Targeted Drug Delivery

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Targeted Drug Delivery : Concepts and Design

Padma V. Devarajan,Sanyog Jain
Targeted Drug Delivery Concepts and Design Book PDF

Author : Padma V. Devarajan,Sanyog Jain
Publisher : Springer
Page : 788 pages
File Size : 47,5 Mb
Release : 2014-12-08
Category : Medical
ISBN : 9783319113555

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Targeted Drug Delivery : Concepts and Design by Padma V. Devarajan,Sanyog Jain Pdf

This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

Targeted Drug Delivery

Rachael W. Sirianni,Bahareh Behkam
Targeted Drug Delivery Book PDF

Author : Rachael W. Sirianni,Bahareh Behkam
Publisher : Humana Press
Page : 230 pages
File Size : 45,9 Mb
Release : 2018-07-27
Category : Medical
ISBN : 1493986597

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Targeted Drug Delivery by Rachael W. Sirianni,Bahareh Behkam Pdf

This volume looks at the latest techniques used to enable therapeutic molecules to be targeted for site-specific delivery. The chapters in this book discuss topics such as approaches to express biologically derived and synthetic nanocarriers; strategies to assist in nanocarrier targeting to specific cells and tissues; and methods for evaluating delivery and efficiency for new classes of agents. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Targeted Drug Delivery: Methods and Protocols is a valuable resource for anyone interested in understanding the diversity of methods used in this evolving field.

Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer

Prashant Kesharwani
Nanotechnology Based Targeted Drug Delivery Systems for Lung Cancer Book PDF

Author : Prashant Kesharwani
Publisher : Academic Press
Page : 340 pages
File Size : 54,7 Mb
Release : 2019-01-26
Category : Business & Economics
ISBN : 9780128163672

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Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer by Prashant Kesharwani Pdf

Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer is an indispensable resource that will help pharmaceutical scientists and clinical researchers design and develop novel drug delivery systems and devices for the treatment of lung cancer. As recent breakthroughs in nanomedicine are now making it possible to deliver drugs, genes and therapeutic agents to localized areas of disease to maximize clinical benefit, while also limiting unwanted side effects, this book explores promising approaches for the diagnosis and treatment of lung cancer using cutting-edge nanomedical technologies. Topics discussed include polymeric nanoparticles, solid lipid nanoparticles, liposomes, dendrimers, micelles and nanoemulsions. Provides an overview of an array of nanotechnology-based drug delivery systems Examines the design, synthesis and application of different nanocarriers in drug and gene delivery Provides an in-depth understanding of the design of targeted nanotherapeutics and technologies and its implication in various site-specific cancers

Brain Targeted Drug Delivery Systems

Huile Gao,Xiaoling Gao
Brain Targeted Drug Delivery Systems Book PDF

Author : Huile Gao,Xiaoling Gao
Publisher : Academic Press
Page : 499 pages
File Size : 46,8 Mb
Release : 2018-09-20
Category : Medical
ISBN : 9780128140024

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Brain Targeted Drug Delivery Systems by Huile Gao,Xiaoling Gao Pdf

Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain. Provides an overview of brain targeting drug delivery that is useful to both academic and industry-based researchers Discusses key points in developing brain targeting drug delivery systems Summarizes and presents currently available strategies for brain targeting drug delivery Covers not only current studies and their strengths, but also gives insight into the pitfalls of current research

Drug Targeting and Stimuli Sensitive Drug Delivery Systems

Alexandru Mihai Grumezescu
Drug Targeting and Stimuli Sensitive Drug Delivery Systems Book PDF

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Page : 836 pages
File Size : 51,9 Mb
Release : 2018-05-21
Category : Science
ISBN : 9780128136904

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Drug Targeting and Stimuli Sensitive Drug Delivery Systems by Alexandru Mihai Grumezescu Pdf

Drug Targeting and Stimuli Sensitive Drug Delivery Systems covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of nanoplatforms. Written by an internationally diverse group of researchers, it is an important reference resource for both biomaterials scientists and those working in the pharmaceutical industry who are looking to help create more effective drug delivery systems. Shows how the use of nanomaterials can help target a drug to specific tissues and cells Explores the development of stimuli-responsive drug delivery systems Includes case studies to showcase how stimuli responsive nanosystems are used in a variety of therapies, including camptothecin delivery, diabetes and cancer therapy

Surface Modification of Nanoparticles for Targeted Drug Delivery

Yashwant V Pathak
Surface Modification of Nanoparticles for Targeted Drug Delivery Book PDF

Author : Yashwant V Pathak
Publisher : Springer
Page : 499 pages
File Size : 45,9 Mb
Release : 2019-03-11
Category : Medical
ISBN : 9783030061159

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Surface Modification of Nanoparticles for Targeted Drug Delivery by Yashwant V Pathak Pdf

This unique book is the only one to discuss various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles. The understanding of the surface characteristics nano-particles is growing significantly with the advent of new analytical techniques. Polymer chemistry is contributing to the development of many new versatile polymers which have abilities to accommodate many different, very reactive chemical groups, and can be used as a diagnostic tool, for better targeting, for more effective therapeutic results as well as for reducing the toxic and side effects of the drugs. Surface modification of such polymeric nanoparticles has been found by many scientists to enhance the application of nanoparticles and also allows the nano particles to carry specific drug molecule and disease /tumor specific antibodies which refine and improve drug delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery is a collection essential information with various applications of surface modification of nanoparticles and their disease specific applications for therapeutic purposes.

Smart Drug Delivery System

Ali Demir Sezer
Smart Drug Delivery System Book PDF

Author : Ali Demir Sezer
Publisher : BoD – Books on Demand
Page : 400 pages
File Size : 47,5 Mb
Release : 2016-02-10
Category : Medical
ISBN : 9789535122470

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Smart Drug Delivery System by Ali Demir Sezer Pdf

This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis

Padma V. Devarajan,Prajakta Dandekar,Anisha A. D'Souza
Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis Book PDF

Author : Padma V. Devarajan,Prajakta Dandekar,Anisha A. D'Souza
Publisher : Springer Nature
Page : 560 pages
File Size : 45,6 Mb
Release : 2019-11-09
Category : Medical
ISBN : 9783030291686

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Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis by Padma V. Devarajan,Prajakta Dandekar,Anisha A. D'Souza Pdf

This book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in , Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. As a result, many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also emphasize commercial products, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. Finally, we briefly discuss the regulatory and toxicity issues that may be associated specifically with the RME approach of intracellular drug delivery.

Handbook of Lung Targeted Drug Delivery Systems

Yashwant Pathak,Nazrul Islam
Handbook of Lung Targeted Drug Delivery Systems Book PDF

Author : Yashwant Pathak,Nazrul Islam
Publisher : CRC Press
Page : 1065 pages
File Size : 51,5 Mb
Release : 2021-10-18
Category : Medical
ISBN : 9781000450804

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Handbook of Lung Targeted Drug Delivery Systems by Yashwant Pathak,Nazrul Islam Pdf

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems

Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors

Prashant Kesharwani,Umesh Gupta
Nanotechnology Based Targeted Drug Delivery Systems for Brain Tumors Book PDF

Author : Prashant Kesharwani,Umesh Gupta
Publisher : Academic Press
Page : 478 pages
File Size : 47,9 Mb
Release : 2018-04-20
Category : Medical
ISBN : 9780128122495

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Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors by Prashant Kesharwani,Umesh Gupta Pdf

Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies. Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors

Targeted Drug Delivery

Rudolph L. Juliano
Targeted Drug Delivery Book PDF

Author : Rudolph L. Juliano
Publisher : Springer Science & Business Media
Page : 374 pages
File Size : 41,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642758621

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Targeted Drug Delivery by Rudolph L. Juliano Pdf

The chapters in this volume describe a powerful emerging approach for the therapy of disease. Targeted drug delivery, that is control of the kinetic behavior, tissue distribution, and subcellular localization of pharmaco logically active agents, offers an important means for improving the efficacy of a wide variety of drug therapies. This is particularly true for therapeutic approaches based on newer agents which are the products of recombinant DNA research. These agents, be they peptides, proteins, or oligonucleotides, tend to be larger, more complex, and less stable than traditional drugs. Thus they stand to benefit most from drug delivery systems which can protect them from premature degradation and which can carry them to critical target sites in the body. This volume examines several important aspects of the current state of drug delivery research; it also attempts to project future directions for this field. Successful approaches to drug targeting are based, first of all, on a sophisticated understanding of the biological barriers encountered by the drug-carrier complex as it moves from the portal of administration to the ultimate target site. A second aspect of successful drug delivery is appro priate matching of the disease entity with the pharmacologically active substance and with the delivery system. Thus it is important to be aware of the variety of delivery technologies which currently exist and to be sensitive to their strengths and limitations.

Multifunctional Nanoparticles for Drug Delivery Applications

Sonke Svenson,Robert K. Prud'homme
Multifunctional Nanoparticles for Drug Delivery Applications Book PDF

Author : Sonke Svenson,Robert K. Prud'homme
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 41,9 Mb
Release : 2012-02-22
Category : Technology & Engineering
ISBN : 9781461423058

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Multifunctional Nanoparticles for Drug Delivery Applications by Sonke Svenson,Robert K. Prud'homme Pdf

This book clearly demonstrates the progression of nanoparticle therapeutics from basic research to applications. This book, unlike others covering nanoparticles used in medical applications, presents the medical challenges that can be reduced or even overcome by recent advances in nanoscale drug delivery. Each chapter highlights recent progress in the design and engineering of select multifunctional nanoparticles with topics covering targeting, imaging, delivery, diagnostics, and therapy.

Targeted Delivery of Small and Macromolecular Drugs

Ajit S. Narang,Ram I. Mahato
Targeted Delivery of Small and Macromolecular Drugs Book PDF

Author : Ajit S. Narang,Ram I. Mahato
Publisher : CRC Press
Page : 630 pages
File Size : 49,6 Mb
Release : 2010-05-12
Category : Medical
ISBN : 9781420087734

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Targeted Delivery of Small and Macromolecular Drugs by Ajit S. Narang,Ram I. Mahato Pdf

Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice. Focusing on the delivery technologies that utilize both systemic and local rou

Handbook of Research on Advancements in Cancer Therapeutics

Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh
Handbook of Research on Advancements in Cancer Therapeutics Book PDF

Author : Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh
Publisher : IGI Global
Page : 913 pages
File Size : 51,5 Mb
Release : 2020-11-27
Category : Medical
ISBN : 9781799865315

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Handbook of Research on Advancements in Cancer Therapeutics by Kumar, Sumit,Rizvi, Moshahid Alam,Verma, Saurabh Pdf

The complexity of cancer demands an integrated approach from both a cancer biology standpoint and a pharmaceutical basis to understand the different anticancer modalities. Current research has been focused on conventional and newer anticancer modalities, recent discoveries in cancer research, and also the advancements in cancer treatment. There is a current need for more research on the advances in cancer therapeutics that bridge the gap between basic research (pharmaceutical drug development processes, regulatory issues, and translational experimentation) and clinical application. Recent promising discoveries such as immunotherapies, promising therapies undergoing clinical trials, synthetic lethality, carbon beam radiation, and other exciting targeted therapies are being studied to improve and advance the studies of modern cancer treatment. The Handbook of Research on Advancements in Cancer Therapeutics serves as a comprehensive guide in modern cancer treatment by combining and merging the knowledge from both cancer biology and the pharmacology of anticancer modalities. The chapters come from multi-disciplinary backgrounds, including scientists and clinicians from both academia and various industries, to discuss nascent personalized therapies and big data-driven cancer treatment. While highlighting topic areas that include cancer prevention, cancer therapeutics, and cancer treatments through the lenses of technology, medicine/drugs, and alternate therapies, this book is ideally intended for oncologists, radiation oncologists, surgical oncologists, and cancer biologists, along with practitioners, stakeholders, researchers, academicians, and students who are interested in understanding the most fundamental aspects of cancer and the available therapeutic opportunities.

Nanocarriers for Drug Delivery

Shyam Mohapatra,Shivendu Ranjan,Nandita Dasgupta,Raghvendra Kumar,Sabu Thomas
Nanocarriers for Drug Delivery Book PDF

Author : Shyam Mohapatra,Shivendu Ranjan,Nandita Dasgupta,Raghvendra Kumar,Sabu Thomas
Publisher : Elsevier
Page : 0 pages
File Size : 40,9 Mb
Release : 2018-10-10
Category : Science
ISBN : 012814033X

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Nanocarriers for Drug Delivery by Shyam Mohapatra,Shivendu Ranjan,Nandita Dasgupta,Raghvendra Kumar,Sabu Thomas Pdf

Nano-carriers for Drug Delivery: Nanoscience and Nanotechnology in Drug Delivery presents recent discoveries in research on the pharmaceutical applications of the various types of nanosystem-based drug delivery systems. As many nanosystems have reached the market over the past decade, this book proves their benefits to patients. It explores these new carriers and the advances in drug delivery they have facilitated. Reflecting the interdisciplinary nature of the subject matter, the book includes experts from different fields, and with various backgrounds and expertise. It will appeal to researchers and students from different disciplines, such as materials science, technology and various biomedical fields. Coverage includes industrial applications that bridge the gap between lab-based research and practical industrial use. The resulting work is a reference and practical source of guidance for researchers, students and scientists working in the fields of nanotechnology, materials science and technology and biomedical science.