Systemic Sclerosis Recent Advances And New Perspectives
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Systemic Sclerosis - Recent Advances and New Perspectives by Katja Perdan Pirkmajer,Blaž Burja,Katja Lakota Pdf
Systemic sclerosis (SSc) is a multisystem autoimmune disease involving vasculopathy and immune activation that leads to the deposition of extracellular matrix and the development of fibrosis, resulting in cardinal clinical problems. Systemic Sclerosis - Recent Advances and New Perspectives provides a comprehensive overview of the pathophysiology, diagnosis, and specific management of the clinical manifestations of SSc. The book addresses the current understanding of the causes and consequences of inflammatory activation, chromosomal instability, and activating factors. Special emphasis is placed on diagnosis, from the recognition of very early systemic sclerosis and consideration of its treatment to diagnostic methods for microvascular and pulmonary involvement. It also highlights the less life-threatening but very common manifestations of bone and skeletal muscle involvement, which affect patient quality of life.
New Insights into Systemic Sclerosis by Michal Tomcik Pdf
Systemic sclerosis (scleroderma) is an incurable connective tissue disease of unknown etiology. Three key processes play a pivotal role in the pathogenesis: immune dysregulation and inflammation, endothelial injury and vasculopathy, and fibrosis. Tissue fibrosis is the dominant and characteristic feature that affects the skin and visceral organs. Life expectancy of scleroderma patients has improved over recent years, mainly because of better treatment of organ involvement and complications; however, no curative disease-modifying therapies exist to date. This book aims to provide students, trainees, rheumatologists, and other specialists interested in this disease with a comprehensive overview of novel pathogenetic mechanisms, management approaches, and therapeutic targets of several major vascular and fibrotic manifestations, and is useful insight into a number of usually neglected aspects of scleroderma.
Interstitial Lung Diseases: New Insights for the Healthcare Professional: 2013 Edition by Anonim Pdf
Interstitial Lung Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Diagnosis and Screening in a concise format. The editors have built Interstitial Lung Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Interstitial Lung Diseases: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Scleroderma by John Varga,Christopher P. Denton,Fredrick M. Wigley,Yannick Allanore,Masataka Kuwana Pdf
Comprised of the authoritative work of international experts, this fully-updated second edition of Scleroderma builds upon the well-regarded approach in the first edition to provide integrated, concise, and up-to-date synthesis of current concepts of pathogenesis and modern approaches to management of systemic sclerosis (scleroderma). With a multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. The new edition includes extensive updated material based on major developments in the field, with new chapters on personalized medicine, cancer complications, global perspectives on scleroderma, and more. It presents a succinct and thoughtful synthesis of current pathomechanistic concepts, providing a valuable reference tool for basic and translational investigators working in the field. Scleroderma: From Pathogenesis to Comprehensive Management serves as an essential, all-inclusive resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.
Recent Advances in γδ T Cell Biology: New Ligands, New Functions, and New Translational Perspectives by Dieter Kabelitz,Julie Dechanet-Merville Pdf
Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional α/β T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and >95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells. Dieter Kabelitz & Julie Déchanet-Merville
Colorectal cancer is one of the most common malignancies worldwide, and the pathogenesis of this neoplasm is probably one of the most studied. The knowledge obtained over time has led to the development of screening and early diagnosis systems, allowing a significant reduction in the incidence of this neoplasm. However, what is currently known probably represents only the tip of the iceberg of the biology of this tumor. It was recently shown that the gut microbiota may contribute to colorectal cancerogenesis. In addition, several novel targeted therapies are now applied to patients with colorectal carcinoma. Nonetheless, several questions are still unanswered. Could the modulation of the gut microbiota modify the risk of tumor progression or the efficacy of therapies? Are there any predictive biomarkers of the risk of tumor progression or the efficacy of target therapies? Is metastatic colorectal cancer one or more diseases? This book collects a series of scientific articles reflecting part of the state of the art regarding colorectal cancer, seeking to answer these questions.
Autoimmune Diseases: New Insights for the Healthcare Professional: 2013 Edition by Anonim Pdf
Autoimmune Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Genetics. The editors have built Autoimmune Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genetics in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Autoimmune Diseases: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
John Varga,Christopher P. Denton,Fredrick M. Wigley
Author : John Varga,Christopher P. Denton,Fredrick M. Wigley Publisher : Springer Science & Business Media Page : 669 pages File Size : 52,8 Mb Release : 2011-12-21 Category : Medical ISBN : 9781441957733
Scleroderma by John Varga,Christopher P. Denton,Fredrick M. Wigley Pdf
This essential book examines the most up-to-date information on scleroderma, offering a clear and concise synthesis of current concepts in pathogenesis and modern approaches to management. Presents a multidisciplinary approach to scleroderma care.
Author : Sir William Osler Publisher : New York : D. Appleton Page : 1116 pages File Size : 55,9 Mb Release : 1892 Category : Diseases ISBN : UOM:39015036652991
Antibiotics - Antineoplastics—Advances in Research and Application: 2012 Edition by Anonim Pdf
Antibiotics - Antineoplastics—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Antibiotics - Antineoplastics. The editors have built Antibiotics - Antineoplastics—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Antibiotics - Antineoplastics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Antibiotics - Antineoplastics—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Recent Advances in Dermatology: 1 by Shirin Zaheri,Iaisha Ali Pdf
Recent Advances in Dermatology: 1 is the ideal resource for keeping abreast of new developments in this constantly changing field. Written by expert authors and featuring topics such as oral lichen planus, allergic contact dermatitis to cosmetics and toiletries, and benign and malignant penile lesions, each chapter highlights the latest developments of relevance to clinical practice. This book is an invaluable update and revision tool for trainees preparing for postgraduate examinations. 11 chapters summarising important recent advances within the field of dermatology All topics are written in a practical and clinically relevant manner, further enhanced by the 'key points for clinical practice' sections at the end of each chapter Provides an effective exam revision tool for the dermatology portion of the MRCP(UK) and the SCE in Dermatology All chapters written by expert authors ensuring authoritative and accurate content Full colour photographs throughout
Recent Advances in Ophthalmology - 13 by HV Nema,Nitin Nema Pdf
This book is the latest volume in the Recent Advances in Ophthalmology series providing ophthalmic trainees and ophthalmologists with the latest surgical and technological developments in the field. Divided into nineteen chapters, each section is dedicated to a specific topic, explaining symptoms, investigation techniques, imaging, differential diagnosis and treatment methods. The pros and cons of various surgical procedures are covered in depth. This new volume features discussion on types of refractive surgery, the latest endovascular interventions, infection control, new avenues for the treatment and progression of glaucoma and much more. The text includes two editorials covering imaging in glaucoma and intravascular interventions, and is highly illustrated with surgical images and tables. Key points Latest volume in Recent Advances in Ophthalmology series Covers latest surgical and technological developments in the field Features two editorials on imaging in glaucoma and intravascular interventions Previous volume (9789351527909) published in 2015
Judith Fraussen,Deborah K. Dunn-Walters,Veerle Somers,Mirjam van der Burg
Author : Judith Fraussen,Deborah K. Dunn-Walters,Veerle Somers,Mirjam van der Burg Publisher : Frontiers Media SA Page : 232 pages File Size : 54,9 Mb Release : 2022-03-04 Category : Medical ISBN : 9782889745654
