Who Interim Guidelines For The Treatment Of Gambiense Human African Trypanosomiasis

Author : World Health Organization
Publisher : Unknown
Page : 44 pages
File Size : 53,5 Mb
Release : 2019
Category : Electronic
ISBN : OCLC:1135360434

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WHO Interim Guidelines for the Treatment of Gambiense Human African Trypanosomiasis by World Health Organization Pdf

Human African trypanosomiasis (HAT), or sleeping sickness, is a parasitic infection that is almost invariably fatal unless treated. It is a neglected tropical disease that occurs in sub-Saharan Africa. The incidence of the disease is declining in response to intensive surveillance and control in endemic areas. As a result, HAT is among the neglected tropical diseases targeted by the World Health Organization (WHO) for elimination. WHO maintains exhaustive records of all declared cases; in 2018, a historically low number of cases (less than 1000) was reported. The remarkable progress in the control of gambiense HAT has relied on case-finding and curative treatment, a strategy that interrupts transmission by depleting the reservoir of parasites in humans. This has been combined occasionally with vector control activities. The subject of these guidelines, therefore, is of utmost importance for the continuation of progress to eliminate HAT. The recent approval of a new medicine (fexinidazole) for the treatment of gambiense HAT has opened new possibilities for the management of cases and thus warrants the new WHO recommendations contained herein. While studies of fexinidazole and other therapies are ongoing, these guidelines are considered interim guidelines until new information becomes available. This document focuses on the management of patients affected by gambiense HAT and constitutes an update to the WHO therapeutic guidance issued in 2013.

Author : World Health Organization
Publisher : World Health Organization
Page : 211 pages
File Size : 52,7 Mb
Release : 2015-08-05
Category : Medical
ISBN : 9789241564861

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Investing to Overcome the Global Impact of Neglected Tropical Diseases by World Health Organization Pdf

"The presence, or absence, of neglected tropical diseases (NTDs) can be seen as a proxy for poverty and for the success of interventions aimed at reducing poverty. Today, coverage of the public-health interventions recommended by the World Health Organization (WHO) against NTDs may be interpreted as a proxy for universal health coverage and shared prosperity - in short, a proxy for coverage against neglect. As the world's focus shifts from development to sustainable development, from poverty eradication to shared prosperity, and from disease-specific goals to universal health coverage, control of NTDs will assume an important role towards the target of achieving universal health coverage, including individual financial risk protection. Success in overcoming NTDs is a "litmus test" for universal health coverage against NTDs in endemic countries. The first WHO report on NTDs (2010) set the scene by presenting the evidence for how these interventions had produced results. The second report (2013) assessed the progress made in deploying them and detailed the obstacles to their implementation. This third report analyses for the first time the investments needed to achieve the scale up of implementation required to achieve the targets of the WHO Roadmap on NTDs and universal coverage against NTDs. INVESTING TO OVERCOME THE GLOBAL IMPACT OF NEGLECTED TROPICAL DISEASES presents an investment strategy for NTDs and analyses the specific investment case for prevention, control, elimination and eradication of 12 of the 17 NTDs. Such an analysis is justified following the adoption by the Sixty-sixth World Health Assembly in 2013 of resolution WHA6612 on neglected tropical diseases, which called for sufficient and predictable funding to achieve the Roadmap's targets and sustain control efforts. The report cautions, however, that it is wise investment and not investment alone that will yield success. The report registers progress and challenges and signals those that lie ahead. Climate change is expected to increase the spread of several vector-borne NTDs, notably dengue, transmission of which is directly influenced by temperature, rainfall, relative humidity and climate variability primarily through their effects on the vector. Investments in vector-borne diseases will avoid the potentially catastrophic expenditures associated with their control. The presence of NTDs will thereby signal an early warning system for climate-sensitive diseases. The ultimate goal is to deliver enhanced and equitable interventions to the most marginalized populations in the context of a changing public-health and investment landscape to ensure that all peoples affected by NTDs have an opportunity to lead healthier and wealthier lives."--Publisher's description.

Author : Centers for Disease Control (U.S.)
Publisher : Unknown
Page : 156 pages
File Size : 51,8 Mb
Release : 1988
Category : Accidents
ISBN : WISC:89030643761

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Biosafety in Microbiological and Biomedical Laboratories by Centers for Disease Control (U.S.) Pdf

Author : Jeremy Farrar,Patricia J. Garcia,Peter J Hotez,Thomas Junghanss,Gagandeep Kang,David Lalloo,Nicholas J. White
Publisher : Elsevier Health Sciences
Page : 1638 pages
File Size : 44,9 Mb
Release : 2023-07-14
Category : Medical
ISBN : 9780702079610

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Manson's Tropical Infectious Diseases by Jeremy Farrar,Patricia J. Garcia,Peter J Hotez,Thomas Junghanss,Gagandeep Kang,David Lalloo,Nicholas J. White Pdf

For 125 years, physicians have relied on Manson's Tropical Diseases for a comprehensive clinical overview of this complex and fast-changing field. The fully revised 24th Edition, Dr. Jeremy Farrar, along with an internationally recognized editorial team, global contributors, and expert authors, delivers the latest coverage on parasitic and infectious diseases from around the world. From the difficult to diagnose to the difficult to treat, this highly readable, award-winning reference prepares you to effectively handle whatever your patients may have contracted. Covers all of tropical medicine in a comprehensive manner, general medicine in the tropics, and non-clinical issues regarding public health and ethics. Serves as an indispensable resource for physicians who treat patients with tropical diseases and/or will be travelling to the tropics, or who are teaching others in this area. Contains a new section on 21st Century Drivers of Tropical Medicine, with chapters covering Poverty and Inequality, Public Health in Settings of Conflict and Political Instability, Climate Change, and Medical Product Quality and Public Health. Includes all-new chapters on Surgery in the Topics, Yellow Fever, Systemic Mycoses, and COVID-19. Covers key topics such as drug resistance; emerging and reemerging infections such as Zika, Ebola, and Chikungunya; novel diagnostics such as PCR-based methods; point-of care-tests such as ultrasound; public health in settings of conflict and political instability; and much more. Differentiates approaches for resource-rich and resource-poor areas. Includes reader-friendly features such as highlighted key information, convenient boxes and tables, extensive cross-referencing, and clinical management diagrams.

Author : Anonim
Publisher : World Health Organization
Page : 90 pages
File Size : 50,6 Mb
Release : 2022-06-06
Category : Medical
ISBN : 9789240045040

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Report of the fourth WHO stakeholders meeting on gambiense and rhodesiense human African trypanosomiasis elimination by Anonim Pdf

Author : Christian Burri
Publisher : MDPI
Page : 280 pages
File Size : 52,8 Mb
Release : 2020-06-17
Category : Medical
ISBN : 9783039289639

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Human African Trypanosomiasis (Sleeping Sickness) by Christian Burri Pdf

As it is a goal to eliminate human African trypanosomiasis (HAT; sleeping sickness) as a public health problem by 2020 and interrupt transmission by 2030, this is a good moment to reflect on what we have achieved, what we want to achieve, and what could get in our way. HAT has a reputation for spectacular reappearances, and the latest peak of 40,000 reported and over 300,000 estimated cases only dates back to 1998. Efforts of the WHO and partners as well as the development of simpler and much better-tolerated treatments, improved diagnostics, and vector control tools made it possible to reduce this number by 95%. Case identification and confirmation remain complex and require specific skills, treatment remains error-prone and reports on long-term survivors have emerged, and the relevance of the animal reservoir for T. b. gambiense HAT needs clarification. In addition, to win the “end game” against this massively stigmatized disease, the human factor will play a key role. This Special Issue addresses many of the burning topics about disease elimination in its 12 research and 7 review articles and one case study. The papers critically reflect the approaches used, investigate the mentioned challenges, and propose novel approaches and interventions from various points of view.

Author : Jeremy Farrar,Patricia J. Garcia,Peter J Hotez,Thomas Junghanss,Gagandeep Kang,David Lalloo,Nicholas J. White
Publisher : Elsevier Health Sciences
Page : 1638 pages
File Size : 44,7 Mb
Release : 2023-07-14
Category : Medical
ISBN : 9780702079610

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Manson's Tropical Infectious Diseases by Jeremy Farrar,Patricia J. Garcia,Peter J Hotez,Thomas Junghanss,Gagandeep Kang,David Lalloo,Nicholas J. White Pdf

For 125 years, physicians have relied on Manson's Tropical Diseases for a comprehensive clinical overview of this complex and fast-changing field. The fully revised 24th Edition, Dr. Jeremy Farrar, along with an internationally recognized editorial team, global contributors, and expert authors, delivers the latest coverage on parasitic and infectious diseases from around the world. From the difficult to diagnose to the difficult to treat, this highly readable, award-winning reference prepares you to effectively handle whatever your patients may have contracted. Covers all of tropical medicine in a comprehensive manner, general medicine in the tropics, and non-clinical issues regarding public health and ethics. Serves as an indispensable resource for physicians who treat patients with tropical diseases and/or will be travelling to the tropics, or who are teaching others in this area. Contains a new section on 21st Century Drivers of Tropical Medicine, with chapters covering Poverty and Inequality, Public Health in Settings of Conflict and Political Instability, Climate Change, and Medical Product Quality and Public Health. Includes all-new chapters on Surgery in the Topics, Yellow Fever, Systemic Mycoses, and COVID-19. Covers key topics such as drug resistance; emerging and reemerging infections such as Zika, Ebola, and Chikungunya; novel diagnostics such as PCR-based methods; point-of care-tests such as ultrasound; public health in settings of conflict and political instability; and much more. Differentiates approaches for resource-rich and resource-poor areas. Includes reader-friendly features such as highlighted key information, convenient boxes and tables, extensive cross-referencing, and clinical management diagrams.

Author : World Health Organization
Publisher : World Health Organization
Page : 111 pages
File Size : 53,9 Mb
Release : 2024-05-03
Category : Medical
ISBN : 9789240091238

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Report of the fifth WHO stakeholders meeting on gambiense and rhodesiense human African trypanosomiasis elimination, Geneva, Switzerland, 7-9 June 2023 by World Health Organization Pdf

Concerted efforts by national programmes, supported by public–private partnerships, nongovernmental organizations, donors and academia under the auspices and coordination of the World Health Organization (WHO), have produced important achievements in the control of human African trypanosomiasis (HAT). As a consequence, the disease was targeted for elimination as a public health problem by 2020. The Sixty-sixth World Health Assembly endorsed this goal in resolution WHA66.12 on Neglected tropical diseases, adopted in 2013. National sleeping sickness control programmes (NSSCPs) are core to progressing in the control of the disease and in adapting to the different epidemiological situations. The involvement of different partners, as well as the support and trust of long-term donors, has been crucial for these achievements. More than 20 years of partnership among WHO, Sanofi and Bayer have enabled WHO to strengthen and sustain financial, technical and material support for the implementation of control activities in countries where HAT is endemic. The long-term support from the Government of Belgium, the Bill & Melinda Gates Foundation (BMGF) and other research institutions in the Democratic Republic of the Congo (DRC) has also been essential. WHO convened the fifth stakeholders meeting on the elimination of HAT due to infection with Trypanosoma brucei gambiense (g-HAT) and Trypanosoma brucei rhodesiense (r-HAT) in Geneva, Switzerland, on 7–9 June 2023. The meeting was held again in person after the coronavirus disease (COVID-19) pandemic and jointly for both forms of the disease. The previous meetings on g-HAT held in 2014, 2016 and 2018, as well as on r-HAT in 2015, 2017 and 2019, and jointly for g-HAT and r-HAT in 2021 (8) reinforced the partnership and commitment for HAT elimination and structured the mechanisms of collaboration within the WHO network for HAT elimination. The network includes NSSCPs, groups developing new tools, international and nongovernmental organizations involved in disease control, and donors. Fewer than 1000 cases of HAT annually have been reported over the past 5 years, which is a historic achievement. The area at risk has been substantially reduced. The elimination of HAT as a public health problem at the global level has been achieved. The new road map for neglected tropical diseases (NTDs) 2021−2030 (“the road map”) with the target to interrupt the transmission of g-HAT requires the strengthened and sustained efforts of all stakeholders, national authorities and partners, under WHO coordination. It will take disproportionally high efforts and innovative strategies to find the last cases of g-HAT and neutralize its transmission. Given the limited resources and other competing public health priorities, this is a challenge that requires our joint commitment.

Author : World Health Organization
Publisher : World Health Organization
Page : 94 pages
File Size : 40,6 Mb
Release : 2023-01-06
Category : Medical
ISBN : 9789240062863

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A compendium of indicators for monitoring and evaluating progress of the road map for neglected tropical diseases 2021–2030 by World Health Organization Pdf

This compendium of indicators provides a comprehensive and standardized listing of recommended indicators, including the 70 core indicators presented in the M&E framework. These indicators will also support reporting on strategies described in other road map companion documents to guide action against neglectedtropical diseases include the sustainability framework, the global strategy on water, sanitation and hygiene, the One Health approach and the strategic framework for integrated control and elimination of skin-related neglected tropical diseases. The purpose of this compendium is to guide monitoring and evaluation of programmes and thereby to improve their quality and effectiveness in alignment with the road map goals. It provides a standardized listing of the most widely used indicators relevant to countries, with uniformity in defining indicators to allow comparisons over time and among different programmes. Detailed metadata are provided for each of these indicators to facilitate validity, internal consistency, standardized measurement, estimation methods and comparability of data across countries.

Author : Willias Masocha,Roberto Furlan,Richard Idro
Publisher : Frontiers Media SA
Page : 221 pages
File Size : 50,5 Mb
Release : 2023-05-29
Category : Medical
ISBN : 9782832524299

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Neuroimmunology in Africa by Willias Masocha,Roberto Furlan,Richard Idro Pdf

Author : William P. Howlett
Publisher : Cambridge University Press
Page : 465 pages
File Size : 52,5 Mb
Release : 2015-08-20
Category : Medical
ISBN : 9781107114227

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Neurology in Africa by William P. Howlett Pdf

This practical, comprehensive and highly illustrated book will be invaluable to students and doctors of neurology and internal medicine in Africa.

Author : World Health Organization
Publisher : World Health Organization
Page : 56 pages
File Size : 50,8 Mb
Release : 2023-11-21
Category : Business & Economics
ISBN : 9789240085176

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Paediatric drug optimization for neglected tropical diseases by World Health Organization Pdf

Priority-setting is the first step to enable a targeted approach to research and development. Developing a prioritized drug portfolio of the most needed formulations for children is essential to streamline researchers’ and supplier’s efforts and resources around specific dosage forms and formulations that address most urgent needs for children. In general, due to limited financial incentives, few new drugs are being developed for Neglected Tropical Diseases (NTDs). Several NTDs disproportionately affect children compared to adults and, as is the case like for most diseases affecting adults and children, the burden to children is compounded by lack of inclusion of paediatric populations in clinical trials and/or lack of age-appropriate dosing regimens and formulations. The PADO-NTD exercise concluded with a final meeting organized in September 2023 with representatives from the four prioritized disease areas to reach consensus on a final PADO-NTD priority list, watch list and research questions and discuss transversal issues for the way forward. The meeting report will include summaries of the background, discussions and deliberations of all PADO exercises, and final conclusions and outputs of the overall PADO for NTD exercises.

Author : Anonim
Publisher : World Health Organization
Page : 74 pages
File Size : 54,8 Mb
Release : 2020-03-30
Category : Medical
ISBN : 9789240002296

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Report of the third WHO stakeholders meeting on gambiense human African trypanosomiasis elimination, Geneva, Switzerland, 18-20 April 2018 by Anonim Pdf

Author : Saif ul Islam
Publisher : Elsevier
Page : 422 pages
File Size : 49,9 Mb
Release : 2023-04-29
Category : Medical
ISBN : 9780443187438

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Infectious Diseases by Saif ul Islam Pdf

Infectious Diseases: Smart Study Guide for Medical Students, Residents, Physicians and Clinical Pharmacists attempts to consolidate knowledge and information into a step-by-step process that would be easy to understand, remember, and apply in a clinical setting. High-yield information presented in this book is necessary for medical students and residents. This book has provided information for all disciplines working in infectious diseases, whether students, residents, physicians, pharmacists, or nurses. The book is organized for quick and easy to retrieve information for all professionals. Medical and pharmacotherapeutic information about infectious diseases are combined into one book Consolidates knowledge and information on infectious diseases Presents content that is easy to understand, remember, and apply in a clinical setting High-yield information for students and residents

Author : WHO Expert Committee on the Selection and Use of Essential Medicines
Publisher : WHO
Page : 144 pages
File Size : 53,7 Mb
Release : 2004
Category : Medical
ISBN : IND:30000093001240

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The Selection and Use of Essential Medicines by WHO Expert Committee on the Selection and Use of Essential Medicines Pdf

This report presents the recommendations of the WHO Expert Committee responsible for updating the WHO Model List of Essential Medicines. The first part contains a progress report on the new procedures for updating the Model List and the development of the WHO Essential Medicines Library. It continues with a section on changes made in revising the Model List followed by a review of some sections such as hypertensive medicines and fast track procedures for deleting items. Annexes include the 13th version of the Model List and items on the list sorted according to their 5-level Anatomical Therapeutic Chemical classification codes.