The Evolution Of Metabolic Function

Author : Robert P. Mortlock
Publisher : CRC Press
Page : 354 pages
File Size : 43,8 Mb
Release : 1992-05-20
Category : Medical
ISBN : 0849388635

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The Evolution of Metabolic Function by Robert P. Mortlock Pdf

The Evolution of Metabolic Function presents comprehensive discussions on a variety of topics that will interest scientists and students studying the evolution of enzyme activities, the evolution of enzymatic pathways, and the evolution and development of metabolic functions. Laboratory experiments designed to develop new enzyme activities and new metabolic pathways are discussed. The most recent techniques comparing protein and gene structures are used to analyze and discuss the evolution and development of such metabolic functions as the bacterial phosphoenolpyruvate:sugar phosphotransferase system, the mandelate pathway of microorganisms, bacterial alcohol metabolism, and certain microbial amino acid biosynthetic pathways. The book also includes some unique speculations regarding the origin of early Archaean cells and the prebiotic evolution of complex molecules.

Author : Eugene V. Koonin,Michael Galperin
Publisher : Springer Science & Business Media
Page : 482 pages
File Size : 50,5 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781475737837

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Sequence — Evolution — Function by Eugene V. Koonin,Michael Galperin Pdf

Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.

Author : R. Ibrahim,L. Varin,V. De Luca,John Romeo
Publisher : Elsevier
Page : 480 pages
File Size : 52,7 Mb
Release : 2000-09-15
Category : Science
ISBN : 0080531326

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Evolution of Metabolic Pathways by R. Ibrahim,L. Varin,V. De Luca,John Romeo Pdf

The past decade has seen major advances in the cloning of genes encoding enzymes of plant secondary metabolism. This has been further enhanced by the recent project on the sequencing of the Arabidopsis genome. These developments provide the molecular genetic basis to address the question of the Evolution of Metabolic Pathways. This volume provides in-depth reviews of our current knowledge on the evolutionary origin of plant secondary metabolites and the enzymes involved in their biosynthesis. The chapters cover five major topics: 1. Role of secondary metabolites in evolution; 2. Evolutionary origins of polyketides and terpenes; 3. Roles of oxidative reactions in the evolution of secondary metabolism; 4. Evolutionary origin of substitution reactions: acylation, glycosylation and methylation; and 5. Biochemistry and molecular biology of brassinosteroids.

Author : William F. Martin,Aloysius G. M. Tielens,Marek Mentel
Publisher : Walter de Gruyter GmbH & Co KG
Page : 269 pages
File Size : 40,6 Mb
Release : 2020-12-07
Category : Science
ISBN : 9783110612417

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Mitochondria and Anaerobic Energy Metabolism in Eukaryotes by William F. Martin,Aloysius G. M. Tielens,Marek Mentel Pdf

Mitochondria are sometimes called the powerhouses of eukaryotic cells, because mitochondria are the site of ATP synthesis in the cell. ATP is the universal energy currency, it provides the power that runs all other life processes. Humans need oxygen to survive because of ATP synthesis in mitochondria. The sugars from our diet are converted to carbon dioxide in mitochondria in a process that requires oxygen. Just like a fire needs oxygen to burn, our mitochondria need oxygen to make ATP. From textbooks and popular literature one can easily get the impression that all mitochondria require oxygen. But that is not the case. There are many groups of organismsm known that make ATP in mitochondria without the help of oxygen. They have preserved biochemical relicts from the early evolution of eukaryotic cells, which took place during times in Earth history when there was hardly any oxygen avaiable, certainly not enough to breathe. How the anaerobic forms of mitochondria work, in which organisms they occur, and how the eukaryotic anaerobes that possess them fit into the larger picture of rising atmospheric oxygen during Earth history are the topic of this book.

Author : John T. Romeo,Phytochemical Society of North America. Meeting
Publisher : Pergamon Press
Page : 467 pages
File Size : 43,7 Mb
Release : 2000
Category : Science
ISBN : 0080438601

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Evolution of Metabolic Pathways by John T. Romeo,Phytochemical Society of North America. Meeting Pdf

The past decade has seen major advances in the cloning of genes encoding enzymes of plant secondary metabolism. This has been further enhanced by the recent project on the sequencing of the Arabidopsis genome. These developments provide the molecular genetic basis to address the question of the Evolution of Metabolic Pathways. This volume provides in-depth reviews of our current knowledge on the evolutionary origin of plant secondary metabolites and the enzymes involved in their biosynthesis. The chapters cover five major topics: 1. Role of secondary metabolites in evolution; 2. Evolutionary origins of polyketides and terpenes; 3. Roles of oxidative reactions in the evolution of secondary metabolism; 4. Evolutionary origin of substitution reactions: acylation, glycosylation and methylation; and 5. Biochemistry and molecular biology of brassinosteroids.

Author : Kenneth B. Storey
Publisher : John Wiley & Sons
Page : 640 pages
File Size : 55,6 Mb
Release : 2005-02-25
Category : Science
ISBN : 9780471675570

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Functional Metabolism by Kenneth B. Storey Pdf

Functional Metabolism of Cells is the first comprehensive survey of metabolism, offering an in-depth examination of metabolism and regulation of carbohydrates, lipids, and amino acids. It provides a basic background on metabolic regulation and adaptation as well as the chemical logic of metabolism, and covers the interrelationship of metabolism to life processes of the whole organism. The book lays out a structured approach to the metabolic basis of disease, including discussion of the normal pathways of metabolism, altered pathways leading to disease, and use of molecular genetics in diagnosis and treatment of disease. It also takes a unique comparative approach in which human metabolism is a reference for metabolism in microorganisms and plant design, and presents novel coverage of development and aging, and human health and animal adaptation. The final chapter reviews the past and future promise of new genetic approaches to treatment and bioinformatics. This, the most exhaustive treatment of metabolism currently available, is a useful text for advanced undergraduates and graduates in biochemistry, cell/molecular biology, and biomedicine, as well as biochemistry instructors and investigators in related fields.

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 570 pages
File Size : 44,7 Mb
Release : 2011-12-30
Category : Science
ISBN : 9780309219396

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The Science and Applications of Synthetic and Systems Biology by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

Author : Gerard Meurant
Publisher : Elsevier
Page : 293 pages
File Size : 54,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323138765

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Cellular Energy Metabolism and its Regulation by Gerard Meurant Pdf

Cellular Energy Metabolism and Its Regulation examines the metabolic and molecular aspects of living organisms. Beginning with a discussion of evolutionary design and its close analogy with human design, it emphasizes the notion that evolution is a process of functional design, and that the characteristics of an organism, whether morphological or molecular, were selected because of functional advantage to the organism's ancestors. Thus, the study of an enzyme, a reaction, or a sequence can be biologically relevant only if its position in the hierarchy of function is kept in mind. This book deals with some aspects of metabolism from that point of view. The key concepts discussed include the conservation of solvent capacity and energy; functional stoichiometric coupling and metabolic prices; adenylate control and the adenylate energy charge; aspects of enzyme behavior that appear to be related to metabolic control; interactions between metabolic sequences; and the adenylate energy charge in intact cells. This book was designed for graduate students in biochemistry, physiology, microbiology, and related fields. However, it may also be useful to senior undergraduate students and more advanced workers who have a direct or peripheral interest in energy metabolism. It assumes a general familiarity with the material covered in a standard biochemistry textbook as well as some knowledge of such related areas as genetics.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 51,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Alex Keene,Masato Yoshizawa,Suzanne Elaine McGaugh
Publisher : Academic Press
Page : 419 pages
File Size : 45,7 Mb
Release : 2015-10-12
Category : Science
ISBN : 9780128023655

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Biology and Evolution of the Mexican Cavefish by Alex Keene,Masato Yoshizawa,Suzanne Elaine McGaugh Pdf

Biology and Evolution of the Mexican Cavefish features contributions by leading researchers in a comprehensive, unique work that examines a number of distinct areas of biology—evolution, development, ecology, and behavior—using the Mexican cavefish as a powerful model system to further understanding of basic biological processes such as eye degeneration, hearing, craniofacial development, sleep, and metabolic function. These fish are currently being used to better understand a number of issues related to human health, including age-related blindness, sleep, obesity, mood-related disorders, and aging. The recent sequencing of the cavefish genome broadens the interest of this system to groups working with diverse biological systems, and has helped researchers identify genes that regulate sleep, eye degeneration, and metabolic function. Mexican cavefish are particularly powerful for the study of biological processes because these fish evolved independently in twenty-nine caves in the Sierra de el Abra Region of Northeast Mexico. These fish have dramatic adaptations to the cave environment, and this can be used to identify genes involved in disease-related traits. This scholarly text will be of interest to researchers and students throughout diverse areas of biology and ecology. It includes photographs of animals and behavior in laboratory and natural settings that will also increase interest and accessibility to non-experts. Includes a mixture of images and illustrations such as the geographical distribution of cave pools and the developmental biology of the nervous system Features a companion site with geographical maps Fills a notable gap in the literature on a topic of broad interest to the scientific community Presents the recent sequencing of the cavefish genome as a groundbreaking development for researchers working with diverse biological systems

Author : Andreas Wagner
Publisher : Current
Page : 306 pages
File Size : 42,9 Mb
Release : 2015-10-06
Category : Science
ISBN : 9781617230219

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Arrival of the Fittest by Andreas Wagner Pdf

"Wagner draws on over fifteen years of research to present the missing piece in Darwin's theory. Using experimental and computational technologies that were heretofore unimagined, he has found that adaptations are not just driven by chance, but by a set of laws that allow nature to discover new molecules and mechanisms in a fraction of the time that random variation would take"--Amazon.com.

Author : Samantha Fowler,Rebecca Roush,James Wise
Publisher : Unknown
Page : 618 pages
File Size : 44,8 Mb
Release : 2018-01-07
Category : Science
ISBN : 9888407457

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Concepts of Biology by Samantha Fowler,Rebecca Roush,James Wise Pdf

Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.

Author : Jonathan C. K. Wells
Publisher : Cambridge University Press
Page : 625 pages
File Size : 40,6 Mb
Release : 2016-07-21
Category : Business & Economics
ISBN : 9781107009479

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The Metabolic Ghetto by Jonathan C. K. Wells Pdf

A multidisciplinary analysis of the role of nutrition in generating hierarchical societies and cultivating a global epidemic of chronic diseases.

Author : Derek Chadwick
Publisher : John Wiley & Sons
Page : 338 pages
File Size : 50,6 Mb
Release : 1992
Category : Medical
ISBN : UOM:39015020855410

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Secondary Metabolites by Derek Chadwick Pdf

Provides a review of current thought on the biosynthesis, function and evolution of secondary metabolites in animals, plants and micro-organisms. Specific topics include the genetic regulation of their synthesis in microbes and plants, and speculation on their possible roles.

Author : Valeria Mapelli
Publisher : Humana
Page : 0 pages
File Size : 43,5 Mb
Release : 2016-08-23
Category : Science
ISBN : 1493952862

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Yeast Metabolic Engineering by Valeria Mapelli Pdf

Yeast Metabolic Engineering: Methods and Protocols provides the widely established basic tools used in yeast metabolic engineering, while describing in deeper detail novel and innovative methods that have valuable potential to improve metabolic engineering strategies in industrial biotechnology applications. Beginning with an extensive section on molecular tools and technology for yeast engineering, this detailed volume is not limited to methods for Saccharomyces cerevisiae, but describes tools and protocols for engineering other yeasts of biotechnological interest, such as Pichia pastoris, Hansenula polymorpha and Zygosaccharomyces bailii. Tools and technologies for the investigation and determination of yeast metabolic features are described in detail as well as metabolic models and their application for yeast metabolic engineering, while a chapter describing patenting and regulations with a special glance at yeast biotechnology closes the volume. Written in the highly successful Methods in Molecular Biology series format, most chapters include an introduction to their respective topic, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Yeast Metabolic Engineering: Methods and Protocols aims to familiarize researchers with the current state of these vital and increasingly useful technologies.