Targeted Drug Delivery Concepts And Design

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Targeted Drug Delivery : Concepts and Design

Padma V. Devarajan,Sanyog Jain
Targeted Drug Delivery Concepts and Design Book PDF

Author : Padma V. Devarajan,Sanyog Jain
Publisher : Springer
Page : 788 pages
File Size : 45,8 Mb
Release : 2014-12-08
Category : Medical
ISBN : 9783319113555

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Targeted Drug Delivery : Concepts and Design by Padma V. Devarajan,Sanyog Jain Pdf

This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.

Drug Targeting And Delivery

H.E. Junginger
Drug Targeting And Delivery Book PDF

Author : H.E. Junginger
Publisher : CRC Press
Page : 276 pages
File Size : 41,9 Mb
Release : 1992-10-31
Category : Medical
ISBN : 0132204681

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Drug Targeting And Delivery by H.E. Junginger Pdf

This is a review of the structure and function of biological membranes and other cellular barriers used in drug transport. It discusses a range of concepts for drug delivery systems, treating the routes of drugs with regard to their characteristics: function, structure, uptake, mechanism and effect. The book also explores the interface between pharmaceutical technology and physiological principles in drug design, a field of increased importance to industry.

Advanced Drug Delivery

Ashim Mitra,Chi H. Lee,Kun Cheng
Advanced Drug Delivery Book PDF

Author : Ashim Mitra,Chi H. Lee,Kun Cheng
Publisher : John Wiley & Sons
Page : 844 pages
File Size : 40,7 Mb
Release : 2013-08-26
Category : Medical
ISBN : 9781118662847

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Advanced Drug Delivery by Ashim Mitra,Chi H. Lee,Kun Cheng Pdf

Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to date with the state of the science, presenting the basics, formulation strategies, and therapeutic applications of advanced drug delivery. The book demonstrates how core concepts of pharmaceutical sciences, chemistry, and molecular biology can be combined and applied in order to spark novel ideas to design and develop advanced drug delivery systems for the treatment of a broad range of human diseases. Advanced Drug Delivery features contributions from an international team of pharmaceutical scientists. Chapters reflect a thorough review and analysis of the literature as well as the authors' firsthand experience developing drug delivery systems. The book is divided into four parts: Part I, Introduction and Basics of Advanced Drug Delivery, explores physiological barriers, stability, transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offers tested and proven strategies for advanced delivery of both small molecules and macromolecules Part III, Translational Research of Advanced Drug Delivery, focuses on regulatory considerations and translational applications of advanced drug delivery systems for the treatment of cardiovascular diseases, cancer, sexually transmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery in Emerging Research Areas, examines stem cell research, cell-based therapeutics, tissue engineering, and molecular imaging Each chapter provides objectives and assessment questions to help readers grasp key concepts and assess their knowledge as they progress through the book. Advanced Drug Delivery is recommended for graduates and upper-level undergraduates in the pharmaceutical sciences who need a solid foundation in the basics. It is also recommended for pharmaceutical professionals who want to take advantage of new and emerging applications in advanced drug delivery systems.

Smart Polymeric Nano-Constructs in Drug Delivery

Suresh P Vyas,Udita Agrawal,Rajeev Sharma
Smart Polymeric Nano Constructs in Drug Delivery Book PDF

Author : Suresh P Vyas,Udita Agrawal,Rajeev Sharma
Publisher : Academic Press
Page : 626 pages
File Size : 53,7 Mb
Release : 2022-11-12
Category : Business & Economics
ISBN : 9780323913997

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Smart Polymeric Nano-Constructs in Drug Delivery by Suresh P Vyas,Udita Agrawal,Rajeev Sharma Pdf

Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems. Provides comprehensive overview of the potential role of polymeric systems in drug delivery Explores the design, synthesis, and application of different smart material-based delivery systems Includes fundamental and clinical applications

Design of Controlled Release Drug Delivery Systems

Xiaoling Li
Design of Controlled Release Drug Delivery Systems Book PDF

Author : Xiaoling Li
Publisher : McGraw Hill Professional
Page : 453 pages
File Size : 49,9 Mb
Release : 2005-11-24
Category : Technology & Engineering
ISBN : 9780071588836

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Design of Controlled Release Drug Delivery Systems by Xiaoling Li Pdf

The goal of every drug delivery system is to deliver the precise amount of a drug at a pre-programmed rate to the desired location in order to achieve the drug level necessary for the treatment. An essential guide for biomedical engineers and pharmaceutical designers, this resource combines physicochemical principles with physiological processes to facilitate the design of systems that will deliver medication at the time and place it is most needed.

Targeted Drug Delivery

Rudolph L. Juliano
Targeted Drug Delivery Book PDF

Author : Rudolph L. Juliano
Publisher : Springer Science & Business Media
Page : 374 pages
File Size : 52,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642758621

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Targeted Drug Delivery by Rudolph L. Juliano Pdf

The chapters in this volume describe a powerful emerging approach for the therapy of disease. Targeted drug delivery, that is control of the kinetic behavior, tissue distribution, and subcellular localization of pharmaco logically active agents, offers an important means for improving the efficacy of a wide variety of drug therapies. This is particularly true for therapeutic approaches based on newer agents which are the products of recombinant DNA research. These agents, be they peptides, proteins, or oligonucleotides, tend to be larger, more complex, and less stable than traditional drugs. Thus they stand to benefit most from drug delivery systems which can protect them from premature degradation and which can carry them to critical target sites in the body. This volume examines several important aspects of the current state of drug delivery research; it also attempts to project future directions for this field. Successful approaches to drug targeting are based, first of all, on a sophisticated understanding of the biological barriers encountered by the drug-carrier complex as it moves from the portal of administration to the ultimate target site. A second aspect of successful drug delivery is appro priate matching of the disease entity with the pharmacologically active substance and with the delivery system. Thus it is important to be aware of the variety of delivery technologies which currently exist and to be sensitive to their strengths and limitations.

Retrometabolic Drug Design and Targeting

Nicholas Bodor,Peter Buchwald
Retrometabolic Drug Design and Targeting Book PDF

Author : Nicholas Bodor,Peter Buchwald
Publisher : John Wiley & Sons
Page : 546 pages
File Size : 48,5 Mb
Release : 2012-08-29
Category : Science
ISBN : 9781118407769

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Retrometabolic Drug Design and Targeting by Nicholas Bodor,Peter Buchwald Pdf

Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.

FASTtrack Pharmaceutics

Yvonne Perrie,Thomas Rades
FASTtrack Pharmaceutics Book PDF

Author : Yvonne Perrie,Thomas Rades
Publisher : Pharmaceutical Press
Page : 257 pages
File Size : 46,5 Mb
Release : 2012
Category : Medical
ISBN : 9780857110596

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FASTtrack Pharmaceutics by Yvonne Perrie,Thomas Rades Pdf

"Pharmaceutics - Drug delivery and targeting focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, key points, tips and an all-important self-assessment section which includes MCQs."--Page 4 of cover.

Drug Delivery

Anya M Hillery,Kinam Park
Drug Delivery Book PDF

Author : Anya M Hillery,Kinam Park
Publisher : CRC Press
Page : 634 pages
File Size : 55,9 Mb
Release : 2016-09-15
Category : Medical
ISBN : 9781482217742

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Drug Delivery by Anya M Hillery,Kinam Park Pdf

This book provides a comprehensive introduction to advanced drug delivery and targeting, covering their principles, current applications, and potential future developments. This edition has been updated to reflect significant trends and cutting-edge advances that have occurred since the first edition was published. All the original chapters have been retained, but the material therein has been updated. Eight new chapters have been added that deal with entirely new technologies and approaches. Features: Offers a comprehensive introduction to the fundamental concepts and underlying scientific principles of drug delivery and targeting Presents an in-depth analysis of the opportunities and obstacles afforded by the application of nanotechnologies for drug delivery and targeting Includes a revised and expanded section on the major epithelial routes of drug delivery currently under investigation Describes the most recent, emerging, and innovative technologies of drug delivery Provides real-life examples of the clinical translation of drug delivery technologies through the use of case studies Discusses the pertinent regulatory hurdles and safety issues of drug delivery and targeting systems—crucial considerations in order to achieve licensing approval for these new technologies

Focal Controlled Drug Delivery

Abraham J. Domb,Wahid Khan
Focal Controlled Drug Delivery Book PDF

Author : Abraham J. Domb,Wahid Khan
Publisher : Springer Science & Business Media
Page : 700 pages
File Size : 44,8 Mb
Release : 2014-02-17
Category : Medical
ISBN : 9781461494348

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Focal Controlled Drug Delivery by Abraham J. Domb,Wahid Khan Pdf

The concept of focal controlled drug delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Controlled drug delivery systems have been focused on oral extended release formulations and on systemic delivery of small drugs and peptides. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on the subject. By comparison, there are numerous authored and edited books on oral, systemic and transdermal drug delivery or books on biodegradable polymers as drug carriers. Thus, the aim of Focal Drug Delivery is to bring together leading experts and researchers in the field to provide an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences underpinning the topic. In addition, the book will review advances in treatment options for diseases localized at a certain tissue or organ.

Drug Targeting and Stimuli Sensitive Drug Delivery Systems

Alexandru Mihai Grumezescu
Drug Targeting and Stimuli Sensitive Drug Delivery Systems Book PDF

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Page : 836 pages
File Size : 43,5 Mb
Release : 2018-05-21
Category : Science
ISBN : 9780128136904

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Drug Targeting and Stimuli Sensitive Drug Delivery Systems by Alexandru Mihai Grumezescu Pdf

Drug Targeting and Stimuli Sensitive Drug Delivery Systems covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of nanoplatforms. Written by an internationally diverse group of researchers, it is an important reference resource for both biomaterials scientists and those working in the pharmaceutical industry who are looking to help create more effective drug delivery systems. Shows how the use of nanomaterials can help target a drug to specific tissues and cells Explores the development of stimuli-responsive drug delivery systems Includes case studies to showcase how stimuli responsive nanosystems are used in a variety of therapies, including camptothecin delivery, diabetes and cancer therapy

Drug Delivery

Eric P. Holowka,Sujata K. Bhatia
Drug Delivery Book PDF

Author : Eric P. Holowka,Sujata K. Bhatia
Publisher : Springer
Page : 368 pages
File Size : 45,8 Mb
Release : 2014-11-22
Category : Technology & Engineering
ISBN : 9781493919987

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Drug Delivery by Eric P. Holowka,Sujata K. Bhatia Pdf

Current pharmaceutical and clinical approaches to the treatment of disease suffer from the inherent limitations in the specialization of drugs introduced to physiological systems. The interface of clinical and material sciences has allowed for a broad spectrum of creative approaches with the potential to alleviate these shortcomings. However, the synergy of these disciplines also presents problems in which nascent technology lacks the necessary evaluation within its intended clinical environment. Given the growing potential for materials science to address a number of unanswered therapeutic needs, it remains even more pressing to validate emerging drug delivery technologies in actual clinical environments. Drug Delivery: Materials Design and Clinical Perspective addresses the core fundamentals of drug delivery using material science and engineering principles, and then applies this knowledge using prominent examples from both the scientific literature and clinical practice. Each chapter focuses on a specific drug delivery technology, such as controlled-release materials, thin-film materials, or smart materials. Within each chapter, an initial section on “Engineering Concepts” reviews the relevant fundamental principles that guide rational design. The following section on “Materials Design” discusses how the design process applies engineering concepts for use in physiological systems. A third section on “Implementation” discusses current approaches in the literature which have demonstrated effective drug delivery in controlled environments. Finally, each chapter contains several sections on “Clinical Applications” which describe the validity of materials approaches from a clinical perspective; these sections review the safety and efficacy of drug delivery systems for specific, compelling medical applications. The book thereby bridges materials science with clinical medicine, and provides the reader with a bench-to-bedside view of novel drug delivery systems. · Provides a comprehensive description of drug delivery systems from a materials perspective · Includes a wide-ranging discussion of clinical applications of drug delivery systems · Presents separate chapters on controlled release materials, thin film materials, self-microemulsifying materials, smart materials, etc. · Covers fundamental engineering principles, rational materials design, implementation testing, and clinical applications for each material type

Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer

Prashant Kesharwani
Nanotechnology Based Targeted Drug Delivery Systems for Lung Cancer Book PDF

Author : Prashant Kesharwani
Publisher : Academic Press
Page : 340 pages
File Size : 48,7 Mb
Release : 2019-01-26
Category : Business & Economics
ISBN : 9780128163672

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Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer by Prashant Kesharwani Pdf

Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer is an indispensable resource that will help pharmaceutical scientists and clinical researchers design and develop novel drug delivery systems and devices for the treatment of lung cancer. As recent breakthroughs in nanomedicine are now making it possible to deliver drugs, genes and therapeutic agents to localized areas of disease to maximize clinical benefit, while also limiting unwanted side effects, this book explores promising approaches for the diagnosis and treatment of lung cancer using cutting-edge nanomedical technologies. Topics discussed include polymeric nanoparticles, solid lipid nanoparticles, liposomes, dendrimers, micelles and nanoemulsions. Provides an overview of an array of nanotechnology-based drug delivery systems Examines the design, synthesis and application of different nanocarriers in drug and gene delivery Provides an in-depth understanding of the design of targeted nanotherapeutics and technologies and its implication in various site-specific cancers

NOVEL DRUG DELIVERY SYSTEM

Dr. N.G. Raghavendra Rao,Dr. L. MATSYAGIRI,Dr.Chatlapelli Kishore,Mr.BARIKI RAJASEKHAR
NOVEL DRUG DELIVERY SYSTEM Book PDF

Author : Dr. N.G. Raghavendra Rao,Dr. L. MATSYAGIRI,Dr.Chatlapelli Kishore,Mr.BARIKI RAJASEKHAR
Publisher : JEC PUBLICATION
Page : 267 pages
File Size : 52,5 Mb
Release : 2024-06-25
Category : Medical
ISBN : 9789358501698

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NOVEL DRUG DELIVERY SYSTEM by Dr. N.G. Raghavendra Rao,Dr. L. MATSYAGIRI,Dr.Chatlapelli Kishore,Mr.BARIKI RAJASEKHAR Pdf

The fascinating world of "Novel Drug Delivery Systems" is yours to explore. In this book, we set out on a thrilling voyage through the constantly changing field of drug distribution, where groundbreaking discoveries and fresh ideas are revolutionizing how we use and perceive medication. It is our honor to expose to the enormous world of innovative drug delivery systems and explore their principles, uses, and promise to transform healthcare as the author of this comprehensive resource. This book's rigorous planning ensures a thorough comprehension of the subject matter by covering a broad variety of subjects that line up with the drug delivery systems curriculum. We go into the fundamentals of controlled medication delivery systems in Unit-I. We discuss controlled release formulation language, meanings, and justifications. We investigate the design concepts of diffusion, dissolution, and ion exchange for creating controlled release formulations. We also look at drug formulation-relevant physicochemical and biological characteristics. Polymers and the creation of formulations and we categorize polymers according to their characteristics and talk about their benefits for controlled release medication delivery systems. Methods for microencapsulation are introduced in Unit II. We explore implantable drug delivery devices and acquire understanding of mucosal drug delivery systems, including bioadhesion and mucoadhesion concepts. Transdermal drug delivery methods are examined in Unit-III, with an emphasis on skin penetration and the variables that affect it. We look into transdermal medication delivery system components and permeability enhancers. We also explore techniques for delivering gastroretentive drugs, such as floating and high-density systems, inflatable systems, and gastro sticky systems. We address nasal and pulmonary routes, formulation strategies, and delivery devices as we examine the Nasopulmonary drug delivery system. Targeted drug delivery is the subject of Unit-IV, which examines theories, methods, and the potential of liposomes, niosomes, nanoparticles, and monoclonal antibodies.

Controlled Drug Delivery

Kinam Park
Controlled Drug Delivery Book PDF

Author : Kinam Park
Publisher : Unknown
Page : 479 pages
File Size : 54,8 Mb
Release : 2000
Category : Drug delivery systems
ISBN : 0841217580

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Controlled Drug Delivery by Kinam Park Pdf

Annotation Despite the public desire for a magic bullet--a drug that cures the ailment and is easy to take--most drugs require a sustained release to the target area as opposed to a burst, hence the need for controlled release devices. This volume devotes separate sections to current work in each of the key aspects for developing these devices, including the route of administration, drug delivery vehicles, drug targeting, and modulated drug delivery.