Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems

Author : Kamal Dua,Philip M. Hansbro,Ridhima Wadhwa,Mehra Haghi,Lisa G. Pont,Kylie A. Williams
Publisher : Academic Press
Page : 620 pages
File Size : 43,8 Mb
Release : 2020-08-04
Category : Technology & Engineering
ISBN : 9780128208885

Get Book

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems by Kamal Dua,Philip M. Hansbro,Ridhima Wadhwa,Mehra Haghi,Lisa G. Pont,Kylie A. Williams Pdf

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development. Explores recent perspectives and challenges regarding the management and diagnosis of chronic respiratory diseases Provides insights into how advanced drug delivery systems can be effectively formulated and delivered for the management of various pulmonary diseases Includes the most recent information on diagnostic methods and treatment strategies using controlled drug delivery systems (including nanotechnology)

Author : Dinesh Kumar Chellappan,Kavita Pabreja,Md. Faiyazuddin
Publisher : Springer Nature
Page : 652 pages
File Size : 44,6 Mb
Release : 2022-03-23
Category : Medical
ISBN : 9789811643927

Get Book

Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases by Dinesh Kumar Chellappan,Kavita Pabreja,Md. Faiyazuddin Pdf

This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.

Author : Kamal Dua,Raimar Löbenberg,Ângela Cristina Malheiros Luzo,Shakti Shukla,Saurabh Satija
Publisher : Springer Nature
Page : 926 pages
File Size : 44,7 Mb
Release : 2021-07-02
Category : Medical
ISBN : 9789813368279

Get Book

Targeting Cellular Signalling Pathways in Lung Diseases by Kamal Dua,Raimar Löbenberg,Ângela Cristina Malheiros Luzo,Shakti Shukla,Saurabh Satija Pdf

The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.

Author : Yashwant Pathak,Nazrul Islam
Publisher : CRC Press
Page : 692 pages
File Size : 46,5 Mb
Release : 2021-10-17
Category : Medical
ISBN : 9781000450767

Get Book

Handbook of Lung Targeted Drug Delivery Systems by Yashwant Pathak,Nazrul Islam Pdf

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems

Author : Philip Chi Lip Kwok,Hak-Kim Chan
Publisher : CRC Press
Page : 246 pages
File Size : 54,7 Mb
Release : 2016-12-19
Category : Medical
ISBN : 9781315311968

Get Book

Advances in Pulmonary Drug Delivery by Philip Chi Lip Kwok,Hak-Kim Chan Pdf

The respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and parenteral administration. Pulmonary drug development is therefore a highly specialized area because of its many unique issues and challenges. Rapid progress is being made and offers novel solutions to existing treatment problems. Advances in Pulmonary Drug Delivery highlights the latest developments in this field.

Author : Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Publisher : Elsevier
Page : 572 pages
File Size : 43,6 Mb
Release : 2021-06-24
Category : Business & Economics
ISBN : 9780323900799

Get Book

Advanced Drug Delivery Systems in the Management of Cancer by Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone Pdf

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Author : Kamal Dua,Srinivas Nammi,Dennis Chang,Dinesh Kumar Chellappan,Gaurav Gupta,Trudi Collet
Publisher : Springer Nature
Page : 626 pages
File Size : 53,8 Mb
Release : 2021-07-30
Category : Medical
ISBN : 9789813368507

Get Book

Medicinal Plants for Lung Diseases by Kamal Dua,Srinivas Nammi,Dennis Chang,Dinesh Kumar Chellappan,Gaurav Gupta,Trudi Collet Pdf

This book summarizes experimentally-supported research on the therapeutic efficacy of plant extracts and their constituents on a range of respiratory diseases including infections. It discusses the pharmacological, cellular and molecular factors involved in the pathogenies of respiratory diseases and their modulation by plant-derived compounds. Additionally, it underlines the growing relevance of medicinal plant-based advanced drug delivery systems for treating lung diseases providing maximal therapeutic efficacy with better patient compliance. Overall, this comprehensive book is a blend of translational, biological, chemical and drug delivery aspects of medicinal plants employed in targeting respiratory diseases and attracts a range of audiences including physiochemist, translational and clinical researchers working in the field of respiratory diseases.

Author : Anonim
Publisher : Unknown
Page : 728 pages
File Size : 52,8 Mb
Release : 2010
Category : Government publications
ISBN : UCSD:31822037817723

Get Book

How Tobacco Smoke Causes Disease by Anonim Pdf

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee on a National Surveillance System for Cardiovascular and Select Chronic Diseases
Publisher : National Academies Press
Page : 200 pages
File Size : 52,9 Mb
Release : 2011-08-26
Category : Medical
ISBN : 9780309212199

Get Book

A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases by Institute of Medicine,Board on Population Health and Public Health Practice,Committee on a National Surveillance System for Cardiovascular and Select Chronic Diseases Pdf

Chronic diseases are common and costly, yet they are also among the most preventable health problems. Comprehensive and accurate disease surveillance systems are needed to implement successful efforts which will reduce the burden of chronic diseases on the U.S. population. A number of sources of surveillance data--including population surveys, cohort studies, disease registries, administrative health data, and vital statistics--contribute critical information about chronic disease. But no central surveillance system provides the information needed to analyze how chronic disease impacts the U.S. population, to identify public health priorities, or to track the progress of preventive efforts. A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases outlines a conceptual framework for building a national chronic disease surveillance system focused primarily on cardiovascular and chronic lung diseases. This system should be capable of providing data on disparities in incidence and prevalence of the diseases by race, ethnicity, socioeconomic status, and geographic region, along with data on disease risk factors, clinical care delivery, and functional health outcomes. This coordinated surveillance system is needed to integrate and expand existing information across the multiple levels of decision making in order to generate actionable, timely knowledge for a range of stakeholders at the local, state or regional, and national levels. The recommendations presented in A Nationwide Framework for Surveillance of Cardiovascular and Chronic Lung Diseases focus on data collection, resource allocation, monitoring activities, and implementation. The report also recommends that systems evolve along with new knowledge about emerging risk factors, advancing technologies, and new understanding of the basis for disease. This report will inform decision-making among federal health agencies, especially the Department of Health and Human Services; public health and clinical practitioners; non-governmental organizations; and policy makers, among others.

Author : Darcy D. Marciniuk,Dean E. Schraufnagel
Publisher : Unknown
Page : 128 pages
File Size : 43,8 Mb
Release : 2017
Category : Electronic
ISBN : 1849840881

Get Book

˜Theœ Global Impact of Respiratory Disease by Darcy D. Marciniuk,Dean E. Schraufnagel Pdf

Author : Yashwant Pathak,Nazrul Islam
Publisher : CRC Press
Page : 1065 pages
File Size : 46,7 Mb
Release : 2021-10-18
Category : Medical
ISBN : 9781000450804

Get Book

Handbook of Lung Targeted Drug Delivery Systems by Yashwant Pathak,Nazrul Islam Pdf

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems

Author : Ahmad Taher Azar
Publisher : Academic Press
Page : 410 pages
File Size : 54,8 Mb
Release : 2021-02-06
Category : Technology & Engineering
ISBN : 9780128211953

Get Book

Modeling and Control of Drug Delivery Systems by Ahmad Taher Azar Pdf

Modeling and Control of Drug Delivery Systems provides comprehensive coverage of various drug delivery and targeting systems and their state-of-the-art related works, ranging from theory to real-world deployment and future perspectives. Various drug delivery and targeting systems have been developed to minimize drug degradation and adverse effect and increase drug bioavailability. Site-specific drug delivery may be either an active and/or passive process. Improving delivery techniques that minimize toxicity and increase efficacy offer significant potential benefits to patients and open up new markets for pharmaceutical companies. This book will attract many researchers working in DDS field as it provides an essential source of information for pharmaceutical scientists and pharmacologists working in academia as well as in the industry. In addition, it has useful information for pharmaceutical physicians and scientists in many disciplines involved in developing DDS, such as chemical engineering, biomedical engineering, protein engineering, gene therapy. Presents some of the latest innovations of approaches to DDS from dynamic controlled drug delivery, modeling, system analysis, optimization, control and monitoring Provides a unique, recent and comprehensive reference on DDS with the focus on cutting-edge technologies and the latest research trends in the area Covers the most recent works, in particular, the challenging areas related to modeling and control techniques applied to DDS

Author : Ali Demir Sezer
Publisher : BoD – Books on Demand
Page : 400 pages
File Size : 49,9 Mb
Release : 2016-02-10
Category : Medical
ISBN : 9789535122470

Get Book

Smart Drug Delivery System by Ali Demir Sezer Pdf

This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Author : Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey
Publisher : Academic Press
Page : 439 pages
File Size : 45,6 Mb
Release : 2021-01-20
Category : Business & Economics
ISBN : 9780128149751

Get Book

Inhaled Medicines by Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey Pdf

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues

Author : Harish Dureja,Raimar Loebenberg,Sachin Kumar Singh,Muralikrishnan Dhanasekaran,Kamal Dua
Publisher : Elsevier
Page : 463 pages
File Size : 44,9 Mb
Release : 2023-11-04
Category : Medical
ISBN : 9780443140457

Get Book

Advanced Drug Delivery Systems for Colonic Disorders by Harish Dureja,Raimar Loebenberg,Sachin Kumar Singh,Muralikrishnan Dhanasekaran,Kamal Dua Pdf

Advanced Drug Delivery Systems for Colonic Disorders present the current state of the art methods for targeted drug delivery to the colon. These methods can prolong drug half-lives, improve bioavailability, optimize pharmacokinetics, and reduce medication dosing frequency. Chapters are written in a way that allows the audience to not only become familiar with the most recent advancement in the field, but to better understand them by referring to various illustrations, figures, and informative tables. The contents cover an overview of colonic diseases, the cellular and molecular mechanisms involved, current and traditional therapeutic approaches, biomaterials, oral drug delivery methods, targeted drug delivery, nutraceuticals and herbal medicine approaches, prebiotics, probiotics and symbiotics, nanomedicine approaches, and the current status of clinical trials in the area. Advanced Drug Delivery Systems for Colonic Disorders is the perfect resources for researchers in pharma, biomaterials, and nutrition to familiarize themselves with new and upcoming therapeutic methods. Research physicians in GI can also benefit from reading this book for its clinical applications. Covers recent perspectives and challenges towards the treatment of colonic disorders Provides insights into how advanced drug delivery systems can be effectively used for the management of various types of colonic disorders Discusses drug delivery strategies to manage inflammatory bowel disease (chronic inflammation in the digestive tract), ulcerative colitis (inflammation and ulcers in colon), Crohn's disease, Colonic polyps, Shigellosis, Colon Bleeding or Hemorrhage, Diverticulosis and colon cancer