Stereoselective Synthesis Of Drugs And Natural Products

Author : Vasyl Andrushko,Natalia Andrushko
Publisher : John Wiley & Sons
Page : 1836 pages
File Size : 55,6 Mb
Release : 2013-08-16
Category : Science
ISBN : 9781118628331

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Stereoselective Synthesis of Drugs and Natural Products by Vasyl Andrushko,Natalia Andrushko Pdf

Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.

Author : Vasyl Andrushko,Natalia Andrushko
Publisher : Wiley
Page : 0 pages
File Size : 52,7 Mb
Release : 2013-10-07
Category : Science
ISBN : 1118032179

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Stereoselective Synthesis of Drugs and Natural Products, 2 Volume Set by Vasyl Andrushko,Natalia Andrushko Pdf

Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.

Author : Vasyl Andrushko,Natalia Andrushko
Publisher : Unknown
Page : 128 pages
File Size : 48,8 Mb
Release : 2013
Category : Chiral drugs
ISBN : OCLC:999636787

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Stereoselective Synthesis of Drugs and Natural Products, Two Volume Set by Vasyl Andrushko,Natalia Andrushko Pdf

Author : Erick M. Carreira,Lisbet Kvaerno
Publisher : John Wiley & Sons
Page : 664 pages
File Size : 48,9 Mb
Release : 2009-02-09
Category : Science
ISBN : 3527324526

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Classics in Stereoselective Synthesis by Erick M. Carreira,Lisbet Kvaerno Pdf

Die wichtigsten und nützlichsten Methoden der modernen stereoselektiven Synthese sind in diesem Band zusammengefasst. Viele anschauliche Beispiele für die Darstellung von Wirkstoffen und Naturstoffen regen zur gezielten Abwandlung und Integration in eigene Synthesewege an. Dabei geht es den Autoren weniger darum, das Gebiet in seiner Gesamtheit darzustellen; vielmehr versuchen sie, die wirklich grundlegenden Ansätze auszuwählen, die jeder organische Synthesechemiker kennen und anwenden sollte.

Author : Atta-ur- Rahman
Publisher : Elsevier
Page : 730 pages
File Size : 50,5 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483100975

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Studies in Natural Products Chemistry by Atta-ur- Rahman Pdf

Studies in Natural Products Chemistry, Volume 10: Stereoselective Synthesis (Part F) is a collection of articles about studies on important organic molecules. The book covers studies such as that on the synthesis of cembranes as well as its natural occurrence and bioactivity; the stereoselective synthesis of Vitamin D; the synthesis of isoquinolinequinone antibiotics; and the nucleophilic addition chemistry of polyunsaturated carbonyl compounds. Also covered in the book are subjects such as developments in the synthesis of medium ring ethers; the biological properties, chemistry, and synthesis of didemnins; and natural products synthesis based on novel ring transformation. The text is recommended for organic chemists who would like to know more about the progresses in the study of important organic molecules and their implications in different fields.

Author : Atta-ur-Rahman,Zahir Shah
Publisher : Springer Science & Business Media
Page : 534 pages
File Size : 55,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461383277

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Stereoselective Synthesis in Organic Chemistry by Atta-ur-Rahman,Zahir Shah Pdf

Author : Atta-ur-Rahman
Publisher : Elsevier
Page : 938 pages
File Size : 44,8 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483163536

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Studies in Natural Products Chemistry by Atta-ur-Rahman Pdf

Studies in Natural Products Chemistry, Volume 14: Stereoselective Synthesis, Part I is a collection of discourses on the stereoselective synthesis of the anticancer anthrucycline antibiotics; tetramic acid antibiotics; 3-and 4-deoxyhexoses; polysaccharides; levoglucosenone as precursor to natural products; synthesis of oligoribonucleotides; and oxidation of guaiazulene. This volume deals with a broad range of natural products focusing on the synthesis of antibiotics and anticancer agents — anthracyclines, tetramic acid, taxodione, vinblastine, and vincristine. These aforementioned drugs are used for the treatment of cancer (anthracyclines) and Hodgkin's disease and childhood acute leukemia (vinblastine and vincristine). The importance of the latest developments in the stereocontrolled synthesis of polysaccharides is discussed as polysaccharides play a fundamental role in cell life and have many technical applications. The synthesis of bioactive carbohydrates 3- and 4-deoxy-hexoses is compared with the more occurring deoxyhexoses in nature such as the 2-deoxy, 6-deoxy, and 2,6-dideoxy-hexoses, because the former are rare compounds and useful tools in the study of biological and biochemical properties of mono- and oligosaccharides, glycoproteins, and antibiotics. Alkaloids derived from Apocynaceae are known for their medicinal properties; hence the synthetic approaches to vinblastine and vincristine are discussed. Because of the minute amounts available from herbal sources, efforts toward their chemical synthesis are given more reference. This book can be a useful reference for the organic chemists. Chemical researchers, pharmaceutical scientists, and professionals of bioorganic chemistry will likewise gain a lot from this collection.

Author : Atta-ur-Rahman
Publisher : Elsevier
Page : 1108 pages
File Size : 54,9 Mb
Release : 1996-05-01
Category : Science
ISBN : 0080541771

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Studies in Natural Products Chemistry by Atta-ur-Rahman Pdf

In Volume 18 of this well-established series, Professor Atta-ur-Rahman again brings together the work of several of the world's leading authorities in organic chemistry. Their contributions demonstrate the rapid, ongoing development of this field by illustrating many of the latest advances in synthetic methods, total synthesis, structure determination, biosynthetic pathways, and biological activity. The opening chapter presents an overview of strategies for the synthesis of several classes of natural products with an emphasis on complex polycyclic systems. Subsequent chapters discuss the synthesis of specific classes of compounds, including morphine, polyketides, acetogenins, nonactic acid derivatives, complex spirocyclic ethers, ä-lactam and pyridone derivatives, inositol phosphates, sphingolipids, brassinosteroids, Hernandia lignans, and dimeric steroidal pyrazine alkaloids. Finally, the ever stronger links between chemistry and biology are reinforced by chapters on the origin and function of secondary metabolites, bioactive conformations of gastrin hormones, and immunochemistry.

Author : Eckhard Ottow,Klaus Schöllkopf,Bernd-Günter Schulz
Publisher : Springer Science & Business Media
Page : 147 pages
File Size : 48,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642784965

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Stereoselective Synthesis by Eckhard Ottow,Klaus Schöllkopf,Bernd-Günter Schulz Pdf

Devising methods and reagents for stereoselective synthesis is an intellectually demanding venture. Six experts on diastereo- and enantioselective synthesis contributed their papers to this volume. They were presented at a symposium on stereoselective synthesis to honour Professor Dr. Dr. h.c. Rudolf Wiechert's achievements in medicinal chemistry research. The symposium was organized by the Schering AG on the occasion of Professor Wiechert's 65th birthday.

Author : Jean Rodriguez,Damien Bonne
Publisher : John Wiley & Sons
Page : 480 pages
File Size : 46,6 Mb
Release : 2015-04-08
Category : Science
ISBN : 9781119006428

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Stereoselective Multiple Bond-Forming Transformations in Organic Synthesis by Jean Rodriguez,Damien Bonne Pdf

Combining the important research topic of multiple bond-forming transformations with green chemistry, this book helps chemists identify recent sustainable stereoselective synthetic sequences. • Combines the important research topic of multiple bond-forming transformations with green chemistry and sustainable development • Offers a valuable resource for preparing compounds with multiple stereogenic centers, an important field for synthetic chemists • Organizes chapters by molecular structure of final products, making for a handbook-style resource • Discusses applications of the synthesis of natural products and of drug intermediates • Brings together otherwise-scattered information about a number of key, efficient chemical reactions

Author : Atta-ur Rahman
Publisher : Elsevier Science Limited
Page : 543 pages
File Size : 51,5 Mb
Release : 1989
Category : Natural products
ISBN : 0444872981

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Stereoselective Synthesis by Atta-ur Rahman Pdf

This is the second volume to be devoted to the area of stereoselective synthesis. It reviews and highlights important and new contributions by eminent scientists on a wide variety of organic reactions and strategies to the stereoselective synthesis of complex structures which will provide stimulating reading for many synthetic organic chemists.

Author : Atta-ur-Rahman
Publisher : Elsevier
Page : 772 pages
File Size : 50,6 Mb
Release : 1995-08-10
Category : Science
ISBN : 008054178X

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Studies in Natural Products Chemistry by Atta-ur-Rahman Pdf

Studies in Natural Products Chemistry

Author : Atta-ur-Rahman
Publisher : Elsevier
Page : 540 pages
File Size : 41,6 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483193243

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Studies in Natural Products Chemistry by Atta-ur-Rahman Pdf

Studies in Natural Products Chemistry Volume 12: Stereoselective Synthesis (Part H) reviews the stereoselective synthetic and mechanistic chemistry of bicyclomycin. It discusses chemical studies of the taxane diterpenes; the synthetic methodology for 2-amino alcohols of biological interest; and the synthesis and structure of hydroxylated indolizidines. Some of the topics covered in the book are the synthetic routes to the oxahydrindene subunit of the avermectin-milbemycin family of antiparasitic agents; isolation, structure elucidation, biosynthesis, and biological activity of the avermectins; two-stage coupling process of macrolide antibiotics synthesis; and synthesis of the rifamycin S ansa-chain compound. The complete synthesis of erythromycin A is also covered. The role of isocyanides in the synthesis of beta lactam antibiotics and the characteristics of the beta lactam antibiotics are discussed. The development of an A-Ring annulation strategy for taxane synthesis is also presented. A chapter is devoted to the advances in the synthesis of tumor-promoting diterpenes. The book can provide useful information to chemists, biologists, students, and researchers.

Author : Atta-ur- Rahman
Publisher : Elsevier Science & Technology
Page : 564 pages
File Size : 42,6 Mb
Release : 1989
Category : Science
ISBN : 0444872981

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Stereoselective Synthesis by Atta-ur- Rahman Pdf

Section 1

Author : Anonim
Publisher : Unknown
Page : 756 pages
File Size : 50,9 Mb
Release : 1989
Category : Electronic
ISBN : OCLC:1123674846

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Stereoselective Synthesis by Anonim Pdf