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Author : Leslie M. Shaw,Tai C. Kwong
Publisher : Amer. Assoc. for Clinical Chemistry
Page : 564 pages
File Size : 41,8 Mb
Release : 2001
Category : Analytical chemistry
ISBN : 1890883530
Author : Barbarajean Magnani
Publisher : Unknown
Page : 286 pages
File Size : 44,5 Mb
Release : 2012
Category : Medical
ISBN : 0983706816
This book is a practical guide to setting up, overseeing, and directing hospital toxicology laboratory operations. It focuses on the complex issues facing the laboratory director or pathologist in this role, as well as those in training in the field of laboratory medicine. It addresses not only pharmacological principles, testing menus, and methodologies, but also clinical test interpretation for specialized areas such as the emergency department, the pain clinic, and the autopsy suite. In addition, it serves as an introduction to such topics as workplace drug testing and relevant regulatory issues. It provides the reader with a comprehensive view of what is needed--and expected--when offering a clinical toxicology service --
Author : Barbarajean Magnani,Tai C. Kwong,Gwendolyn A. McMillin,Alan H. B. Wu
Publisher : Unknown
Page : 375 pages
File Size : 53,7 Mb
Release : 2020
Category : Toxicity testing
ISBN : 1941096506
"A comprehensive overview of clinical laboratory toxicology services and analytes"--
Author : Hema Ketha,Uttam Garg
Publisher : Academic Press
Page : 542 pages
File Size : 53,9 Mb
Release : 2020-06-20
Category : Medical
ISBN : 9780128163733
Toxicology Cases for the Clinical and Forensic Laboratory brings together carefully selected case studies to teach important principles relating to drug and toxin exposures. Each case study includes contemporary clinical and forensic toxicologist studies that include a comprehensive analytical and clinical approach to patient management and address overdoses from designer drugs, to NSAIDS, to opioids, to stimulants. These cases present a comprehensive, analytical and clinical approach to managing a drug overdose. This is a must-have reference for clinical and forensic laboratory scientists, along with toxicology and pathology residents who need to know aspects of both. Brings together expert cases encompassing analytical toxicology, clinical medicine and basic science in a consolidated format Presents unique and challenging cases in clinical laboratories contributed by experts in the field Consolidated format that make concepts in toxicology easy to learn and teach Key learning points highlighted with multiple choice questions
Author : John E. Whalan
Publisher : Springer
Page : 151 pages
File Size : 40,9 Mb
Release : 2015-03-25
Category : Medical
ISBN : 9783319158532
This guide provides an easy-to-use desk reference for diagnostic information on commonly used hematology, clinical chemistry and urinalysis parameters. Additional reference materials are provided as an aid in evaluating clinical pathology data. For many toxicologists, the evaluation of hematology, clinical chemistry and urinalysis data can be the most challenging aspect of animal toxicity studies. In a typical toxicity study, dozens of parameters are measured several times over the course of the study. There may be hundreds of data points, each of which needs to be considered. A Toxicologist’s Guide to Clinical Pathology in Animals will serve as an essential primer for toxicologists in training and in industry as well as for researchers and professionals in a veterinary practice or a laboratory.
Author : John Joseph Fenton
Publisher : CRC Press
Page : 585 pages
File Size : 40,8 Mb
Release : 2001-10-10
Category : Law
ISBN : 9781420042061
REAL-LIFE CASES, TUTORIAL QUESTIONS, NARRATIVE HISTORY Intriguing anecdotal pedagogy, like the alleged arsenical poisonings of Napoleon and President Taylor and the probable mercury overdose of Isaac Newton, is one of the things that set Toxicology: A Case-Oriented Approach apart from other toxicology texts. Based on an undergraduate-graduat
Author : Michael G. Bissell
Publisher : Elsevier Health Sciences
Page : 240 pages
File Size : 47,6 Mb
Release : 2012-09-24
Category : Medical
ISBN : 9781455747870
This issue of Clinics in Laboratory Medicine, titled Toxicology Testing, includes the following topics; Progress in Clinical Toxicology Testing, The Prescription Drug Abuse Epidemic, Substance Abuse Among Healthcare Professionals, Pain Management Drug Testing, Ethanol Biomarkers, Newly-emerging Drugs of Abuse, Synthetic Cannabinoids, Synthetic Cathenones, Immunoassay Methodology in Drugs-of-abuse Testing, Toxicology Testing in Alternative Specimen Matrices, Principles and Procedures in Postmortem Toxicology, and Pharmacogenetics and the Future of Toxicology Testing. Advances in toxicology testing are paving the way for major improvements in the way scientists evaluate health risks posed by toxic chemicals. Toxicity tests help scientists better understand how the human body carries out normal functions that are key to maintaining health. Therefore, this topic is important to the field of Laboratory Medicine.
Author : Hari Nair,William Clarke
Publisher : Academic Press
Page : 304 pages
File Size : 47,8 Mb
Release : 2016-11-02
Category : Medical
ISBN : 9780128009925
Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab
Author : Robert M. White
Publisher : Amer. Assoc. for Clinical Chemistry
Page : 144 pages
File Size : 52,8 Mb
Release : 2002
Category : Medical
ISBN : 1890883743
Author : Robert J. Flanagan,Andrew A. Taylor,Ian D. Watson,Robin Whelpton
Publisher : John Wiley & Sons
Page : 605 pages
File Size : 44,6 Mb
Release : 2008-03-03
Category : Science
ISBN : 9780470319345
The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens. After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques - colour tests and spectrophotometry, chromatography and electrophoresis, mass spectrometry, and immunoassay – are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results. A clearly written, practical, integrated approach to the basics of analytical toxicology. Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications. Assumes only a basic knowledge of analytical chemistry. An accompanying website provides additional material and links to related sites. Written by an experienced team of authors,Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development. Praise from the reviews: “This is an ambitious effort to describe in detail the many and varied aspects of the science of toxicological analysis. The 17 chapters cover every foreseeable aspect, from specimen collection through analytical techniques and quality control to pharmacological principles and interpretation of results. The authors bring together a great deal of experience in the field and have succeeded admirably in achieving their goal: "to give principles and practical information on the analysis of drugs, poisons and other relevant analytes in biological specimens...". The book is very readable and quite up-to-date, and contains many illustrative figures, charts and tables. Both the student and the practicing professional would do well to study this material carefully, as there is something here for every conceivable level of interest.” Review from Randall Baselt "This text comes highly recommended for any analytical toxicology trainee." The Bulletin of the Royal College of Pathologists “Overall, this book provides a comprehensive, thorough, clear, up to date and practical treatment of analytical toxicology at a high standard. Understanding of the text is enhanced by the use of many illustrations. Specifications, guidelines, and methods are highlighted in grey background “Boxes”. The many and up to date literature references in each chapter demonstrate the authors’ thorough work and permit easy access to deeper information. Therefore this book can be highly recommended as a valuable source of knowledge in analytical toxicology both as an introduction and for the advanced reader.” GTFCh Bulletin “Toxichem + Krimtech”, May 2008 (translated, original review in German) “Many toxicologists will add this important reference to their libraries because it competently fills a need ...” International Journal of Toxicology “The book is very well illustrated, easy to understand and pleasant to read, and contains a wealth of dedicated information.” International Journal of Environmental Analytical Chemistry
Author : Eleanor Berman
Publisher : Charles C. Thomas Publisher
Page : 0 pages
File Size : 45,8 Mb
Release : 1996
Category : Analytical toxicology
ISBN : 0398065829
An overview of the analytic techniques and methodologies used by clinical laboratories to meet the increasing demand for investigations related to drug abuse, therapeutic drug monitoring, sequelae of exposures to trace metals, and miscellaneous toxins present in industrial and nonindustrial environments; and also the increasing reliance of clinicians on laboratory scientists for information on the significance of different symptoms and physical signs of the patient as well as the chemical and instrumental data. Paper edition (unseen), $36.95. Annotation copyright by Book News, Inc., Portland, OR
Author : Elizabeth McInnes
Publisher : John Wiley & Sons
Page : 210 pages
File Size : 40,6 Mb
Release : 2017-05-01
Category : Science
ISBN : 9781118755419
Non-pathologists, such as toxicologists and study personnel, can find it difficult to understand the data they receive from pathologists. Toxicological pathologists write long, detailed and highly technical reports. Study personnel are under daily pressure to decide whether lesions described in pathology reports are treatment-related and thus important to the pharmaceutical company or whether the lesions are background changes and thus of little significance. Written by experienced toxicological pathologists, Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel serves to bridge the gap in the understanding of pathology data, enabling non-pathologists to more easily comprehend pathology reports, better integrate pathology data into final study reports and ask pathologists relevant questions about the test compound. This succinct, fully referenced, full colour book is suitable for toxicologists at all stages of their training or career who want to know more about the pathology encountered in laboratory animals used in safety studies. Key features include important chapters on spontaneous and target organ lesions in rats, mice, non-human primates, mini pigs, rabbits and beagle dogs as well as information on general pathology, macroscopic target organ lesions, ancillary pathology techniques, haematology, biochemistry and adversity. Pathology for Toxicologists: Principles and Practices of Laboratory Animal Pathology for Study Personnel includes: Colour diagrams explaining how lesions are caused by either external compounds or spontaneously The anatomic variations and background lesions of laboratory animals Advice on sampling tissues, necropsy, ancillary pathology techniques and recording data A chapter on the haematology and biochemistry of laboratory animals Full colour photographs of common macroscopic lesions encountered in laboratory animals A comprehensive glossary
Author : G.O. Evans
Publisher : CRC Press
Page : 230 pages
File Size : 45,8 Mb
Release : 1996-04-29
Category : Medical
ISBN : 9780748403509
By presenting background information on the selection and application of biochemical tests in safety assessment studies, this text seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies. In addition to chapters which discuss the assessment of specific organ toxicity (such as the liver, kidney and thyroid), the book also covers pre-analytical variables, regulatory requirements and statistical approaches, and highlights some of the major differences between man and different laboratory animals. The editor and contributor are all members of the Animal Clinical Chemistry Association, a group formed to advance the science of animal clinical chemistry in safety evaluation, toxicology and veterinary science.
Author : Daniel E. Rusyniak
Publisher : Unknown
Page : 0 pages
File Size : 51,6 Mb
Release : 2006
Category : Electronic books
ISBN : 1416037330
Author : H.M. Bolt,Frederik A.de Wolff,Peter T. Henderson
Publisher : Springer Science & Business Media
Page : 281 pages
File Size : 51,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642772603
The book contains reviews and posters of the 31st Congress of the EUROTOX (Maastricht 1991). - Forensic Toxicology - Drug Toxicology - Environmental Toxicology
