The Basics Of Cancer Immunotherapy

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The Basics of Cancer Immunotherapy

Haidong Dong,Svetomir N. Markovic
The Basics of Cancer Immunotherapy Book PDF

Author : Haidong Dong,Svetomir N. Markovic
Publisher : Springer
Page : 160 pages
File Size : 50,9 Mb
Release : 2018-01-05
Category : Medical
ISBN : 9783319706221

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The Basics of Cancer Immunotherapy by Haidong Dong,Svetomir N. Markovic Pdf

This book provides patients and their physicians (especially “non-oncologist” health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient’s own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize complications of therapy. The patient-friendly, concise, easy-to-understand, and up-to-date knowledge presented in this book will inform patients about the benefits and risks of cancer immunotherapy, and help them and their care providers to understand how immunotherapy would control their unique disease. Researchers and academic professionals in the field of cancer immunotherapy will also find clear and useful information to help them communicate with patients or address unresolved problems. Some key features of the book are: Expertise. All editors and authors are scientists and oncologists specializing in cancer immunotherapy, and are involved in scientific discovery from the early stage of immune-checkpoint inhibitors to today’s daily patient care. Their insights, expertise and experience guarantee the high quality and authority in the science, medicine and practice of cancer immunotherapy. Patient-friendly. This book is written for cancer patients in order to meet their needs when considering immunotherapy. As an educational tool, this book will help the reader balance the risks and benefits based on both science and clinical facts, and therefore to make the best choice in receiving or withdrawing from immunotherapy. Disease Specificity. Cancer is a complicated disease involving multiple stages and pathology. Its response to immunotherapy is individualized and varies depending on cancer types. The authors’ expertise in treating different types of cancers, including melanoma, lung, kidney, bladder, and lymphoma, provides disease-specific insights in applying immunotherapy to each disease.

Cancer Immunology and Immunotherapy

Mansoor M. Amiji,Lara Scheherazade Milane
Cancer Immunology and Immunotherapy Book PDF

Author : Mansoor M. Amiji,Lara Scheherazade Milane
Publisher : Academic Press
Page : 550 pages
File Size : 49,5 Mb
Release : 2021-08-18
Category : Business & Economics
ISBN : 9780128236376

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Cancer Immunology and Immunotherapy by Mansoor M. Amiji,Lara Scheherazade Milane Pdf

Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO

Cancer Immunotherapy Principles and Practice, Second Edition

Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS
Cancer Immunotherapy Principles and Practice Second Edition Book PDF

Author : Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS
Publisher : Springer Publishing Company
Page : 1339 pages
File Size : 52,9 Mb
Release : 2021-08-25
Category : Medical
ISBN : 9780826137432

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Cancer Immunotherapy Principles and Practice, Second Edition by Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS Pdf

Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer. The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field. Key Features: Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the field Covers the basic principles and science behind cancer immunotherapy and tumor immunology Includes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapies Provides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicities Discusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapy Clarifies the complex regulatory aspects behind the development and approval of immunotherapy drugs

Cancer Immunotherapy Principles and Practice

Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS
Cancer Immunotherapy Principles and Practice Book PDF

Author : Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS
Publisher : Springer Publishing Company
Page : 920 pages
File Size : 40,7 Mb
Release : 2017-06-28
Category : Medical
ISBN : 9781617052736

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Cancer Immunotherapy Principles and Practice by Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS Pdf

Cancer Immunotherapy Principles and Practice, from the Society of Immunotherapy of Cancer (SITC), is the authoritative reference on cancer immunobiology and the immunotherapy treatments that harness the immune system to combat malignant disease. Featuring five sections and over 50 chapters covering the Basic Principles of Tumor Immunology, Cancer Immunotherapy Targets and Classes, Immune Function in Cancer Patients, Disease Specific Treatments and Outcomes, and Regulatory Aspects of Cancer Immunotherapy, this book covers all major topics that have shaped the development of immunotherapy and propelled it to its current place at the forefront of cancer treatment innovation. This volume is a comprehensive resource for oncologists and fellows, immunologists, cancer researchers, and related practitioners seeking understanding of the basic science and clinical applications of cancer immunotherapy. As well as presenting the evidence for immune-based cancer treatment, it positions immunotherapy in the context of other available cancer treatments and provides data on response rates, risks, and toxicities across a variety of diseases. Filled with detailed tables, and instructive illustrations, as well as key points for quick reference, Cancer Immunotherapy Principles and Practice simplifies a challenging and dynamic subject. Key Features: Clearly summarizes the basic principles and research supporting cancer immunotherapy clinical translation Contains expert guidance and treatment strategies for all immunotherapy classes and agents, including cell-based therapies, monoclonal antibodies, cytokine therapies, checkpoint inhibitors, oncolytic viruses, adjuvant approaches, and treatment combinations Includes expert perspectives from leading authorities in the field Provides information on all FDA-approved immunotherapies, including clinical management and outcome data Discusses clinical aspects of immunotherapy for individual cancer types, including melanoma and other skin cancers, lung cancers, gynecologic cancers, gastrointestinal cancers, hematologic cancers, genitourinary cancers, head and neck cancers, sarcomas, brain and other CNS cancers, breast cancer, and pediatric malignancies. Explains regulatory aspects behind the development and approval of immunotherapy drugs Includes Online Access to the Digital Book

Gene and Cellular Immunotherapy for Cancer

Armin Ghobadi,John F. DiPersio
Gene and Cellular Immunotherapy for Cancer Book PDF

Author : Armin Ghobadi,John F. DiPersio
Publisher : Springer Nature
Page : 371 pages
File Size : 40,5 Mb
Release : 2022-01-01
Category : Medical
ISBN : 9783030878498

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Gene and Cellular Immunotherapy for Cancer by Armin Ghobadi,John F. DiPersio Pdf

Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.

Basics of Chimeric Antigen Receptor (CAR) Immunotherapy

Mumtaz Y. Balkhi
Basics of Chimeric Antigen Receptor CAR Immunotherapy Book PDF

Author : Mumtaz Y. Balkhi
Publisher : Academic Press
Page : 92 pages
File Size : 42,6 Mb
Release : 2019-07-31
Category : Medical
ISBN : 9780128197479

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Basics of Chimeric Antigen Receptor (CAR) Immunotherapy by Mumtaz Y. Balkhi Pdf

Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope that we may be on the verge of finally curing cancer. Over the years, huge progress has been made in controlling several stage IV metastasized cancers through the clinical application of checkpoint receptor inhibitory drugs and CAR-Therapy that has seen unprecedented interest in the immunotherapy field. Presents the first book to provide a basic understanding of chimeric antigen receptor (CARs) design, production and clinical application protocols Provides unique authority as the editor has worked directly with CARs Discusses the challenges encountered in actual clinical trials and how these challenges can be overcome Includes a full chapter on various challenges researchers should expect to encounter in the CAR-therapy field

The Breakthrough

Charles Graeber
The Breakthrough Book PDF

Author : Charles Graeber
Publisher : Twelve
Page : 298 pages
File Size : 44,8 Mb
Release : 2018-11-13
Category : Health & Fitness
ISBN : 9781455568499

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The Breakthrough by Charles Graeber Pdf

Follow along as this New York Times bestselling author details the astonishing scientific discovery of the code to unleashing the human immune system to fight in this "captivating and heartbreaking" book (The Wall Street Journal). For decades, scientists have puzzled over one of medicine's most confounding mysteries: Why doesn't our immune system recognize and fight cancer the way it does other diseases, like the common cold? As it turns out, the answer to that question can be traced to a series of tricks that cancer has developed to turn off normal immune responses -- tricks that scientists have only recently discovered and learned to defeat. The result is what many are calling cancer's "penicillin moment," a revolutionary discovery in our understanding of cancer and how to beat it. In The Breakthrough, New York Times bestselling author of The Good Nurse Charles Graeber guides readers through the revolutionary scientific research bringing immunotherapy out of the realm of the miraculous and into the forefront of twenty-first-century medical science. As advances in the fields of cancer research and the human immune system continue to fuel a therapeutic arms race among biotech and pharmaceutical research centers around the world, the next step -- harnessing the wealth of new information to create modern and more effective patient therapies -- is unfolding at an unprecedented pace, rapidly redefining our relationship with this all-too-human disease. Groundbreaking, riveting, and expertly told, The Breakthrough is the story of the game-changing scientific discoveries that unleash our natural ability to recognize and defeat cancer, as told through the experiences of the patients, physicians, and cancer immunotherapy researchers who are on the front lines. This is the incredible true story of the race to find a cure, a dispatch from the life-changing world of modern oncological science, and a brave new chapter in medical history.

Fast Facts: Immuno-Oncology

S. Clarke,B.T. Li
Fast Facts Immuno Oncology Book PDF

Author : S. Clarke,B.T. Li
Publisher : Karger Medical and Scientific Publishers
Page : 128 pages
File Size : 43,6 Mb
Release : 2021-06-29
Category : Medical
ISBN : 9783318068221

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Fast Facts: Immuno-Oncology by S. Clarke,B.T. Li Pdf

The treatment of cancer has been revolutionized by therapies that modulate the immune system, with benefits for quality of life and survival. Standards of care have changed to reflect developments, but the area is moving fast. Keeping abreast of new therapies and trial data can be challenging. This second edition of 'Fast Facts: Immuno-Oncology' takes you from the fundamentals of immunology through to the new concepts of immunoediting and immunotherapy and likely future directions. Whether you have worked in oncology for decades and need a refresher or you are just starting out and need a crash course, this book provides all you need to know about immuno-oncology, concisely summarized. Table of Contents: • Components of the immune system • How cancers evade the immune system • How cancer immunotherapy works • Clinical use of immune checkpoint inhibitors • The future of immuno-oncology

General Principles of Tumor Immunotherapy

Howard L. Kaufman,Jedd D. Wolchok
General Principles of Tumor Immunotherapy Book PDF

Author : Howard L. Kaufman,Jedd D. Wolchok
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 53,6 Mb
Release : 2007-10-22
Category : Medical
ISBN : 9781402060861

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General Principles of Tumor Immunotherapy by Howard L. Kaufman,Jedd D. Wolchok Pdf

This book brings together the world’s leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated.

Immunotherapy of Cancer

Mary L. Disis
Immunotherapy of Cancer Book PDF

Author : Mary L. Disis
Publisher : Springer Science & Business Media
Page : 516 pages
File Size : 50,7 Mb
Release : 2007-10-28
Category : Medical
ISBN : 9781597450119

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Immunotherapy of Cancer by Mary L. Disis Pdf

Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.

Immunotherapy

Aung Naing,Joud Hajjar
Immunotherapy Book PDF

Author : Aung Naing,Joud Hajjar
Publisher : Springer Nature
Page : 339 pages
File Size : 50,7 Mb
Release : 2020-04-16
Category : Medical
ISBN : 9783030410087

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Immunotherapy by Aung Naing,Joud Hajjar Pdf

Immunotherapy is a rapidly evolving field that mandates frequent revision of the book as new insights to fight cancer emerge. The third edition of Immunotherapy is an updated overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. It explores the breath of immunotherapeutic strategies available to treat a wide range of cancers, from melanoma and non-small cell lung cancer to gastrointestinal, genitourinary, gynecologic and nervous system malignancies. With increasing use of checkpoint inhibitors as standard of care and in clinical trials, the challenges associated with their use undoubtedly increase. As objective response is limited to a subset of patients and is often associated with distinct immune related side effects that are potentially life threatening, it is essential to identify patients who are likely to respond to immunotherapy and those who are at a risk for developing treatment-related side effects. In the absence of a validated predictive biomarker, innovative technologies and assays are being used to identify critical biomarkers that drive the immune response. Hence, a chapter to provide a basic understanding of the diagnostic procedures has been included besides the chapter on the cellular components of the human immune system. This new edition will also inform readers on use of novel microbiome and imaging approaches. Finally, the book includes a chapter on patient-reported outcomes in patients treated with immunotherapies as the authors recognize the importance of including missing patient voice in clinical trials and longitudinal assessment of symptom reports. In short, the third edition of this book provides a comprehensive overview of the latest developments in the field of immune-oncology that will help health care professionals make informed treatment decisions. The book’s chapters are written by a diverse cast of experts conducting cutting-edge research, providing the reader with the most up-to-date science.

Cancer Immunotherapy in Clinical Practice

Michael M. Boyiadzis
Cancer Immunotherapy in Clinical Practice Book PDF

Author : Michael M. Boyiadzis
Publisher : McGraw Hill Professional
Page : 624 pages
File Size : 44,6 Mb
Release : 2021-05-22
Category : Health & Fitness
ISBN : 9781259642050

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Cancer Immunotherapy in Clinical Practice by Michael M. Boyiadzis Pdf

A top-to-bottom overview of cancer immunotherapy–from basic science to clinical application The rapidly evolving field of immunotherapy is thoroughly and expertly covered in this cutting-edge text. Written by a world-renowned author team, this innovative resource provides readers with a solid grasp of the fundamental principles of basic immunology so they can better understand the medical uses of immunotherapy. The book then advances to practical application and toxicity management. Presented in a concise, templated, and easy-to-read format, Cancer Immunotherapy is the single-best resource for readers to familiarize themselves with the medical use of immunotherapy. The book includes an entire section on eighteen individual cancer types (brain, breast, etc.) with listings of approved drugs, information on each drug, and discussion of emerging therapies for each of the cancers. • Groundbreaking in that it is the first cancer immunology book to combine the basic science with actual clinical application • Includes the latest guidelines for immunotherapy, cancer immunotherapy, and toxicity management • Valuable opening section includes discussion of introduction to immunotherapy, components of the immune system, vaccines, the immune system in cancer, and more

Vaccines for Cancer Immunotherapy

Nima Rezaei,Mahsa Keshavarz-Fathi
Vaccines for Cancer Immunotherapy Book PDF

Author : Nima Rezaei,Mahsa Keshavarz-Fathi
Publisher : Academic Press
Page : 198 pages
File Size : 54,7 Mb
Release : 2018-10-17
Category : Medical
ISBN : 9780128140406

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Vaccines for Cancer Immunotherapy by Nima Rezaei,Mahsa Keshavarz-Fathi Pdf

Therapeutic cancer vaccines represent a type of active cancer immunotherapy. Clinicians, scientists, and researchers working on cancer treatment require evidence-based and up-to-date resources relating to therapeutic cancer vaccines. Vaccines for Cancer Immunotherapy provides a reference for cancer treatment for clinicians and presents a well-organized resource for determining high-potential research areas. The book considers that this promising modality can be made more feasible as a treatment for cancer. Chapters cover cancer immunology, general approaches to cancer immunotherapy, vaccines, tumor antigens, the strategy of allogeneic and autologous cancer vaccines, personalized vaccines, whole-tumor antigen vaccines, protein and peptide vaccines, dendritic cell vaccines, genetic vaccines, candidate cancers for vaccination, obstacles to developing therapeutic cancer vaccines, combination therapy, future perspectives and concluding remarks on therapeutic cancer vaccines. Introduces the feasible immunotherapeutic vaccines for patients with different types of cancer Presents the status of past and current vaccines for cancer treatment Considers advantages and disadvantages of different therapeutic cancer vaccines Looks at the combination of vaccines and other modalities, including immunotherapeutic and conventional methods Analyzes obstacles to development of therapeutic cancer vaccines Gives a view on future perspectives in the application of therapeutic cancer vaccines

The Immunotherapy Revolution

Jason R. Williams
The Immunotherapy Revolution Book PDF

Author : Jason R. Williams
Publisher : Unknown
Page : 216 pages
File Size : 55,5 Mb
Release : 2019-10-15
Category : Cancer
ISBN : 170011493X

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The Immunotherapy Revolution by Jason R. Williams Pdf

The Future Of Treating Cancer Has Finally Arrived.Cancer treatments can be torture! Surgery, chemotherapy, and radiation are not only extreme but can be just as painful and dangerous as the cancer itself. When doctors treat cancer aggressively it leaves the body in a weakened, susceptible state open to contracting other diseases or relapses. Most of the medical field refuses to acknowledge the major problems with the way they treat cancer. So is there really a better way to heal from cancer against all odds? YES!In this eye-opening book, Dr. Williams shares his most groundbreaking, shocking conclusions from his decades of in-depth research on cancer. He provides life-changing advice in the most critical and overlooked areas in cancer treatment and recovery. He has personally developed a revolutionary medical treatment that will change the way we treat cancer - forever.Dr. Jason R. Williams is a board-certified radiologist, image-guided oncologist, researcher, and professor. He is the Founder and Director of Interventional Oncology for the Williams CancerInstitute and adjunct professor at Case Western Reserve University. He has pioneered a brand new less invasive, less toxic solution to treating cancer.Committed to further advance research in intra-tumoral immunotherapy and help those who are struggling financially to cover medical costs, Dr. Williams is donating all proceeds from this book for this cause. Grab your copy now, and discover the promising solution to cancer!

Bio-Engineering Approaches to Cancer Diagnosis and Treatment

Azadeh Shahidian,Majid Ghassemi,Javad Mohammadi,Mohadeseh Hashemi
Bio Engineering Approaches to Cancer Diagnosis and Treatment Book PDF

Author : Azadeh Shahidian,Majid Ghassemi,Javad Mohammadi,Mohadeseh Hashemi
Publisher : Academic Press
Page : 276 pages
File Size : 53,9 Mb
Release : 2020-05-14
Category : Technology & Engineering
ISBN : 9780128178102

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Bio-Engineering Approaches to Cancer Diagnosis and Treatment by Azadeh Shahidian,Majid Ghassemi,Javad Mohammadi,Mohadeseh Hashemi Pdf

Bioengineering Approaches to Cancer Diagnosis and Treatment is written for an audience of senior undergraduate students and graduate students in mechanical, electrical and biomedical engineering fields and other professionals in medicine. It is ideally structured for teaching and for those who are working in cancer bioengineering or interdisciplinary projects. The book's authors bring a unique perspective from their expertise in immunology, nanobiomaterials and heat transfer. Topical coverage includes an introduction to the fundamentals of bioengineering and engineering approaches for cancer diagnosis, cancer treatment via case studies, and sections on imaging, immunotherapy, cell therapy, drug delivery, ultrasound and microfluidics in cancer treatment. Provides fully supported case studies relating to cancer diagnosis and therapy Pairs the basic fundamentals of engineering and biomedical engineering and applies them to the diagnosis of cancer