Stereoselective Multiple Bond Forming Transformations In Organic Synthesis

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Stereoselective Multiple Bond-Forming Transformations in Organic Synthesis

Jean Rodriguez,Damien Bonne
Stereoselective Multiple Bond Forming Transformations in Organic Synthesis Book PDF

Author : Jean Rodriguez,Damien Bonne
Publisher : John Wiley & Sons
Page : 480 pages
File Size : 54,7 Mb
Release : 2015-04-08
Category : Science
ISBN : 9781119006428

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Stereoselective Multiple Bond-Forming Transformations in Organic Synthesis by Jean Rodriguez,Damien Bonne Pdf

Combining the important research topic of multiple bond-forming transformations with green chemistry, this book helps chemists identify recent sustainable stereoselective synthetic sequences. • Combines the important research topic of multiple bond-forming transformations with green chemistry and sustainable development • Offers a valuable resource for preparing compounds with multiple stereogenic centers, an important field for synthetic chemists • Organizes chapters by molecular structure of final products, making for a handbook-style resource • Discusses applications of the synthesis of natural products and of drug intermediates • Brings together otherwise-scattered information about a number of key, efficient chemical reactions

Stereoselective Multiple Bond-Forming Transformations in Organic Synthesis

Jean Rodriguez,Damien Bonne
Stereoselective Multiple Bond Forming Transformations in Organic Synthesis Book PDF

Author : Jean Rodriguez,Damien Bonne
Publisher : John Wiley & Sons
Page : 471 pages
File Size : 46,7 Mb
Release : 2015-04-27
Category : Science
ISBN : 9781118672716

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Stereoselective Multiple Bond-Forming Transformations in Organic Synthesis by Jean Rodriguez,Damien Bonne Pdf

Combining the important research topic of multiple bond-forming transformations with green chemistry, this book helps chemists identify recent sustainable stereoselective synthetic sequences. • Combines the important research topic of multiple bond-forming transformations with green chemistry and sustainable development • Offers a valuable resource for preparing compounds with multiple stereogenic centers, an important field for synthetic chemists • Organizes chapters by molecular structure of final products, making for a handbook-style resource • Discusses applications of the synthesis of natural products and of drug intermediates • Brings together otherwise-scattered information about a number of key, efficient chemical reactions

C-H Activation for Asymmetric Synthesis

Françoise Colobert,Joanna Wencel-Delord
C H Activation for Asymmetric Synthesis Book PDF

Author : Françoise Colobert,Joanna Wencel-Delord
Publisher : John Wiley & Sons
Page : 356 pages
File Size : 45,9 Mb
Release : 2019-08-29
Category : Science
ISBN : 9783527810864

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C-H Activation for Asymmetric Synthesis by Françoise Colobert,Joanna Wencel-Delord Pdf

Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed. Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods. -Covers one of the most rapidly developing fields in organic synthesis and catalysis -Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds) -Edited by two leading experts in C-H activation in asymmetric synthesis CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.

Stereoselective Organocatalysis

Ramon Rios Torres
Stereoselective Organocatalysis Book PDF

Author : Ramon Rios Torres
Publisher : John Wiley & Sons
Page : 581 pages
File Size : 45,5 Mb
Release : 2013-04-29
Category : Science
ISBN : 9781118604700

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Stereoselective Organocatalysis by Ramon Rios Torres Pdf

Sets forth an important group of environmentally friendly organic reactions With contributions from leading international experts in organic synthesis, this book presents all the most important methodologies for stereoselective organocatalysis, fully examining both the activation mode as well as the type of bond formed. Clear explanations guide researchers through all the most important methods used to form key chemical bonds, including carbon-carbon (C–C), carbon-nitrogen (C–N), and carbon-halogen (C–X) bonds. Moreover, readers will discover how the use of non-metallic catalysts facilitates a broad range of important reactions that are environmentally friendly and fully meet the standards of green chemistry. Stereoselective Organocatalysis begins with an historical overview and a review of activation modes in asymmetric organocatalysis. The next group of chapters is organized by bond type, making it easy to find bonds according to their applications. The first of these chapters takes a detailed look at the many routes to C–C bond formation. Next, the book covers: Organocatalytic C–N bond formation C–O bond formation C–X bond formation C–S, C–Se, and C–B bond formation Enantioselective organocatalytic reductions Cascade reactions forming both C–C bonds and C–heteroatom bonds The final chapter is devoted to the use of organocatalysis for the synthesis of natural products. All the chapters in the book are extensively referenced, serving as a gateway to the growing body of original research reports and reviews in the field. Based on the most recent findings and practices in organic synthesis, Stereoselective Organocatalysis equips synthetic chemists with a group of organocatalytic reactions that will help them design green reactions and overcome many challenges in organic synthesis.

Enantioselective C-C Bond Forming Reactions

Anonim
Enantioselective C C Bond Forming Reactions Book PDF

Author : Anonim
Publisher : Elsevier
Page : 338 pages
File Size : 46,5 Mb
Release : 2023-12-01
Category : Science
ISBN : 9780443237003

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Enantioselective C-C Bond Forming Reactions by Anonim Pdf

Enantioselective C-C Bond Forming Reactions: From Metal Complex-, Organo-, and Bio-catalyzed Perspectives, Volume 73 in the Advances in Catalysis series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as An introduction to Chirality, Metal-catalyzed stereoselective C-C-bond forming reactions, Enantioselective C-C bond forming reactions promoted by organocatalysts based on unnatural amino acid derivatives, Enantioselective C-C bond formation in complex multicatalytic system, Gold-based multicatalytic systems for enantioselective C-C Bond forming reactions, Novel enzymatic tools for C-C bond formation through the development of new-to-nature biocatalysis, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Advances in Catalysis serials Updated release includes the latest information in the field

Stereoselective Synthesis in Organic Chemistry

Atta-ur-Rahman,Zahir Shah
Stereoselective Synthesis in Organic Chemistry Book PDF

Author : Atta-ur-Rahman,Zahir Shah
Publisher : Springer
Page : 0 pages
File Size : 51,6 Mb
Release : 2011-12-21
Category : Science
ISBN : 1461383293

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Stereoselective Synthesis in Organic Chemistry by Atta-ur-Rahman,Zahir Shah Pdf

This monumental tome by Prof. Atta-ur-Rahman and Dr. Zahir Shah pres­ ents a broad overall perspective of stereo selectivity in the synthesis of or­ ganic molecules. Thus it treats a problem that is of fundamental importance and will be even more important in the future as the drug industry is required to supply 1000/0 optically pure compounds. After an exposition of general principles, the following subjects are treated: Catalytic Reductions, Heterogeneous Catalytic Hydrogenations, Stereoselective Non-Catalytic Reductions, Stereos elective Carbon-Carbon Bond Forming Reactions, Asymmetric Oxidations, Asymmetric Carbon­ Heteroatom Bond Formations, Enzyme Catalyzed Reactions, Stereo­ selective Free Radical Reactions, and finally Miscellaneous Stereoselective Reactions. For each subject, a wealth of examples are given. The highly selective reactions are mentioned along with reactions that are not. This is helpful as it will teach the practical chemist what to avoid. Much progress has been made in the last two decades in the design of new, very stereoselective reactions which can be applied in industry. For example, and in alphabetical order, we can mention (among other peers): H.C. Brown (hydroboration), D.C. Evans (carbon-carbon bond forma­ tion), R. Noyori (BINAP reagents for hydrogenation), and K.B. Sharpless (epoxidation and dihydroxylation of double bonds). Thus the field has completely changed since the 1950s, when optically pure compounds were always obtained by difficult resolutions of racemates and not by stereoselec­ tive reactions.

Innovative Catalysis in Organic Synthesis

Pher G. Andersson
Innovative Catalysis in Organic Synthesis Book PDF

Author : Pher G. Andersson
Publisher : John Wiley & Sons
Page : 375 pages
File Size : 46,6 Mb
Release : 2012-04-16
Category : Science
ISBN : 9783527646609

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Innovative Catalysis in Organic Synthesis by Pher G. Andersson Pdf

C-H, C-O, C-C, and C-Heteroatom bond forming processes by using metal-ligand approaches for the synthesis of organic compounds of biological, pharmacological and organic nanotechnological utility are the key areas addressed in this book. Authored by a European team of leaders in the field, it brings together innovative approaches for a variety of catalysis reactions and processes frequently applied in organic synthesis into a handy reference work. It covers all major types of catalysis, including homogeneous, heterogeneous, and organocatalysis, as well as mechanistic and computational studies. Special attention is paid to the improvements in efficiency and sustainability of important catalytic processes, such as selective oxidations, hydrogenation, and cross-coupling reactions, and to their utilization in industry. The result is a valuable resource for advanced researchers in both academia and industry, as well as graduate students in organic chemistry aiming for chemo-, regio- or stereoselective synthesis of organic compounds by using novel catalytic systems.

Comprehensive Organic Functional Group Transformations

Alan R. Katritzky,Stanley M. Roberts,Otto Meth-Cohn,Charles Wayne Rees
Comprehensive Organic Functional Group Transformations Book PDF

Author : Alan R. Katritzky,Stanley M. Roberts,Otto Meth-Cohn,Charles Wayne Rees
Publisher : Elsevier
Page : 1452 pages
File Size : 53,6 Mb
Release : 1995
Category : Mathematics
ISBN : 0080423221

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Comprehensive Organic Functional Group Transformations by Alan R. Katritzky,Stanley M. Roberts,Otto Meth-Cohn,Charles Wayne Rees Pdf

This Volume covers the formation of carbon-carbon single-, double- and triple bonds by substitution and addition reactions as well as by various rearrangements. The formation of carbon-carbon multiple bonds by elimination and condensation procedures is fully documented. In addition the synthesis of carbon-hydrogen bonds principally by substitution and addition reactions is featured as is the preparation of a wide variety of carbon-centred anions, cations and radicals.

Organic Chemistry in Action

F. Serratosa,J. Xicart
Organic Chemistry in Action Book PDF

Author : F. Serratosa,J. Xicart
Publisher : Elsevier
Page : 539 pages
File Size : 48,6 Mb
Release : 1996-05-09
Category : Science
ISBN : 0080538142

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Organic Chemistry in Action by F. Serratosa,J. Xicart Pdf

The first edition of this book was welcomed with great enthusiasm by teachers and students. It therefore seemed opportune to publish a second, revised, updated and extended edition. Unfortunately, Professor Fèlix Serratosa died before he could complete this task. Some new material has been added, the more significant changes being:. The book has been restructured into two well-differentiated sections: Part A, dealing with conventional organic synthesis, and Part B, devoted exclusively to computer-assisted organic synthesis and based on the former Chapter 11 and Appendices 2, 3 and 4 of the first edition. As decided in advance, Part B was to be the sole responsibility of Dr. Josep Xicart, who prepared the first versions of the CHAOS (Computerisation and Heuristics Applied to Organic Synthesis) program under the direction of Professor Serratosa.

Organic Reactions, Volume 73

Dennis G. Hall,Hugo Lachance
Organic Reactions Volume 73 Book PDF

Author : Dennis G. Hall,Hugo Lachance
Publisher : John Wiley & Sons
Page : 6 pages
File Size : 45,5 Mb
Release : 2012-05-29
Category : Science
ISBN : 9781118344453

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Organic Reactions, Volume 73 by Dennis G. Hall,Hugo Lachance Pdf

Allylic boron compounds have gained a prominent position as a truly practical class of synthetic reagents in the past twenty-five years. Their main application as a method for the stereoselective synthesis of homoallylic alcohols by allyl-transfer to carbonyl compounds is essentially unmatched. In this process, a new carbon-carbon bond is formed, and up to two new stereogenic centers are created in a predictably controlled manner. Highly effective and general enantioselective variants are available, with countless applications in the total syntheses of polyacetate and polypropionate natural products. Furthermore, the residual allylic unit can be manipulated through a number of different transformations such as oxidative cleavage, olefin metathesis, hydrometalations, and many others. The discovery of Lewis and Brønsted acid catalyzed manifolds recently, has opened new doors for further development of this important reaction. This book provides an up-to-date, comprehensive survey of the literature of this rich chemistry as it pertains to organic synthesis. Consistent with the goal of Organic Reactions, the content and presentation emphasize the preparative aspects of the reactions, giving considerable attention to the scope and limitations of the individual transformations along with detailed experimental procedures. A tabular survey of all examples of carbonyl allylboration used in organic synthesis is presented in nine tables organized by type of allylic boron reagent with listings within each table according to increasing carbon number of the carbonyl substrates. The literature is covered through December 2010, including a new listing of nearly 200 literature citations that supplement the original coverage of 834 references used in the earlier hard cover version of the chapter. Allylboration of Carbonyl Compounds is intended to be a useful, easily read reference book for all practitioners of synthetic organic chemistry working in academic and industrial laboratories.

Biotransformations in Organic Chemistry

Kurt Faber
Biotransformations in Organic Chemistry Book PDF

Author : Kurt Faber
Publisher : Springer
Page : 423 pages
File Size : 43,5 Mb
Release : 2011-07-28
Category : Science
ISBN : 3642173926

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Biotransformations in Organic Chemistry by Kurt Faber Pdf

The use of biocatalysts, employed either as isolated enzymes or whole microbial cells, offers a remarkable arsenal of highly selective transformations for state-of-the-art synthetic organic chemistry. Over the last two decades, this methodology has become an indispensable tool for asymmetric synthesis, not only at the academic level, but also on an industrial scale. This well-established textbook on biocatalysis provides a basis for undergraduate and graduate courses in modern organic chemistry, as well as a condensed introduction into this field. After a basic introduction into the use of biocatalysts—principles of stereoselective transformations, enzyme properties and kinetics—the different types of reactions are explained according to the 'reaction principle', such as hydrolysis, reduction, oxidation, C–C bond formation, etc. Special techniques, such as the use of enzymes in organic solvents, immobilization techniques and modified or artificial enzymes, are treated in a separate section. A final chapter deals with thebasic rules for the safe and practical handling of biocatalysts. In this completely revised 6th edition, emphasis has been given to an improved didactic style including colored graphics in order to facilitate a deeper understanding of the underlying principles. New developments, such as transamination, enzyme promiscuity and applications on industrial scale within the field of 'white biotechnology' are included.

Stereoselective Synthesis of Drugs and Natural Products

Vasyl Andrushko,Natalia Andrushko
Stereoselective Synthesis of Drugs and Natural Products Book PDF

Author : Vasyl Andrushko,Natalia Andrushko
Publisher : John Wiley & Sons
Page : 1836 pages
File Size : 46,9 Mb
Release : 2013-08-16
Category : Science
ISBN : 9781118628331

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Stereoselective Synthesis of Drugs and Natural Products by Vasyl Andrushko,Natalia Andrushko Pdf

Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.

Advances in Heterocyclic Chemistry

Anonim
Advances in Heterocyclic Chemistry Book PDF

Author : Anonim
Publisher : Academic Press
Page : 346 pages
File Size : 46,7 Mb
Release : 2018-01-02
Category : Science
ISBN : 9780128137611

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Advances in Heterocyclic Chemistry by Anonim Pdf

Advances in Heterocyclic Chemistry, Volume 124, is the definitive series in the field—one of great importance to organic chemists, polymer chemists, and many biological scientists. Updates in this new volume include sections on the Organometallic Complexes of Azines, The Literature of Heterocyclic Chemistry, Part XV, Heterocycles Incorporating a Pentacoordinated, Hypervalent Phosphorus Atom, and Tautomerism and the Structure of Azoles: NMR Spectroscopy, amongst other related topics. Written by established authorities in the field, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists Provides the latest comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insights to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds

Multi-component Reactions in Molecular Diversity

Jean-Philippe Goddard,Max Malacria,Cyril Ollivier
Multi component Reactions in Molecular Diversity Book PDF

Author : Jean-Philippe Goddard,Max Malacria,Cyril Ollivier
Publisher : John Wiley & Sons
Page : 198 pages
File Size : 49,6 Mb
Release : 2020-04-28
Category : Science
ISBN : 9781786305114

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Multi-component Reactions in Molecular Diversity by Jean-Philippe Goddard,Max Malacria,Cyril Ollivier Pdf

While very useful for studying syntheses of molecular diversity, multi-component reactions also offer rapid access to a variety of complex molecules that are relevant for biological applications. Multi-component Reactions in Molecular Diversity analyzes these reactions, whether they are realized by organometallic, ionic or even radical processes. It highlights popular methods based on monotype reactions (cascade, tandem, domino) and their efficiency and academic industrial domain are illustrated. This book also investigates the most efficient ways to prepare complex molecules. Multi-component reactions are in tune with the concepts of atom and steps economy, which are of prior importance in all the reported processes ? from the laboratory to the pilot scale. The essential criteria for green chemistry are also examined in the book in detail.

Dienamine Catalysis for Organic Synthesis

Kengadarane Anebouselvy,Dhevalapally B. Ramachary,Indresh Kumar
Dienamine Catalysis for Organic Synthesis Book PDF

Author : Kengadarane Anebouselvy,Dhevalapally B. Ramachary,Indresh Kumar
Publisher : Royal Society of Chemistry
Page : 206 pages
File Size : 51,5 Mb
Release : 2018-03-02
Category : Electronic
ISBN : 9781782620907

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Dienamine Catalysis for Organic Synthesis by Kengadarane Anebouselvy,Dhevalapally B. Ramachary,Indresh Kumar Pdf

In the last decade a new era in asymmetric catalysis has been realised by the discovery of L-proline induced chiral enamines from carbonyls. Inspired by this, researchers have developed many other primary catalytic species in situ, more recently secondary catalytic species such as aminals have been identified for use in asymmetric synthesis. High-yielding asymmetric synthesis of bioactive and natural products through mild catalysis is an efficient approach in reaction engineering. In the early days, synthetic chemists mainly focused on the synthesis of complex molecules, with less attention on the reaction efficiency and eco-friendly conditions. Recent investigations have been directed towards the development of atom economy, eco-friendly and enantioselective synthesis for more targeted and efficient synthesis. Building on the momentum of this rapidly expanding research area, Dienamine catalysis for organic synthesis will provide a comprehensive introduction, from the preformed species, in situ generation and onto their applications in the synthesis of bioactive molecules and natural products.