Surface Modification Of Nanoparticles For Targeted Drug Delivery
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Surface Modification of Nanoparticles for Targeted Drug Delivery by Yashwant V Pathak Pdf
This unique book is the only one to discuss various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles. The understanding of the surface characteristics nano-particles is growing significantly with the advent of new analytical techniques. Polymer chemistry is contributing to the development of many new versatile polymers which have abilities to accommodate many different, very reactive chemical groups, and can be used as a diagnostic tool, for better targeting, for more effective therapeutic results as well as for reducing the toxic and side effects of the drugs. Surface modification of such polymeric nanoparticles has been found by many scientists to enhance the application of nanoparticles and also allows the nano particles to carry specific drug molecule and disease /tumor specific antibodies which refine and improve drug delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery is a collection essential information with various applications of surface modification of nanoparticles and their disease specific applications for therapeutic purposes.
Synthesis, Functionalization and Surface Treatment of Nanoparticles by Marie-Isabelle Baraton Pdf
Synthesis, Functionalization and Surface Treatment of Nanoparticles is an area of crucial importance in the emerging field of nanotechnology. Controlling the surface chemical composition and mastering its modification at the nanometer scale are critical issues for high-added value applications involving nanoparticles. The basic applications of surface functionalization range from altering the wetting or adhesion characteristics and improving the nanoparticles dispersion in matrices to enhancing the catalytic properties and ordering the interfacial region, and such. The creation of specific surface sites on nanoparticles for selective molecular attachment is considered a promising approach for their applications in nanofabrication, nanopatterning, selfassembly, nanosensors, bioprobes, drug delivery, pigments, photocatalysis, LEDs, etc. This book presents novel and improved synthesis methods and approaches for controlling and functionalizing the nanoparticle surfaces to enhance the overall performance of the nanoparticles for targeted applications.
Nanotechnology for Cancer Therapy by Mansoor M. Amiji Pdf
While simultaneous breakthroughs occurring in molecular biology and nanoscience/technology will ultimately revolutionize all of medicine, it is with our efforts to prevent, diagnose, and treat cancer that many of the most dramatic advances will occur. In support of this potential, the U.S. National Cancer Institute (NCI) established the Alliance fo
Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration by Sudesh Kumar Yadav Pdf
This book is the first of its kind to offer a comprehensive and up-to-date discussion of the use of nanoscale materials for biomedical applications, with a particular focus on drug delivery, theragnosis and tissue regeneration. It also describes in detail the methods used in the preparation of nanoparticles. Response of nanoparticles in biological systems are also explored. Nanotechnology has led to the advent of a new field, nanomedicine, which focuses on the use of nanomaterials as drug-delivery vehicles to develop highly selective and effective drugs. The combination of molecular imaging and nanotechnology has produced theragnostic nanoparticles, which allow the simultaneous detection and monitoring of diseases. Nanotechnology can also be combined with biomaterials to create scaffolds for tissue regeneration. Further, significant advances have been made in the areas of drug delivery, theragnostic nanoparticles and tissue regeneration materials. Some nanomedicines and tissue regeneration materials are already commercially available, while others are undergoing clinical trials, and promising results have been documented. Despite the rapid advances in nanomedicine, there is a relative dearth of literature on the biomedical applications of nanoscale materials.
Nanoparticles for Drug Delivery by K. S. Joshy,Sabu Thomas,Vijay Kumar Thakur Pdf
This book introduces the reader to drug delivery with specific emphasis on the use of nanoparticles. It covers properties, characterization, and preparation of different types of nanoparticles and discusses recent advances in their structural design and biomedical application, as well as the issues and challenges associated with their design and use. Some of the topics covered include the potential application of nanoparticles in biomedical fields, hazards associated with use of nanoparticles for drug delivery, size-dependent factors in drug delivery applications, different organic, inorganic and their hybrid systems used in drug delivery, etc. It also highlights use of nanoparticles in controlled and targeted drug delivery, and their application in stimuli-responsive, especially pH-responsive, drug release. Additionally, it also focuses on biomimetic nanoparticles, challenges faced in the designing of nanoparticles for drug delivery in cancer, viral and bacterial diseases. The contents of this volume will be useful to researchers and professionals working on advances in targeted drug delivery systems.
Pharmaceutical Nanotechnology by Volkmar Weissig,Tamer Elbayoumi Pdf
This volume details protocols on formulation, surface modification, characterization, and application of a variety of pharmaceutical nanocarriers such as micelles, nanoparticles, dendrimers, carbon dots, polymersomes, and others. Chapters are targeted toward investigators working in academic and industrial laboratories conducting research in the broad field of pharmaceutical sciences, with an emphasis on drug delivery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Pharmaceutical Nanotechnology: Basic Protocols aims to be a source of inspiration to all investigators who are interested in the potential of the merger of nanotechnology with pharmaceutical sciences.
Nanoparticle Toxicity and Compatibility by Jorddy N. Cruz Pdf
The book focuses on the interplay between nanoparticles and biological systems. Topics covered include the synthesis, characterization, and application of nanomaterials in tissue engineering; the interaction of nanoparticles with macromolecules; biomedical and food science applications; the cardiovascular toxicity of nanoparticles; colon targeted nano drug delivery systems; the biocompatibility and immunogenicity of nanoparticles; plasmon-enhanced biosensing applications; strategies for enhancing the biocompatibility of nanoparticles; the environmental impact of nanoparticles; as well as the intricate dynamics between nanoparticles and living organisms. Keywords: Tissue Engineering, Cardiovascular Toxicity, Drug Delivery Systems, Plasmon-Enhanced Biosensing, Biocompatibility of Nanoparticles, Ecotoxicology of Nanoparticles, Bioinspired Nanosynthesis, Hepatotoxicity, Nano Drug Delivery, Nanofabrication, Nanorobots, Plasmonics, Probiotics, Protein.
Diamond-based materials for biomedical applications by A.E. Mengesha,B-B.C. Youan Pdf
Nanodiamonds offer a potential novel template for drug delivery and targeting, because of their small primary particle size, purity, excellent properties, facile surface functionalization, high biocompatibility, and inexpensive large-scale synthesis. However, nanodiamond properties such as aggregation state, surface chemistry, and presence of impurities, as well as the localization and accumulation behavior at the organism level, must be controlled to maintain safety and retain efficacy of conjugated therapeutic agents. A clinically applicable approach requires investigation of biocompatibility, biodistribution, and biological fate of the nanodiamond as well as its conjugates.
Nanoparticulate Drug Delivery Systems by Deepak Thassu,Michel Deleers,Yashwant Vishnupant Pathak Pdf
With the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. Nanoparticulate Drug Delivery Systems addresses the scientific methodologies, formulation, processing, applications, recent trends, and e
Targeted Drug Delivery : Concepts and Design by Padma V. Devarajan,Sanyog Jain Pdf
This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.
Drug Delivery with Targeted Nanoparticles by Yılmaz Çapan,Adem Sahin,Hayrettin Tonbul Pdf
Nanotechnology has the potential to change every part of our lives. Today, nanotechnology-based products are used in many areas, and one of the most important areas is drug delivery. Nanoparticulate drug delivery systems not only provide controlled delivery of drugs and improved drug solubility but also improve drug efficiency and reduce side effects via targeting mechanisms. However, compared with conventional drug delivery systems, few nanoparticle-based products are on the market and almost all are nontargeted or only passively targeted systems. In addition, obtaining targeted nanoparticle systems is quite complex and requires several evaluation mechanisms. This book discusses the production, characterization, regulation, and currently marketed targeted nanoparticle systems in a broad framework. It provides an overview of targeted nanoparticles’ (i) in vitro characterization, such as particle size, stability, ligand density, and type; (ii) in vivo behavior for different targeting areas, such as tumor, brain, and vagina; and (iii) current advances in this field, including clinical trials and regulation processes.
Multifunctional Nanoparticles for Drug Delivery Applications by Sonke Svenson,Robert K. Prud'homme Pdf
This book clearly demonstrates the progression of nanoparticle therapeutics from basic research to applications. This book, unlike others covering nanoparticles used in medical applications, presents the medical challenges that can be reduced or even overcome by recent advances in nanoscale drug delivery. Each chapter highlights recent progress in the design and engineering of select multifunctional nanoparticles with topics covering targeting, imaging, delivery, diagnostics, and therapy.
Advances in Nanomaterials for Drug Delivery by Mahdi Karimi,Maryam Rad Mansouri,Navid Rabiee,Michael R Hamblin Pdf
Nanomedicine is a developing field, which includes different disciplines such as material science, chemistry, engineering and medicine devoted to the design, synthesis and construction of high-tech nanostructures. The ability of these structures to have their chemical and physical properties tuned by structural modification, has allowed their use in drug delivery systems, gene therapy delivery, and various types of theranostic approaches. Colloidal noble metal nanoparticles and other nanostructures have many therapeutic and diagnostic applications. The concept of drug targeting as a magic bullet has led to much research in chemical modification to design and optimize the binding to targeted receptors. It is important to understand the precise relationship between the drug and the carrier and its ability to target specific tissues, and pathogens to make an efficient drug delivery system. This book covers advances based on different drug delivery systems: polymeric and hyper branched nanomaterials, carbon-based nanomaterials, nature-inspired nanomaterials, and pathogen-based carriers.
Role of Novel Drug Delivery Vehicles in Nanobiomedicine by Rajeev K. Tyagi,Neeraj Garg,Rahul Shukla,Prakash Singh Bisen Pdf
Medical Nanotechnology and Nanomedicine introduces non-experts to the world of nanomedicine and its evolving organizational infrastructure. Considering the fluid nature of nano breakthroughs and the delicate balance between benefits and consequences as they apply to medicine, readers at all levels will gain a practical, understandable base of information on these developments so that they may take the greatest advantage of them. This practical reference investigates the impact of nanotechnology on applications in medicine and biomedical sciences, and the broader societal and economic effects. Eschewing technological details, it focuses on enhancing awareness of the business, regulatory, and administrative aspects of medical applications. It gives readers a critical, balanced, and realistic evaluation of existing nanomedicine developments and future prospects and provides an ideal foundation upon which to plan and make decisions.
SYNTHESIS AND CHARACTERIZATION OF NANOCOMPOSITES FOR DRUG DELIVERY APPLICATIONS by V. Karthika Pdf
The synthesis and characterization of nanocomposites for drug delivery applications is an emerging field that aims to develop safe and effective drug delivery systems with enhanced therapeutic efficacy. Nanocomposites are composed of different types of nanoparticles, polymers, and other materials that can be precisely engineered to achieve specific drug delivery goals. These materials are typically biocompatible and biodegradable, allowing for controlled release of drugs over an extended period of time. The synthesis and characterization of nanocomposites involve the preparation of the nanoparticles and their subsequent incorporation into the polymer matrix or other material. Different types of nanoparticles, such as magnetic nanoparticles, gold nanoparticles, carbon nanotubes, and lipid-based nanoparticles, can be utilized depending on the intended application. Surface modification techniques can be employed to enhance the stability, biocompatibility, and specificity of the nanocomposites for targeted drug delivery. Characterization of nanocomposites is crucial to understanding their physicochemical properties, drug-loading capacity, and drug release kinetics. Techniques such as dynamic light scattering, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and Fourier-transform infrared spectroscopy can be used to characterize the nanocomposites. The use of nanocomposites for drug delivery applications has several advantages, including improved drug solubility, enhanced bioavailability, and reduced toxicity. Moreover, the development of stimuli-responsive nanocomposites that respond to changes in environmental factors such as pH, temperature, and magnetic field can further enhance drug delivery efficacy. The synthesis and characterization of nanocomposites for drug delivery applications represent a promising approach for the development of safe and effective drug delivery systems with enhanced therapeutic efficacy. However, further studies are needed to optimize the design of nanocomposites and to assess their toxicity and biocompatibility. Nanomaterial has promising application of all technology development. Nanomaterial has one or more dimension in the nanometer scale (100 nm) range and subsequently show novel properties from their bulk materials. Nanotechnology, led by the development of nanoparticles (NPs) -based drug delivery systems and imaging contrast agents, has had an important role in diagnosis, prevention, and treatment of the disease. The use of nanotechnology for cancer therapy and imaging is expected to overcome the limitations of conventional treatments, such as poor drug bioavailability, nonspecific systemic drug distribution, inadequate drug concentrations reaching the tumor and inability to monitor therapeutic responses in real time.