Stereotaxic Neurosurgery In Laboratory Rodent

Author : Barbara Ferry,Damien Gervasoni,Catherine Vogt
Publisher : Springer Science & Business
Page : 181 pages
File Size : 42,9 Mb
Release : 2014-04-22
Category : Medical
ISBN : 9782817804729

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Stereotaxic Neurosurgery in Laboratory Rodent by Barbara Ferry,Damien Gervasoni,Catherine Vogt Pdf

Stereotaxic neurosurgery in rodents is used by a variety of people working at research laboratories (research staff, technicians, students at animal facilities...). The present handbook presents all the steps necessary to complete a stereotaxic neurosurgery protocol in accordance with current animal welfare guidelines. This book will guide surgeons step by step, from anesthesia to the post-surgery recovery procedures, including asepsis of the surgical tools and surgical zone, analgesia, correctly identifying the reference points on the skull and brain targets, etc. In keeping with the current international trends, the authors above all focus on the following points: the consideration of pain and how to best treat it depending on the type of surgery; and ensuring asepsis. This book will serve as an important reference work and valuable guidebook for the scientific community.

Author : Keith B. J. Franklin,George Paxinos
Publisher : Academic Press
Page : 0 pages
File Size : 40,5 Mb
Release : 2008
Category : Brain
ISBN : 0123743303

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The Mouse Brain in Stereotaxic Coordinates by Keith B. J. Franklin,George Paxinos Pdf

"The Mouse Brain in Stereotaxic Coordinates is the most widely used and cited atlas of the mouse brain in print. It provides researchers and students with both accurate stereotaxic coordinates for laboratory use, and detailed delineations and indexing of structures for reference. The accompanying DVD provides drawings of brains structures that can be used as templates for making figures for publication. The 3rd edition is both a major revision and an expansion of previous editions. Delineations and photographs in the horizontal plane of section now complement the coronal and sagittal series, and all the tissue sections are now shown in high resolution digital color photography. The photographs of the sections and the intermediate sections are also provided on the accompanying DVD in high-resolution JP 2000 format. The delineations of structures have been revised, and naming conventions made consistent with Paxinos and Watson's Rat Brain in Stereotaxic Coordinates, 6th Edition. The 3rd edition of this atlas is now in more practical 14"x11" format for convenient lab use."--Publisher's website.

Author : Miguel A. L. Nicolelis
Publisher : CRC Press
Page : 296 pages
File Size : 47,7 Mb
Release : 2007-12-03
Category : Science
ISBN : 142000641X

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Methods for Neural Ensemble Recordings, Second Edition by Miguel A. L. Nicolelis Pdf

In the last ten years neural ensemble recording grew into a well-respected and highly data-lucrative science. New experimental paradigms, including the fabrication of high-density microelectrodes, new surgical implantation techniques, multi-channel signal processing, and the establishment of direct real-time brain-machine interfaces, hold promise not just for neurophysiology research, but also for new-generation prosthetic devices aimed at restoring mobility and communication skills in severely disabled patients. Extensively updated and expanded, Methods for Neural Ensemble Recording, Second Edition distills the current state-of-the-science and provides the nuts and bolts foundation from which to advance the field for the next ten years. With contributions from pioneering researchers, this second edition begins with an overview of microwire array design for chronic neural recordings. Demonstrating the diversity now enjoyed in the field, the book reviews new surgical techniques for chronic implantation of microwire arrays in not just rodents, but primates as well. It explores microelectrode microstimulation of brain tissue, discusses multielectrode recordings in the somatosensory system and during learning, and analyzes neural ensemble recordings from the central gustatory-reward pathways in awake and behaving animals. An exploration of new strategies for neural ensemble data analysis for Brain-Machine Interface (BMI) applications foreshadows an investigation into employing BMI to restore neurological function. Using multielectrode field potential recordings, contributions define global brain states and propose conceptual and technical approaches to human neural ensemble recordings in the future.

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research
Publisher : National Academies Press
Page : 223 pages
File Size : 51,7 Mb
Release : 2003-08-22
Category : Science
ISBN : 9780309167857

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Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research Pdf

Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Author : Firas H. Kobeissy
Publisher : CRC Press
Page : 725 pages
File Size : 45,5 Mb
Release : 2015-02-25
Category : Science
ISBN : 9781466565999

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Brain Neurotrauma by Firas H. Kobeissy Pdf

Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result in death. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma, including brain injury pathophysiology, biomarker research, experimental models of CNS injury, diagnostic methods, and neurotherapeutic interventions as well as neurorehabilitation strategies in the field of neurotraum research. The book includes several sections on neurotrauma mechanisms, biomarker discovery, neurocognitive/neurobehavioral deficits, and neurorehabilitation and treatment approaches. It also contains a section devoted to models of mild CNS injury, including blast and sport-related injuries. Over the last decade, the field of neurotrauma has witnessed significant advances, especially at the molecular, cellular, and behavioral levels. This progress is largely due to the introduction of novel techniques, as well as the development of new animal models of central nervous system (CNS) injury. This book, with its diverse coherent content, gives you insight into the diverse and heterogeneous aspects of CNS pathology and/or rehabilitation needs.

Author : Eila Kaliste
Publisher : Springer Science & Business Media
Page : 351 pages
File Size : 48,6 Mb
Release : 2007-04-18
Category : Science
ISBN : 9781402022715

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The Welfare of Laboratory Animals by Eila Kaliste Pdf

This book examines the general principles of laboratory animal maintenance and experimental use as well as factors that have to be taken into account when good research is done with animals. In addition, it provides species specific coverage, concentrating on the species most used as laboratory animals. The book gives a comprehensive description of the welfare questions considered to be important for each species under laboratory conditions.

Author : Animal Welfare Institute
Publisher : Unknown
Page : 106 pages
File Size : 40,6 Mb
Release : 1956*
Category : Animal welfare
ISBN : OCLC:4854072

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Comfortable Quarters for Laboratory Animals by Animal Welfare Institute Pdf

Author : Monica Levy Andersen,Sergio Tufik
Publisher : Springer
Page : 516 pages
File Size : 52,6 Mb
Release : 2015-11-26
Category : Medical
ISBN : 9783319115788

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Rodent Model as Tools in Ethical Biomedical Research by Monica Levy Andersen,Sergio Tufik Pdf

​The objective of this book is to concisely present information with respect to appropriate use of experimental rodents in research. The principles elaborated seek to provide knowledge of the techniques involved in both management and scientific research to all who use laboratory animals, with a focus on the well-being and ethics regarding rodents and also to fortify the awareness of the importance of the animal as a study object and to offer orientation and assistance in conducting laboratory research, education or tests.

Author : Jean-Claude Béïque,Yves De Koninck,Edward S. Ruthazer
Publisher : Frontiers Media SA
Page : 250 pages
File Size : 44,5 Mb
Release : 2022-07-01
Category : Science
ISBN : 9782889764815

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Shedding Light on the Nervous System: Progress in Neurophotonics Research by Jean-Claude Béïque,Yves De Koninck,Edward S. Ruthazer Pdf

Author : Andres M. Lozano,Andres M.. Lozano,Philip L. Gildenberg,Ronald R. Tasker
Publisher : Springer Science & Business Media
Page : 3247 pages
File Size : 42,8 Mb
Release : 2009-06-22
Category : Medical
ISBN : 9783540699590

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Textbook of Stereotactic and Functional Neurosurgery by Andres M. Lozano,Andres M.. Lozano,Philip L. Gildenberg,Ronald R. Tasker Pdf

This book covers stereotactic principles as well as functional stereotaxis, covering the history and uses of the techniques, treatments for specific conditions, and future developments. Includes a DVD demonstrating surgical procedures.

Author : Anonim
Publisher : Unknown
Page : 208 pages
File Size : 45,6 Mb
Release : 1980
Category : Animal experimentation
ISBN : 0919087108

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Guide to the Care and Use of Experimental Animals by Anonim Pdf

Author : Miroslaw Janowski
Publisher : Humana
Page : 0 pages
File Size : 55,6 Mb
Release : 2016-06-08
Category : Medical
ISBN : 1493937286

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Experimental Neurosurgery in Animal Models by Miroslaw Janowski Pdf

This volume provides a full explanation and technical details to perform surgical techniques properly on small and large animal models. The first six chapters of Experimental Neurosurgery in Animal Models focus primarily on the brain, while the next six chapters concern the spinal cord in rodents. The last four chapters provide a description of operative procedures in large animals. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory. Authoritative and practical, Experimental Neurosurgery in Animal Models aims to ensure successful results in the further study of this vital field.

Author : Mitchell Khan
Publisher : Nova Science Publishers
Page : 134 pages
File Size : 44,6 Mb
Release : 2021
Category : Science
ISBN : 1536192244

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Human Mesenchymal Stem Cells by Mitchell Khan Pdf

"In Chapter 1, the COVID-19 pandemic and the damage mechanisms on the cellular level which can be ameliorated with the cellular therapies is thoroughly evaluated. Previous and ongoing stem cell clinical trial data from diseases with similar symptoms is gathered. All this accumulated data and current clinical trial results indicate that the cellular therapies could be the most effective treatment option for COVID-19 patients to ameliorate the damaged tissues and save lives. In Chapter 2, the authors examine activated mesenchymal stem cells for stroke repair. Stem Cell treatment has shown recovery in animal models of stroke, indicating an improved regenerative and repair potential. Though stem cells are still being used in clinical trials, there is no evidence that they enhance recovery in ischemic stroke patients. Nevertheless, the multipotent mesenchymal stem has widely been explored for stroke recovery. An'Activated MSC' as a therapeutic alternative to tackling ischemic stroke is proposed, thereby the activation of MSCs by cytokines, growth factors, hypoxia, pharmacological drugs, etc., could be a novel approach to improving stroke patients' responses to receiving MSCs. In Chapter 3, the potential benefits of in vitro culture of therapeutic stem cells in the presence of HB along with the ketogenic diet, whereby higher physiological concentrations of ketone bodies can be achieved in vivo, as an adjuvant to stem cell transplantation is assessed"--

Author : John R. Smythies,Lawrence Edelstein,Vilayanur S. Ramachandran
Publisher : Academic Press
Page : 408 pages
File Size : 46,7 Mb
Release : 2013-11-11
Category : Science
ISBN : 9780124047228

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The Claustrum by John R. Smythies,Lawrence Edelstein,Vilayanur S. Ramachandran Pdf

The present day is witnessing an explosion of our understanding of how the brain works at all levels, in which complexity is piled on complexity, and mechanisms of astonishing elegance are being continually discovered. This process is most developed in the major areas of the brain, such as the cortex, thalamus, and striatum. The Claustrum instead focuses on a small, remote, and, until recently, relatively unknown area of the brain. In recent years, researchers have come to believe that the claustrum is concerned with consciousness, a bold hypothesis supported by the claustrum’s two-way connections with nearly every other region of the brain and its seeming involvement with multisensory integrations—the hallmark of consciousness. The claustrum, previously in a humble position at the back of the stage, might in fact be the conductor of the brain’s orchestra. The Claustrum brings together leading experts on the claustrum from the varied disciplines of neuroscience, providing a state-of-the-art presentation of what is currently known about the claustrum, promising lines of current research (including epigenetics), and projections of new lines of investigation on the horizon. Develops a unifying hypothesis about the claustrum’s role in consciousness, as well as the integration of sensory information and other higher brain functions. Discusses the involvement of the claustrum with autism, schizophrenia, epilepsy, Alzheimer’s disease, and Parkinson’s disease Coverage of all aspects of the claustrum, from its evolution and development to promising new lines of research, including epigenetics, provides a platform and point of reference for future investigative efforts

Author : Alexandra J. Golby
Publisher : Academic Press
Page : 536 pages
File Size : 48,6 Mb
Release : 2015-05-05
Category : Medical
ISBN : 9780128011898

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Image-Guided Neurosurgery by Alexandra J. Golby Pdf

Image-Guided Neurosurgery provides readers with an update on the revolutionary improvements in imaging and visualization relating to neurosurgery. From the development of the pneumoencephalogram, to the operating microscope, to cross sectional imaging with CT and later MRI, to stereotaxy and neuronavigation, the ability to visualize the pathology and surrounding neural structures has been the driving factor leading surgical innovation and improved outcomes. The book provides a comprehensive reference on the application of contemporary imaging technologies used in neurosurgery. Specific techniques discussed include brain biopsies, brain tumor resection, deep brain stimulation, and more. The book is ideal for neurosurgeons, interventional radiologists, neurologists, psychiatrists, and radiologists, as well as technical experts in imaging, image analysis, computer science, and biomedical engineering. A comprehensive reference on image-guided neurosurgery Includes coverage of neuronavigation in cranial surgery and advanced imaging, including functional imaging, adoption of intra-operative MRI and emerging technologies Covers all image-guided neurosurgery tools, including robotic surgical devices Ideal reference for topics relating to neurosurgery, imaging, stereotaxis, radiosurgery, radiology, epilepsy, MRI, the use of medical robotics, lasers, and more