Single Cell Omics Analyses In Cardiovascular Diseases

Author : Anonim
Publisher : Frontiers Media SA
Page : 150 pages
File Size : 52,7 Mb
Release : 2024-05-14
Category : Medical
ISBN : 9782832549001

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Single-Cell OMICs Analyses in Cardiovascular Diseases by Anonim Pdf

Single-cell OMICs analyses have recently become one of the most promising tools to probe biology at the cellular level, in large part due to its ability to address issues beyond the bulk analysis – a window into cellular heterogeneity. The ability to profile transcriptomic, epigenomic, proteomics, and metabolomics at the single cell level including more recently the spatial information has enhanced our ability to understand interactions between biomolecules in different contexts leading to the discovery of specific cellular subpopulations as well as biological mechanisms underlying pathologies which may be amenable to therapeutic interventions. The scale and availability of a variety of technologies to measure intricate molecular details have provided an impetus to research in many disease areas, including cardiovascular medicine.

Author : Jyoti Sharma,Lavanya Balakrishnan,Sandeep Kaushik,Manoj Kumar Kashyap
Publisher : Frontiers Media SA
Page : 154 pages
File Size : 47,5 Mb
Release : 2020-11-18
Category : Science
ISBN : 9782889661251

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Multi-Omics Approaches to Study Signaling Pathways by Jyoti Sharma,Lavanya Balakrishnan,Sandeep Kaushik,Manoj Kumar Kashyap Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Publisher : National Academies Press
Page : 354 pages
File Size : 46,8 Mb
Release : 2012-09-13
Category : Science
ISBN : 9780309224185

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Evolution of Translational Omics by Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials Pdf

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Author : Debmalya Barh,Vasco Azevedo
Publisher : Academic Press
Page : 384 pages
File Size : 51,7 Mb
Release : 2019-07-31
Category : Electronic
ISBN : 9780128175323

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Single-Cell Omics by Debmalya Barh,Vasco Azevedo Pdf

Single-cell Omics, Volume 2: Advances in Applications provides the latest single-cell omics applications in the field of biomedicine. The advent of omics technologies have enabled us to identify the differences between cell types and subpopulations at the level of the genome, proteome, transcriptome, epigenome, and in several other fields of omics. The book is divided into two sections: the first is dedicated to biomedical applications, such as cell diagnostics, non-invasive prenatal testing (NIPT), circulating tumor cells, breast cancer, gliomas, nervous systems and autoimmune disorders, and more. The second focuses on cell omics in plants, discussing micro algal and single cell omics, and more. This book is a valuable source for bioinformaticians, molecular diagnostic researchers, clinicians and several members of biomedical field interested in understanding more about single-cell omics and its potential for research and diagnosis. Covers the diverse single cell omics applications in the biomedical field Summarizes the latest progress in single cell omics and discusses potential future developments for research and diagnosis Written by experts across the world, it brings different points-of-view and study cases to fully give a comprehensive overview of the topic

Author : Elena Aikawa
Publisher : BoD – Books on Demand
Page : 544 pages
File Size : 55,6 Mb
Release : 2013-06-12
Category : Medical
ISBN : 9789535111504

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Calcific Aortic Valve Disease by Elena Aikawa Pdf

Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.

Author : Seitaro Nomura,Kaoru Ito
Publisher : Frontiers Media SA
Page : 155 pages
File Size : 53,9 Mb
Release : 2022-06-21
Category : Medical
ISBN : 9782889763931

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Genomic Architecture of Cardiovascular Diseases by Seitaro Nomura,Kaoru Ito Pdf

Author : Maarten M. G. van den Hoogenhof,Hamid El Azzouzi,Abdelaziz Beqqali
Publisher : Frontiers Media SA
Page : 151 pages
File Size : 42,8 Mb
Release : 2021-12-06
Category : Science
ISBN : 9782889718085

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RNA Biology in Cardiovascular Disease by Maarten M. G. van den Hoogenhof,Hamid El Azzouzi,Abdelaziz Beqqali Pdf

Author : Shouneng Peng,Ailan Wang,Junjun Ding,Lilach Soreq
Publisher : Frontiers Media SA
Page : 139 pages
File Size : 42,7 Mb
Release : 2024-03-13
Category : Science
ISBN : 9782832546321

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Bioinformatics analysis of single cell sequencing and multi-omics in the aging and age-associated diseases by Shouneng Peng,Ailan Wang,Junjun Ding,Lilach Soreq Pdf

Author : Ying Wang,Michal Mokry,Kathryn L. Howe
Publisher : Frontiers Media SA
Page : 141 pages
File Size : 43,5 Mb
Release : 2023-11-20
Category : Medical
ISBN : 9782832539354

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Revolutions in Human Biospecimen Study: Leveraging new technologies to explore the pathology, therapeutics and biomarkers for atherosclerotic disease by Ying Wang,Michal Mokry,Kathryn L. Howe Pdf

Over the last few years, new high-throughput biotechnologies are revolutionizing our ways to utilize human biospecimens for understanding atherosclerotic disease. These recent advances allow deep profiling of individual cells at the genomics, epigenomics, transcriptomics and proteomics levels, or even simultaneous detection of various combinations of ‘Omics’ in the same cell. Additionally, novel methods to integrate data at different levels from tissue sections and dissociated tissues are the emerging trends in large and institutional biobank studies. Growing literature has shown the value of such sequencing and bioinformatic strategies in shedding light on (1) how risk genes, as identified by the Genome-Wide Association Study, contribute to atherogenesis (genotype to phenotype), and (2) how features of atherosclerotic lesions affect patient response in clinical trials (phenotype to the clinical outcome). The hybrid of cutting-edge biotechnologies and bioinformatic approaches helps us maximize biobank resources to accelerate bench-to-bedside research.

Author : Lei Xing,Maryellen L. Giger,James K. Min
Publisher : Academic Press
Page : 570 pages
File Size : 46,7 Mb
Release : 2020-09-03
Category : Medical
ISBN : 9780128212585

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Artificial Intelligence in Medicine by Lei Xing,Maryellen L. Giger,James K. Min Pdf

Artificial Intelligence Medicine: Technical Basis and Clinical Applications presents a comprehensive overview of the field, ranging from its history and technical foundations, to specific clinical applications and finally to prospects. Artificial Intelligence (AI) is expanding across all domains at a breakneck speed. Medicine, with the availability of large multidimensional datasets, lends itself to strong potential advancement with the appropriate harnessing of AI. The integration of AI can occur throughout the continuum of medicine: from basic laboratory discovery to clinical application and healthcare delivery. Integrating AI within medicine has been met with both excitement and scepticism. By understanding how AI works, and developing an appreciation for both limitations and strengths, clinicians can harness its computational power to streamline workflow and improve patient care. It also provides the opportunity to improve upon research methodologies beyond what is currently available using traditional statistical approaches. On the other hand, computers scientists and data analysts can provide solutions, but often lack easy access to clinical insight that may help focus their efforts. This book provides vital background knowledge to help bring these two groups together, and to engage in more streamlined dialogue to yield productive collaborative solutions in the field of medicine. Provides history and overview of artificial intelligence, as narrated by pioneers in the field Discusses broad and deep background and updates on recent advances in both medicine and artificial intelligence that enabled the application of artificial intelligence Addresses the ever-expanding application of this novel technology and discusses some of the unique challenges associated with such an approach

Author : Michael S. Goligorsky
Publisher : Academic Press
Page : 528 pages
File Size : 54,5 Mb
Release : 2021-06-12
Category : Science
ISBN : 9780128233191

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Regenerative Nephrology by Michael S. Goligorsky Pdf

Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition. A significant expansion of section on induced pluripotent cells and trajectories of their differentiation. This will be followed by mechanisms and modalities of cell reprogramming for therapeutic purposes A new section on tissue engineering of the kidney of interest to nephrologists and urologists An entire section dedicated to causes of regenerative failure with the emphasis on recent discoveries of senescent cells in kidney disease, pathologic effects of senescent cells, advents in senotherapies and rejuvenation therapies A vastly expanded section on pharmacotherapies promoting kidney regeneration, trials of engineered organs, manufacturing in regenerative medicine and smooth transition to the clinical trials, with an update on some ethical issues

Author : Paolo Madeddu,Gabor Foldes
Publisher : Frontiers Media SA
Page : 116 pages
File Size : 53,8 Mb
Release : 2019-03-25
Category : Electronic
ISBN : 9782889457922

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Multicellularity in the Cardiovascular System by Paolo Madeddu,Gabor Foldes Pdf

Author : Dhavendra Kumar,Arthur A.M. Wilde,Perry Mark Elliott
Publisher : Elsevier
Page : 462 pages
File Size : 46,8 Mb
Release : 2024-06-24
Category : Science
ISBN : 9780128229200

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Genomic and Molecular Cardiovascular Medicine by Dhavendra Kumar,Arthur A.M. Wilde,Perry Mark Elliott Pdf

The Genomic and Molecular Cardiovascular Medicine largely focuses on pertinent genomic and molecular aspects of cardiovascular medicine relevant to all levels of clinical practice, from primary care to preventive healthcare. The book also focuses on practice applications of translational genomic and molecular developments and advances that impact on cardiovascular system structure and function. Each chapter is evidence-based and comprehensive, with in-depth, cutting-edge knowledge relevant to the practice of clinical cardiology and cardiovascular surgery. The book aims to fill a major gap of knowledge resource focused on genomic and molecular aspects of contemporary cardiovascular medicine and surgery practice. In view of scientific and technical complexities of the field, the book is written by a team of globally acknowledged experts in respective clinical, investigative, therapeutic and preventive aspects. The current practices within cardiovascular medicine and surgery offer excellent opportunity for genomic and molecular applications to achieve the high order effectiveness with maximum efficiency. Includes clinical applications of genomic and molecular new knowledge, along with advances in the practice of cardiovascular medicine and surgery Provides wide coverage of all major clinical and preventive aspects of clinical cardiology, including multi-disciplinary team care Focuses on targeted gene and molecular therapy in clinical cardiovascular medicine and surgery

Author : Silke Rickert-Sperling
Publisher : Springer Nature
Page : 1098 pages
File Size : 48,9 Mb
Release : 2024-06-29
Category : Electronic
ISBN : 9783031440878

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Congenital Heart Diseases: The Broken Heart by Silke Rickert-Sperling Pdf

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences
Publisher : National Academies Press
Page : 201 pages
File Size : 53,5 Mb
Release : 2020-12-18
Category : Science
ISBN : 9780309676731

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Next Steps for Functional Genomics by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences Pdf

One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.