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Systems Biology in Cancer Research and Drug Discovery

Asfar S Azmi

Author : Asfar S Azmi
Publisher : Springer Science & Business Media
Page : 424 pages
File Size : 40,5 Mb
Release : 2012-09-29
Category : Medical
ISBN : 9789400748187

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Systems Biology in Cancer Research and Drug Discovery by Asfar S Azmi Pdf

Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer.

A Practical Guide To Cancer Systems Biology

Juan Hsueh-fen,Huang Hsuan-cheng

Author : Juan Hsueh-fen,Huang Hsuan-cheng
Publisher : World Scientific
Page : 152 pages
File Size : 43,5 Mb
Release : 2017-11-29
Category : Medical
ISBN : 9789813229167

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A Practical Guide To Cancer Systems Biology by Juan Hsueh-fen,Huang Hsuan-cheng Pdf

Systems biology combines computational and experimental approaches to analyze complex biological systems and focuses on understanding functional activities from a systems-wide perspective. It provides an iterative process of experimental measurements, data analysis, and computational simulation to model biological behavior. This book provides explained protocols for high-throughput experiments and computational analysis procedures central to cancer systems biology research and education. Readers will learn how to generate and analyze high-throughput data, therapeutic target protein structure modeling and docking simulation for drug discovery. This is the first practical guide for students and scientists who wish to become systems biologists or utilize the approach for cancer research. Contents: Introduction to Cancer Systems Biology (Hsueh-Fen Juan and Hsuan-Cheng Huang)Transcriptome Analysis: Library Construction (Hsin-Yi Chang and Hsueh-Fen Juan)Quantitative Proteome: The Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) (Yi-Hsuan Wu and Hsueh-Fen Juan)Phosphoproteome: Sample Preparation (Chia-Wei Hu and Hsueh-Fen Juan)Transcriptomic Data Analysis: RNA-Seq Analysis Using Galaxy (Chia-Lang Hsu and Chantal Hoi Yin Cheung)Proteomic Data Analysis: Functional Enrichment (Hsin-Yi Chang and Hsueh-Fen Juan)Phosphorylation Data Analysis (Chia-Lang Hsu and Wei-Hsuan Wang)Pathway and Network Analysis (Chen-Tsung Huang and Hsueh-Fen Juan)Dynamic Modeling (Yu-Chao Wang)Protein Structure Modeling (Chia-Hsien Lee and Hsueh-Fen Juan)Docking Simulation (Chia-Hsien Lee and Hsueh-Fen Juan) Readership: Graduate students and researchers entering the cancer systems biology field. Keywords: Systems Biology;Transcriptomics;Proteomics;Network Biology;Dynamic Modeling;Protein Structure Modeling;Docking Simulation;BioinformaticsReview: Key Features: Written by two active researchers in the fieldCovers both experimental and computational areas in cancer systems biologyStep-by-step instructions help beginners who are interested in creating biological data and analyzing the data by themselvesReaders will gain the skills to generate and analyze omics data and discover potential therapeutic targets and drug candidates

Systems Biomedicine Approaches in Cancer Research

Shailza Singh

Author : Shailza Singh
Publisher : Springer Nature
Page : 170 pages
File Size : 48,5 Mb
Release : 2022-08-10
Category : Science
ISBN : 9789811919534

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Systems Biomedicine Approaches in Cancer Research by Shailza Singh Pdf

This book presents the applications of systems biology and synthetic biology in cancer medicine. It highlights the use of computational and mathematical models to decipher the complexity of cancer heterogeneity. The book emphasizes the modeling approaches for predicting behavior of cancer cells, tissues in context of drug response, and angiogenesis. It introduces cell-based therapies for the treatment of various cancers and reviews the role of neural networks for drug response prediction. Further, it examines the system biology approaches for the identification of medicinal plants in cancer drug discovery. It explores the opportunities for metabolic engineering in the realm of cancer research towards development of new cancer therapies based on metabolically derived targets. Lastly, it discusses the applications of data mining techniques in cancer research. This book is an excellent guide for oncologists and researchers who are involved in the latest cancer research.

Cancer Systems Biology, Bioinformatics and Medicine

Alfredo Cesario,Frederick Marcus

Author : Alfredo Cesario,Frederick Marcus
Publisher : Springer Science & Business Media
Page : 484 pages
File Size : 54,8 Mb
Release : 2011-08-21
Category : Medical
ISBN : 9400715676

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Cancer Systems Biology, Bioinformatics and Medicine by Alfredo Cesario,Frederick Marcus Pdf

This teaching monograph on systems approaches to cancer research and clinical applications provides a unique synthesis, by world-class scientists and doctors, of laboratory, computational, and clinical methods, thereby establishing the foundations for major advances not possible with current methods. Specifically, the book: 1) Sets the stage by describing the basis of systems biology and bioinformatics approaches, and the clinical background of cancer in a systems context; 2) Summarizes the laboratory, clinical, data systems analysis and bioinformatics tools, along with infrastructure and resources required; 3) Demonstrates the application of these tools to cancer research; 4) Extends these tools and methods to clinical diagnosis, drug development and treatment applications; and 5) Finishes by exploring longer term perspectives and providing conclusions. This book reviews the state-of-the-art, and goes beyond into new applications. It is written and highly referenced as a textbook and practical guide aimed at students, academics, doctors, clinicians, industrialists and managers in cancer research and therapeutic applications. Ideally, it will set the stage for integration of available knowledge to optimize communication between basic and clinical researchers involved in the ultimate fight against cancer, whatever the field of specific interest, whatever the area of activity within translational research.

Systems Biology of Cancer

Sam Thiagalingam

Author : Sam Thiagalingam
Publisher : Cambridge University Press
Page : 597 pages
File Size : 49,8 Mb
Release : 2015-04-09
Category : Mathematics
ISBN : 9780521493390

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Systems Biology of Cancer by Sam Thiagalingam Pdf

An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Systems Biology

Hsueh-Fen Juan,Hsuan-Cheng Huang

Author : Hsueh-Fen Juan,Hsuan-Cheng Huang
Publisher : World Scientific
Page : 339 pages
File Size : 44,7 Mb
Release : 2012
Category : Medical
ISBN : 9789814324458

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Systems Biology by Hsueh-Fen Juan,Hsuan-Cheng Huang Pdf

This volume presents an overview of recent developments in systems biology and their applications in cancer-related research. The ongoing advances in our understanding of genomics and proteomics, coupled with the development of new and more robust tools, have led to an emphasis on analyzing biological systems at multiple levels. Thus, there is a need to integrate different types of data into a comprehensive "systems" view. Written by active researchers in the emerging areas, this book gives senior undergraduate students, graduate students and new researchers an idea of where the frontiers of systems biology are and an opportunity to learn high-throughput techniques in use. One of the particular emphases of the book is to elucidate the molecular mechanisms in cancer. The discovery of biomarkers and anti-cancer drugs using systems biology approach is also extensively discussed.

Systems Biology in Drug Discovery and Development

Daniel L. Young,Seth Michelson

Author : Daniel L. Young,Seth Michelson
Publisher : John Wiley & Sons
Page : 398 pages
File Size : 54,9 Mb
Release : 2011-09-23
Category : Medical
ISBN : 9781118016428

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Systems Biology in Drug Discovery and Development by Daniel L. Young,Seth Michelson Pdf

The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.

High Content Screening

Steven A. Haney

Author : Steven A. Haney
Publisher : John Wiley & Sons
Page : 442 pages
File Size : 42,7 Mb
Release : 2008-01-18
Category : Medical
ISBN : 9780470039991

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High Content Screening by Steven A. Haney Pdf

The authoritative reference on High Content Screening (HCS) in biological and pharmaceutical research, this guide covers: the basics of HCS: examples of HCS used in biological applications and early drug discovery, emphasizing oncology and neuroscience; the use of HCS across the drug development pipeline; and data management, data analysis, and systems biology, with guidelines for using large datasets. With an accompanying CD-ROM, this is the premier reference on HCS for researchers, lab managers, and graduate students.

Approaching Complex Diseases

Mariano Bizzarri

Author : Mariano Bizzarri
Publisher : Springer Nature
Page : 493 pages
File Size : 40,5 Mb
Release : 2020-04-17
Category : Medical
ISBN : 9783030328573

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Approaching Complex Diseases by Mariano Bizzarri Pdf

This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.

Systems Biology in Biotech & Pharma

Ales Prokop,Seth Michelson

Author : Ales Prokop,Seth Michelson
Publisher : Springer Science & Business Media
Page : 137 pages
File Size : 42,9 Mb
Release : 2012-01-05
Category : Medical
ISBN : 9789400728486

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Systems Biology in Biotech & Pharma by Ales Prokop,Seth Michelson Pdf

The US is currently well ahead of the rest of the world in the development and application of SB and its principles especially as they pertain to basic medical research and development. This lead is largely due to its earlier start in the academic arena. However, there is evidence of rapid development in both the UK/EU and Japan, and the gap is narrowing, particularly in the UK. From an industrial point of view, the Pharmaceutical Industry based in the US and UK can capitalize on these opportunities and gain the benefits of this technology. Many educational institutions (particularly their medical divisions) at present are heavily business-oriented, realize that in this particular industrial environment, that every dollar counts.

Systems Cancer Biology

Bor-Sen Chen

Author : Bor-Sen Chen
Publisher : Cambridge Scholars Publishing
Page : 632 pages
File Size : 43,9 Mb
Release : 2021-07-13
Category : Medical
ISBN : 9781527572348

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Systems Cancer Biology by Bor-Sen Chen Pdf

Cancer is a complex and heterogeneous (systematic) disease that exhibits high levels of robustness against various therapeutic interventions. Due to the complex, heterogeneous, and evolving nature of cancer, it is essential for a system-oriented view to be adopted in order to understand the pathogenic mechanism of cancer which will eventually lead to the drug discovery and treatment of patients. This book not only provides new insights from system modeling and large scale experimental data, but also will allow the reader to perceive the systematic characteristics of cancer under some micro-environments. Based on the systems biology method and genome-wide high throughput data, the book presents the PPI network, gene regulatory network and epigenetic network as an integrated genetic and epigenetic cellular network of lung cancer, bladder cancer, thyroid cancer, colorectal cancer, and liver cancer to investigate their core signaling pathways of the carcinogenesis process to identify their corresponding significant carcinogenic biomarkers as drug targets for systems drug discovery and design. Consequently, the book presents the design of a multiple-molecule drug that can target these biomarkers for the therapeutic treatment of cancer with fewer side effects.

Computational Systems Biology of Cancer

Emmanuel Barillot,Laurence Calzone,Philippe Hupe,Jean-Philippe Vert,Andrei Zinovyev

Author : Emmanuel Barillot,Laurence Calzone,Philippe Hupe,Jean-Philippe Vert,Andrei Zinovyev
Publisher : CRC Press
Page : 463 pages
File Size : 52,8 Mb
Release : 2012-08-25
Category : Science
ISBN : 9781439831441

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Computational Systems Biology of Cancer by Emmanuel Barillot,Laurence Calzone,Philippe Hupe,Jean-Philippe Vert,Andrei Zinovyev Pdf

The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models—integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools. Novel Approaches to Fighting Cancer Drawn from the authors’ decade-long work in the cancer computational systems biology laboratory at Institut Curie (Paris, France), Computational Systems Biology of Cancer explains how to apply computational systems biology approaches to cancer research. The authors provide proven techniques and tools for cancer bioinformatics and systems biology research. Effectively Use Algorithmic Methods and Bioinformatics Tools in Real Biological Applications Suitable for readers in both the computational and life sciences, this self-contained guide assumes very limited background in biology, mathematics, and computer science. It explores how computational systems biology can help fight cancer in three essential aspects: Categorising tumours Finding new targets Designing improved and tailored therapeutic strategies Each chapter introduces a problem, presents applicable concepts and state-of-the-art methods, describes existing tools, illustrates applications using real cases, lists publically available data and software, and includes references to further reading. Some chapters also contain exercises. Figures from the text and scripts/data for reproducing a breast cancer data analysis are available at www.cancer-systems-biology.net.

Systems Biology

P. Bringmann,E. Butcher,G. Parry,B. Weiss

Author : P. Bringmann,E. Butcher,G. Parry,B. Weiss
Publisher : Springer Science & Business Media
Page : 184 pages
File Size : 46,7 Mb
Release : 2007-05-26
Category : Medical
ISBN : 9783540313397

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Systems Biology by P. Bringmann,E. Butcher,G. Parry,B. Weiss Pdf

This volume features contributions from participants of an ESRF Workshop on "Systems Biology" held in Berkeley, USA, in November 2005. Significant progress has been made in developing technologies that enable systems interrogations at a molecular level. Recent successes and challenges of applying systems level measurements to the different steps of drug discovery and development in the pharmaceutical industry are summarized.

Cancer Systems Biology, Bioinformatics and Medicine

Alfredo Cesario,Frederick Marcus

Author : Alfredo Cesario,Frederick Marcus
Publisher : Springer
Page : 484 pages
File Size : 51,9 Mb
Release : 2011-08-21
Category : Medical
ISBN : 9400715668

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Cancer Systems Biology, Bioinformatics and Medicine by Alfredo Cesario,Frederick Marcus Pdf

This teaching monograph on systems approaches to cancer research and clinical applications provides a unique synthesis, by world-class scientists and doctors, of laboratory, computational, and clinical methods, thereby establishing the foundations for major advances not possible with current methods. Specifically, the book: 1) Sets the stage by describing the basis of systems biology and bioinformatics approaches, and the clinical background of cancer in a systems context; 2) Summarizes the laboratory, clinical, data systems analysis and bioinformatics tools, along with infrastructure and resources required; 3) Demonstrates the application of these tools to cancer research; 4) Extends these tools and methods to clinical diagnosis, drug development and treatment applications; and 5) Finishes by exploring longer term perspectives and providing conclusions. This book reviews the state-of-the-art, and goes beyond into new applications. It is written and highly referenced as a textbook and practical guide aimed at students, academics, doctors, clinicians, industrialists and managers in cancer research and therapeutic applications. Ideally, it will set the stage for integration of available knowledge to optimize communication between basic and clinical researchers involved in the ultimate fight against cancer, whatever the field of specific interest, whatever the area of activity within translational research.

Animal Models in Cancer Drug Discovery

Asfar Azmi,Ramzi M. Mohammad

Author : Asfar Azmi,Ramzi M. Mohammad
Publisher : Academic Press
Page : 470 pages
File Size : 40,6 Mb
Release : 2019-04-16
Category : Business & Economics
ISBN : 9780128147054

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Animal Models in Cancer Drug Discovery by Asfar Azmi,Ramzi M. Mohammad Pdf

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Systems Biology In Cancer Research And Drug Discovery

Systems Biology in Cancer Research and Drug Discovery by Asfar S Azmi Pdf

A Practical Guide To Cancer Systems Biology by Juan Hsueh-fen,Huang Hsuan-cheng Pdf

Systems Biomedicine Approaches in Cancer Research by Shailza Singh Pdf

Cancer Systems Biology, Bioinformatics and Medicine by Alfredo Cesario,Frederick Marcus Pdf

Systems Biology of Cancer by Sam Thiagalingam Pdf

Systems Biology by Hsueh-Fen Juan,Hsuan-Cheng Huang Pdf

Systems Biology in Drug Discovery and Development by Daniel L. Young,Seth Michelson Pdf

High Content Screening by Steven A. Haney Pdf

Approaching Complex Diseases by Mariano Bizzarri Pdf

Systems Biology in Biotech & Pharma by Ales Prokop,Seth Michelson Pdf

Systems Cancer Biology by Bor-Sen Chen Pdf

Computational Systems Biology of Cancer by Emmanuel Barillot,Laurence Calzone,Philippe Hupe,Jean-Philippe Vert,Andrei Zinovyev Pdf

Systems Biology by P. Bringmann,E. Butcher,G. Parry,B. Weiss Pdf

Cancer Systems Biology, Bioinformatics and Medicine by Alfredo Cesario,Frederick Marcus Pdf

Animal Models in Cancer Drug Discovery by Asfar Azmi,Ramzi M. Mohammad Pdf

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