The Chemistry And Biology Of Nitroxyl Hno

Author : Fabio Doctorovich,Patrick J. Farmer,Marcelo A. Marti
Publisher : Elsevier
Page : 424 pages
File Size : 55,7 Mb
Release : 2016-09-01
Category : Science
ISBN : 9780128011645

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The Chemistry and Biology of Nitroxyl (HNO) by Fabio Doctorovich,Patrick J. Farmer,Marcelo A. Marti Pdf

The Chemistry and Biology of Nitroxyl (HNO) provides first-of-its-kind coverage of the intriguing biologically active molecule called nitroxyl, or azanone per IUPAC nomenclature, which has been traditionally elusive due to its intrinsically high reactivity. This useful resource provides the scientific basis to understand the chemistry, biology, and technical aspects needed to deal with HNO. Building on two decades of nitric oxide and nitroxyl research, the editors and authors have created an indispensable guide for investigators across a wide variety of areas of chemistry (inorganic, organic, organometallic, biochemistry, physical, and analytical); biology (molecular, cellular, physiological, and enzymology); pharmacy; and medicine. This book begins by exploring the unique molecule’s structure and reactivity, including important reactions with small molecules, thiols, porphyrins, and key proteins, before discussing chemical and biological sources of nitroxyl. Advanced chapters discuss methods for both trapping and detecting nitroxyl by spectroscopy, electrochemistry, and fluorescent inorganic cellular probing. Expanding on the compound’s foundational chemistry, this book then explores its molecular physiology to offer insight into its biological implications, pharmacological effects, and practical issues. Presents the first book on HNO (nitroxyl or azanone), an increasingly important molecule in biochemistry and pharmaceutical research Provides a valuable coverage of HNO’s chemical structure and significant reactions, including practical guidance on working with this highly reactive molecule Contains high quality content from recognized experts in both industry and academia

Author : D.L.H. Williams
Publisher : Elsevier
Page : 281 pages
File Size : 50,7 Mb
Release : 2004-12-16
Category : Science
ISBN : 9780080473604

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Nitrosation Reactions and the Chemistry of Nitric Oxide by D.L.H. Williams Pdf

Since 1988, there has been much literature published on the chemistry of nitric oxide, particularly in the field of S-nitrosation and the chemistry of S-nitroso compounds. Written by a chemist for the chemistry community, this book provides an update of the chemistry of nitrosation reactions, dealing with both the synthetic and mechanistic aspects of these reactions. It also looks at the chemistry of nitric oxide in relation to the amazing biological properties of this simple diatomic molecule, which were unknown until around 1990. * Provides an update on previously published literature on nitric oxide chemistry* Contains chapters on reagents for nitrosation, nitrosation at nitrogen, aliphatic and aromatic carbon, oxygen, sulfur and metal centres* Looks at hot research topics such as synthesis, properties and reactions of s-nitrosothiols

Author : Lucia Morbidelli,Benjamin Bonavida,Jordi Muntané
Publisher : Elsevier
Page : 366 pages
File Size : 54,7 Mb
Release : 2023-04-13
Category : Computers
ISBN : 9780443133435

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Nitric Oxide in Health and Disease by Lucia Morbidelli,Benjamin Bonavida,Jordi Muntané Pdf

Nitric Oxide in Health and Disease: Therapeutic Applications in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities. The book discusses many examples of research related to the application of novel therapeutic compounds that focus on a chemical—nitric oxide—and its applications that have been shown to exert significant therapeutic activities against various resistant cancers unresponsive to current treatments and different inflammatory diseases which continue to require novel treatments. This is a valuable resource for cancer researchers, oncologists, graduate students and researchers from medical and biomedical fields who want to know more about NO and its therapeutic applications in cancer and inflammatory diseases. Provides updated reviews on the chemistry and signaling of newly derived therapeutic nitric oxide (NO) donors/inhibitors and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities Discusses the application of NO in monotherapy or in combination with conventional therapies in a variety of cancers and inflammatory diseases Encompasses real-world examples of recent research related to NO and cancer

Author : Frederick A. Villamena
Publisher : Elsevier
Page : 340 pages
File Size : 55,5 Mb
Release : 2016-10-23
Category : Science
ISBN : 9780124200807

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Reactive Species Detection in Biology by Frederick A. Villamena Pdf

Reactive Species Detection in Biology: From Fluorescence to Electron Paramagnetic Resonance Spectroscopy discusses the reactive oxygen species that have been implicated in the pathogenesis of various diseases, presenting theories, chemistries, methodologies, and various applications for the detection of reactive species in biological systems, both in-vitro and in-vivo. Techniques covered include fluorescence, high performance chromatography, mass spectrometry, immunochemistry, and electron paramagnetic resonance spectroscopy. Probe design and development are also reviewed in order to advance new approaches in radical detection through synthesis, computations, or experimental applications. Reviews all current advances in radical detection Emphasizes chemical structures and reaction schemes fundamental to radical detection and identification Describes the uses, advantages, and disadvantages of various probe designs Examines new approaches to radical probe development

Author : Anonim
Publisher : ScholarlyEditions
Page : 108 pages
File Size : 54,8 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464929939

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Porphyrins: Advances in Research and Application: 2011 Edition by Anonim Pdf

Porphyrins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Porphyrins. The editors have built Porphyrins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Porphyrins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Porphyrins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Bess B. Ward,Daniel J. Arp,Martin G. Klotz
Publisher : American Society for Microbiology Press
Page : 610 pages
File Size : 50,8 Mb
Release : 2011-03-25
Category : Science
ISBN : 9781555814816

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Nitrification by Bess B. Ward,Daniel J. Arp,Martin G. Klotz Pdf

A full review of the latest research findings on microbes involved in conventional aerobic nitrification, anaerobic ammonia oxidation, and related processes. • Examines the four principal groups of nitrifying microbes including conventional aerobic bacterial ammonia oxidizers, recently discovered aerobic archaeal ammonia oxidizers, anaerobic ammonia-oxidizing planctomycetes, and nitrite-oxidizing bacteria. • Provides current information on the ecology, phylogeny, biochemistry, molecular biology, and genomics of each group of microbes. • Discusses the latest industrial applications of nitrification and anammox processes, and explores the ecology of nitrification in marine, freshwater, soil, and wastewater environments.

Author : Lester Packer,Enrique Cadenas
Publisher : Gulf Professional Publishing
Page : 730 pages
File Size : 42,5 Mb
Release : 2005-08-18
Category : Science
ISBN : 0121828018

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Methods in Enzymology by Lester Packer,Enrique Cadenas Pdf

Since the inception of the series, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all field of life sciences. This final volume in the five-part Nitric Oxide series supplements MIE volumes 268, 269, 301 and 359. Nitric Oxide impinges on a wide range of fields in biological research, particularly in the areas of biomedicine and cell and organic biology, as well as fundamental chemistry. These volumes are a valuable resource for the experienced researcher and for those entering the field. *One of the most highly respected publication in the field of biochemistry since 1955 *Frequently consulted and praised by researchers and reviewers alike *Truly an essential publication for anyone in any field of the life sciences

Author : Matthew Irick Jackson
Publisher : Unknown
Page : 378 pages
File Size : 51,7 Mb
Release : 2008
Category : Electronic
ISBN : UCLA:L0100089903

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Biochemical Targets of Nitroxyl (HNO) and the Inhibition of Hydrogen Peroxide Metabolism by Matthew Irick Jackson Pdf

Author : Anonim
Publisher : Academic Press
Page : 450 pages
File Size : 51,9 Mb
Release : 2017-06-30
Category : Science
ISBN : 9780128128350

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Inorganic Reaction Mechanisms by Anonim Pdf

Inorganic Reaction Mechanisms, Volume 70 is the latest volume in the Advances in Inorganic Chemistry series that presents timely summaries of current progress in inorganic chemistry, ranging from bio-inorganic to solid state studies. Topics covered in this updated volume include The Kinetics and Mechanism of Complex Redox Reactions in Aqueous Solution: The Tools of the Trade, O-O Bond Activation in Cu and Fe-Based Coordination Complexes: Breaking it Makes the Difference, μ-Nitrido Diiron Phthalocyanine and Porphyrin Complexes: Unusual Structures With Interesting Catalytic Properties, and The Role of Nonheme Transition Metal-Oxo, -Peroxo and -Superoxo Intermediates in Enzyme Catalysis and Reactions of Bioinspired Complexes. This acclaimed serial features reviews written by experts in the field, serving as an indispensable reference to advanced researchers. Each volume contains an index and chapters are fully referenced. Features comprehensive reviews on the latest developments in inorganic reaction mechanisms, a subfield of inorganic chemistry Includes contributions from leading experts in the field of inorganic reaction mechanisms Serves as an indispensable reference to advanced researchers in inorganic reaction mechanisms

Author : Yann A. Henry,Annie Guissani,Beatrice Ducastel
Publisher : Springer Science & Business Media
Page : 343 pages
File Size : 52,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461311850

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Nitric Oxide Research from Chemistry to Biology: EPR Spectroscopy of Nitrosylated Compounds by Yann A. Henry,Annie Guissani,Beatrice Ducastel Pdf

Author : Anonim
Publisher : Academic Press
Page : 512 pages
File Size : 50,7 Mb
Release : 2011-09-02
Category : Science
ISBN : 0080877613

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Nitric Oxide, Part F by Anonim Pdf

The discovery that nitrogen monoxide or nitric oxide (NO)is a biologically produced free radical has revolutionized our thinking about physiological and pathological processes. This discovery has ignited enormous interest in the scientific community. When generated at low levels, NO is a signaling molecule, but at high concentration, NO is a cytotoxic molecule. The physiological and pathological processes of NO production and metabolism and its targets, currently areas of intensive research, have important pharmacologic implications for health and disease.

Author : P. David Josephy,Bengt Mannervik
Publisher : Unknown
Page : 620 pages
File Size : 50,9 Mb
Release : 2006
Category : Molecular toxicology
ISBN : 0195176200

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Molecular Toxicology by P. David Josephy,Bengt Mannervik Pdf

The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair,among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses,as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

Author : A. B. P. Lever,H. B. Gray
Publisher : Wiley-VCH
Page : 322 pages
File Size : 54,5 Mb
Release : 1989-03-31
Category : Science
ISBN : 0471187151

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Iron Porphyrins by A. B. P. Lever,H. B. Gray Pdf

Porphyrins play a vital role in many biological functions including oxygen transport, electron transfer and catalyzing the incorporation of oxygen into other molecules. This current survey discusses the use of modern physical techniques to probe porphyrin structure and function. The authors review the data available through a particular technique and show what can be learned therefrom about the (electronic) structure and function of biologically important porphyrins. The techniques include magnetic circular dichroism, X-ray absorption fine structure (EXAFS) and Mössbauer spectroscopies. All contributors are well known in their respective fields, enjoying world-wide reputation.

Author : Abhik Ghosh
Publisher : Elsevier
Page : 627 pages
File Size : 52,9 Mb
Release : 2011-10-13
Category : Science
ISBN : 9780080556321

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The Smallest Biomolecules: Diatomics and their Interactions with Heme Proteins by Abhik Ghosh Pdf

This is not a book on NO biology, nor about hemoglobin, nor about heme-based sensors per se. Of course, it covers all these topics and more, but above all, it aims at providing a truly multidisciplinary perspective of heme-diatomic interactions. The overarching goal is to build bridges among disciplines, to bring about a meeting of minds. The contributors to this book hail from diverse university departments and disciplines – chemistry, biochemistry, molecular biology, microbiology, zoology, physics, medicine and surgery, bringing with them very different views of heme-diatomic interactions. The hope is that the juxtaposition of this diversity will lead to increased exchanges of ideas, approaches, and techniques across traditional disciplinary boundaries. The authors represent a veritable Who’s Who of heme protein research and include John Olson, Tom Spiro, Walter Zumft, F. Ann Walker, Teizo Kitagawa, W. Robert Scheidt, Pat Farmer, Marie-Alda Gilles-Gonzalez, and many other equally distinguished scientists. Extremely distinguished list of authors Multidisciplinary character – equally suitable for chemists and biochemists Covers the hottest topics in heme protein research: sensors, NO biology, new roles of hemoglobin, etc.

Author : Thomas S. Hofer,Sam P. de Visser
Publisher : Frontiers Media SA
Page : 188 pages
File Size : 47,5 Mb
Release : 2018-11-28
Category : Electronic
ISBN : 9782889456260

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Quantum Mechanical/Molecular Mechanical Approaches for the Investigation of Chemical Systems – Recent Developments and Advanced Applications by Thomas S. Hofer,Sam P. de Visser Pdf

The QM/MM method, short for quantum mechanical/molecular mechanical, is a highly versatile approach for the study of chemical phenomena, combining the accuracy of quantum chemistry to describe the region of interest with the efficiency of molecular mechanical potentials to represent the remaining part of the system. Originally conceived in the 1970s by the influential work of the the Nobel laureates Martin Karplus, Michael Levitt and Arieh Warshel, QM/MM techniques have evolved into one of the most accurate and general approaches to investigate the properties of chemical systems via computational methods. Whereas the first applications have been focused on studies of organic and biomolecular systems, a large variety of QM/MM implementations have been developed over the last decades, extending the range of applicability to address research questions relevant for both solution and solid-state chemistry as well. Despite approaching their 50th anniversary in 2022, the formulation of improved QM/MM methods is still an active field of research, with the aim to (i) extend the applicability to address an even broader range of research questions in chemistry and related disciplines, and (ii) further push the accuracy achieved in the QM/MM description beyond that of established formulations. While being a highly successful approach on its own, the combination of the QM/MM strategy with other established theoretical techniques greatly extends the capabilities of the computational approaches. For instance the integration of a suitable QM/MM technique into the highly successful Monte-Carlo and molecular dynamics simulation protocols enables the description of the chemical systems on the basis of an ensemble that is in part constructed on a quantum-mechanical basis. This eBook presents the contributions of a recent Research Topic published in Frontiers in Chemistry, that highlight novel approaches as well as advanced applications of QM/MM method to a broad variety of targets. In total 2 review articles and 10 original research contributions from 48 authors are presented, covering 12 different countries on four continents. The range of research questions addressed by the individual contributions provide a lucid overview on the versatility of the QM/MM method, and demonstrate the general applicability and accuracy that can be achieved for different problems in chemical sciences. Together with the development of improved algorithms to enhance the capabilities of quantum chemical methods and the continuous advancement in the capacities of computational resources, it can be expected that the impact of QM/MM methods in chemical sciences will be further increased already in the near future.