9 Mb
Release : 2020-05-29
Category : Medical
ISBN : 9783030444365

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Tissue-Specific Cell Signaling by Joana Vieira Silva,Maria João Freitas,Margarida Fardilha Pdf

Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters. This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors. Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Signal Transduction in Health and Disease

Paul Greengard,Angus C. Nairn,Shirish Shenolikar
Signal Transduction in Health and Disease Book PDF

Author : Paul Greengard,Angus C. Nairn,Shirish Shenolikar
Publisher : Academic Press
Page : 336 pages
File Size : 42,8 Mb
Release : 1998-07
Category : Medical
ISBN : 0120361310

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Signal Transduction in Health and Disease by Paul Greengard,Angus C. Nairn,Shirish Shenolikar Pdf

This volume contains papers presented at the Ninth International Conference on Second Messengers and Phosphoproteins. Written by leading scientists - including two Nobel Laureates - the papers highlight contemporary advances in the rapidly evolving field of signal transduction. The findings presented are of vital significance to researchers in virtually all biomedical fields, including pharmacology, molecular biology, cell biology, biochemistry, the neurosciences, and physiology. The contributors offer new insights into fundamental cell signalling mechanisms and explore the role of these mechanisms in physiological and pathophysiological responses in a variety of systems. Coverage includes many topics that are currently under intensive study, such as growth factors and special signalling systems; protein phosphatases and metabolic pathways; calcium and ion channels; cyclic GMP and cyclic AMP; and receptors and G proteins.

Apoptosis, Cell Signaling, and Human Diseases

Rakesh Srivastava
Apoptosis Cell Signaling and Human Diseases Book PDF

Author : Rakesh Srivastava
Publisher : Springer Science & Business Media
Page : 402 pages
File Size : 44,9 Mb
Release : 2007-11-05
Category : Science
ISBN : 9781597451994

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Apoptosis, Cell Signaling, and Human Diseases by Rakesh Srivastava Pdf

Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 and 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer. These comprehensive volumes integrate the most innovative and current findings. The contributors are at the forefront of scientific discovery.

Smad Signal Transduction

Peter Dijke,Carl-Henrik Heldin
Smad Signal Transduction Book PDF

Author : Peter Dijke,Carl-Henrik Heldin
Publisher : Springer Science & Business Media
Page : 489 pages
File Size : 43,8 Mb
Release : 2007-05-10
Category : Science
ISBN : 9781402047091

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Smad Signal Transduction by Peter Dijke,Carl-Henrik Heldin Pdf

This is the first comprehensive book on Smad signal transduction. Forward looking reviews of Smads are provided in a series of 22 cutting-edge chapters. The book is written for an audience with basic understanding of molecular and cell biology. This volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided.