Sirtuin Biology In Medicine

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Sirtuin Biology in Medicine

Kenneth Maiese

Author : Kenneth Maiese
Publisher : Academic Press
Page : 420 pages
File Size : 45,8 Mb
Release : 2021-03-04
Category : Medical
ISBN : 9780128141199

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Sirtuin Biology in Medicine by Kenneth Maiese Pdf

Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who discuss the broad role of sirtuins in health and disease Details the basic and clinical role of sirtuins for the development of new clinical treatments Summarizes the multidiscipline views and publications for the compelling discipline of sirtuins by covering systems throughout the body Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

Sirtuins

Riekelt H. Houtkooper

Author : Riekelt H. Houtkooper
Publisher : Springer
Page : 288 pages
File Size : 45,7 Mb
Release : 2016-11-17
Category : Medical
ISBN : 9789402409628

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Sirtuins by Riekelt H. Houtkooper Pdf

The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.

Sirtuin Biology in Cancer and Metabolic Disease

Kenneth Maiese

Author : Kenneth Maiese
Publisher : Elsevier
Page : 300 pages
File Size : 53,8 Mb
Release : 2021-02-20
Category : Medical
ISBN : 9780128224847

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Sirtuin Biology in Cancer and Metabolic Disease by Kenneth Maiese Pdf

Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who elucidate the intimate relationship between cancer and metabolic disease that intersects with sirtuin pathways Presents the basic and clinical role of sirtuins in regard to cancer and metabolic disease Summarizes the multidiscipline views and publications for this exciting field of sirtuins for the development of new clinical treatments for cancer and metabolic disease Provides a vital foundation for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

Introductory Review on Sirtuins in Biology, Aging, and Disease

Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev

Author : Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev
Publisher : Academic Press
Page : 220 pages
File Size : 40,5 Mb
Release : 2018-04-20
Category : Science
ISBN : 9780128135006

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Introductory Review on Sirtuins in Biology, Aging, and Disease by Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev Pdf

Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses

Sirtuins in Biology and Disease

Tiago F. Outeiro,Aleksey G. Kazantsev

Author : Tiago F. Outeiro,Aleksey G. Kazantsev
Publisher : Frontiers E-books
Page : 101 pages
File Size : 40,6 Mb
Release : 2024-06-05
Category : Electronic
ISBN : 9782889191178

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Sirtuins in Biology and Disease by Tiago F. Outeiro,Aleksey G. Kazantsev Pdf

Sirtuins comprise a family of NAD+-dependent enzymes that have been shown to impact longevity in a number of eukaryotic organisms. Sir2 (Silent Information Regulator 2) was the first sirtuin protein discovered. The discovery that Sir2 requires NAD+ for its activity suggested a link between Sir2 activity and the phenomenon of caloric restriction in prolonging longevity. This link was strengthened by the observation that lifespan extension by caloric restriction requires Sir2 protein. Under conditions of caloric restriction, NAD+ levels are high, Sir2 is activated, and the rate of aging is decreased. These effects have been replicated in invertebrate organisms, where a close structural and functional homologue of Sir2 was found in C. elegans and Drosophila. The sirtuin-dependent effects on metabolism and ageing, observed in lower organisms, have ignited intensive investigation of their biological and therapeutic roles in mammals. There are seven known mammalian sirtuins, SIRTs 1-7, the most studied of which is SIRT1, a close structural and functional homologue of yeast Sir2. Enhancement of organismal longevity and other health-promoting effects of mammalian SIRT1 have frequently been attributed to the regulation of metabolism. A recognized molecular link between metabolism and aging stimulated a firestorm of investigations, aiming to combat metabolic and age-dependent human diseases. It has become clear, however, that the sirtuin family of proteins regulates a diverse repertoire of cellular functions in mammals. Mounting evidence implicating SIRT1 in important clinical indications, such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease, suggest that modality as attractive therapeutic target. Subsequently, drug discovery and development, targeting sirtuin activation, has been intensified in the recent years. Despite rapid progress and accumulation of new data, the biological roles of other mammalian sirtuins have been less studied and remain poorly understood. There are several important questions that remain to be addressed. What are the functions of sirtuins in different cell types and tissues? Are all sirtuins involved in the regulation of metabolism and aging? What is the functional relationship between different sirtuins? What are the mechanisms of regulation of sirtuin activities? What is the role of sirtuins in disease and therapy? This issue aims to address these and other critical questions, relevant to Research Topic on sirtuin biology and therapeutics. To that end the issue solicits expert opinions of sirtuin research on structural biology, biochemistry, cell biology, animal genetics, pharmacology, medicinal chemistry and drug discovery, and on areas of investigation studying human conditions, like diabetes, cancer, cardio-vascular, and neutodegeneration. Of particular interest are the new methods and assays to study sirtuins in various organisms and developing sirtuin-based therapeutics. Furthermore, we propose to encourage contributors to discuss new concepts and paradigms, and to express their perspectives on the future development of the sirtuin research field. Altogether, we believe this issue provides a unique opportunity for comprehensive and diverse coverage of the topic, and will be of broad interest for the journal’s readership.

Sirtuin Biology in Endocrinology and Metabolic Disease

Shay Welch

Author : Shay Welch
Publisher : American Medical Publishers
Page : 0 pages
File Size : 50,9 Mb
Release : 2023-09-26
Category : Medical
ISBN : 9798887404554

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Sirtuin Biology in Endocrinology and Metabolic Disease by Shay Welch Pdf

Sirtuins refer to a class of signaling proteins involved in metabolic regulation. They are members of the class III family of NAD-dependent histone deacetylases (HDAC). They are involved in a variety of physiological processes ranging from metabolism and endocrine function control to immune coordination and cellular responses to stress. Sirtuin-1 (SIRT1) plays an important role in epigenetics, immunology, and endocrinology. SIRT1's diverse roles include energy sensing metabolic homeostasis regulation, and deacetylation of histone and non-histone proteins in numerous tissues. It also facilitates neuro-endocrine regulation through hypothalamus-pituitary axis stimulation, and synthesis and maintenance of reproductive hormones via steroidogenesis. Some of the other functions involve maintenance of innate and adaptive immune systems via T and B cell maturation regulation, chronic inflammation, and autoimmune diseases. This book provides significant information of sirtuin biology as well as its importance in endocrinology and metabolic disease. It will provide comprehensive knowledge to the readers.

Histone Deacetylases: the Biology and Clinical Implication

Tso-Pang Yao,Edward Seto

Author : Tso-Pang Yao,Edward Seto
Publisher : Springer Science & Business Media
Page : 269 pages
File Size : 42,7 Mb
Release : 2011-08-31
Category : Medical
ISBN : 9783642216312

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Histone Deacetylases: the Biology and Clinical Implication by Tso-Pang Yao,Edward Seto Pdf

The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.

Handbook of the Biology of Aging

Matt Kaeberlein,George Martin

Author : Matt Kaeberlein,George Martin
Publisher : Academic Press
Page : 576 pages
File Size : 49,7 Mb
Release : 2015-08-20
Category : Medical
ISBN : 9780124116207

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Handbook of the Biology of Aging by Matt Kaeberlein,George Martin Pdf

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

A Time for Metabolism and Hormones

Paolo Sassone-Corsi,Yves Christen

Author : Paolo Sassone-Corsi,Yves Christen
Publisher : Springer
Page : 132 pages
File Size : 51,7 Mb
Release : 2016-04-04
Category : Medical
ISBN : 9783319270692

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A Time for Metabolism and Hormones by Paolo Sassone-Corsi,Yves Christen Pdf

Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.

Oxford Textbook of Old Age Psychiatry

Tom Dening,Alan Thomas,John Paul Taylor,Robert Stewart

Author : Tom Dening,Alan Thomas,John Paul Taylor,Robert Stewart
Publisher : Oxford University Press, USA
Page : 961 pages
File Size : 51,7 Mb
Release : 2020-11-05
Category : Medical
ISBN : 9780198807292

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Oxford Textbook of Old Age Psychiatry by Tom Dening,Alan Thomas,John Paul Taylor,Robert Stewart Pdf

Part of the authoritative Oxford Textbooks in Psychiatry series, Oxford Textbook of Old Age Psychiatry, Third Edition has been thoroughly updated to reflect the developments in old age psychiatry since publication of the Second Edition in 2013, and remains an essential reference for anyone interested in the mental health care of older people.

Handbook of Nutrition, Diet, and Epigenetics

Vinood B. Patel,Victor R. Preedy

Author : Vinood B. Patel,Victor R. Preedy
Publisher : Springer
Page : 0 pages
File Size : 45,9 Mb
Release : 2019-02-27
Category : Medical
ISBN : 3319555294

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Handbook of Nutrition, Diet, and Epigenetics by Vinood B. Patel,Victor R. Preedy Pdf

This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting. Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.

Mitochondrial Signaling in Health and Disease

Sten Orrenius,Lester Packer,Enrique Cadenas

Author : Sten Orrenius,Lester Packer,Enrique Cadenas
Publisher : CRC Press
Page : 530 pages
File Size : 48,8 Mb
Release : 2012-06-20
Category : Medical
ISBN : 9781439880036

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Mitochondrial Signaling in Health and Disease by Sten Orrenius,Lester Packer,Enrique Cadenas Pdf

Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include: Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.

Molecular Basis and Emerging Strategies for Anti-aging Interventions

Syed Ibrahim Rizvi,Ufuk Çakatay

Author : Syed Ibrahim Rizvi,Ufuk Çakatay
Publisher : Springer
Page : 386 pages
File Size : 46,7 Mb
Release : 2018-11-02
Category : Medical
ISBN : 9789811316999

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Molecular Basis and Emerging Strategies for Anti-aging Interventions by Syed Ibrahim Rizvi,Ufuk Çakatay Pdf

This book describes the nature of aging, age-related disorders, and the molecular principles of emerging strategies for anti-aging interventions, while also discussing the discovery of targets for geroprotective drugs. Although significant medical advances in the treatment and eradication of life-threatening conditions such as cardiovascular and infectious disease have been made over the past five decades, the prevalence of age-related disorders still remains high in older populations. Intervening into aging is the next frontier in contemporary medicine, and will be of increasing importance over time, as other sources of poor health are combated more and more successfully. Given the universal interest in anti-aging strategies, the book will appeal to a very broad audience. It addresses a diverse range of anti-aging interventions – including stem cells, autophagy, senolytics, anti-inflammatory methods, and telomerase induction – that will be of interest to scientists and researchers from various disciplines in the life sciences.

Lifespan

David A. Sinclair,Matthew D. LaPlante

Author : David A. Sinclair,Matthew D. LaPlante
Publisher : Atria Books
Page : 432 pages
File Size : 55,8 Mb
Release : 2019-09-10
Category : Science
ISBN : 9781501191978

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Lifespan by David A. Sinclair,Matthew D. LaPlante Pdf

A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.” —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

The Future of Aging

Anonim

Author : Anonim
Publisher : Springer Science & Business Media
Page : 866 pages
File Size : 53,5 Mb
Release : 2010-07-28
Category : Medical
ISBN : 9789048139996

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The Future of Aging by Anonim Pdf

Just as the health costs of aging threaten to bankrupt developed countries, this book makes the scientific case that a biological "bailout" could be on the way, and that human aging can be different in the future than it is today. Here 40 authors argue how our improving understanding of the biology of aging and selected technologies should enable the successful use of many different and complementary methods for ameliorating aging, and why such interventions are appropriate based on our current historical, anthropological, philosophical, ethical, evolutionary, and biological context. Challenging concepts are presented together with in-depth reviews and paradigm-breaking proposals that collectively illustrate the potential for changing aging as never before. The proposals extend from today to a future many decades from now in which the control of aging may become effectively complete. Examples include sirtuin-modulating pills, new concepts for attacking cardiovascular disease and cancer, mitochondrial rejuvenation, stem cell therapies and regeneration, tissue reconstruction, telomere maintenance, prevention of immunosenescence, extracellular rejuvenation, artificial DNA repair, and full deployment of nanotechnology. The Future of Aging will make you think about aging differently and is a challenge to all of us to open our eyes to the future therapeutic potential of biogerontology.

Sirtuin Biology In Medicine

Sirtuin Biology in Medicine by Kenneth Maiese Pdf

Sirtuins by Riekelt H. Houtkooper Pdf

Sirtuin Biology in Cancer and Metabolic Disease by Kenneth Maiese Pdf

Introductory Review on Sirtuins in Biology, Aging, and Disease by Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev Pdf

Sirtuins in Biology and Disease by Tiago F. Outeiro,Aleksey G. Kazantsev Pdf

Sirtuin Biology in Endocrinology and Metabolic Disease by Shay Welch Pdf

Histone Deacetylases: the Biology and Clinical Implication by Tso-Pang Yao,Edward Seto Pdf

Handbook of the Biology of Aging by Matt Kaeberlein,George Martin Pdf

A Time for Metabolism and Hormones by Paolo Sassone-Corsi,Yves Christen Pdf

Oxford Textbook of Old Age Psychiatry by Tom Dening,Alan Thomas,John Paul Taylor,Robert Stewart Pdf

Handbook of Nutrition, Diet, and Epigenetics by Vinood B. Patel,Victor R. Preedy Pdf

Mitochondrial Signaling in Health and Disease by Sten Orrenius,Lester Packer,Enrique Cadenas Pdf

Molecular Basis and Emerging Strategies for Anti-aging Interventions by Syed Ibrahim Rizvi,Ufuk Çakatay Pdf

Lifespan by David A. Sinclair,Matthew D. LaPlante Pdf

The Future of Aging by Anonim Pdf

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