Stromal Immunology

Author : Benjamin M.J Owens,Matthew A. Lakins
Publisher : Springer
Page : 151 pages
File Size : 54,5 Mb
Release : 2018-08-28
Category : Medical
ISBN : 9783319781273

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Stromal Immunology by Benjamin M.J Owens,Matthew A. Lakins Pdf

Research into and interest in the role of stromal cells in immunology has exploded over the past 15 years. The conventional view that placed non-hematopoietic stromal cells as passive, structural, and supportive entities has now been replaced with an appreciation that these cells have active, dynamic roles during immune responses, and thus impact on the pathophysiology of multiple immune-mediated diseases. This book serves to provide solid grounding in the fundamentals of stromal immunology, focusing on the biological aspects of their function in addition to highlighting key areas for the development of the field in the future. The book is also a unique source of information on emerging concepts that place stromal cells from outside lymphoid organs as major contributors to the biology of diverse conditions, such as rheumatoid arthritis, chronic parasitic infection, inflammatory bowel disease, and cancer.

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 42,6 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : Anthony Carter,Vibeke Dantzer,Thomas Jansson
Publisher : Boydell & Brewer
Page : 456 pages
File Size : 50,9 Mb
Release : 1998
Category : Maternal-fetal exchange
ISBN : 1580460437

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The Maternal Fetal Interface by Anthony Carter,Vibeke Dantzer,Thomas Jansson Pdf

The 29 papers contained in this volume look closely at various aspects of what is termed, "The Maternal-Fetal Interface," as it relates to the latest research in placental science. A substantial section of the book is devoted to the troublesome question of vertical transmission of infectious agents: namely, the HIV-1 virus. However, other sections of the volume examine related issues such as drug and toxin transfer across the term placenta and the diversity of placental types and how this can affect a placenta's effectiveness as a barrier. Anthony Carter is at the University of Odense, Denmark Vibeke Dantzer is at the University of Copenhagen, DenmarkThomas Jansson is at the University of Gothenburg, Sweden

Author : Burkhard Ludewig,Mark Christopher Coles,Paul Kaye,Christopher G Mueller
Publisher : Frontiers E-books
Page : 162 pages
File Size : 46,8 Mb
Release : 2014-12-17
Category : Allergy
ISBN : 9782889193622

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Emerging immune functions of non-hematopoietic stromal cells by Burkhard Ludewig,Mark Christopher Coles,Paul Kaye,Christopher G Mueller Pdf

The development and function of the immune system is dependent on interactions between haematopoietic cells and non-hematopoietic stromal cells. The non-hematopoietic stromal cells create the microenvironment in which the immune system operates, providing an architectural landscape for hematopoietic cell-cell interactions and molecular cues governing haematopoietic cell positioning, growth and survival. Not surprisingly, therefore, aberrant stromal cell function has recently been shown to play a key role in the development of disease pathologies associated with immune dysfunction. For example, remodelling of lymphoid tissue stroma and the development of ectopic tertiary lymphoid tissues are characteristic of many infectious and inflammatory diseases and stromal cells have a recognised role in lymphoma and tumour development and resistance to therapy. An increased understanding of the molecular basis of stromal cell differentiation and function in these varied contexts will provide new tools to promote research on stromal cell biology and immune dysfunction, and potential new targets for therapeutic intervention in diseases with a major impact on public health. The importance of stromal cells and the molecular mechanisms of stromal cell function in the regulation of immune responses have only recently been appreciated and thus represent an exciting new area in immunology.

Author : Takeshi Watanabe,Yousuke Takahama
Publisher : Springer
Page : 200 pages
File Size : 50,5 Mb
Release : 2016-06-09
Category : Medical
ISBN : 9784431560272

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Synthetic Immunology by Takeshi Watanabe,Yousuke Takahama Pdf

This book reviews the emerging studies of synthetic immunology, including the development and regeneration of immune cells, immune organ development and artificial regeneration, and the synthetic approach towards understanding human immune system. Immunology has developed rapidly over the last 50 years through the incorporation of new methods and concepts in cell and molecular biology, genetics, genomics and proteomics. This progress is the result of works by many excellent researchers all over the world. Currently, immunological research has accumulated detailed knowledge on basic mechanisms of immunity and is in the process to change medical practices. Yet, due to the enormous complexity of the immune system, many aspects on the regulation and function of this system remain unknown. Synthetic biology uses gain-of-function rather than loss-of-function approaches. The goals of synthetic biology can be described in a simple phrase “rebuild, alter, and understand,” namely, to rebuild minimal functional systems using well-defined parts from nature and then to perturb the system to understand its working principles. Given the richness of accumulated knowledge in molecular and cellular mechanisms of the immune system, we now begin adapting the concepts of synthetic biology to immunology. An immune response is a spatiotemporal phenomenon occurring at a given time and at a specialized place in the body. One goal of synthetic immunology is to reconstruct artificial microenvironments for better understanding of an immune response. We hope this yet-to-be-experimental approach of synthetic immunology and the compilation of this book will aid our further understanding of the immune system and future devising the tools to manipulate the immune system for therapy and prevention of the diseases.

Author : Nima Rezaei
Publisher : Springer Nature
Page : 681 pages
File Size : 52,8 Mb
Release : 2020-09-24
Category : Medical
ISBN : 9783030502874

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Cancer Immunology by Nima Rezaei Pdf

This translational, clinically oriented book describes in detail novel approaches to cancer immunotherapy, current strategies to target tumor immunosuppression, and prognostic biomarkers for personalized cancer treatments. Since the first, very successful edition of the book was published in 2015, the original chapters have been significantly updated and entirely new chapters are included on, for example, cancer immunoprevention, aptamer-mediated cancer gene therapy, haploidentical bone marrow transplantation for pediatric malignancies, and nanoimmunotherapy. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and cancer immunotherapy for organ-specific tumors. Cancer Immunology: Bench to Bedside Immunotherapy of Cancers will be of special value to clinical immunologists, hematologists, and oncologists.

Author : Rifat Hamoudi,Daniel Olive,Lucia Conti,Alexander John MacRobert
Publisher : Frontiers Media SA
Page : 563 pages
File Size : 55,9 Mb
Release : 2024-01-02
Category : Medical
ISBN : 9782832541357

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Understanding the Immuno-Oncological Mechanism of Cancer Using Systems Immunology Approaches by Rifat Hamoudi,Daniel Olive,Lucia Conti,Alexander John MacRobert Pdf

Author : Phillip Smith,Richard Blumberg,Thomas MacDonald,Society for Mucosal Immunology
Publisher : Garland Science
Page : 615 pages
File Size : 52,9 Mb
Release : 2020-04-21
Category : Medical
ISBN : 9781000754490

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Principles of Mucosal Immunology by Phillip Smith,Richard Blumberg,Thomas MacDonald,Society for Mucosal Immunology Pdf

This respected graduate-level textbook provides comprehensive and accessible coverage of the basic and clinical aspects of the mucosal immune system, addressing the major components of the mucosal barrier ̶ gastrointestinal, upper and lower respiratory, ocular, and genitourinary mucosal immune systems ̶ in a highly user-friendly style. The editors of and contributors to the book, all internationally-recognized leaders, present the current principles, concepts, and basic processes involved in mucosal immunology, mucosal diseases, and host defense at mucosal surfaces. Topics discussed include the development and structure of the mucosal immune system and its cellular constituents, host-microbe relationships, infection, mucosal diseases, and vaccines. The second edition has been carefully updated throughout to reflect the latest developments from clinical research and key literature has been fully updated.

Author : Sudhir Gupta,Graham Pawelec
Publisher : Frontiers Media SA
Page : 151 pages
File Size : 43,5 Mb
Release : 2019-11-05
Category : Electronic
ISBN : 9782889631100

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Immunology of Aging by Sudhir Gupta,Graham Pawelec Pdf

Author : Darlene A. Dartt,Reza Dana,Patricia D’Amore,Jerry Niederkorn
Publisher : Academic Press
Page : 451 pages
File Size : 42,7 Mb
Release : 2011-02-26
Category : Medical
ISBN : 9780123819758

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Immunology, Inflammation and Diseases of the Eye by Darlene A. Dartt,Reza Dana,Patricia D’Amore,Jerry Niederkorn Pdf

This selection of articles from the Encyclopedia of the Eye provides a comprehensive overview of immunological features, diseases and inflammation of the eye and its support structures and organs. Rather than taking an immunological focus that is strictly suitable for clinicians, the volume offers a considerable basic science background and addresses a broad range of topics - the immune system of the eye, its various disorders, mechanisms of inflammation of the eye and visual system, treatment, wound healing mechanisms, stem cells, and more. The first single volume to integrate comparative studies into a comprehensive resource on the neuroscience of ocular immunology Chapters are carefully selected from the Encyclopedia of the Eye by the world's leading vision researchers The best researchers in the field provide their conclusions in the context of the latest experimental results

Author : Gil Mor
Publisher : Academic Press
Page : 462 pages
File Size : 44,8 Mb
Release : 2021-02-12
Category : Medical
ISBN : 9780128189306

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Reproductive Immunology by Gil Mor Pdf

Reproductive Immunology: Basic Concepts gives a holistic insight into the understanding of the complex interactions between the maternal immune system and the fetal/placental unit necessary for the success of pregnancy. This interaction is critical for the support of the human fetal semiallograft and the protection against infections. The book covers various topics such as B cells, macrophages, T cells, discussion on fetal signals and their impact on maternal reproductive cells such as endometrial cells, mast cells, and the role of fetal Hofbauer cells, the immune regulatory role of glucorticoids, and many other novel topics within the field of reproductive immunology. Edited and written by experts in the field, this book introduces the up-to-date knowledge of the role of the immune system during pregnancy and provides the necessary background to understand pregnancy complications associated with alterations in the functioning of the immune system. The book provides a complete discussion on the immunological aspects of pregnancy and serves as a great tool for research scientists, students, reproductive immunologists and OBGYNs. Shows the detailed evaluation of the knowledge related to each immune cell type in the pregnant and not pregnant uterus Evaluates each immune cell type and its function during specific reproductive events Provides the biological background for understanding the clinical aspects that will be discussed in subsequent volumes in the series

Author : Fritz Melchers
Publisher : Springer Science & Business Media
Page : 212 pages
File Size : 48,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642572760

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Lymphoid Organogenesis by Fritz Melchers Pdf

It has been clear for a long time that after transplantation of a lymphoid organ, hematopoietic stem cells can regenerate the compartments of the organ, provided that the rest of its architecture - the strome, the epithelia and the vessels - is intact. Ahead lies the even greater challenge to assemble also these other architectural elements of a lymphoid organ by transplanting stem cells. The workshop on lymphoid organogenesis was convened to review current knowledge of and experimental skills involved in this grand project to build a lymphoid organ from its individual cellular components.

Author : Mani T. Valarmathi
Publisher : BoD – Books on Demand
Page : 262 pages
File Size : 48,7 Mb
Release : 2019-01-23
Category : Science
ISBN : 9781789849844

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Stromal Cells by Mani T. Valarmathi Pdf

Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ. Stromal/stromal stem cells are fundamentally a heterogeneous population of cells with contradictory differentiation potential depending upon their environmental niche. Stromal cell biology is not only intriguing, but equally stromal cell ontogeny in vivo remains challenging. In recent years there has been substantial advances in our understanding of stromal cell biology, especially stromal cell isolation, characterization, differentiation, and interactions in physiological (epithelial-stromal interactions) as well as pathophysiological (stromal-cancer interactions) contexts. In addition, stromal cells are also utilized more and more as a therapeutic tool not only in the field of gene therapy but also in the translational field of tissue engineering and regenerative medicine. Therefore, the goal of this book is to consolidate the recent advances in the area of stromal/stromal stem cell biology covering a broad range of interrelated topics in a timely fashion and to disseminate that knowledge in a lucid way to a greater scientific audience. This book will prove highly useful for students, researchers, and clinicians in stem cell biology, developmental biology, cancer biology, pathology, oncology, as well as tissue engineering and regenerative medicine. This quick reference will benefit anyone desiring a thorough overview of stromal cell structure, function, and its therapeutic implications.

Author : Takashi Nagasawa
Publisher : Springer Nature
Page : 138 pages
File Size : 54,9 Mb
Release : 2021-12-01
Category : Medical
ISBN : 9783030860165

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Bone Marrow Niche by Takashi Nagasawa Pdf

This volume summarizes recent advances in research on mesenchymal cell populations in the bone marrow. It explores how mesenchymal cells create niches for immune cells in extramedullary organs and it discusses new concepts of lympho-hematopoietic microenvironments. Readers are introduced to the fundamentals of hematopoietic stem cells (HSCs) differentiation to all types of blood cells, including immune cells, in the bone marrow. The book highlights how this process is supported and regulated by the individual microenvironments of stem cells, termed niches. The identity of HSC niches has been subject to longstanding debates. Recent studies identified the population of mesenchymal stem cells as the major cellular component of niches, for hematopoietic stem and progenitor cells (HSPCs) and their candidate developmental origin. Furthermore, candidate cellular niches for immune cells in lymph nodes and adipose and connective tissues were identified. The authors of this volume focus on shared features between those and HSPC niche cells in the bone marrow. Covering latest research results, this book serves as fascinating read for researchers and clinicians in hematology and immunology.

Author : David J Webb
Publisher : Academic Press
Page : 352 pages
File Size : 49,9 Mb
Release : 2013-02-18
Category : Medical
ISBN : 9780124051843

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Immunopharmacology by David J Webb Pdf

This new volume of Advances in Pharmacology explores the current state of Alzheimer's disease research and therapeutics. Chapters cover such topics as the B cell targeted therapies, Lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. Explores the current state of Alzheimer's disease research and therapeutics Chapters cover a variety of topics such as the B cell targeted therapies, lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike