Target Product Profile For A Gambiense Human African Trypanosomiasis Test To Identify Individuals To Receive Widened Treatment

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Target product profile for a gambiense human African trypanosomiasis individual test to assess infection in low prevalence settings

Author : World Health Organization
Publisher : World Health Organization
Page : 14 pages
File Size : 51,5 Mb
Release : 2022-12-15
Category : Medical
ISBN : 9789240064195

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Target product profile for a gambiense human African trypanosomiasis individual test to assess infection in low prevalence settings by World Health Organization Pdf

The WHO Department of Control of Neglected Tropical Diseases (NTD) manages a diverse portfolio of twenty diseases, each with its own unique challenges, including the diagnostic aspect. In order to identify and prioritize diagnostic needs, a WHO NTD Diagnostics Technical Advisory Group (DTAG) was formed, and a specific subgroup was created to advise on the human African trypanosomiasis (HAT) diagnostic innovation needs. The purpose of this TPP is to communicate the minimum and ideal characteristics desired to meet the need for a simpler and more performant test able to confirm an infection with Trypanosoma brucei gambiense, usable by non-specialised personnel in the context of disease elimination. The primary target audience is the potential developers of diagnostic tests and the potential donors that could provide funding for this tools that are considered priorities by the experts convened by WHO.

Report of the fifth WHO stakeholders meeting on gambiense and rhodesiense human African trypanosomiasis elimination, Geneva, Switzerland, 7-9 June 2023

Author : World Health Organization
Publisher : World Health Organization
Page : 111 pages
File Size : 45,5 Mb
Release : 2024-05-03
Category : Medical
ISBN : 9789240091238

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Report of the fifth WHO stakeholders meeting on gambiense and rhodesiense human African trypanosomiasis elimination, Geneva, Switzerland, 7-9 June 2023 by World Health Organization Pdf

Concerted efforts by national programmes, supported by public–private partnerships, nongovernmental organizations, donors and academia under the auspices and coordination of the World Health Organization (WHO), have produced important achievements in the control of human African trypanosomiasis (HAT). As a consequence, the disease was targeted for elimination as a public health problem by 2020. The Sixty-sixth World Health Assembly endorsed this goal in resolution WHA66.12 on Neglected tropical diseases, adopted in 2013. National sleeping sickness control programmes (NSSCPs) are core to progressing in the control of the disease and in adapting to the different epidemiological situations. The involvement of different partners, as well as the support and trust of long-term donors, has been crucial for these achievements. More than 20 years of partnership among WHO, Sanofi and Bayer have enabled WHO to strengthen and sustain financial, technical and material support for the implementation of control activities in countries where HAT is endemic. The long-term support from the Government of Belgium, the Bill & Melinda Gates Foundation (BMGF) and other research institutions in the Democratic Republic of the Congo (DRC) has also been essential. WHO convened the fifth stakeholders meeting on the elimination of HAT due to infection with Trypanosoma brucei gambiense (g-HAT) and Trypanosoma brucei rhodesiense (r-HAT) in Geneva, Switzerland, on 7–9 June 2023. The meeting was held again in person after the coronavirus disease (COVID-19) pandemic and jointly for both forms of the disease. The previous meetings on g-HAT held in 2014, 2016 and 2018, as well as on r-HAT in 2015, 2017 and 2019, and jointly for g-HAT and r-HAT in 2021 (8) reinforced the partnership and commitment for HAT elimination and structured the mechanisms of collaboration within the WHO network for HAT elimination. The network includes NSSCPs, groups developing new tools, international and nongovernmental organizations involved in disease control, and donors. Fewer than 1000 cases of HAT annually have been reported over the past 5 years, which is a historic achievement. The area at risk has been substantially reduced. The elimination of HAT as a public health problem at the global level has been achieved. The new road map for neglected tropical diseases (NTDs) 2021−2030 (“the road map”) with the target to interrupt the transmission of g-HAT requires the strengthened and sustained efforts of all stakeholders, national authorities and partners, under WHO coordination. It will take disproportionally high efforts and innovative strategies to find the last cases of g-HAT and neutralize its transmission. Given the limited resources and other competing public health priorities, this is a challenge that requires our joint commitment.

Global report on neglected tropical diseases 2023

Author : World Health Organization
Publisher : World Health Organization
Page : 82 pages
File Size : 40,6 Mb
Release : 2023-01-30
Category : Medical
ISBN : 9789240067295

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Global report on neglected tropical diseases 2023 by World Health Organization Pdf

The Global report on neglected tropical diseases 2023 provides a consolidated, up-to-date assessment of progress towards control, elimination and eradication of 20 diseases and disease groups (NTDs) globally, regionally and nationally. Progress is reported in the context of global commitments, strategies and targets set in the NTD road map 2021-2030. The document covers the first two years of implementation of the road map (2021 and 2022). The information presented is based primarily on epidemiological and programmatic data for interventions conducted in 2021 and gathered in 2022, but the report also describes a wide range of activities and accomplishments that were registered in both 2021 and 2022; comparisons are often made against 2020 and 2019 data, especially with regard to COVID-19 disruptions. It has four sections: Section 1 is an introduction. Section 2 presents the status of the global NTD response. Section 3 charts progress and developments against the three road map pillars. Section 4 sets out priority actions for 2023 and beyond to sustain implementation of the road map and its companion documents. Five annexes to the report provide information for 2021–2022 on regional progress (Annex 1), Weekly Epidemiology Record articles on NTDs (Annex 2), progress and challenges by disease (Annex 3), diagnostic target product profiles (Annex 4) and the status of commitments for donated medicines and health products (Annex 5).

Global report on neglected tropical diseases 2024

Author : World Health Organization
Publisher : World Health Organization
Page : 86 pages
File Size : 44,7 Mb
Release : 2024-05-04
Category : Medical
ISBN : 9789240091535

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Global report on neglected tropical diseases 2024 by World Health Organization Pdf

This document is the second in a series of global reports describing progress towards the 2030 targets set in Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021–2030. It describes a wide range of activities, accomplishments and challenges across the portfolio of NTDs and across all six WHO regions. The report presents epidemiological and programmatic data for 2022, which were gathered, compiled and analysed in 2023. In some cases, 2023 data are available and presented; in other cases, less recent information is included, when 2022 data are not available. In addition, it presents the main facts or events that occurred in 2023. In line with the road map’s companion document Ending the neglect to attain the Sustainable Development Goals: a framework for monitoring and evaluating progress of the road map for neglected tropical diseases 2021−2030, the report includes quantitative information on the status of the overarching, cross-cutting and disease-specific indicators. This is followed by qualitative information on each of the three road map pillars and on regional and country progress. The conclusions of the report and way forward are further complemented by annexes on cross-cutting indicator 6, status of donated medicines for treatment of NTDs, articles on NTDs published in the Weekly Epidemiological Record, target product profiles published as of 31 December 2023 and the list of global NTD reports published by WHO so far.

Investing to Overcome the Global Impact of Neglected Tropical Diseases

Author : World Health Organization
Publisher : World Health Organization
Page : 211 pages
File Size : 45,6 Mb
Release : 2015-08-05
Category : Medical
ISBN : 9789241564861

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Investing to Overcome the Global Impact of Neglected Tropical Diseases by World Health Organization Pdf

"The presence, or absence, of neglected tropical diseases (NTDs) can be seen as a proxy for poverty and for the success of interventions aimed at reducing poverty. Today, coverage of the public-health interventions recommended by the World Health Organization (WHO) against NTDs may be interpreted as a proxy for universal health coverage and shared prosperity - in short, a proxy for coverage against neglect. As the world's focus shifts from development to sustainable development, from poverty eradication to shared prosperity, and from disease-specific goals to universal health coverage, control of NTDs will assume an important role towards the target of achieving universal health coverage, including individual financial risk protection. Success in overcoming NTDs is a "litmus test" for universal health coverage against NTDs in endemic countries. The first WHO report on NTDs (2010) set the scene by presenting the evidence for how these interventions had produced results. The second report (2013) assessed the progress made in deploying them and detailed the obstacles to their implementation. This third report analyses for the first time the investments needed to achieve the scale up of implementation required to achieve the targets of the WHO Roadmap on NTDs and universal coverage against NTDs. INVESTING TO OVERCOME THE GLOBAL IMPACT OF NEGLECTED TROPICAL DISEASES presents an investment strategy for NTDs and analyses the specific investment case for prevention, control, elimination and eradication of 12 of the 17 NTDs. Such an analysis is justified following the adoption by the Sixty-sixth World Health Assembly in 2013 of resolution WHA6612 on neglected tropical diseases, which called for sufficient and predictable funding to achieve the Roadmap's targets and sustain control efforts. The report cautions, however, that it is wise investment and not investment alone that will yield success. The report registers progress and challenges and signals those that lie ahead. Climate change is expected to increase the spread of several vector-borne NTDs, notably dengue, transmission of which is directly influenced by temperature, rainfall, relative humidity and climate variability primarily through their effects on the vector. Investments in vector-borne diseases will avoid the potentially catastrophic expenditures associated with their control. The presence of NTDs will thereby signal an early warning system for climate-sensitive diseases. The ultimate goal is to deliver enhanced and equitable interventions to the most marginalized populations in the context of a changing public-health and investment landscape to ensure that all peoples affected by NTDs have an opportunity to lead healthier and wealthier lives."--Publisher's description.

Paniker's Textbook of Medical Parasitology

Author : C. K. Jayaram Paniker,Sougata Ghosh
Publisher : JP Medical Ltd
Page : 278 pages
File Size : 48,8 Mb
Release : 2017-09-14
Category : Medical
ISBN : 9789352701865

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Paniker's Textbook of Medical Parasitology by C. K. Jayaram Paniker,Sougata Ghosh Pdf

The new edition of this textbook is a complete guide to parasitology for undergraduate medical students. Divided into 23 chapters, each topic has been thoroughly updated and expanded to cover the most recent advances and latest knowledge in the field. The book begins with an overview of parasitology, then discusses numerous different types of parasite, concluding with a chapter on diagnosis methods. Many chapters have been rewritten and the eighth edition of the book features many new tables, flow charts and photographs. Each chapter concludes with a ‘key points’ box to assist with revision. Key points Eighth edition providing undergraduates with a complete guide to parasitology Fully revised text with many new topics, tables and photographs Each chapter concludes with ‘key points’ box to assist revision Previous edition (9789350905340) published in 2013

Working to Overcome the Global Impact of Neglected Tropical Diseases

Author : World Health Organization. Department of Control of Neglected Tropical Diseases,World Health Organization
Publisher : World Health Organization
Page : 184 pages
File Size : 44,8 Mb
Release : 2010
Category : Medical
ISBN : 9789241564090

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Working to Overcome the Global Impact of Neglected Tropical Diseases by World Health Organization. Department of Control of Neglected Tropical Diseases,World Health Organization Pdf

"Neglected tropical diseases (NTDs) blight the lives of a billion people worldwide and threaten the health of millions more. These ancient companions of poverty weaken impoverished populations, frustrate the achievement of health in the Millennium Development Goals and impede global health and economies has convinced governments, donors, the pharmaceutical industry and other agencies, including nongovernmental organizations (NGOs), to invest in preventing and controlling this diverse group of diseases. Global efforts to control "hidden" diseases, such as dracunculiasis (guinea-worm disease), leprosy, gains including the imminent eradication of dracunculiasis. Since 1989 (when most endemic countries began reporting monthly from each endemic village), the number of new dracunculiasis cases has fallen from 892 055 in 12 endemic countries to 3190 in 4 countries in 2009, a decrease of more than 99%. The World Health Organization (WHO) recommends five public-health strategies for the prevention and control of NTDs: preventive chemotherapy; intensified case-management; vector control; the provision of safe water, sanitation and hygiene; and veterinary public health (that is, applying veterinary sciences to ensure the health and well-being of humans). Although one approach and delivered locally." - p. vii

Natural Remedies in the Fight Against Parasites

Author : Hanem Khater,M. Govindarajan,Giovanni Benelli
Publisher : BoD – Books on Demand
Page : 250 pages
File Size : 41,9 Mb
Release : 2017-07-12
Category : Medical
ISBN : 9789535132899

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Natural Remedies in the Fight Against Parasites by Hanem Khater,M. Govindarajan,Giovanni Benelli Pdf

This book emphasizes past and current research efforts about principles of natural control of major parasites affecting humans, animals, and crops. Each chapter is a complete and integrated subject that presents a problem and confers on the safe alternatives to chemicals. This book discusses and updates information about three major topics of natural remedies. The first topic is represented in a chapter outlining important information on biological control of parasites, the second topic is represented in three chapters dealing with botanicals as promising antiparasitic agents, and the last four chapters deal with miscellaneous control strategies against parasites. This easily readable book is designed precisely for students as well as professors linked with the field of parasitic control. We enhanced words with breathing areas in the form of graphical abstracts, figures, photographs, and tables.

Transgenesis and the Management of Vector-Borne Disease

Author : Serap Aksoy
Publisher : Springer Science & Business Media
Page : 187 pages
File Size : 42,9 Mb
Release : 2008-08-21
Category : Science
ISBN : 9780387782256

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Transgenesis and the Management of Vector-Borne Disease by Serap Aksoy Pdf

Parasitic, bacterial and viral agents continue to challenge the welfare of humans, livestock, wild life and plants worldwide. The public health impact and financial consequences of these diseases are particularly hard on the already overburdened economies of developing countries especially in the tropics. Many of these disease agents utilize insect hosts (vectors) to achieve their transmission to mammals. In the past, these diseases were largely controlled by insecticide-based vector reduction strategies. Now, many of these diseases have reemerged in the tropics, recolonizing their previous range, and expanding into new territories previously not considered to be endemic. Habitat change, irrigation practices, atmospheric and climate change, insecticide and drug resistance as well as increases in global tourism, human traffic and commercial activities, have driven the reemergence and spread of vector borne diseases. While these diseases can be controlled through interventions aimed at both their vertebrate and invertebrate hosts, no effective vaccines exist, and only limited therapeutic prospects are available for their control in mammalian hosts. Molecular technologies such as transgenesis, which is the subject of this book, stand to increase the toolbox and benefit disease management strategies.

WHO Interim Guidelines for the Treatment of Gambiense Human African Trypanosomiasis

Author : World Health Organization
Publisher : Unknown
Page : 44 pages
File Size : 50,9 Mb
Release : 2019
Category : Electronic
ISBN : OCLC:1135360434

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WHO Interim Guidelines for the Treatment of Gambiense Human African Trypanosomiasis by World Health Organization Pdf

Human African trypanosomiasis (HAT), or sleeping sickness, is a parasitic infection that is almost invariably fatal unless treated. It is a neglected tropical disease that occurs in sub-Saharan Africa. The incidence of the disease is declining in response to intensive surveillance and control in endemic areas. As a result, HAT is among the neglected tropical diseases targeted by the World Health Organization (WHO) for elimination. WHO maintains exhaustive records of all declared cases; in 2018, a historically low number of cases (less than 1000) was reported. The remarkable progress in the control of gambiense HAT has relied on case-finding and curative treatment, a strategy that interrupts transmission by depleting the reservoir of parasites in humans. This has been combined occasionally with vector control activities. The subject of these guidelines, therefore, is of utmost importance for the continuation of progress to eliminate HAT. The recent approval of a new medicine (fexinidazole) for the treatment of gambiense HAT has opened new possibilities for the management of cases and thus warrants the new WHO recommendations contained herein. While studies of fexinidazole and other therapies are ongoing, these guidelines are considered interim guidelines until new information becomes available. This document focuses on the management of patients affected by gambiense HAT and constitutes an update to the WHO therapeutic guidance issued in 2013.