Statistical Methods For Hospital Monitoring With R

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Statistical Methods for Hospital Monitoring with R

Author : Anthony Morton,Kerrie L. Mengersen,Geoffrey Playford,Michael Whitby
Publisher : John Wiley & Sons
Page : 462 pages
File Size : 53,7 Mb
Release : 2013-06-27
Category : Medical
ISBN : 9781118639177

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Statistical Methods for Hospital Monitoring with R by Anthony Morton,Kerrie L. Mengersen,Geoffrey Playford,Michael Whitby Pdf

Hospitals monitoring is becoming more complex and is increasing both because staff want their data analysed and because of increasing mandated surveillance. This book provides a suite of functions in R, enabling scientists and data analysts working in infection management and quality improvement departments in hospitals, to analyse their often non-independent data which is frequently in the form of trended, over-dispersed and sometimes auto-correlated time series; this is often difficult to analyse using standard office software. This book provides much-needed guidance on data analysis using R for the growing number of scientists in hospital departments who are responsible for producing reports, and who may have limited statistical expertise. This book explores data analysis using R and is aimed at scientists in hospital departments who are responsible for producing reports, and who are involved in improving safety. Professionals working in the healthcare quality and safety community will also find this book of interest Statistical Methods for Hospital Monitoring with R: Provides functions to perform quality improvement and infection management data analysis. Explores the characteristics of complex systems, such as self-organisation and emergent behaviour, along with their implications for such activities as root-cause analysis and the Pareto principle that seek few key causes of adverse events. Provides a summary of key non-statistical aspects of hospital safety and easy to use functions. Provides R scripts in an accompanying web site enabling analyses to be performed by the reader http://www.wiley.com/go/hospital_monitoring Covers issues that will be of increasing importance in the future, such as, generalised additive models, and complex systems, networks and power laws.

Statistical Methods for Healthcare Performance Monitoring

Author : Alex Bottle,Paul Aylin
Publisher : CRC Press
Page : 184 pages
File Size : 41,6 Mb
Release : 2016-08-05
Category : Mathematics
ISBN : 9781315355467

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Statistical Methods for Healthcare Performance Monitoring by Alex Bottle,Paul Aylin Pdf

Healthcare is important to everyone, yet large variations in its quality have been well documented both between and within many countries. With demand and expenditure rising, it’s more crucial than ever to know how well the healthcare system and all its components – from staff member to regional network – are performing. This requires data, which inevitably differ in form and quality. It also requires statistical methods, the output of which needs to be presented so that it can be understood by whoever needs it to make decisions. Statistical Methods for Healthcare Performance Monitoring covers measuring quality, types of data, risk adjustment, defining good and bad performance, statistical monitoring, presenting the results to different audiences and evaluating the monitoring system itself. Using examples from around the world, it brings all the issues and perspectives together in a largely non-technical way for clinicians, managers and methodologists. Statistical Methods for Healthcare Performance Monitoring is aimed at statisticians and researchers who need to know how to measure and compare performance, health service regulators, health service managers with responsibilities for monitoring performance, and quality improvement scientists, including those involved in clinical audits.

Statistical Methods for Evaluating Safety in Medical Product Development

Author : A. Lawrence Gould
Publisher : John Wiley & Sons
Page : 392 pages
File Size : 46,5 Mb
Release : 2014-12-08
Category : Medical
ISBN : 9781118763100

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Statistical Methods for Evaluating Safety in Medical Product Development by A. Lawrence Gould Pdf

This book gives professionals in clinical research valuable information on the challenging issues of the design, execution, and management of clinical trials, and how to resolve these issues effectively. It also provides understanding and practical guidance on the application of contemporary statistical methods to contemporary issues in safety evaluation during medical product development. Each chapter provides sufficient detail to the reader to undertake the design and analysis of experiments at various stages of product development, including comprehensive references to the relevant literature. Provides a guide to statistical methods and application in medical product development Assists readers in undertaking design and analysis of experiments at various stages of product development Features case studies throughout the book, as well as, SAS and R code

Data Monitoring Committees in Clinical Trials

Author : Susan S. Ellenberg,Thomas R. Fleming,David L. DeMets
Publisher : John Wiley & Sons
Page : 268 pages
File Size : 51,5 Mb
Release : 2019-01-15
Category : Medical
ISBN : 9781119512677

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Data Monitoring Committees in Clinical Trials by Susan S. Ellenberg,Thomas R. Fleming,David L. DeMets Pdf

The authoritative guide for Data Monitoring Committees—fully revised and updated The number of clinical trials sponsored by government agencies and pharmaceutical companies has grown in recent years, prompting an increased need for interim monitoring of data on safety and efficacy. Data Monitoring Committees (DMCs) are an essential component of many clinical trials, safeguarding trial participants and protecting the credibility and validity of the study. Data Monitoring Committees in Clinical Trials: A Practical Perspective, 2nd Edition offers practical advice for those managing and conducting clinical trials and serving on Data Monitoring Committees, providing a practical overview of the establishment, purpose, and responsibilities of these committees. Examination of topics such as the composition and independence of DMCs, statistical, philosophical and ethical considerations, and determining when a DMC is needed, presents readers with a comprehensive foundational knowledge of clinical trial oversight. Providing recent examples to illustrate DMC principles, this fully-updated guide reflects current developments and practices in clinical trial oversight and offers expanded coverage of emerging issues and challenges in the field. This new second edition covers the most current information on DMC policies, issues in monitoring trials using new designs, and recent trial publications relevant to DMC decision-making. • Presents practical advice for those managing and conducting clinical trials and serving on Data Monitoring Committees • Illustrates the types of challenging issues Data Monitoring Committees face in practical situations • Provides updated and expanded coverage of topics including regulatory and funding agency guidelines and trial designs and their associated demands and limitations • Includes a new chapter addressing legal issues that affect DMC members and discusses general litigation concerns relevant to clinical research • Expands treatment of current journal publications addressing DMC issues Data Monitoring Committees in Clinical Trials: A Practical Perspective, 2nd Edition is a must-have text for anyone engaged in DMC activities as well as trial sponsors, clinical trial researchers, regulatory and bioethics professionals, and those associated with clinical trials in academic, government and industry settings.

Crossover Designs

Author : Kung-Jong Lui
Publisher : John Wiley & Sons
Page : 248 pages
File Size : 53,6 Mb
Release : 2016-08-08
Category : Medical
ISBN : 9781119114697

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Crossover Designs by Kung-Jong Lui Pdf

A comprehensive and practical resource for analyses of crossover designs For ethical reasons, it is vital to keep the number of patients in a clinical trial as low as possible. As evidenced by extensive research publications, crossover design can be a useful and powerful tool to reduce the number of patients needed for a parallel group design in studying treatments for non-curable chronic diseases. This book introduces commonly-used and well-established statistical tests and estimators in epidemiology that can easily be applied to hypothesis testing and estimation of the relative treatment effect for various types of data scale in crossover designs. Models with distribution-free random effects are assumed and hence most approaches considered here are semi-parametric. The book provides clinicians and biostatisticians with the exact test procedures and exact interval estimators, which are applicable even when the number of patients in a crossover trial is small. Systematic discussion on sample size determination is also included, which will be a valuable resource for researchers involved in crossover trial design. Key features: Provides exact test procedures and interval estimators, which are especially of use in small-sample cases. Presents most test procedures and interval estimators in closed-forms, enabling readers to calculate them by use of a pocket calculator or commonly-used statistical packages. Each chapter is self-contained, allowing the book to be used a reference resource. Uses real-life examples to illustrate the practical use of test procedures and estimators Provides extensive exercises to help readers appreciate the underlying theory, learn other relevant test procedures and understand how to calculate the required sample size. Crossover Designs: Testing, Estimation and Sample Size will be a useful resource for researchers from biostatistics, as well as pharmaceutical and clinical sciences. It can also be used as a textbook or reference for graduate students studying clinical experiments.

A Practical Guide to Designing Phase II Trials in Oncology

Author : Sarah R. Brown,Walter M. Gregory,Christopher J. Twelves,Julia M. Brown
Publisher : John Wiley & Sons
Page : 260 pages
File Size : 42,9 Mb
Release : 2014-05-12
Category : Medical
ISBN : 9781118570906

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A Practical Guide to Designing Phase II Trials in Oncology by Sarah R. Brown,Walter M. Gregory,Christopher J. Twelves,Julia M. Brown Pdf

How to identify optimal phase II trial designs Providing a practical guide containing the information needed to make crucial decisions regarding phase II trial designs, A Practical Guide to Designing Phase II Trials in Oncology sets forth specific points for consideration between the statistician and clinician when designing a phase II trial, including issues such as how the treatment works, choice of outcome measure and randomization, and considering both academic and industry perspectives. A comprehensive and systematic library of available phase II trial designs is included, saving time otherwise spent considering multiple manuscripts, and real-life practical examples of using this approach to design phase II trials in cancer are given. A Practical Guide to Designing Phase II Trials in Oncology: Offers a structured and practical approach to phase II trial design Considers trial design from both an academic and industry perspective Includes a structured library of available phase II trial designs Is relevant to both clinical and statistical researchers at all levels Includes real life examples of applying this approach For those new to trial design, A Practical Guide to Designing Phase II Trials in Oncology will be a unique and practical learning tool, providing an introduction to the concepts behind informed decision making in phase II trials. For more experienced practitioners, the book will offer an overview of new, less familiar approaches to phase II trial design, providing alternative options to those which they may have previously used.

Modern Industrial Statistics

Author : Shelemyahu Zacks,Ron S. Kenett,Daniele Amberti
Publisher : John Wiley & Sons
Page : 740 pages
File Size : 44,8 Mb
Release : 2013-12-16
Category : Mathematics
ISBN : 9781118763698

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Modern Industrial Statistics by Shelemyahu Zacks,Ron S. Kenett,Daniele Amberti Pdf

Fully revised and updated, this book combines a theoretical background with examples and references to R, MINITAB and JMP, enabling practitioners to find state-of-the-art material on both foundation and implementation tools to support their work. Topics addressed include computer-intensive data analysis, acceptance sampling, univariate and multivariate statistical process control, design of experiments, quality by design, and reliability using classical and Bayesian methods. The book can be used for workshops or courses on acceptance sampling, statistical process control, design of experiments, and reliability. Graduate and post-graduate students in the areas of statistical quality and engineering, as well as industrial statisticians, researchers and practitioners in these fields will all benefit from the comprehensive combination of theoretical and practical information provided in this single volume. Modern Industrial Statistics: With applications in R, MINITAB and JMP: Combines a practical approach with theoretical foundations and computational support. Provides examples in R using a dedicated package called MISTAT, and also refers to MINITAB and JMP. Includes exercises at the end of each chapter to aid learning and test knowledge. Provides over 40 data sets representing real-life case studies. Is complemented by a comprehensive website providing an introduction to R, and installations of JMP scripts and MINITAB macros, including effective tutorials with introductory material: www.wiley.com/go/modern_industrial_statistics.

Bayesian Networks for Probabilistic Inference and Decision Analysis in Forensic Science

Author : Franco Taroni,Alex Biedermann,Silvia Bozza,Paolo Garbolino,Colin Aitken
Publisher : John Wiley & Sons
Page : 472 pages
File Size : 47,8 Mb
Release : 2014-07-21
Category : Mathematics
ISBN : 9781118914748

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Bayesian Networks for Probabilistic Inference and Decision Analysis in Forensic Science by Franco Taroni,Alex Biedermann,Silvia Bozza,Paolo Garbolino,Colin Aitken Pdf

"This book should have a place on the bookshelf of every forensic scientist who cares about the science of evidence interpretation" Dr. Ian Evett, Principal Forensic Services Ltd, London, UK Continuing developments in science and technology mean that the amounts of information forensic scientists are able to provide for criminal investigations is ever increasing. The commensurate increase in complexity creates difficulties for scientists and lawyers with regard to evaluation and interpretation, notably with respect to issues of inference and decision. Probability theory, implemented through graphical methods, and specifically Bayesian networks, provides powerful methods to deal with this complexity. Extensions of these methods to elements of decision theory provide further support and assistance to the judicial system. Bayesian Networks for Probabilistic Inference and Decision Analysis in Forensic Science provides a unique and comprehensive introduction to the use of Bayesian decision networks for the evaluation and interpretation of scientific findings in forensic science, and for the support of decision-makers in their scientific and legal tasks. • Includes self-contained introductions to probability and decision theory. • Develops the characteristics of Bayesian networks, object-oriented Bayesian networks and their extension to decision models. • Features implementation of the methodology with reference to commercial and academically available software. • Presents standard networks and their extensions that can be easily implemented and that can assist in the reader’s own analysis of real cases. • Provides a technique for structuring problems and organizing data based on methods and principles of scientific reasoning. • Contains a method for the construction of coherent and defensible arguments for the analysis and evaluation of scientific findings and for decisions based on them. • Is written in a lucid style, suitable for forensic scientists and lawyers with minimal mathematical background. • Includes a foreword by Ian Evett. The clear and accessible style of this second edition makes this book ideal for all forensic scientists, applied statisticians and graduate students wishing to evaluate forensic findings from the perspective of probability and decision analysis. It will also appeal to lawyers and other scientists and professionals interested in the evaluation and interpretation of forensic findings, including decision making based on scientific information.

Clinical Trials with Missing Data

Author : Michael O'Kelly,Bohdana Ratitch
Publisher : John Wiley & Sons
Page : 472 pages
File Size : 54,7 Mb
Release : 2014-04-07
Category : Medical
ISBN : 9781118460702

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Clinical Trials with Missing Data by Michael O'Kelly,Bohdana Ratitch Pdf

This book provides practical guidance for statisticians, clinicians, and researchers involved in clinical trials in the biopharmaceutical industry, medical and public health organisations. Academics and students needing an introduction to handling missing data will also find this book invaluable. The authors describe how missing data can affect the outcome and credibility of a clinical trial, show by examples how a clinical team can work to prevent missing data, and present the reader with approaches to address missing data effectively. The book is illustrated throughout with realistic case studies and worked examples, and presents clear and concise guidelines to enable good planning for missing data. The authors show how to handle missing data in a way that is transparent and easy to understand for clinicians, regulators and patients. New developments are presented to improve the choice and implementation of primary and sensitivity analyses for missing data. Many SAS code examples are included – the reader is given a toolbox for implementing analyses under a variety of assumptions.

Weight-of-Evidence for Forensic DNA Profiles

Author : David J. Balding,Christopher D. Steele
Publisher : John Wiley & Sons
Page : 232 pages
File Size : 50,7 Mb
Release : 2015-07-20
Category : Mathematics
ISBN : 9781118814550

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Weight-of-Evidence for Forensic DNA Profiles by David J. Balding,Christopher D. Steele Pdf

DNA evidence is widely used in the modern justice system. Statistical methodology plays a key role in ensuring that this evidence is collected, interpreted, analysed and presented correctly. This book is a guide to assessing DNA evidence and presenting that evidence in a courtroom setting. It offers practical guidance to forensic scientists with little dependence on mathematical ability, and provides the scientist with the understanding they require to apply the methods in their work. Since the publication of the first edition of this book in 2005 there have been many incremental changes, and one dramatic change which is the emergence of low template DNA (LTDNA) profiles. This second edition is edited and expanded to cover the basics of LTDNA technology. The author's own open-source R code likeLTD is described and used for worked examples in the book. Commercial and free software are also covered.

How to Design, Analyse and Report Cluster Randomised Trials in Medicine and Health Related Research

Author : Michael J. Campbell,Stephen J. Walters
Publisher : John Wiley & Sons
Page : 272 pages
File Size : 40,6 Mb
Release : 2014-03-28
Category : Medical
ISBN : 9781118763605

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How to Design, Analyse and Report Cluster Randomised Trials in Medicine and Health Related Research by Michael J. Campbell,Stephen J. Walters Pdf

A complete guide to understanding cluster randomised trials Written by two researchers with extensive experience in the field, this book presents a complete guide to the design, analysis and reporting of cluster randomised trials. It spans a wide range of applications: trials in developing countries, trials in primary care, trials in the health services. A key feature is the use of R code and code from other popular packages to plan and analyse cluster trials, using data from actual trials. The book contains clear technical descriptions of the models used, and considers in detail the ethics involved in such trials and the problems in planning them. For readers and students who do not intend to run a trial but wish to be a critical reader of the literature, there are sections on the CONSORT statement, and exercises in reading published trials. Written in a clear, accessible style Features real examples taken from the authors’ extensive practitioner experience of designing and analysing clinical trials Demonstrates the use of R, Stata and SPSS for statistical analysis Includes computer code so the reader can replicate all the analyses Discusses neglected areas such as ethics and practical issues in running cluster randomised trials How to Design, Analyse and Report Cluster Randomised Trials in Medicine and Health Related Research provides an excellent reference tool and can be read with profit by statisticians, health services researchers, systematic reviewers and critical readers of cluster randomised trials.

Statistical Methods in Healthcare

Author : Frederick W. Faltin,Ron S. Kenett,Fabrizio Ruggeri
Publisher : John Wiley & Sons
Page : 533 pages
File Size : 55,8 Mb
Release : 2012-07-24
Category : Medical
ISBN : 9781119942047

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Statistical Methods in Healthcare by Frederick W. Faltin,Ron S. Kenett,Fabrizio Ruggeri Pdf

Statistical Methods in Healthcare In recent years the number of innovative medicinal products and devices submitted and approved by regulatory bodies has declined dramatically. The medical product development process is no longer able to keep pace with increasing technologies, science and innovations and the goal is to develop new scientific and technical tools and to make product development processes more efficient and effective. Statistical Methods in Healthcare focuses on the application of statistical methodologies to evaluate promising alternatives and to optimize the performance and demonstrate the effectiveness of those that warrant pursuit is critical to success. Statistical methods used in planning, delivering and monitoring health care, as well as selected statistical aspects of the development and/or production of pharmaceuticals and medical devices are also addressed. With a focus on finding solutions to these challenges, this book: Provides a comprehensive, in-depth treatment of statistical methods in healthcare, along with a reference source for practitioners and specialists in health care and drug development. Offers a broad coverage of standards and established methods through leading edge techniques. Uses an integrated case study based approach, with focus on applications. Looks at the use of analytical and monitoring schemes to evaluate therapeutic performance. Features the application of modern quality management systems to clinical practice, and to pharmaceutical development and production processes. Addresses the use of modern statistical methods such as Adaptive Design, Seamless Design, Data Mining, Bayesian networks and Bootstrapping that can be applied to support the challenging new vision. Practitioners in healthcare-related professions, ranging from clinical trials to care delivery to medical device design, as well as statistical researchers in the field, will benefit from this book.

Applied Mixed Models in Medicine

Author : Helen Brown,Robin Prescott
Publisher : John Wiley & Sons
Page : 536 pages
File Size : 40,7 Mb
Release : 2014-12-12
Category : Medical
ISBN : 9781118778241

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Applied Mixed Models in Medicine by Helen Brown,Robin Prescott Pdf

A fully updated edition of this key text on mixed models, focusing on applications in medical research The application of mixed models is an increasingly popular way of analysing medical data, particularly in the pharmaceutical industry. A mixed model allows the incorporation of both fixed and random variables within a statistical analysis, enabling efficient inferences and more information to be gained from the data. There have been many recent advances in mixed modelling, particularly regarding the software and applications. This third edition of Brown and Prescott’s groundbreaking text provides an update on the latest developments, and includes guidance on the use of current SAS techniques across a wide range of applications. Presents an overview of the theory and applications of mixed models in medical research, including the latest developments and new sections on incomplete block designs and the analysis of bilateral data. Easily accessible to practitioners in any area where mixed models are used, including medical statisticians and economists. Includes numerous examples using real data from medical and health research, and epidemiology, illustrated with SAS code and output. Features the new version of SAS, including new graphics for model diagnostics and the procedure PROC MCMC. Supported by a website featuring computer code, data sets, and further material. This third edition will appeal to applied statisticians working in medical research and the pharmaceutical industry, as well as teachers and students of statistics courses in mixed models. The book will also be of great value to a broad range of scientists, particularly those working in the medical and pharmaceutical areas.

Modeling and Analysis of Compositional Data

Author : Vera Pawlowsky-Glahn,Juan José Egozcue,Raimon Tolosana-Delgado
Publisher : John Wiley & Sons
Page : 272 pages
File Size : 47,7 Mb
Release : 2015-02-17
Category : Mathematics
ISBN : 9781119003137

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Modeling and Analysis of Compositional Data by Vera Pawlowsky-Glahn,Juan José Egozcue,Raimon Tolosana-Delgado Pdf

Modeling and Analysis of Compositional Data presents a practical and comprehensive introduction to the analysis of compositional data along with numerous examples to illustrate both theory and application of each method. Based upon short courses delivered by the authors, it provides a complete and current compendium of fundamental to advanced methodologies along with exercises at the end of each chapter to improve understanding, as well as data and a solutions manual which is available on an accompanying website. Complementing Pawlowsky-Glahn’s earlier collective text that provides an overview of the state-of-the-art in this field, Modeling and Analysis of Compositional Data fills a gap in the literature for a much-needed manual for teaching, self learning or consulting.

Introduction to Statistical Methods for Biosurveillance

Author : Ronald D. Fricker
Publisher : Cambridge University Press
Page : 128 pages
File Size : 47,7 Mb
Release : 2013-02-25
Category : Medical
ISBN : 9781107328068

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Introduction to Statistical Methods for Biosurveillance by Ronald D. Fricker Pdf

Bioterrorism is not a new threat, but in an increasingly interconnected world, the potential for catastrophic outcomes is greater today than ever. The medical and public health communities are establishing biosurveillance systems designed to proactively monitor populations for possible disease outbreaks as a first line of defense. The ideal biosurveillance system should identify trends not visible to individual physicians and clinicians in near-real time. Many of these systems use statistical algorithms to look for anomalies and to trigger epidemiologic investigation, quantification, localization and outbreak management. This book discusses the design and evaluation of statistical methods for effective biosurveillance for readers with minimal statistical training. Weaving public health and statistics together, it presents basic and more advanced methods, with a focus on empirically demonstrating added value. Although the emphasis is on epidemiologic and syndromic surveillance, the statistical methods can be applied to a broad class of public health surveillance problems.