Spotlight On Familial And Hereditary Gastric Cancer
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Spotlight on Familial and Hereditary Gastric Cancer by Giovanni Corso,Franco Roviello Pdf
In this book we have taken a comprehensive look at the subject of familial and hereditary gastric tumors. In particular, the aim of this novel editorial work is to propose the correct management of hereditary diffuse gastric cancer patients, focusing in particular on E-cadherin germline mutations, clinical criteria definition, genetic screening and molecular mechanisms, pathology and microscopic features, surgical treatment and clinical approach for asymptomatic mutation carriers. We also describe other inherited predispositions involving gastric carcinoma.
Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract by Marnix Jansen,Nicholas A. Wright Pdf
This book is a comprehensive understanding of the evolution of pre-malignant disease, emphasizing common themes in the field, including stem cell biology and histologic modes of cancer progression between the distal esophagus and stomach. Its sixteen chapters discuss metaplastic tissue change in the upper GI, clonalexpansion of early neoplasia, stem cell dynamics in experimental models, pathology of early esophageal squamous cell carcinoma, therapeutic modalities for esophageal squamous cell carcinoma, pathology of Barrett’s esophagus, screening, early detection and novel diagnostic tools for Barrett's esophagus, clonal evolution of Barrett’s esophagus, endoscopic therapeutic modalities of early esophageal cancer, pathology of early gastric cancer, and experimental models for gastric cancer. Stem Cells, Pre-neoplasia and Early Cancer of the Upper Gastrointestinal Tract is an integrative text on both the current state of translational research on every cancer development of the upper gastrointestinal tract as well as on novel clinical diagnostic and therapeutic modalities. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike. Springer’s Advances in Experimental Medicine and Biology series presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research.
Primary Care, Second Edition by Robert V. DiGregorio, PharmD, BCACP,Carol Green-Hernandez, PhD, ARNP, FNP-BC, FNS,Stephen Paul Holzemer, PhD, RN Pdf
A complete, state-of-the-art bible of interprofessional primary care in one easy-to-use resource for Interprofessional Primary Care A truly interprofessional primary care textbook, created by DNPs/APRNs, MDs, PharmDs, PAs, CNSs, and CNMs Evidence-based practice guidelines for Primary Care Includes community care, team work, and wellness coachings Strong guidance on differential diagnosis, disease prevention, risk reduction and lifestyle management Across the lifespan focus PLUS gender, occupational and palliative care considerations Case Studies in PPT format available to faculty adopting the text This second edition of Primary Care delivers succinct, current, and integrated information on the assessment, differential diagnosis, treatment, and management of individuals with commonly seen conditions in primary care settings. Written and edited by APNs, MDs, PAs, PharmDs and other health professionals, it emphasizes guidance on differential diagnosis, interprofessional primary care, lifestyle management, health promotion, risk reduction, and disease prevention. The text features ërelationship-centered care, extensive coverage of age, gender, and occupational considerations; complementary approaches; nutritional assessment; violence exposure and vulnerability assessment; family, community, and cultural assessment; palliative care; and evidence-based practice guidelines. This important text presents current diagnostic criteria for each condition and includes relevant anatomy, pathology, and physiology, epidemiology of the condition, including cultural and economic factors, risk identification, and disease prevention strategies. Also included are related laboratory studies, the focused physical exam, wellness coaching, treatment options, potential pitfalls, and much more. Additionally, the book includes clinical "pearls", clinical warnings, referrals and warning points, and references. The text is of value to all interprofessional primary care providers, with a special focus on the needs of advanced practice nurses and MSN/DNP students, and as a course textbook for teaching primary health care topics New to the Second Edition: Increased focus on interprofessional primary care, including community care, team work, and wellness coaching Strong guidance on differential diagnosis, disease prevention, risk reduction and lifestyle management Broad team of interprofessional authors and editors Special focus on elder/geriatric primary care and palliative care Evidence-based practice guidelines Stronger focus on age, gender, and occupational considerationsFocus on age, gender, and occupational considerations Case Studies in PPT format available to faculty adopting the text
Hereditary Gastric and Breast Cancer Syndrome by Giovanni Corso,Paolo Veronesi,Franco Roviello Pdf
In this book the editors and authors provide a comprehensive overview on basic research and clinical aspects of hereditary breast and gastric tumors. In particular, this updated editorial work aims to suggest guidelines for the clinical management of patients with hereditary diffuse gastric and lobular breast cancer. Special attention is given to E-cadherin (CDH1 gene) germline mutations, genetic screening approaches, the underlying molecular mechanisms and pathological and microscopic features. In addition, the book aims to define clinical criteria for genetic screening, and highlights current surgical treatment and clinical approaches for asymptomatic mutation carriers. Other inherited predispositions involving gastric and breast carcinoma are discussed as well. Divided into eight sections, the book starts by providing an epidemiological overview of gastric and breast cancers, followed by a section dealing with new descriptions of genetic pathways in hereditary cancer predispositions. The third section focuses on pathological features of the diseases, in an effort to bridge the gap between discovery and cancer therapy development. Subsequent sections of the book are dedicated to endoscopy and breast imaging, as well as risk-reducing surgeries to curb the risk of developing cancer. The sixth section focuses on the generation of ideas for the identification of targets and novel treatment strategies. Finally, in the seventh section the authors share the story of two patients and their experiences with the diagnosis and treatment of hereditary cancer. This multidisciplinary book brings together multiple disciplines in science and technology; specifically, medicine, surgery and biology. The majority of authors are members of the International Gastric Cancer Linkage Consortium (IGCLC) and of the European Cancer Prevention Organization (EJCPO), with relevant experience in this context. Offering in-depth insights into hereditary cancers, this book represents essential reading for students, researchers, and specialists who want to extend their knowledge on hereditary gastric and breast cancers.
Joanne K. Singleton,Robert V. DiGregorio, PharmD, BCACP,Carol Green-Hernandez,Stephen Paul Holzemer, PhD, RN,Eve S. Faber, MD,Lucille R. Ferrara,Jason T. Slyer
Author : Joanne K. Singleton,Robert V. DiGregorio, PharmD, BCACP,Carol Green-Hernandez,Stephen Paul Holzemer, PhD, RN,Eve S. Faber, MD,Lucille R. Ferrara,Jason T. Slyer Publisher : Springer Publishing Company Page : 1096 pages File Size : 51,9 Mb Release : 2014-11-12 Category : Medical ISBN : 9780826171474
Primary Care, Second Edition by Joanne K. Singleton,Robert V. DiGregorio, PharmD, BCACP,Carol Green-Hernandez,Stephen Paul Holzemer, PhD, RN,Eve S. Faber, MD,Lucille R. Ferrara,Jason T. Slyer Pdf
Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs by Sundas Fayyaz,Ammad Ahmad Farooqi Pdf
Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics. This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments.
Spotlight on Gluten: New Symptoms for the New Millennium? Or Long-Standing Symptoms Now Being Recognized? by Lucille Cholerton Pdf
Lucille Cholerton is a specialist in gluten sensitivity and coeliac disease. She and her three grown children all suffer from gluten sensitivity. Read her story in Spotlight on Gluten: New symptoms for the new millennium? Or long-standing symptoms now being recognized? "Age is very pertinent to the subject of gluten sensitivity. This disorder should really be diagnosed in childhood, but if the diagnosis is missed, people can suffer for many years with unexplained symptoms, when something that they are eating every day could be the root cause of their ill health." This book covers the symptoms that Cholerton and her children suffered, and how they improved their health dramatically on a gluten-free diet. The author's research spans twenty years. "In my research I discovered that gluten may be responsible for many autoimmune disorders, of which there are some eighty-eight documented. My doctors knew nothing about this, so I really had to be my own "guinea pig." A former teacher, Lucille Cholerton is now a nutrition counselor and is writing her next books on gluten sensitivity. "There is a dire need for better diagnosis and understanding of this disorder." She is married and lives in Durban, South Africa. She started the Gluten Intolerance/Coeliac Support Group in Durban in 1995. For more information about gluten, visit http: //www.allergysa.org . Publisher's website: http: //sbpra.com/LucilleCholerton Author's Website: http: //spotlightongluten.com
Hereditary Colorectal Cancer by Laura Valle,Stephen B. Gruber,Gabriel Capellá Pdf
This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.
Breast Cancer Metastasis and Drug Resistance by Aamir Ahmad Pdf
Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.
A guide to recent insights into the genetic and epigenetic parameters of cancer biology and pathology and emerging clinical applications The thoroughly updated second edition of The Biology and Treatment of Cancer, now titled Cancer: Prevention, Early Detection, Treatment and Recovery, goes beyond reviewing the fundamental properties of cancer biology and the relevant issues associated with treatment of the disease. The new edition contains coverage of additional "patient centric" topics and presents cancer biology with selection of topics, facts, and perspectives written in easy-to-understand terms. With contributions from noted experts, the book explores recent advances in the understanding of cancer including breakthroughs in the molecular and cellular basis of cancer and provides strategies for approaching cancer prevention, early detection, and treatment. The authors incorporate recent information on the genetic and epigenetic parameters of cancer biology and pathology with indications of emerging clinical applications. The text offers a unique guide to cancer prevention, early detection, treatment, and recovery for students, caregivers, and most importantly cancer patients. This significant book: Incorporates current insight into the genetic and epigenetic parameters of cancer biology and pathology and information on emerging clinical applications Contains contributions from leaders in cancer research, care, and clinical trials Offers an accessible guide to an accurate and balanced understanding of cancer and the cancer patient Focuses on the importance of cancer prevention, early detection, treatment, and survivorship Written for medical students, students of cancer biology, and caregivers and cancer patients, Cancer: Prevention, Early Detection, Treatment and Recovery offers an authoritative overview of the challenges and opportunities associated with cancer biology, cancer research, and the spectrum of clinical considerations.
This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.
This book provides detailed information on the various types of cancer, etiology, effects, and challenges associated with current cancer treatment regimes. The present edition has been written to reflect recent developments, success rates and lacunae in herbal and modern cancer therapies. It also describes the use of several herbal formulations to boost patients’ immunity, in order to prevent or help them cope with several cancers. The book highlights several herbs/shrubs/trees that have been reported to possess anti-cancer properties, paving the way for in-depth research into the dose standardization and efficacy of plant-based bioactive molecules. It also focuses on the sustainable conservation of medicinal flora, so that, in future, novel biomolecules be extracted and made available for the treatment of various cancers. Given its highly relevant content, the book will benefit the entire cancer research community (students, scientists, pharmacists, herbalists and lecturers) at universities, research institutions and industry in the areas of oncology, herbal cancer therapy, biotechnology, drug discovery, pharmaceuticals, agriculture, and various disciplines of the biomedical sciences.