Small Dna Tumour Viruses

Author : Kevin Gaston
Publisher : Caister Academic Press Limited
Page : 0 pages
File Size : 47,9 Mb
Release : 2012
Category : Science
ISBN : 1904455999

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Small DNA Tumour Viruses by Kevin Gaston Pdf

Small DNA tumor viruses are a fascinating group of double-stranded DNA viruses, made up of the polyomavirus, the adenovirus, and the papillomavirus families. These viruses continue to provide fundamental insights into mammalian cell transformation, cell cycle control, and tumor formation. The causal link between papillomaviruses and some human cancers is well known, and a role for polyomavirus in human cancer has recently been established. Adenoviruses do not cause cancer in humans, but, as well as providing excellent tools for the study of host cell processes, these viruses have been exploited as delivery vehicles in gene therapy for diseases, such as cystic fibrosis and cancer. A common feature of small DNA tumor viruses is their heavy reliance on the host for survival and replication. Understanding the virus-host relationship is critical to understanding the tumorigenic process and how these viruses subvert the host's immune system. In this timely book, leading scientists from around the world review current hot topics in this area, providing a fascinating overview of the molecular biology of these viruses and their interactions with the host. The topics covered include: HPV infections and the production of HPV virion stocks * viral oncoproteins and their functions * the replication and maintenance of viral genomes * virus-induced alterations in cellular miRNAs * viral deregulation of DNA damage responses * the initiation of viral DNA replication * induction of genomic instability by viral oncoproteins * targeting of PML proteins and PML nuclear bodies by these viruses * adenoviruses and gene therapy. The book will be essential reading for scientists and researchers working on small DNA tumor viruses and their associated diseases. It is also a recommended text for anyone involved with DNA replication, DNA damage responses and genome instability, virus-host interactions, and viral tumorigenesis or antiviral drug development.

Author : Blossom Damania,James Pipas
Publisher : Springer Science & Business Media
Page : 805 pages
File Size : 42,6 Mb
Release : 2008-12-19
Category : Medical
ISBN : 9780387689456

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DNA Tumor Viruses by Blossom Damania,James Pipas Pdf

This unique book focuses on the DNA viruses in the human population that are associated with cancers. It covers most of the viruses that are thought to contribute to human malignancy. This book represents a comprehensive review of the field of DNA tumor virology. Right now, while there are books out there that cover individual viruses that are also covered in this book, there is no single book that covers this topic comprehensively. This book is the first current, comprehensive review of its kind in the market.

Author : Leonard J. Rosenthal
Publisher : Karger Medical and Scientific Publishers
Page : 171 pages
File Size : 49,5 Mb
Release : 2001-01-01
Category : Medical
ISBN : 9783805572477

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Mechanisms of DNA Tumor Virus Transformation by Leonard J. Rosenthal Pdf

Approximately 15% of human cancer incidence can be attributed to virus infection, i.e. viruses represent the second most important risk factor (after tobacco consumption) for cancer development in humans. Today, five virus types are known to be involved in causing human cancer: papillomaviruses, retroviruses, herpesviruses, hepadnaviruses, and flaviviruses. This volume provides a comprehensive review of a number of DNA tumor viruses. Leading experts in the field of tumor virology discuss up-to-date information, focusing on the transforming genes of DNA tumor viruses, the mechanisms of transformation and the in vitro methodology used for their identification and characterization. In vitro studies have revealed several common mechanisms of viral transformation. Presented in a clear and concise manner, this book will be of value to students as well as researchers in the fields of general biology, molecular biology, cell biology and microbiology.

Author : Roger J. A. Grand
Publisher : Gulf Professional Publishing
Page : 540 pages
File Size : 53,6 Mb
Release : 2001-04-20
Category : Medical
ISBN : 0444504966

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Viruses, Cell Transformation, and Cancer by Roger J. A. Grand Pdf

Viruses are the agent responsible for perhaps up to one million cases of cancer worldwide each year. Significantly, the study of viruses has also provided important clues to the causes and development of the most common human cancers. This volume presents an account of those viruses which have been directly associated with common human malignancies such as human papillomavirus (HPV), cervical carcinoma, Epstein-Barr virus (EBV) and Burkitt's lymphoma. In addition, the biology and biochemistry of those viruses which have been shown to be capable of transforming cells in culture are described in detail. Thus adenovirus are discussed, as are the other small DNA tumour viruses - Simian virus 40 (SV40) and polyoma virus. Consideration has also been given to human T-cell leukaemia virus (HTLV), hepatitis B virus (HBV) and human herpes virus 8 (HHV8), amongst others. General themes such as the host's immune response to viral infection, virally-induced apoptosis and the use of viruses as a delivery system in gene therapy have been discussed. Individual chapters have been written by an international group of experts in their own field of research.

Author : Giuseppe Barbanti-Brodano,Mauro Bendinelli,Herman Friedman
Publisher : Springer Science & Business Media
Page : 440 pages
File Size : 47,5 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781489911001

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DNA Tumor Viruses by Giuseppe Barbanti-Brodano,Mauro Bendinelli,Herman Friedman Pdf

DNA tumor viruses have long been useful experimental models of carcinogenesis and have elucidated several important mechanisms of cell transformation. Re search in recent years has shown that human tumors have a multifactorial nature and that some DNA tumor viruses may playa key role in their etiology. The aim of this book is to assess our knowledge of DNA tumor viruses by reviewing animal models, mechanisms of transformation, association with human tumors, and possi bilities of prevention and control by vaccination. Animal models of tumor virology have contributed significantly to our under standing of the epidemiology and pathogenesis of virus-induced tumors. Bovine papillomaviruses induce papillomas in the intestine of cattle. The papillomas undergo a transition to carcinomas in cows feeding on bracken fern, which pro duces a toxin with radiomimetic and immunosuppressive functions. This example of cooperation between a virus and chemical carcinogens parallels the cooperative role of human papillomaviruses (HPVs) and herpes simplex virus type 2 (HSV-2) with environmental carcinogens in the pathogenesis of cervical cancer. Likewise, hepatocarcinomas appearing in woodchucks chronically infected by woodchuck hepatitis virus (WIN) provide strong support for the relationship between hepatitis B virus (HBV) infection and human hepatocellular carcinoma. Also, the fact that WIN DNA integrates closely to cellular oncogenes suggests a possible molecular mechanism for the tumorigenesis induced by HBV.

Author : Anonim
Publisher : ScholarlyEditions
Page : 19 pages
File Size : 45,6 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464960253

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DNA Tumor Viruses: Advances in Research and Treatment: 2011 Edition by Anonim Pdf

DNA Tumor Viruses: Advances in Research and Treatment: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about DNA Tumor Viruses in a compact format. The editors have built DNA Tumor Viruses: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about DNA Tumor Viruses in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of DNA Tumor Viruses: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : John Tooze
Publisher : Cold Spring Harbor Laboratory Press
Page : 988 pages
File Size : 44,9 Mb
Release : 1980
Category : Medical
ISBN : UOM:39015000318462

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DNA Tumor Viruses by John Tooze Pdf

Author : Joanna Parish
Publisher : MDPI
Page : 471 pages
File Size : 51,6 Mb
Release : 2018-10-02
Category : Electronic book
ISBN : 9783038421511

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Tumour Viruses by Joanna Parish Pdf

This book is a printed edition of the Special Issue "Tumour Viruses" that was published in Viruses

Author : Rolf Knippers,Arnold J. Levine
Publisher : Springer Science & Business Media
Page : 271 pages
File Size : 40,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642745782

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Transforming Proteins of DNA Tumor Viruses by Rolf Knippers,Arnold J. Levine Pdf

It is surprising, and even disappointing, that there have been very few meetings and published volumes resulting from these meetings that focus attention upon all of the groups of DNA tumor viruses. Historically, separate meetings were held each year for the adenovirus-SV40-polyoma researchers, the herpes viruses, hepatitis B virus and the papillomaviruses. It was as if these four virus groups were four fields of study developing independently with a literature and culture of their own. When a virologist crossed the field from the adenovirus group to the herpesvirus or papillomaviruses, he or she was lost to their former group because of the structure of separate meetings and remote literature. This, of course, has resulted from historical accident and is being rectified by the rapid progress made in our understanding of how these viruses contribute to the causation of cancer in animals and humans. It was pre cisely because of these factors that it was time to hold a meeting and publish its proceedings on the subject of transforming proteins of DNA tumor viruses. For the first time, DNA tumor viruses were defined as all of the virus groups that can contribute to cancer in animals with the exception, unfortunately, of the . poxviruses. The purpose of the meeting was to bring together scientists who rarely attend meetings together but actually work on the same problems with different viruses.

Author : Anonim
Publisher : Unknown
Page : 1254 pages
File Size : 54,9 Mb
Release : 1984
Category : Oncogenic viruses
ISBN : UOM:39015013229722

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RNA Tumor Viruses: Supplements and appendixes by Anonim Pdf

Author : Luis P. Villarreal
Publisher : Amer Society for Microbiology
Page : 259 pages
File Size : 41,8 Mb
Release : 1989-01
Category : Science
ISBN : 1555810136

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Common Mechanisms of Transformation by Small DNA Tumor Viruses by Luis P. Villarreal Pdf

Based on a 1989 conference in Newport Beach, California. Contributors, mostly from the US and France, present 17 papers that give overviews of common paths to transformation and present mechanisms of transformation and early gene function, the molecular basis for regulation of early gene expression,

Author : Sally Roberts
Publisher : Caister Academic Press Limited
Page : 0 pages
File Size : 55,6 Mb
Release : 2018-05
Category : Medical
ISBN : 1910190799

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DNA Tumour Viruses by Sally Roberts Pdf

Topics covered range from an overview of the contribution of DNA tumour viruses to the cancer burden worldwide, and the molecular pathogenesis of virus driven cancers to vaccine development.

Author : M. A. Epstein,B. G. Achong
Publisher : Springer Science & Business Media
Page : 467 pages
File Size : 52,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642672361

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The Epstein-Barr Virus by M. A. Epstein,B. G. Achong Pdf

The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.

Author : Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi
Publisher : Cambridge University Press
Page : 1325 pages
File Size : 44,8 Mb
Release : 2007-08-16
Category : Medical
ISBN : 9781139461641

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Human Herpesviruses by Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi Pdf

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Author : Leo A. Phillips
Publisher : Unknown
Page : 678 pages
File Size : 43,9 Mb
Release : 1983
Category : Oncogenic viruses
ISBN : UCAL:B4513972

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Viruses Associated with Human Cancer by Leo A. Phillips Pdf