Sirna Design

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siRNA Design

Debra J. Taxman
siRNA Design Book PDF

Author : Debra J. Taxman
Publisher : Humana Press
Page : 0 pages
File Size : 55,5 Mb
Release : 2012-10-02
Category : Science
ISBN : 1627031189

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siRNA Design by Debra J. Taxman Pdf

The discovery of RNA interference (RNAi) as a methodology for gene silencing has revolutionized biological research, providing an invaluable avenue for therapeutics, and small interfering RNA (siRNA) is the most common strategy utilized for enacting RNAi. siRNA Design: Methods and Protocols offers expertly crafted guidelines and protocols for the selection of siRNA targeting sequences, for the strategic incorporation of chemical modifications, and for advantageous structural modifications to the classic siRNA design. Protocols are provided for using endogenous cellular machinery to produce siRNA from optimized precursor short hairpin RNA (shRNA) and artificial microRNA (amiRNA) molecules. Strategies are also described for specific applications such as immunostimulatory siRNA that may provide therapeutic benefit against viral infections in mammals, the simultaneous targeting of multiple siRNAs, and siRNA-mediated crop virus resistance. The design of RNAi for gene silencing in embryonic, invertebrate, and plant systems requires a variety of unique approaches, several of which are described towards the end of this volume. Written for the highly successful Methods in Molecular BiologyTM series, this work contains the kind of detailed description and implementation advice that guarantees successful results. Authoritative and easy to use, siRNA Design: Methods and Protocols will provide researchers, educators, clinicians, and biotech specialists with a broad understanding of the issues in RNAi and how they can be overcome strategically through design.

Sirna Design

Debra J. Taxman
Sirna Design Book PDF

Author : Debra J. Taxman
Publisher : Humana Press
Page : 408 pages
File Size : 43,8 Mb
Release : 2016-05-01
Category : Medical
ISBN : 1493959786

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Sirna Design by Debra J. Taxman Pdf

A fresh addition to Springer s successful series Methods in Molecular Biology, this publication updates researchers and technicians with the latest protocols in RNA interference, the gene silencing methodology that is revolutionizing biological research."

Design and Delivery of SiRNA Therapeutics

Henrik J. Ditzel,Martina Tuttolomondo,Sakari Kauppinen
Design and Delivery of SiRNA Therapeutics Book PDF

Author : Henrik J. Ditzel,Martina Tuttolomondo,Sakari Kauppinen
Publisher : Humana
Page : 469 pages
File Size : 53,9 Mb
Release : 2022-05-14
Category : Medical
ISBN : 1071613006

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Design and Delivery of SiRNA Therapeutics by Henrik J. Ditzel,Martina Tuttolomondo,Sakari Kauppinen Pdf

This volume details protocols on rationale design of therapeutic siRNA molecules and its encapsulation with smart vehicles to overcome the barriers to an effective administration in vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Design and Delivery of SiRNA Therapeutics aims to ensure successful results in the further study of this vital field.

In Silico Technologies in Drug Target Identification and Validation

Darryl Leon,Scott Markel
In Silico Technologies in Drug Target Identification and Validation Book PDF

Author : Darryl Leon,Scott Markel
Publisher : CRC Press
Page : 510 pages
File Size : 43,7 Mb
Release : 2006-06-13
Category : Medical
ISBN : 9781420015737

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In Silico Technologies in Drug Target Identification and Validation by Darryl Leon,Scott Markel Pdf

The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyze potential drug targets. These in silico methods are often predictive, yielding faster and less expensive analyses than traditional in vivo or in vitro procedures. In Silico Technologies in Drug Target Ide

RNA Interference

Dr. Tim Doran,Chris Helliwell
RNA Interference Book PDF

Author : Dr. Tim Doran,Chris Helliwell
Publisher : CABI
Page : 269 pages
File Size : 47,6 Mb
Release : 2009
Category : Science
ISBN : 9781845934101

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RNA Interference by Dr. Tim Doran,Chris Helliwell Pdf

This methods manual provides an introduction to RNA interference, the theory behind its many applications, and specific protocols for RNAi, in organisms from plants and C.elegans to Drosophila and mammals. There are also chapters covering small hairpin RNAs and viral-induced gene silencing.

ADME-Enabling Technologies in Drug Design and Development

Donglu Zhang,Sekhar Surapaneni
ADME Enabling Technologies in Drug Design and Development Book PDF

Author : Donglu Zhang,Sekhar Surapaneni
Publisher : John Wiley & Sons
Page : 622 pages
File Size : 55,9 Mb
Release : 2012-04-30
Category : Science
ISBN : 9780470542781

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ADME-Enabling Technologies in Drug Design and Development by Donglu Zhang,Sekhar Surapaneni Pdf

A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME). ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides: A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.

RNA Interference Technology

Krishnarao Appasani
RNA Interference Technology Book PDF

Author : Krishnarao Appasani
Publisher : Cambridge University Press
Page : 564 pages
File Size : 42,6 Mb
Release : 2005-01-17
Category : Science
ISBN : 1139442651

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RNA Interference Technology by Krishnarao Appasani Pdf

RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.

Systems Biomedicine

Edison T. Liu,Douglas A. Lauffenburger
Systems Biomedicine Book PDF

Author : Edison T. Liu,Douglas A. Lauffenburger
Publisher : Academic Press
Page : 450 pages
File Size : 49,5 Mb
Release : 2009-09-17
Category : Science
ISBN : 9780080919836

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Systems Biomedicine by Edison T. Liu,Douglas A. Lauffenburger Pdf

Systems biology is a critical emerging field that quantifies and annotates the complexity of biological systems in order to construct algorithmic models to predict outcomes from component input. Applications in medicine are revolutionizing our understanding of biological processes and systems. Systems Biomedicine is organized around foundations, computational modeling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the underlying genomic, proteomic, and computational biology principles provides researchers with guidance in the use of qualitative systems and hypothesis generators. To reflect the highly interdisciplinary nature of the field, careful detail has been extended to ensure explanations of complex mathematical and biological principles are clear with minimum technical jargon. Organized to reflect the important distinguishing characteristics of systems strategies in experimental biology and medicine Provides precise and comprehensive measurement tools for constructing a model of the system and tools for defining complexity as an experimental dependent variable Includes a thorough discussion of the applications of quantitative principles to biomedical problems

Contemporary Computing

Sanjay Ranka,Arunava Banerjee,Kanad Kishore Biswas,Sumeet Dua,Prabhat Mishra,Rajat Moona,Sheung-Hung Poon,Cho-Li Wang
Contemporary Computing Book PDF

Author : Sanjay Ranka,Arunava Banerjee,Kanad Kishore Biswas,Sumeet Dua,Prabhat Mishra,Rajat Moona,Sheung-Hung Poon,Cho-Li Wang
Publisher : Springer Science & Business Media
Page : 633 pages
File Size : 47,6 Mb
Release : 2010-07-23
Category : Computers
ISBN : 9783642148330

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Contemporary Computing by Sanjay Ranka,Arunava Banerjee,Kanad Kishore Biswas,Sumeet Dua,Prabhat Mishra,Rajat Moona,Sheung-Hung Poon,Cho-Li Wang Pdf

This volume constitutes the refereed proceedings of the Third International Conference on Contemporary Computing, IC3 2010, held in Noida, India, in August 2010.

Optimal High-Throughput Screening

Xiaohua Douglas Zhang
Optimal High Throughput Screening Book PDF

Author : Xiaohua Douglas Zhang
Publisher : Cambridge University Press
Page : 223 pages
File Size : 41,6 Mb
Release : 2011-02-21
Category : Medical
ISBN : 9781139498371

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Optimal High-Throughput Screening by Xiaohua Douglas Zhang Pdf

This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.

Gene Silencing by RNA Interference

Muhammad Sohail
Gene Silencing by RNA Interference Book PDF

Author : Muhammad Sohail
Publisher : CRC Press
Page : 398 pages
File Size : 40,9 Mb
Release : 2004-08-27
Category : Medical
ISBN : 9780203489253

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Gene Silencing by RNA Interference by Muhammad Sohail Pdf

Maximizing the potential of RNA interference in functional genomics - as well as in the development of therapeutics - continues to be at the forefront of biomedical research. Unlike journal articles, Gene Silencing by RNA Interference: Technology and Application combines essential background to the RNAi field with practical techniques designed by r

Bioinformatics

Horacio Pérez-Sánchez
Bioinformatics Book PDF

Author : Horacio Pérez-Sánchez
Publisher : BoD – Books on Demand
Page : 340 pages
File Size : 51,5 Mb
Release : 2012-11-28
Category : Computers
ISBN : 9789535108788

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Bioinformatics by Horacio Pérez-Sánchez Pdf

This book is divided into different research areas relevant in Bioinformatics such as biological networks, next generation sequencing, high performance computing, molecular modeling, structural bioinformatics, molecular modeling and intelligent data analysis. Each book section introduces the basic concepts and then explains its application to problems of great relevance, so both novice and expert readers can benefit from the information and research works presented here.

RNA Technologies in Cardiovascular Medicine and Research

Volker A. Erdmann,Wolfgang Poller,Jan Barciszewski
RNA Technologies in Cardiovascular Medicine and Research Book PDF

Author : Volker A. Erdmann,Wolfgang Poller,Jan Barciszewski
Publisher : Springer Science & Business Media
Page : 358 pages
File Size : 42,9 Mb
Release : 2008-07-16
Category : Science
ISBN : 9783540787099

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RNA Technologies in Cardiovascular Medicine and Research by Volker A. Erdmann,Wolfgang Poller,Jan Barciszewski Pdf

In this book the authors review the field and explore the potential role of RNAi and other RNA technologies in cardiovascular medicine and research. They highlight the impressive recent progress but also the hurdles that still must be overcome before this promising technology is finally ready for translation and clinical use.

Current trends in Bioinformatics: An Insight

Gulshan Wadhwa,P. Shanmughavel,Atul Kumar Singh,Jayesh R. Bellare
Current trends in Bioinformatics An Insight Book PDF

Author : Gulshan Wadhwa,P. Shanmughavel,Atul Kumar Singh,Jayesh R. Bellare
Publisher : Springer
Page : 332 pages
File Size : 48,8 Mb
Release : 2018-07-09
Category : Science
ISBN : 9789811074837

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Current trends in Bioinformatics: An Insight by Gulshan Wadhwa,P. Shanmughavel,Atul Kumar Singh,Jayesh R. Bellare Pdf

This book highlights the latest breakthrough developments in bioinformatics. It presents a series of timely, in-depth reviews, drug clinical trial studies, biodiversity informatics and thematic issues. In addition, it includes insightful reviews on advances in computational molecular/structural biology, which address areas such as computing in biomedicine and genomics, computational proteomics and systems biology, and metabolic pathway engineering. Innovations in these fields have direct impacts on key issues related to healthcare, medicine, genetic disorders, the development of agricultural products, renewable energy, and environmental protection. Written by respected leaders in the field and covering a wide range of topics involving the integration of biology with computer and information science, the book offers an ideal basis for teaching at the undergraduate and graduate levels. It can also be used for self-instruction by research investigators interested in applying bioinformatics-based analytical methods and information technologists working with academic and industrial laboratories.

Design and Delivery of SiRNA Therapeutics

Henrik J. Ditzel,Martina Tuttolomondo,Sakari Kauppinen
Design and Delivery of SiRNA Therapeutics Book PDF

Author : Henrik J. Ditzel,Martina Tuttolomondo,Sakari Kauppinen
Publisher : Unknown
Page : 469 pages
File Size : 55,8 Mb
Release : 2021
Category : Drug development
ISBN : 1071612980

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Design and Delivery of SiRNA Therapeutics by Henrik J. Ditzel,Martina Tuttolomondo,Sakari Kauppinen Pdf

This volume details protocols on rationale design of therapeutic siRNA molecules and its encapsulation with smart vehicles to overcome the barriers to an effective administration in vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Design and Delivery of SiRNA Therapeutics aims to ensure successful results in the further study of this vital field. This volume details protocols on rationale design of therapeutic siRNA molecules and its encapsulation with smart vehicles to overcome the barriers to an effective administration in vivo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Design and Delivery of SiRNA Therapeutics aims to ensure successful results in the further study of this vital field.