The Calcitonin Gene Related Peptide Family

Author : Deborah L. Hay,Ian M. Dickerson
Publisher : Springer Science & Business Media
Page : 236 pages
File Size : 45,6 Mb
Release : 2009-10-03
Category : Medical
ISBN : 9789048129096

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The calcitonin gene-related peptide family by Deborah L. Hay,Ian M. Dickerson Pdf

In 1925, J. B. Collip (1925) reported that extracts of parathyroid gland contained an activity that raised calcium levels in the blood of parathyroidectomized animals, and suggested that this was due to a hormone produced in the parathyroid gland. The story of parathyroid hormone discovery was indicative of ever-increasing sophistication in sample preparation and protein isolation techniques. This paper resolved earlier controversies over the function of the parathyroid glands and c- trol of blood calcium. The year 1961 was a banner year for parathyroid research, in which the peptides parathyroid hormone and calcitonin were purified, and in which it was suggested that calcitonin could lower blood calcium (Copp and Cameron 1961). In 1982 it was discovered that in neurons the primary RNA transcript for calcitonin could be alternatively-spliced to give calcitonin gene-reated peptide (CGRP), and shortly thereafter amylin (previously named islet amyloid polyp- tide, IAPP) was identified and shown to have homology to CGRP. Since then a and b CGRP have been delineated and adrenomedullin and intermedin discovered, and this family of homologous peptides has emerged. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition.

Author : David Poyner
Publisher : CRC Press
Page : 294 pages
File Size : 44,5 Mb
Release : 1999-10-01
Category : Science
ISBN : 9781498713573

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The CGRP Family by David Poyner Pdf

This book is based on presentations given at CGRP '98, the Third International Meeting on CGRP and related peptides held in the UK in May 1998. The principal speakers have each contributed a chapter and many of the short and poster communications will also be found here. This book follows from the tradition set by the First and Second Meetings in 1

Author : Deborah L. Hay,Ian M. Dickerson
Publisher : Unknown
Page : 246 pages
File Size : 54,8 Mb
Release : 2009-10-04
Category : MEDICAL
ISBN : 9048129109

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The Calcitonin Gene-Related Peptide Family by Deborah L. Hay,Ian M. Dickerson Pdf

Author : Deborah L. Hay,Ian M. Dickerson
Publisher : Springer
Page : 236 pages
File Size : 43,5 Mb
Release : 2009-10-14
Category : Medical
ISBN : 9048129087

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The calcitonin gene-related peptide family by Deborah L. Hay,Ian M. Dickerson Pdf

In 1925, J. B. Collip (1925) reported that extracts of parathyroid gland contained an activity that raised calcium levels in the blood of parathyroidectomized animals, and suggested that this was due to a hormone produced in the parathyroid gland. The story of parathyroid hormone discovery was indicative of ever-increasing sophistication in sample preparation and protein isolation techniques. This paper resolved earlier controversies over the function of the parathyroid glands and c- trol of blood calcium. The year 1961 was a banner year for parathyroid research, in which the peptides parathyroid hormone and calcitonin were purified, and in which it was suggested that calcitonin could lower blood calcium (Copp and Cameron 1961). In 1982 it was discovered that in neurons the primary RNA transcript for calcitonin could be alternatively-spliced to give calcitonin gene-reated peptide (CGRP), and shortly thereafter amylin (previously named islet amyloid polyp- tide, IAPP) was identified and shown to have homology to CGRP. Since then a and b CGRP have been delineated and adrenomedullin and intermedin discovered, and this family of homologous peptides has emerged. This family of peptide hormones has a diverse and constantly expanding range of important physiologic functions, including regulation of blood calcium, vascular tension, feeding behavior and pain recognition.

Author : David Poyner,Ian Marshall
Publisher : R. G. Landes
Page : 261 pages
File Size : 54,7 Mb
Release : 2000
Category : Adrenomedullin
ISBN : 1570595925

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The CGRP Family by David Poyner,Ian Marshall Pdf

Author : Alfredo Martínez,Frank Cuttitta
Publisher : IOS Press
Page : 410 pages
File Size : 40,6 Mb
Release : 1998
Category : Adrenomedullin
ISBN : 9051993609

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Adrenomedullin by Alfredo Martínez,Frank Cuttitta Pdf

Adrenomedullin is a recently discovered peptide hormone which involved in many physiological and pathological processes. This book reviews all the information available on this intriguing molecule, covering topics as diverse as blood pressure regulation, growth of tumours and normal cells, the central nervous system, and comparative studies from sharks to mammals. An international group of experts has contributed to this volume which will be of interest to professionals, researchers, and those who will benefit from a broad review of the literature and the main trends in adrenomedullin research.

Author : Susan D. Brain,Pierangelo Geppetti
Publisher : Springer Nature
Page : 198 pages
File Size : 43,8 Mb
Release : 2019-08-31
Category : Medical
ISBN : 9783030214548

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Calcitonin Gene-Related Peptide (CGRP) Mechanisms by Susan D. Brain,Pierangelo Geppetti Pdf

This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine. The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention.

Author : Peter J. Barnes,Jeffrey M. Drazen,Stephen I. Rennard,Neil C. Thomson
Publisher : Elsevier
Page : 897 pages
File Size : 44,5 Mb
Release : 2009-03-19
Category : Medical
ISBN : 9780080920603

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Asthma and COPD by Peter J. Barnes,Jeffrey M. Drazen,Stephen I. Rennard,Neil C. Thomson Pdf

The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations

Author : Anonim
Publisher : Elsevier
Page : 442 pages
File Size : 54,8 Mb
Release : 2020-09-05
Category : Science
ISBN : 9780128211090

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Update on Emerging Treatments for Migraine by Anonim Pdf

Update on Emerging Treatments for Migraine, Volume 255, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Progress in Brain Research series Updated release includes the latest information on Update on Emerging Treatments for Migraine

Author : Fabio Doctorovich,Patrick J. Farmer,Marcelo A. Marti
Publisher : Elsevier
Page : 424 pages
File Size : 45,6 Mb
Release : 2016-09-01
Category : Science
ISBN : 9780128011645

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The Chemistry and Biology of Nitroxyl (HNO) by Fabio Doctorovich,Patrick J. Farmer,Marcelo A. Marti Pdf

The Chemistry and Biology of Nitroxyl (HNO) provides first-of-its-kind coverage of the intriguing biologically active molecule called nitroxyl, or azanone per IUPAC nomenclature, which has been traditionally elusive due to its intrinsically high reactivity. This useful resource provides the scientific basis to understand the chemistry, biology, and technical aspects needed to deal with HNO. Building on two decades of nitric oxide and nitroxyl research, the editors and authors have created an indispensable guide for investigators across a wide variety of areas of chemistry (inorganic, organic, organometallic, biochemistry, physical, and analytical); biology (molecular, cellular, physiological, and enzymology); pharmacy; and medicine. This book begins by exploring the unique molecule’s structure and reactivity, including important reactions with small molecules, thiols, porphyrins, and key proteins, before discussing chemical and biological sources of nitroxyl. Advanced chapters discuss methods for both trapping and detecting nitroxyl by spectroscopy, electrochemistry, and fluorescent inorganic cellular probing. Expanding on the compound’s foundational chemistry, this book then explores its molecular physiology to offer insight into its biological implications, pharmacological effects, and practical issues. Presents the first book on HNO (nitroxyl or azanone), an increasingly important molecule in biochemistry and pharmaceutical research Provides a valuable coverage of HNO’s chemical structure and significant reactions, including practical guidance on working with this highly reactive molecule Contains high quality content from recognized experts in both industry and academia

Author : Antoinette Maassen van den Brink,Paolo Martelletti
Publisher : Springer Nature
Page : 172 pages
File Size : 46,8 Mb
Release : 2021-04-28
Category : Medical
ISBN : 9783030690328

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Monoclonal Antibodies in Headache by Antoinette Maassen van den Brink,Paolo Martelletti Pdf

Intended to promote a more appropriate and modern therapeutic approach to migraine management, this book is the first to deal with monoclonal antibodies in this context. Authored by the most respected migraine experts from around the globe and drawing on the lessons learned in both clinical trials and clinical practice, it reviews the current state of knowledge on this important therapeutic innovation, which has produced impressive data in randomized controlled trials, and the efficacy and safety of which have been confirmed in day-to-day real-world use. Given its scope, the book will appeal to a broad range of specialists, including pharmacologists, clinical pharmacologists, neurologists and internists, but also to residents and medical students.

Author : Abba Kastin,Abba J. Kastin
Publisher : Elsevier
Page : 1682 pages
File Size : 41,8 Mb
Release : 2011-04-28
Category : Science
ISBN : 9780080463797

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Handbook of Biologically Active Peptides by Abba Kastin,Abba J. Kastin Pdf

Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar. *Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.

Author : Alexander Mauskop
Publisher : New York Headache Center
Page : 128 pages
File Size : 54,7 Mb
Release : 2021-01-04
Category : Medical
ISBN : 9781736286814

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The End of Migraines: 150 Ways to Stop Your Pain by Alexander Mauskop Pdf

Alexander Mauskop, M.D., is the founder and medical director of the New York Headache Center. He is also a Professor of Clinical Neurology at the State University of New York Downstate Medical Center in Brooklyn, New York. A leading authority in the field of headache medicine, Dr. Mauskop has lectured widely throughout the world. The End of Migraine: 150 Ways to Stop Your Pain is a comprehensive resource based on Dr. Mauskop’s extensive experience in treating thousands of patients with migraine. In addition to scientific evidence, clinical observations, and practical suggestions, The End of Migraine describes and evaluates the immense amount of information available about every imaginable option that has been shown to impact the occurrence and treatment of migraines. The 150 approaches to ending migraine pain include non-pharmacologic treatments such as avoidance of triggers, diet, physical and behavioral measures, neuro-modulation, and various supplements. It also describes and ranks a wide range of acute and preventive prescription drugs, from the traditional to all of the latest innovations and treatments. The book is written in a clear, concise, and accessible style. Dr. Mauskop’s warm, reassuring voice enables the reader to feel that they are sitting with him, hearing his advice first-hand. Above all, readers of The End of Migraine: 150 Ways to Stop Your Pain will, perhaps for the first time, feel that they are not alone, because there is hope. The book is directed not only to those suffering from migraines but also to neurologists and other health care providers who treat migraine patients.

Author : Robert Vink,Mihai Nechifor
Publisher : University of Adelaide Press
Page : 354 pages
File Size : 47,7 Mb
Release : 2011
Category : Medical
ISBN : 9780987073051

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Magnesium in the Central Nervous System by Robert Vink,Mihai Nechifor Pdf

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Author : Ronald F. Tuma,Walter N. Duran,Klaus Ley
Publisher : Academic Press
Page : 1000 pages
File Size : 48,9 Mb
Release : 2011-04-28
Category : Science
ISBN : 0080569935

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Microcirculation by Ronald F. Tuma,Walter N. Duran,Klaus Ley Pdf

This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume