Animal Models In Cancer Drug Discovery

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Animal Models in Cancer Drug Discovery

Asfar Azmi,Ramzi M. Mohammad
Animal Models in Cancer Drug Discovery Book PDF

Author : Asfar Azmi,Ramzi M. Mohammad
Publisher : Academic Press
Page : 470 pages
File Size : 51,6 Mb
Release : 2019-04-16
Category : Business & Economics
ISBN : 9780128147054

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Animal Models in Cancer Drug Discovery by Asfar Azmi,Ramzi M. Mohammad Pdf

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Animal Models for Human Cancer

Marianne I. Martic-Kehl,Pius August Schubiger
Animal Models for Human Cancer Book PDF

Author : Marianne I. Martic-Kehl,Pius August Schubiger
Publisher : John Wiley & Sons
Page : 272 pages
File Size : 46,7 Mb
Release : 2016-05-18
Category : Medical
ISBN : 9783527695911

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Animal Models for Human Cancer by Marianne I. Martic-Kehl,Pius August Schubiger Pdf

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long-term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development.

Translational Animal Models in Drug Discovery and Development

Xinkang Wang
Translational Animal Models in Drug Discovery and Development Book PDF

Author : Xinkang Wang
Publisher : Bentham Science Publishers
Page : 287 pages
File Size : 40,7 Mb
Release : 2012-10-03
Category : Science
ISBN : 9781608054695

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Translational Animal Models in Drug Discovery and Development by Xinkang Wang Pdf

Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between animal and human disease models, several proposed therapeutic agents in the past decades have been demonstrated to be effective in preclinical models but failed in clinical studies. This e-book focuses on animal models of diseases from a translational perspective and highlights the key advantages and limitations of each model described to facilitate drug discovery and development. A unique feature of the volume is that it contains a selection of details disease models in various therapeutic niches with significant unmet medical needs, including inflammation, neurological diseases, cardiovascular and metabolic diseases, and oncology. This e-book is, therefore, of considerable value to researchers and clinicians involved in drug discovery and development as well as pathology.

In vivo Models for Drug Discovery

José Miguel Vela,Rafael Maldonado,Michel Hamon
In vivo Models for Drug Discovery Book PDF

Author : José Miguel Vela,Rafael Maldonado,Michel Hamon
Publisher : John Wiley & Sons
Page : 600 pages
File Size : 51,8 Mb
Release : 2014-08-11
Category : Medical
ISBN : 9783527333288

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In vivo Models for Drug Discovery by José Miguel Vela,Rafael Maldonado,Michel Hamon Pdf

This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a general introduction to the topic, the expert contributors from research-driven pharmaceutical companies discuss the basic considerations of using animal models, including ethical issues. The main part of the book systematically surveys the most important disease areas for current drug development, from cardiovascular to endocrine disorders, and from infectious to neurological diseases. For each area, the availability of animal models for target validation, hit finding and lead profiling is reviewed, backed by numerous examples of both successes and failures among the use of animal models. The whole is rounded off with a discussion of perspectives and challenges. Key knowledge for drug researchers in industry as well as academia.

Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine

National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Publisher : National Academies Press
Page : 139 pages
File Size : 42,8 Mb
Release : 2018-05-29
Category : Science
ISBN : 9780309471190

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Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use Pdf

Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.

Tumor Models in Cancer Research

Beverly A. Teicher
Tumor Models in Cancer Research Book PDF

Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
Page : 994 pages
File Size : 42,7 Mb
Release : 2001-11-07
Category : Medical
ISBN : 9781592591008

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Tumor Models in Cancer Research by Beverly A. Teicher Pdf

Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Handbook of Animal Models and its Uses in Cancer Research

Surajit Pathak,Antara Banerjee,Atil Bisgin
Handbook of Animal Models and its Uses in Cancer Research Book PDF

Author : Surajit Pathak,Antara Banerjee,Atil Bisgin
Publisher : Springer Nature
Page : 1158 pages
File Size : 48,6 Mb
Release : 2023-01-31
Category : Medical
ISBN : 9789811938245

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Handbook of Animal Models and its Uses in Cancer Research by Surajit Pathak,Antara Banerjee,Atil Bisgin Pdf

This reference book compiles together different animal models in cancer research. It provides knowledge and a better understanding of the advancement of the molecular and cellular mechanisms associated with the progression, formation, and clinical results of various types of cancer from the evidence collected from animal models utilized for cancer research. It discusses animal models for screening anti-cancer drugs and exploration of gene therapy. It presents different methods used to construct cancer animal models and the progress of each animal model in tumor research. The book also highlights the applications of genetic engineering, including CRISP/Cas9, in designing and developing animal models for cancer research. Further, it discusses strategies for modeling animals for investigating growth, metastasis, tumor-associated inflammation and microenvironment, cancer stem cells, tumor heterogeneity, and therapeutic resistance. This book is s a valuable resource for basic and translational cancer researchers, clinicians, and health care.

Alternatives to Animal Testing

Hajime Kojima,Troy Seidle,Horst Spielmann
Alternatives to Animal Testing Book PDF

Author : Hajime Kojima,Troy Seidle,Horst Spielmann
Publisher : Springer
Page : 130 pages
File Size : 41,9 Mb
Release : 2018-12-27
Category : Medical
ISBN : 9789811324475

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Alternatives to Animal Testing by Hajime Kojima,Troy Seidle,Horst Spielmann Pdf

This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.

Tumor Models in Cancer Research

Beverly A. Teicher
Tumor Models in Cancer Research Book PDF

Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
Page : 682 pages
File Size : 42,9 Mb
Release : 2010-12-01
Category : Medical
ISBN : 9781607619680

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Tumor Models in Cancer Research by Beverly A. Teicher Pdf

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.

Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach

Kakoli Bose,Pradip Chaudhari
Unravelling Cancer Signaling Pathways A Multidisciplinary Approach Book PDF

Author : Kakoli Bose,Pradip Chaudhari
Publisher : Springer Nature
Page : 587 pages
File Size : 51,5 Mb
Release : 2019-11-25
Category : Medical
ISBN : 9789813298163

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Unravelling Cancer Signaling Pathways: A Multidisciplinary Approach by Kakoli Bose,Pradip Chaudhari Pdf

Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of therapy that are coming up for its treatment. Other than that, a major portion of the book is focused on studying different disciplines at the interface of biology and other areas of science that are being used to understand cancer biology in depth.

Mouse Models for Drug Discovery

Gabriele Proetzel,Michael V. Wiles
Mouse Models for Drug Discovery Book PDF

Author : Gabriele Proetzel,Michael V. Wiles
Publisher : Humana
Page : 421 pages
File Size : 42,6 Mb
Release : 2016-08-23
Category : Medical
ISBN : 1493961217

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Mouse Models for Drug Discovery by Gabriele Proetzel,Michael V. Wiles Pdf

As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of techniques involving general methods as well as specific disease topics such as type 1 and 2 diabetes, cardiovascular disease, arthritis, skin disorders, cancer, the use of behavioral models for depression and anxiety, neurodegenerative diseases, neuromuscular diseases, and infectious diseases. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy-to-use, Mouse Models for Drug Discovery: Methods and Protocols will stimulate those not familiar with the power of the mouse and its potential for the drug discovery process, and it will encourage the development of new models and new ways to utilize existing models in order to further the use of this dynamic animal in this vital field.

Animal Models for the Development of Cancer Immunotherapy

Seng-Lai Tan
Animal Models for the Development of Cancer Immunotherapy Book PDF

Author : Seng-Lai Tan
Publisher : John Wiley & Sons
Page : 324 pages
File Size : 50,9 Mb
Release : 2022-08-08
Category : Medical
ISBN : 9781119535317

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Animal Models for the Development of Cancer Immunotherapy by Seng-Lai Tan Pdf

Animal Models for the Development of Cancer Immunotherapy Provides readers with a clear understanding of the value and challenges of using common and emerging preclinical models in cancer immunotherapy research and development. Animal models are essential tools for studying a range of issues in preclinical and clinical research on therapies targeting cancerous tumors. As clinical trials of advances in cancer immunotherapy are predicted to outpace preclinical research in the near future, there remains an urgent need to develop better animal models for preclinical evaluation of novel modulators. Animal Models for the Development of Cancer Immunotherapy provides a detailed overview of different preclinical model systems for development of novel cancer immunotherapies while highlighting how key aspects of individual models translate into clinical findings. Covering the introduction, development, and therapeutic applications of animal models for cancer immunotherapy, this comprehensive volume helps pharmacologists identify suitable animal models, design pharmacological or translational studies, and advance their mechanistic understanding of therapeutic agents, and increase the possibility of success for novel immunotherapies in clinical settings. Chapters written by prominent leaders in the field address specific models that evaluate immuno-oncology drugs are supported by in-depth case studies and extensive references throughout. Emphasizes the importance of modeling tumor metastasis in preclinical models for efficient translation of findings into the clinic Explores recently discovered mechanisms of resistance and their preclinical modeling Highlights the unique characteristics and features of autologous and allogeneic approaches for humanization of mouse models Reviews development of bone marrow-liver-thymus (BLT) immune humanized mice and emerging alternative models such as genetically engineered mouse models (GEMM) Discusses alternative animal models for cancer research such as severe combined immunodeficiency (SCID) pigs Animal Models for the Development of Cancer Immunotherapy is an essential resource for scientists and researchers in the pharmaceutical and biotechnology industries, medicinal chemists and biochemists, cell and molecular biologists, pharmacologists, immunologists, and clinicians.

Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine

National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Publisher : National Academies Press
Page : 139 pages
File Size : 41,6 Mb
Release : 2018-06-29
Category : Science
ISBN : 9780309471169

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Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use Pdf

Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.

Animal Models in Light of Evolution

Niall Shanks,C. Ray Greek
Animal Models in Light of Evolution Book PDF

Author : Niall Shanks,C. Ray Greek
Publisher : Universal-Publishers
Page : 445 pages
File Size : 45,6 Mb
Release : 2009
Category : Medical
ISBN : 9781599425023

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Animal Models in Light of Evolution by Niall Shanks,C. Ray Greek Pdf

The central concern of this book is with the "prediction problem" in biomedical research. In particular, the authors examine the use of animal models to predict human responses in drug and disease research. The arguments discussed are drawn from both biological and biomedical theory (with numerous examples and case studies drawn from evolutionary biology, complex systems theory, oncology, teratology, and AIDS research), and analyses of empirical evidence (concerning, for example, data on intra- and inter-species differences revealed by recent results from genome analyses of various species, human population studies, and statistical studies of the predictive utility of animal models). This book comes to the unique conclusion that while animals can be successfully used for many endeavors in science such as basic and comparative research, they cannot be used to predict drug and disease response in humans. The arguments presented are rooted in the history, philosophy, and methodology of biomedical research. This book will be of interest to anyone involved, directly or indirectly, in biomedical research (including physicians, veterinarians and scientists), and anyone interested in the history, philosophy and methodology of science. In contrast to books written by and for the animal rights movement and books written by and for the animal-based research industry, this book honestly examines all sides of the scientific arguments for using animals in science and concludes that each group in turn exaggerates the flaws or strengths of using animals. There are areas in science where animals can be viably used but there are also areas where they cannot be so used. REVIEWS See Philosophies, Ethics, and Humanities in Medicine 17 August 2010

“Humanized” Large Animal Cancer Models: Accelerating Time and Effectiveness of Clinical Trials

Kyle M. Schachtschneider,Gregers Jungersen,Lawrence B. Schook,Dhanansayan Shanmuganayagam
Humanized Large Animal Cancer Models Accelerating Time and Effectiveness of Clinical Trials Book PDF

Author : Kyle M. Schachtschneider,Gregers Jungersen,Lawrence B. Schook,Dhanansayan Shanmuganayagam
Publisher : Frontiers Media SA
Page : 113 pages
File Size : 55,6 Mb
Release : 2019-12-23
Category : Electronic
ISBN : 9782889632497

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“Humanized” Large Animal Cancer Models: Accelerating Time and Effectiveness of Clinical Trials by Kyle M. Schachtschneider,Gregers Jungersen,Lawrence B. Schook,Dhanansayan Shanmuganayagam Pdf

This eBook provides futuristic perspectives with respect to the emerging requirements of large animal cancer models to address unmet clinical needs. As the vast majority of drugs tested in small animal cancer models fail in human clinical trials, there is a need for large animal models to translate results obtained in small animal models to human clinical practice.