Statistical Evaluation Of Diagnostic Performance

Author : Kelly H. Zou,Aiyi Liu,Andriy I. Bandos,Lucila Ohno-Machado,Howard E. Rockette
Publisher : CRC Press
Page : 245 pages
File Size : 53,7 Mb
Release : 2016-04-19
Category : Mathematics
ISBN : 9781439812235

Get Book

Statistical Evaluation of Diagnostic Performance by Kelly H. Zou,Aiyi Liu,Andriy I. Bandos,Lucila Ohno-Machado,Howard E. Rockette Pdf

Statistical evaluation of diagnostic performance in general and Receiver Operating Characteristic (ROC) analysis in particular are important for assessing the performance of medical tests and statistical classifiers, as well as for evaluating predictive models or algorithms. This book presents innovative approaches in ROC analysis, which are relevant to a wide variety of applications, including medical imaging, cancer research, epidemiology, and bioinformatics. Statistical Evaluation of Diagnostic Performance: Topics in ROC Analysis covers areas including monotone-transformation techniques in parametric ROC analysis, ROC methods for combined and pooled biomarkers, Bayesian hierarchical transformation models, sequential designs and inferences in the ROC setting, predictive modeling, multireader ROC analysis, and free-response ROC (FROC) methodology. The book is suitable for graduate-level students and researchers in statistics, biostatistics, epidemiology, public health, biomedical engineering, radiology, medical imaging, biomedical informatics, and other closely related fields. Additionally, clinical researchers and practicing statisticians in academia, industry, and government could benefit from the presentation of such important and yet frequently overlooked topics.

Author : Margaret Sullivan Pepe
Publisher : OUP Oxford
Page : 319 pages
File Size : 43,9 Mb
Release : 2003-03-13
Category : Medical
ISBN : 9780191588617

Get Book

The Statistical Evaluation of Medical Tests for Classification and Prediction by Margaret Sullivan Pepe Pdf

This book describes statistical techniques for the design and evaluation of research studies on medical diagnostic tests, screening tests, biomarkers and new technologies for classification and prediction in medicine.

Author : National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer
Publisher : National Academies Press
Page : 384 pages
File Size : 55,9 Mb
Release : 2005-03-18
Category : Medical
ISBN : 9780309165945

Get Book

Saving Women's Lives by National Research Council,Institute of Medicine,Policy and Global Affairs,Board on Science, Technology, and Economic Policy,National Cancer Policy Board,Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer Pdf

The outlook for women with breast cancer has improved in recent years. Due to the combination of improved treatments and the benefits of mammography screening, breast cancer mortality has decreased steadily since 1989. Yet breast cancer remains a major problem, second only to lung cancer as a leading cause of death from cancer for women. To date, no means to prevent breast cancer has been discovered and experience has shown that treatments are most effective when a cancer is detected early, before it has spread to other tissues. These two facts suggest that the most effective way to continue reducing the death toll from breast cancer is improved early detection and diagnosis. Building on the 2001 report Mammography and Beyond, this new book not only examines ways to improve implementation and use of new and current breast cancer detection technologies but also evaluates the need to develop tools that identify women who would benefit most from early detection screening. Saving Women's Lives: Strategies for Improving Breast Cancer Detection and Diagnosis encourages more research that integrates the development, validation, and analysis of the types of technologies in clinical practice that promote improved risk identification techniques. In this way, methods and technologies that improve detection and diagnosis can be more effectively developed and implemented.

Author : Institute of Medicine,Council on Health Care Technology
Publisher : National Academies Press
Page : 152 pages
File Size : 45,8 Mb
Release : 1989-02-01
Category : Medical
ISBN : 9780309040990

Get Book

Assessment of Diagnostic Technology in Health Care by Institute of Medicine,Council on Health Care Technology Pdf

Technology assessment can lead to the rapid application of essential diagnostic technologies and prevent the wide diffusion of marginally useful methods. In both of these ways, it can increase quality of care and decrease the cost of health care. This comprehensive monograph carefully explores methods of and barriers to diagnostic technology assessment and describes both the rationale and the guidelines for meaningful evaluation. While proposing a multi-institutional approach, it emphasizes some of the problems involved and defines a mechanism for improving the evaluation and use of medical technology and essential resources needed to enhance patient care.

Author : Xiao-Hua Zhou,Nancy A. Obuchowski,Donna K. McClish
Publisher : John Wiley & Sons
Page : 592 pages
File Size : 47,5 Mb
Release : 2014-08-21
Category : Medical
ISBN : 9781118626047

Get Book

Statistical Methods in Diagnostic Medicine by Xiao-Hua Zhou,Nancy A. Obuchowski,Donna K. McClish Pdf

Praise for the First Edition " . . . the book is a valuable addition to the literature in thefield, serving as a much-needed guide for both clinicians andadvanced students."—Zentralblatt MATH A new edition of the cutting-edge guide to diagnostic tests inmedical research In recent years, a considerable amount of research has focusedon evolving methods for designing and analyzing diagnostic accuracystudies. Statistical Methods in Diagnostic Medicine, Second Editioncontinues to provide a comprehensive approach to the topic, guidingreaders through the necessary practices for understanding thesestudies and generalizing the results to patient populations. Following a basic introduction to measuring test accuracy andstudy design, the authors successfully define various measures ofdiagnostic accuracy, describe strategies for designing diagnosticaccuracy studies, and present key statistical methods forestimating and comparing test accuracy. Topics new to the SecondEdition include: Methods for tests designed to detect and locate lesions Recommendations for covariate-adjustment Methods for estimating and comparing predictive values andsample size calculations Correcting techniques for verification and imperfect standardbiases Sample size calculation for multiple reader studies when pilotdata are available Updated meta-analysis methods, now incorporating randomeffects Three case studies thoroughly showcase some of the questions andstatistical issues that arise in diagnostic medicine, with allassociated data provided in detailed appendices. A related web sitefeatures Fortran, SAS®, and R software packages so thatreaders can conduct their own analyses. Statistical Methods in Diagnostic Medicine, Second Edition is anexcellent supplement for biostatistics courses at the graduatelevel. It also serves as a valuable reference for clinicians andresearchers working in the fields of medicine, epidemiology, andbiostatistics.

Author : Giuseppe Biondi-Zoccai
Publisher : Springer
Page : 319 pages
File Size : 53,7 Mb
Release : 2018-07-24
Category : Medical
ISBN : 9783319789668

Get Book

Diagnostic Meta-Analysis by Giuseppe Biondi-Zoccai Pdf

This book is the first exclusively devoted to the systematic synthesis of diagnostic test accuracy studies. It builds upon the major recent developments in reporting standards, search methods, and, in particular, statistical tools specifically devoted to diagnostic studies. In addition, it borrows extensively from the latest advances in systematic reviews and meta-analyses of intervention studies. After a section dedicated to methods for designing reviews, synthesizing evidence and appraising inconsistency in research, the application of these approaches is demonstrated in the context of case studies from various clinical disciplines. Diagnosis is central in medical decision-making, and in many other fields of human endeavor, such as education and psychology. The plurality of sources of evidence on diagnostic test accuracy poses a huge challenge for practitioners and researchers, as do the multiple dimensions of evidence validity, which include sensitivity, specificity, predictive values, and likelihood ratios. This book offers an invaluable resource for anyone aiming to improve decision-making processes in diagnosis, classification or risk prognostication, from epidemiologists to biostatisticians, radiologists, laboratory physicians and graduate students, as any physician interested in refining his methodological skills in clinical diagnosis.

Author : Francesco Sardanelli,Giovanni Di Leo
Publisher : Springer Science & Business Media
Page : 244 pages
File Size : 46,9 Mb
Release : 2009-03-31
Category : Medical
ISBN : 9788847011335

Get Book

Biostatistics for Radiologists by Francesco Sardanelli,Giovanni Di Leo Pdf

The aim of this book is to present statistical problems and methods in a friendly way to radiologists, emphasizing statistical issues and methods most frequently used in radiological studies (e.g., nonparametric tests, analysis of intra- and interobserver reproducibility, comparison of sensitivity and specificity among different imaging modality, difference between clinical and screening application of diagnostic tests, ect.). The tests will be presented starting from a radiological "problem" and all examples of statistical methods applications will be "radiological".

Author : John Swets
Publisher : Elsevier
Page : 270 pages
File Size : 44,5 Mb
Release : 2012-12-02
Category : Reference
ISBN : 9780323141642

Get Book

Evaluation of diagnostic systems by John Swets Pdf

Evaluation of Diagnostic Systems: Methods from Signal Detection Theory addresses the many issues that arise in evaluating the performance of a diagnostic system, across the wide range of settings in which such systems are used. These settings include clinical medicine, industrial quality control, environmental monitoring and investigation, machine and metals inspection, military monitoring, information retrieval, and crime investigation. The book is divided into three parts encompassing 11 chapters that emphasize the interpretation of diagnostic visual images by human observers. The first part of the book describes quantitative methods for measuring the accuracy of a system and the statistical techniques for drawing inferences from performance tests. The subsequent part covers study design and includes a detailed description of the form and conduct of an image-interpretation test. The concluding part examines the case study of a medical imaging system that serves as an example of both simple and complex applications. In this part, three mammographic modalities are used: industrial film radiography, low-dose film radiography, and xeroradiography. The case study focuses on the overall reliability of accuracy indices made by its main components, that is, the variabilities across cases, across readers, and within individual readers. The supplementary texts provide study protocols, a computer program for processing test results, and an extensive list of references that will assist the reader in applying those evaluative methods to diagnostic systems in any setting. This book is of value to scientists and engineers, as well as to applied, quantitative, or experimental psychologists who are engaged in the study of the human processes of discrimination and decision making in either perceptual or cognitive tasks.

Author : Matthew Thompson,Ann Van den Bruel
Publisher : John Wiley & Sons
Page : 114 pages
File Size : 54,8 Mb
Release : 2011-09-29
Category : Medical
ISBN : 9781119951803

Get Book

Diagnostic Tests Toolkit by Matthew Thompson,Ann Van den Bruel Pdf

Diagnostic Tests Toolkit Diagnostic Tests Toolkit Finding the evidence for diagnostic tests Establishing an evidence-based methodology to assess the effectiveness of diagnostic tests has posed problems for many years. Now that the framework is in place health professionals can find and appraise the evidence for themselves. With Diagnostic Tests Toolkit clinicians and junior researchers can interpret the evidence for the effectiveness of different types of diagnostic tests, or develop their own research using the successful ‘step-by-step’ format of the Toolkit series. Written by renowned clinical researchers, this is the first basic guide to evidence-based diagnosis. It is equally valuable to starters in clinical research and those needing a quick refresher on the core elements of evidence-based diagnosis.

Author : Wojtek J. Krzanowski,David J. Hand
Publisher : CRC Press
Page : 232 pages
File Size : 44,7 Mb
Release : 2009-05-21
Category : Business & Economics
ISBN : 1439800227

Get Book

ROC Curves for Continuous Data by Wojtek J. Krzanowski,David J. Hand Pdf

Since ROC curves have become ubiquitous in many application areas, the various advances have been scattered across disparate articles and texts. ROC Curves for Continuous Data is the first book solely devoted to the subject, bringing together all the relevant material to provide a clear understanding of how to analyze ROC curves. The fundamental theory of ROC curves The book first discusses the relationship between the ROC curve and numerous performance measures and then extends the theory into practice by describing how ROC curves are estimated. Further building on the theory, the authors present statistical tests for ROC curves and their summary statistics. They consider the impact of covariates on ROC curves, examine the important special problem of comparing two ROC curves, and cover Bayesian methods for ROC analysis. Special topics The text then moves on to extensions of the basic analysis to cope with more complex situations, such as the combination of multiple ROC curves and problems induced by the presence of more than two classes. Focusing on design and interpretation issues, it covers missing data, verification bias, sample size determination, the design of ROC studies, and the choice of optimum threshold from the ROC curve. The final chapter explores applications that not only illustrate some of the techniques but also demonstrate the very wide applicability of these techniques across different disciplines. With nearly 5,000 articles published to date relating to ROC analysis, the explosive interest in ROC curves and their analysis will continue in the foreseeable future. Embracing this growth of interest, this timely book will undoubtedly guide present and future users of ROC analysis.

Author : Dev P. Chakraborty
Publisher : CRC Press
Page : 591 pages
File Size : 40,5 Mb
Release : 2017-12-14
Category : Medical
ISBN : 9781482214864

Get Book

Observer Performance Methods for Diagnostic Imaging by Dev P. Chakraborty Pdf

Gives an accessible overview of R programming for medical imaging and the methods of observer performance testing. Explains the fundamental statistical concepts. Reinforces learning using worked problems and R software code, in addition to examples that utilize standalone ROC software. Starts with basic ROC analysis and builds to extensions of ROC methods for solving more complex but clinically realistic tasks. Emphasizes psychophysical models of observer performance (e.g., binormal model, contaminated binormal model, proper ROC model), and demonstrates how they can give better results than from purely statistical approaches. Supplementary tools and materials available at: www.devchakraborty.com; www.expertcadanalytics.com.

Author : David Rapaport,Roy Schafer
Publisher : Unknown
Page : 598 pages
File Size : 41,6 Mb
Release : 1946
Category : Clinical psychology
ISBN : UCAL:B4438788

Get Book

Diagnostic Psychological Testing by David Rapaport,Roy Schafer Pdf

Author : National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,Committee on Diagnostic Error in Health Care
Publisher : National Academies Press
Page : 473 pages
File Size : 44,8 Mb
Release : 2015-12-29
Category : Medical
ISBN : 9780309377720

Get Book

Improving Diagnosis in Health Care by National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Care Services,Committee on Diagnostic Error in Health Care Pdf

Getting the right diagnosis is a key aspect of health care - it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care, a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001), finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€"has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety.

Author : Jacob Cohen
Publisher : Routledge
Page : 625 pages
File Size : 54,9 Mb
Release : 2013-05-13
Category : Psychology
ISBN : 9781134742776

Get Book

Statistical Power Analysis for the Behavioral Sciences by Jacob Cohen Pdf

Statistical Power Analysis is a nontechnical guide to power analysis in research planning that provides users of applied statistics with the tools they need for more effective analysis. The Second Edition includes: * a chapter covering power analysis in set correlation and multivariate methods; * a chapter considering effect size, psychometric reliability, and the efficacy of "qualifying" dependent variables and; * expanded power and sample size tables for multiple regression/correlation.

Author : Steven Piantadosi,Curtis L. Meinert
Publisher : Springer Nature
Page : 2573 pages
File Size : 53,7 Mb
Release : 2022-07-19
Category : Medical
ISBN : 9783319526362

Get Book

Principles and Practice of Clinical Trials by Steven Piantadosi,Curtis L. Meinert Pdf

This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this point in time. Principles in Practice of Clinical Trials is truly an interdisciplinary that will be divided into the following areas: 1) Clinical Trials Basic Perspectives 2) Regulation and Oversight 3) Basic Trial Designs 4) Advanced Trial Designs 5) Analysis 6) Trial Publication 7) Topics Related Specific Populations and Legal Aspects of Clinical Trials The Work is designed to be comprised of 175 chapters and approximately 2500 pages. The Work will be oriented like many of our SpringerReference Handbooks, presenting detailed and comprehensive expository chapters on broad subjects. The Editors are major figures in the field of clinical trials, and both have written textbooks on the topic. There will also be a slate of 7-8 renowned associate editors that will edit individual sections of the Reference.