Cancer And Zebrafish

Author : David M. Langenau
Publisher : Springer
Page : 552 pages
File Size : 52,7 Mb
Release : 2016-05-10
Category : Medical
ISBN : 9783319306544

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Cancer and Zebrafish by David M. Langenau Pdf

This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.

Author : Samuel Cartner,Judith S. Eisen,Susan F. Farmer,Karen J. Guillemin,Michael L. Kent,George E. Sanders
Publisher : Academic Press
Page : 720 pages
File Size : 40,8 Mb
Release : 2019-11-22
Category : Science
ISBN : 9780128124321

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The Zebrafish in Biomedical Research by Samuel Cartner,Judith S. Eisen,Susan F. Farmer,Karen J. Guillemin,Michael L. Kent,George E. Sanders Pdf

The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications Includes the work of world-renowned authors Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series

Author : Anonim
Publisher : Academic Press
Page : 746 pages
File Size : 43,5 Mb
Release : 2017-01-25
Category : Science
ISBN : 9780128034873

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The Zebrafish: Disease Models and Chemical Screens by Anonim Pdf

The Zebrafish: Disease Models and Chemical Screens

Author : Gokhan Dalgin,Rebecca Ann Wingert,Ryan M. Anderson
Publisher : Frontiers Media SA
Page : 157 pages
File Size : 53,7 Mb
Release : 2019-12-06
Category : Electronic
ISBN : 9782889632480

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Zebrafish in Development and Disease by Gokhan Dalgin,Rebecca Ann Wingert,Ryan M. Anderson Pdf

There are only a few vertebrate systems that can be used to model human diseases for biomedical discovery. The zebrafish model provides key advantages over existing models. Their externally developing embryos provide high-throughput non-invasive imaging, chemical screening, forward and reverse genetics, and their regeneration capacity make zebrafish a valuable system for novel discovery. Developmental studies using zebrafish has influenced discoveries in many human health-related conditions. This Research Topic covers all aspects of zebrafish studies, providing developmental mechanisms to human health conditions. The aim of the Research Topic was to foster a platform to bring all levels of zebrafish research including but not limited to development, disease, regeneration, drug screening, bioinformatics and Omics studies.

Author : Ulrike S. Stein
Publisher : Humana
Page : 348 pages
File Size : 55,9 Mb
Release : 2022-04-03
Category : Medical
ISBN : 1071613529

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Metastasis by Ulrike S. Stein Pdf

This volume provides the most recent developments and methodologies on metastatic process, formation, and detection. Chapters guide readers through functional metastasis in vitro assays, non-mouse and mice metastasis models, methods for imaging metastasis, analyzing the tumor microenvironment, senescence and inflammation with respect to metastasis, methods to investgate the premetastatic/ metastatic, detecting biomarkers in patient, and bioinformatics to simulate the metastatic process. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Metastasis: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.

Author : Rajesh Uthamanthil,Peggy Tinkey,Elisa de Stanchina
Publisher : Academic Press
Page : 486 pages
File Size : 54,8 Mb
Release : 2016-10-13
Category : Medical
ISBN : 9780128040614

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Patient Derived Tumor Xenograft Models by Rajesh Uthamanthil,Peggy Tinkey,Elisa de Stanchina Pdf

Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory. Offers guidance on data interpretation and regulatory aspects Provides useful techniques and strategies for working with PDX models Includes practical tools and potential pitfalls for best practices Compiles all knowledge of PDX models research in one resource Presents the results of first ever global survey on standards of PDX development and usage in academia and industry

Author : Alexander Birbrair
Publisher : Springer Nature
Page : 548 pages
File Size : 51,6 Mb
Release : 2021-10-18
Category : Medical
ISBN : 9783030731199

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Tumor Microenvironment by Alexander Birbrair Pdf

This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.

Author : Liqing Zang,Norihiro Nishimura,Vincenzo Torraca,Yasuhito Shimada
Publisher : Frontiers Media SA
Page : 496 pages
File Size : 51,6 Mb
Release : 2022-04-04
Category : Science
ISBN : 9782889748327

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Zebrafish Models for Human Disease Studies by Liqing Zang,Norihiro Nishimura,Vincenzo Torraca,Yasuhito Shimada Pdf

Author : FableVision
Publisher : Simon and Schuster
Page : 128 pages
File Size : 54,9 Mb
Release : 2012-06-26
Category : Juvenile Fiction
ISBN : 9781442406094

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Zebrafish by FableVision Pdf

Vita is a purple-haired singing queen, and she has big dreams for her rock group, Zebrafish. But when she holds auditions for the back-up band, tryouts are sorely lacking in the musical ability department. Luckily her new bandmates—Walt, Tanya, Jay, and Plinko—have other talents. But lately Tanya has been missing a lot of rehearsals. When Vita discovers why, she realizes that the group can be about much more than one person, one band, or even one school. A concert won’t cure Tanya’s cancer or make her treatments any less painful, but, in their own way, Zebrafish can make a difference—and the tale of their unlikely success is sure to strike a chord with young readers looking to make their world a better place.

Author : Prasan R. Bhandari,Kala Kumar Bharani,Amit Khurana
Publisher : Springer Nature
Page : 493 pages
File Size : 42,9 Mb
Release : 2022-05-30
Category : Medical
ISBN : 9789811652172

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Zebrafish Model for Biomedical Research by Prasan R. Bhandari,Kala Kumar Bharani,Amit Khurana Pdf

This book provides the latest information on the significance of zebrafish as an ideal model for researching the biomedical field, with references. This book also focused on the evidence of zebrafish as a model in cardiovascular, neurologic, psychiatric and metabolic research. In addition, the book also includes the research carried out on zebrafish in hepatic, renal, ophthalmic, and ENT related areas. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish models including specific research in the area of skin disorders, endocrine diseases, nutritional disorders, gastrointestinal, hematological disorders and cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and its suitability for modeling various diseases, providing a critical resource on the potential attributes of the zebrafish as a pharmacological model. In terms of scope, this book is a useful tool for young researchers, professors and pharmaceutical scientists for understanding the significance of zebrafish as an emerging pharmacological model that can significantly aid in the process of drug discovery and development.

Author : Patricia McGrath
Publisher : John Wiley & Sons
Page : 360 pages
File Size : 40,7 Mb
Release : 2012-01-03
Category : Science
ISBN : 9781118102145

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Zebrafish by Patricia McGrath Pdf

Zebrafish: Methods for Assessing Drug Safety and Toxicity offers a practical guide for using zebrafish as a tool for toxicology studies. Consolidating key protocols and approaches to help researchers navigate the important and evolving field of zebrafish models for toxicity screening, this new title describes the methods for using the zebrafish as a model organism to assess compound-induced toxicity on all major organs. Individual chapters that concentrate on assays for each organ system are included and various analytical tools including microscopy, microplate readers, high content imaging systems, ECG, blood pressure monitors, high speed video and motion detectors are described.

Author : Gagan Deep
Publisher : Humana
Page : 0 pages
File Size : 49,7 Mb
Release : 2023-02-03
Category : Medical
ISBN : 1071618989

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Cancer Biomarkers by Gagan Deep Pdf

This detailed volume explores numerous methods used in basic science laboratories to characterize cancer-related biomarkers, vital for better managing cancer burden, including cancer risk assessment, cancer diagnosis, determining cancer progression, and therapeutic response. From a radiography method to an examination of single-cell RNA-seq and computational analysis tools in cancer research, this book delves into many techniques that could provide valuable molecular information about the tumor and its microenvironment components. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cancer Biomarkers: Methods and Protocols offers researchers multiple helpful ways to study cancer-associated molecular biomarkers.

Author : H. William Detrich,Monte Westerfield,Leonard I. Zon
Publisher : Academic Press
Page : 591 pages
File Size : 46,5 Mb
Release : 2011-09-23
Category : Medical
ISBN : 9780123813206

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The Zebrafish: Disease Models and Chemical Screens by H. William Detrich,Monte Westerfield,Leonard I. Zon Pdf

This volume of Methods in Cell Biology is the 3e, and provides comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 2004. This new volume on Disease Models and Chemical Screens, covers two rapidly emerging and compelling applications of the zebrafish. Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls This volume concentrates on Disease Models and Chemical Screens

Author : Anonim
Publisher : Academic Press
Page : 0 pages
File Size : 51,5 Mb
Release : 2011-04-29
Category : Technology & Engineering
ISBN : 0123870364

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The Zebrafish: Cellular and Developmental Biology, Part B by Anonim Pdf

This volume of Methods in Cell Biology, the second of two parts on the subject of zebrafish, provides a comprehensive compendium of laboratory protocols and reviews covering all the new methods developed since 1999.

Author : Hajime Kojima,Troy Seidle,Horst Spielmann
Publisher : Springer
Page : 130 pages
File Size : 53,5 Mb
Release : 2018-12-27
Category : Medical
ISBN : 9789811324475

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Alternatives to Animal Testing by Hajime Kojima,Troy Seidle,Horst Spielmann Pdf

This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.