Structure And Intrinsic Disorder In Enzymology

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Structure and Intrinsic Disorder in Enzymology

Munishwar Nath Gupta,Vladimir N. Uversky
Structure and Intrinsic Disorder in Enzymology Book PDF

Author : Munishwar Nath Gupta,Vladimir N. Uversky
Publisher : Elsevier
Page : 529 pages
File Size : 41,5 Mb
Release : 2022-11-17
Category : Science
ISBN : 9780323995344

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Structure and Intrinsic Disorder in Enzymology by Munishwar Nath Gupta,Vladimir N. Uversky Pdf

Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics and functions of intrinsically disordered enzymes, along with valuable notes and technical insights powering new research in this emerging field. Here, more than twenty international experts examine protein flexibility and cryo-enzymology, hierarchies of intrinsic disorder, methods for measurement of disorder in proteins, bioinformatics tools for predictions of structure, disorder and function, protein promiscuity, protein moonlighting, globular enzymes, intrinsic disorder and allosteric regulation, protein crowding, intrinsic disorder in post-translational, and much more. Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial and pharmaceutical labs. Unifies the roles of intrinsic disorder and structure in the functioning of enzymes and proteins Examines a range of enzyme and protein characteristics, their relationship to intrinsic disorder, and methods for study Features chapter contributions from international leaders in the field

Structure and Function of Intrinsically Disordered Proteins

Peter Tompa,Alan Fersht
Structure and Function of Intrinsically Disordered Proteins Book PDF

Author : Peter Tompa,Alan Fersht
Publisher : CRC Press
Page : 359 pages
File Size : 48,9 Mb
Release : 2009-11-18
Category : Science
ISBN : 1420078933

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Structure and Function of Intrinsically Disordered Proteins by Peter Tompa,Alan Fersht Pdf

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug development. Structure and Function of Intrinsically Disordered Proteins thoroughly covers the history up to the latest developments in this field. After examining the principles of protein structure, the classical paradigm, and the history of structural disorder, the book focuses on physical techniques for the identification and characterization of IDPs. It discusses proteomic and bioinformatic approaches and shows how IDPs behave under crowding conditions in living cells. The next several chapters describe the structure, correlating biological processes, and molecular mechanisms of IDPs. The author also explores the evolutionary advancement of structural disorder in proteomes and possible ways of extending the structure-function paradigm to encompass both ordered and disordered states of proteins. He concludes with discussions on the involvement of IDPs in various diseases and how to establish rational drug design through detailed characterization of IDPs. Although drug discovery rates have leveled off, new insight generated by the study of IDPs may offer fresh strategies for drug development. This work illustrates how these proteins defy the structure-function paradigm and play important regulatory and signaling roles.

Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A

Anonim
Dancing protein clouds Intrinsically disordered proteins in health and disease Part A Book PDF

Author : Anonim
Publisher : Academic Press
Page : 0 pages
File Size : 45,9 Mb
Release : 2019-09-12
Category : Science
ISBN : 012816851X

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Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A by Anonim Pdf

"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A

Anonim
Dancing protein clouds Intrinsically disordered proteins in health and disease Part A Book PDF

Author : Anonim
Publisher : Academic Press
Page : 424 pages
File Size : 51,9 Mb
Release : 2019-09-11
Category : Science
ISBN : 9780128168523

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Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A by Anonim Pdf

"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the field

Structure and Function of Intrinsically Disordered Proteins

Peter Tompa,Alan Fersht
Structure and Function of Intrinsically Disordered Proteins Book PDF

Author : Peter Tompa,Alan Fersht
Publisher : Chapman and Hall/CRC
Page : 359 pages
File Size : 41,8 Mb
Release : 2009-11-18
Category : Science
ISBN : 1420078925

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Structure and Function of Intrinsically Disordered Proteins by Peter Tompa,Alan Fersht Pdf

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug development. Structure and Function of Intrinsically Disordered Proteins thoroughly covers the history up to the latest developments in this field. After examining the principles of protein structure, the classical paradigm, and the history of structural disorder, the book focuses on physical techniques for the identification and characterization of IDPs. It discusses proteomic and bioinformatic approaches and shows how IDPs behave under crowding conditions in living cells. The next several chapters describe the structure, correlating biological processes, and molecular mechanisms of IDPs. The author also explores the evolutionary advancement of structural disorder in proteomes and possible ways of extending the structure-function paradigm to encompass both ordered and disordered states of proteins. He concludes with discussions on the involvement of IDPs in various diseases and how to establish rational drug design through detailed characterization of IDPs. Although drug discovery rates have leveled off, new insight generated by the study of IDPs may offer fresh strategies for drug development. This work illustrates how these proteins defy the structure-function paradigm and play important regulatory and signaling roles.

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C

Anonim
Dancing Protein Clouds Intrinsically Disordered Proteins in the Norm and Pathology Part C Book PDF

Author : Anonim
Publisher : Academic Press
Page : 438 pages
File Size : 44,7 Mb
Release : 2021-10-14
Category : Science
ISBN : 9780323853002

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Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C by Anonim Pdf

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more. Provides recent studies on the intrinsically disordered proteins and their functions, along with the involvement of intrinsically disordered proteins in the pathogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams and tables) to help readers delve into the information provided Includes contributions from recognized experts in the field

Intrinsically Disordered Proteins

Vladimir N. Uversky
Intrinsically Disordered Proteins Book PDF

Author : Vladimir N. Uversky
Publisher : Springer
Page : 61 pages
File Size : 53,6 Mb
Release : 2014-08-05
Category : Science
ISBN : 9783319089218

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Intrinsically Disordered Proteins by Vladimir N. Uversky Pdf

In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.

Fuzziness

Monika Fuxreiter,Peter Tompa
Fuzziness Book PDF

Author : Monika Fuxreiter,Peter Tompa
Publisher : Springer Science & Business Media
Page : 190 pages
File Size : 48,7 Mb
Release : 2012-03-07
Category : Medical
ISBN : 9781461406594

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Fuzziness by Monika Fuxreiter,Peter Tompa Pdf

Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.

Instrumental Analysis of Intrinsically Disordered Proteins

Vladimir Uversky,Sonia Longhi
Instrumental Analysis of Intrinsically Disordered Proteins Book PDF

Author : Vladimir Uversky,Sonia Longhi
Publisher : John Wiley & Sons
Page : 792 pages
File Size : 51,6 Mb
Release : 2011-01-31
Category : Science
ISBN : 9780470602607

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Instrumental Analysis of Intrinsically Disordered Proteins by Vladimir Uversky,Sonia Longhi Pdf

Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation provides researchers with a much-needed, comprehensive summary of recent achievements in the methods for structural characterization of intrinsically disordered proteins (IDPs). Chapters discuss: Assessment of IDPs in the living cell Spectroscopic techniques for the analysis of IDPs, including NMR and EPR spectroscopies, FTIR, circular dichroism, fluorescence spectroscopy, vibrational methods, and single-molecule analysis Single-molecule techniques applied to the study of IDPs Assessment of IDP size and shape Tools for the analysis of IDP conformational stability Mass spectrometry Approaches for expression and purification of IDPs With contributions from an international selection of leading researchers, Instrumental Analysis of Intrinsically Disordered Proteins: Assessing Structure and Conformation fills an important need in a rapidly growing field. It is required reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, physiologists, and specialists in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

Structural and Mechanistic Enzymology

Anonim
Structural and Mechanistic Enzymology Book PDF

Author : Anonim
Publisher : Academic Press
Page : 472 pages
File Size : 50,7 Mb
Release : 2012-10-22
Category : Science
ISBN : 9780123983183

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Structural and Mechanistic Enzymology by Anonim Pdf

Both strategies for investigation (computational and experimental) in structural and mechanistic Enzymology have developed to some extent independently. However, over the last few years a trend has emerged for strengthening their integration. This combination not only brings together computations and experiments focused on the same enzymatic problems, but also provides complementary insights into the investigated properties and has a powerful synergy effect. This thematic volume of Advances in Protein Chemistry and Structural Biology focuses on the recent success in structural and mechanistic enzymology and has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches. The selected contributions demonstrate how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design. Focuses on the recent success in structural and mechanistic enzymology Has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches Demonstrates how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design

Fuzziness

Monika Fuxreiter,Peter Tompa
Fuzziness Book PDF

Author : Monika Fuxreiter,Peter Tompa
Publisher : Springer
Page : 0 pages
File Size : 54,9 Mb
Release : 2011-12-14
Category : Medical
ISBN : 1461406587

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Fuzziness by Monika Fuxreiter,Peter Tompa Pdf

Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.

Intrinsically Disordered Proteins (IDPs)

Violet Weber
Intrinsically Disordered Proteins IDPs Book PDF

Author : Violet Weber
Publisher : Unknown
Page : 115 pages
File Size : 50,8 Mb
Release : 2016
Category : Science
ISBN : 163484422X

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Intrinsically Disordered Proteins (IDPs) by Violet Weber Pdf

Intrinsically disordered proteins (IDPs) are biomolecules that do not have a definite 3D structure; their role in the biochemical network of a cell relates to their ability to switch rapidly among different secondary and tertiary structures. The emergence of IDPs has challenged the classical protein structure-function paradigm. IDPs play an important role in cellular regulation, signaling and control in health and disease. However, the unusual biophysics of these proteins makes structural characterization of IDPs and their complexes not only challenging but often resulting in opposite conclusions. This book studies the structural characterization and future directions of IDPs. Chapter One focuses on the DNA-binding IDPs and how intrinsic disorder affects their function. Chapter Two discusses the use of a computer atomistic simulation for the structural analysis of IDPs. The final chapter, Chapter Three, examines two long-standing contradictions concerning dimerization and membrane-binding activities of IDPs; provides an explanation of these discrepancies; and demonstrates how the resolution of these critical issues in the field results in the expanded understanding of cell function with multiple applications in biology and medicine.

Some Key Topics in Chemistry and Biochemistry for Biotechnologists

Munishwar Nath Gupta
Some Key Topics in Chemistry and Biochemistry for Biotechnologists Book PDF

Author : Munishwar Nath Gupta
Publisher : CRC Press
Page : 223 pages
File Size : 42,5 Mb
Release : 2023-08-04
Category : Science
ISBN : 9781000954654

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Some Key Topics in Chemistry and Biochemistry for Biotechnologists by Munishwar Nath Gupta Pdf

The book is aimed at providing an exposure to some important topics which are generally not covered adequately in formal courses in biotechnology. It informs the readers about: How micro-fluidics are proving useful in enzyme kinetics. Chemi-proteomics; combinatorial chemistry and high-throughput screening in the context of drug discovery. How enzymes can be used with gaseous substrates? How to source more robust enzymes from marine resources for diverse applications? Why some nano-materials can be chiral? Synthesis of diverse quantum dots as powerful fluorescent probes in biology. How basics of surface chemistry and immunology are vital in dealing with endemics/pandemics like Covid-19.

Flexible Viruses

Vladimir Uversky,Sonia Longhi
Flexible Viruses Book PDF

Author : Vladimir Uversky,Sonia Longhi
Publisher : John Wiley & Sons
Page : 532 pages
File Size : 46,8 Mb
Release : 2012-02-07
Category : Science
ISBN : 9780470618318

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Flexible Viruses by Vladimir Uversky,Sonia Longhi Pdf

This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.

Enzymes

Robert Allen Copeland
Enzymes Book PDF

Author : Robert Allen Copeland
Publisher : Wiley-VCH
Page : 336 pages
File Size : 54,8 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015037847798

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Enzymes by Robert Allen Copeland Pdf

Supplemented with appendices providing contact information for suppliers of reagents and equipment for enzyme studies, as well as a survey of useful Internet sites and computer software for enzymatic data analysis, Enzymes, Second Edition is the ultimate practical guide for scientists and students in biochemical, pharmaceutical, biotechnical, medicinal, and agricultural/food-related research.