Statistical Methods In Diagnostic Medicine

Author : Xiao-Hua Zhou,Nancy A. Obuchowski,Donna K. McClish
Publisher : John Wiley & Sons
Page : 592 pages
File Size : 48,9 Mb
Release : 2014-08-21
Category : Medical
ISBN : 9781118626047

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Statistical Methods in Diagnostic Medicine by Xiao-Hua Zhou,Nancy A. Obuchowski,Donna K. McClish Pdf

Praise for the First Edition " . . . the book is a valuable addition to the literature in thefield, serving as a much-needed guide for both clinicians andadvanced students."—Zentralblatt MATH A new edition of the cutting-edge guide to diagnostic tests inmedical research In recent years, a considerable amount of research has focusedon evolving methods for designing and analyzing diagnostic accuracystudies. Statistical Methods in Diagnostic Medicine, Second Editioncontinues to provide a comprehensive approach to the topic, guidingreaders through the necessary practices for understanding thesestudies and generalizing the results to patient populations. Following a basic introduction to measuring test accuracy andstudy design, the authors successfully define various measures ofdiagnostic accuracy, describe strategies for designing diagnosticaccuracy studies, and present key statistical methods forestimating and comparing test accuracy. Topics new to the SecondEdition include: Methods for tests designed to detect and locate lesions Recommendations for covariate-adjustment Methods for estimating and comparing predictive values andsample size calculations Correcting techniques for verification and imperfect standardbiases Sample size calculation for multiple reader studies when pilotdata are available Updated meta-analysis methods, now incorporating randomeffects Three case studies thoroughly showcase some of the questions andstatistical issues that arise in diagnostic medicine, with allassociated data provided in detailed appendices. A related web sitefeatures Fortran, SAS®, and R software packages so thatreaders can conduct their own analyses. Statistical Methods in Diagnostic Medicine, Second Edition is anexcellent supplement for biostatistics courses at the graduatelevel. It also serves as a valuable reference for clinicians andresearchers working in the fields of medicine, epidemiology, andbiostatistics.

Author : Xiao-Hua Zhou,Donna K. McClish,Nancy A. Obuchowski
Publisher : John Wiley & Sons
Page : 464 pages
File Size : 49,8 Mb
Release : 2009-09-25
Category : Mathematics
ISBN : 9780470317921

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Statistical Methods in Diagnostic Medicine by Xiao-Hua Zhou,Donna K. McClish,Nancy A. Obuchowski Pdf

An important role of diagnostic medicine research is to estimate and compare the accuracies of diagnostic tests. This book provides a comprehensive account of statistical methods for design and analysis of diagnostic studies, including sample size calculations, estimation of the accuracy of a diagnostic test, comparison of accuracies of competing diagnostic tests, and regression analysis of diagnostic accuracy data. Discussing recently developed methods for correction of verification bias and imperfect reference bias, methods for analysis of clustered diagnostic accuracy data, and meta-analysis methods, Statistical Methods in Diagnostic Medicine explains: * Common measures of diagnostic accuracy and designs for diagnostic accuracy studies * Methods of estimation and hypothesis testing of the accuracy of diagnostic tests * Meta-analysis * Advanced analytic techniques-including methods for comparing correlated ROC curves in multi-reader studies, correcting verification bias, and correcting when an imperfect gold standard is used Thoroughly detailed with numerous applications and end-of-chapter problems as well as a related FTP site providing FORTRAN program listings, data sets, and instructional hints, Statistical Methods in Diagnostic Medicine is a valuable addition to the literature of the field, serving as a much-needed guide for both clinicians and advanced students.

Author : Zhou
Publisher : Wiley-Blackwell
Page : 0 pages
File Size : 51,7 Mb
Release : 2024-12-19
Category : Electronic
ISBN : 1394220219

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Statistical Methods in Diagnostic Medicine, 3rd Ed Ition by Zhou Pdf

Author : Margaret Sullivan Pepe
Publisher : OUP Oxford
Page : 319 pages
File Size : 53,9 Mb
Release : 2003-03-13
Category : Medical
ISBN : 9780191588617

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The Statistical Evaluation of Medical Tests for Classification and Prediction by Margaret Sullivan Pepe Pdf

This book describes statistical techniques for the design and evaluation of research studies on medical diagnostic tests, screening tests, biomarkers and new technologies for classification and prediction in medicine.

Author : Amir Momeni,Matthew Pincus,Jenny Libien
Publisher : Springer
Page : 317 pages
File Size : 44,9 Mb
Release : 2017-09-07
Category : Medical
ISBN : 9783319605432

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Introduction to Statistical Methods in Pathology by Amir Momeni,Matthew Pincus,Jenny Libien Pdf

This text provides a comprehensive and practical review of the main statistical methods in pathology and laboratory medicine. It introduces statistical concepts used in pathology and laboratory medicine. The information provided is relevant to pathologists both for their day to day clinical practice as well as in their research and scholarly activities. The text will begins by explaining the fundamentals concepts in statistics. In the later sections, these fundamental concepts are expanded and unique applications of statistical methods in pathology and laboratory medicine practice are introduced. Other sections of the text explain research methodology in pathology covering a broad range of topics from study design to analysis of data. Finally, data-heavy novel concepts that are emerging in pathology and pathology research are presented such as molecular pathology and pathology informatics. Introduction to Statistical Methods in Pathology will be of great value for pathologists, pathology residents, basic and translational researchers, laboratory managers and medical students.

Author : Kelly H. Zou,Aiyi Liu,Andriy I. Bandos,Lucila Ohno-Machado,Howard E. Rockette
Publisher : CRC Press
Page : 245 pages
File Size : 52,9 Mb
Release : 2016-04-19
Category : Mathematics
ISBN : 9781439812235

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Statistical Evaluation of Diagnostic Performance by Kelly H. Zou,Aiyi Liu,Andriy I. Bandos,Lucila Ohno-Machado,Howard E. Rockette Pdf

Statistical evaluation of diagnostic performance in general and Receiver Operating Characteristic (ROC) analysis in particular are important for assessing the performance of medical tests and statistical classifiers, as well as for evaluating predictive models or algorithms. This book presents innovative approaches in ROC analysis, which are relevant to a wide variety of applications, including medical imaging, cancer research, epidemiology, and bioinformatics. Statistical Evaluation of Diagnostic Performance: Topics in ROC Analysis covers areas including monotone-transformation techniques in parametric ROC analysis, ROC methods for combined and pooled biomarkers, Bayesian hierarchical transformation models, sequential designs and inferences in the ROC setting, predictive modeling, multireader ROC analysis, and free-response ROC (FROC) methodology. The book is suitable for graduate-level students and researchers in statistics, biostatistics, epidemiology, public health, biomedical engineering, radiology, medical imaging, biomedical informatics, and other closely related fields. Additionally, clinical researchers and practicing statisticians in academia, industry, and government could benefit from the presentation of such important and yet frequently overlooked topics.

Author : Charan Singh Rayat
Publisher : Springer
Page : 158 pages
File Size : 53,9 Mb
Release : 2018-08-23
Category : Medical
ISBN : 9789811308277

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Statistical Methods in Medical Research by Charan Singh Rayat Pdf

This book covers all aspects of statistical methods in detail with applications. It presents solutions to the needs of post-graduate medical students, doctors and basic medical scientists for statistical evaluation of data. In present era, dependency on softwares for statistical analysis is eroding the basic understanding of the statistical methods and their applications. As a result, there are very few basic medical scientists capable of analyzing their research data due to lack of knowledge and ability. This book has been written in systematic way supported by figures and tables for basic understanding of various terms, definitions, formulae and applications of statistical methods with solved examples and graphic presentation of data to create interest in this mathematical science.

Author : Lyle D. Broemeling
Publisher : CRC Press
Page : 216 pages
File Size : 49,9 Mb
Release : 2007-07-12
Category : Mathematics
ISBN : 1584887680

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Bayesian Biostatistics and Diagnostic Medicine by Lyle D. Broemeling Pdf

There are numerous advantages to using Bayesian methods in diagnostic medicine, which is why they are employed more and more today in clinical studies. Exploring Bayesian statistics at an introductory level, Bayesian Biostatistics and Diagnostic Medicine illustrates how to apply these methods to solve important problems in medicine and biology. After focusing on the wide range of areas where diagnostic medicine is used, the book introduces Bayesian statistics and the estimation of accuracy by sensitivity, specificity, and positive and negative predictive values for ordinal and continuous diagnostic measurements. The author then discusses patient covariate information and the statistical methods for estimating the agreement among observers. The book also explains the protocol review process for cancer clinical trials, how tumor responses are categorized, how to use WHO and RECIST criteria, and how Bayesian sequential methods are employed to monitor trials and estimate sample sizes. With many tables and figures, this book enables readers to conduct a Bayesian analysis for a large variety of interesting and practical biomedical problems.

Author : P. W. Strike
Publisher : Butterworth-Heinemann
Page : 553 pages
File Size : 41,8 Mb
Release : 2014-05-16
Category : Medical
ISBN : 9781483161921

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Statistical Methods in Laboratory Medicine by P. W. Strike Pdf

Statistical Methods in Laboratory Medicine focuses on the application of statistics in laboratory medicine. The book first ponders on quantitative and random variables, exploratory data analysis (EDA), probability, and probability distributions. Discussions focus on negative binomial distribution, non-random distributions, binomial distribution, fitting the binomial model to sample data, conditional probability and statistical independence, rules of probability, and Bayes' theorem. The text then examines inference, regression, and measurement and control. Topics cover analytical goals for assay precision, estimating the error variance components, indirect structural assays, functional assays, bivariate regression model, and least-squares estimates of the functional relation parameters. The manuscript takes a look at assay method comparison studies, multivariate analysis, forecasting and control, and test interpretation. Concerns include time series structure and terminology, polynomial regression, assessing the performance of the classification rule, quantitative screening tests, sample correlation coefficient, and computer assisted diagnosis. The book is a dependable reference for medical experts and statisticians interested in the employment of statistics in laboratory medicine.

Author : Janet Peacock,Philip Peacock
Publisher : Oxford University Press
Page : 540 pages
File Size : 54,7 Mb
Release : 2011
Category : Medical
ISBN : 9780199551286

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Oxford Handbook of Medical Statistics by Janet Peacock,Philip Peacock Pdf

The majority of medical research involves quantitative methods and so it is essential to be able to understand and interpret statistics. This book shows readers how to develop the skills required to critically appraise research evidence effectively, and how to conduct research and communicate their findings.

Author : Lawrence Rosenberg
Publisher : CRC Press
Page : 244 pages
File Size : 54,9 Mb
Release : 2000-01-01
Category : Science
ISBN : 9781498713634

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Surgical Arithmetic by Lawrence Rosenberg Pdf

This book is intended for the practicing surgeon. It is designed to offer practical insights into the essentials of an epidemiological, statistical and outcomes-based approach to surgical practice. Surgeons are invited to begin to develop the requisite skills that will allow them to communicate effectively with their colleagues in epidemiology and

Author : David E. Matthews,Vernon T. Farewell
Publisher : Karger Medical and Scientific Publishers
Page : 264 pages
File Size : 52,8 Mb
Release : 1996-01-01
Category : Medical
ISBN : 3805562764

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Using and Understanding Medical Statistics by David E. Matthews,Vernon T. Farewell Pdf

This latest edition is highly recommended both as an excellent introduction to medical statistics and as a valuable tool in explaining the more complex statistical methods and techniques used today.

Author : David Bowers
Publisher : John Wiley & Sons
Page : 303 pages
File Size : 48,8 Mb
Release : 2008-04-15
Category : Medical
ISBN : 0470724447

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Medical Statistics from Scratch by David Bowers Pdf

This long awaited second edition of this bestseller continues toprovide a comprehensive, user friendly, down-to-earth guide toelementary statistics. The book presents a detailed account ofthe most important procedures for the analysis of data, from thecalculation of simple proportions, to a variety of statisticaltests, and the use of regression models for modeling of clinicaloutcomes. The level of mathematics is kept to a minimum to make thematerial easily accessible to the novice, and a multitude ofillustrative cases are included in every chapter, drawn from thecurrent research literature. The new edition has beencompletely revised and updated and includes new chapters on basicquantitative methods, measuring survival, measurement scales,diagnostic testing, bayesian methods, meta-analysis and systematicreviews. "... After years of trying and failing, this is the only book onstatistics that i have managed to read and understand" - NaveedKirmani, Surgical Registrar, South London Healthcare HHS Trust,UK

Author : Francesco Sardanelli,Giovanni Di Leo
Publisher : Springer Science & Business Media
Page : 244 pages
File Size : 52,8 Mb
Release : 2009-03-31
Category : Medical
ISBN : 9788847011335

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Biostatistics for Radiologists by Francesco Sardanelli,Giovanni Di Leo Pdf

The aim of this book is to present statistical problems and methods in a friendly way to radiologists, emphasizing statistical issues and methods most frequently used in radiological studies (e.g., nonparametric tests, analysis of intra- and interobserver reproducibility, comparison of sensitivity and specificity among different imaging modality, difference between clinical and screening application of diagnostic tests, ect.). The tests will be presented starting from a radiological "problem" and all examples of statistical methods applications will be "radiological".

Author : Dev P. Chakraborty
Publisher : CRC Press
Page : 591 pages
File Size : 42,9 Mb
Release : 2017-12-14
Category : Medical
ISBN : 9781482214864

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Observer Performance Methods for Diagnostic Imaging by Dev P. Chakraborty Pdf

Gives an accessible overview of R programming for medical imaging and the methods of observer performance testing. Explains the fundamental statistical concepts. Reinforces learning using worked problems and R software code, in addition to examples that utilize standalone ROC software. Starts with basic ROC analysis and builds to extensions of ROC methods for solving more complex but clinically realistic tasks. Emphasizes psychophysical models of observer performance (e.g., binormal model, contaminated binormal model, proper ROC model), and demonstrates how they can give better results than from purely statistical approaches. Supplementary tools and materials available at: www.devchakraborty.com; www.expertcadanalytics.com.