The Exposome

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Unraveling the Exposome

Sonia Dagnino,Anthony Macherone
Unraveling the Exposome Book PDF

Author : Sonia Dagnino,Anthony Macherone
Publisher : Springer
Page : 447 pages
File Size : 54,9 Mb
Release : 2018-10-08
Category : Medical
ISBN : 9783319893211

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Unraveling the Exposome by Sonia Dagnino,Anthony Macherone Pdf

This volume presents a comprehensive overview of the science and application of the Exposome through seventeen chapters from leaders in the field. At just over ten years since the term was coined by Christopher Wild in 2005, this is the first, field-defining volume to offer a holistic picture of the important and growing field of Exposomics. The term “Exposome” describes the sum of all exposures (not only chemical) that an individual can receive over a lifetime from both exogenous sources (environmental contaminants, food, lifestyle, drugs, air, etc.) and endogenous sources (metabolism, oxidative stress, lipid peroxidation, chemicals synthesized by the microbiome, etc.). The first section of this book contains chapters that discuss how the Exposome is defined and how the concept fits into the fields of public health and epidemiology. The second section provides an overview of techniques and methods to measure the human Exposome. The third section contains methods and applications for measuring the Exposome through external exposures. Section four provides an overview on statistical and computational techniques- including big data analysis - for characterizing the Exposome. Section five presents a global collection of case studies

The Exposome

Gary W. Miller
The Exposome Book PDF

Author : Gary W. Miller
Publisher : Elsevier
Page : 118 pages
File Size : 55,6 Mb
Release : 2013-11-16
Category : Science
ISBN : 9780124172180

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The Exposome by Gary W. Miller Pdf

The Exposome: A Primer is the first book dedicated to exposomics, detailing the purpose and scope of this emerging field of study, its practical applications and how it complements a broad range of disciplines. Genetic causes account for up to a third of all complex diseases. (As genomic approaches improve, this is likely to rise.) Environmental factors also influence human disease but, unlike with genetics, there is no standard or systematic way to measure the influence of environmental exposures. The exposome is an emerging concept that hopes to address this, measuring the effects of life-long environmental exposures on health and how these exposures can influence disease. This systematic introduction considers topics of managing and integrating exposome data (including maps, models, computation, and systems biology), "-omics"-based technologies, and more. Both students and scientists in disciplines including toxicology, environmental health, epidemiology, and public health will benefit from this rigorous yet readable overview.

The Exposome

Gary W. Miller
The Exposome Book PDF

Author : Gary W. Miller
Publisher : Academic Press
Page : 298 pages
File Size : 47,5 Mb
Release : 2020-06-17
Category : Science
ISBN : 9780128140796

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The Exposome by Gary W. Miller Pdf

The Exposome: A New Paradigm for the Environment and Health, Second Edition, is a thoroughly expanded and updated edition of The Exposome: A Primer, the first book dedicated to the topic. This new release outlines the purpose and scope of this emerging field of study, its practical applications, and how it complements a broad range of disciplines. The book contains sections on -omics-based technologies, newer detection methods, managing and integrating exposome data (including maps, models, computation and systems biology), and more. Both students and scientists in toxicology, environmental health, epidemiology and public health will benefit from this rigorous, yet readable, overview. This updated edition includes a more in-depth examination of the exposome, including full references, further reading and thought questions. Addresses an emerging field that connects with other exciting disciplines Written by a single author who is a leader in the field Includes new content that widely expands on the first edition

Lung Health and the Exposome

Sumita B. Khatri,Emily J. Pennington
Lung Health and the Exposome Book PDF

Author : Sumita B. Khatri,Emily J. Pennington
Publisher : Humana
Page : 0 pages
File Size : 51,6 Mb
Release : 2023-02-23
Category : Medical
ISBN : 3030901874

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Lung Health and the Exposome by Sumita B. Khatri,Emily J. Pennington Pdf

This book is ideal for the practicing clinician looking to better understand how our environment impacts the lung. A compilation of reviews explores how clinicians can be aware and better determine environmental effects on lung health, and provides guidelines for medical providers to diagnose, counsel and mitigate risk. Various lung diseases are affected by the external environment. Asthma is common, however other airways diseases, such as interstitial lung disease, malignancies, and even adverse effects from reactions treatments for other medical conditions can affect the health of the lungs. While there are books and chapters written on occupational lung disease and environmental causes of asthma, the intent of this body of work is to address the exposome and the effects on a broader group of lung disease. In addition to information on traditional exposure sources, such as air pollution and occupational exposures, this resource explores newer areas of interest, including lung disease from recreational inhalants and the role of climate change on lung health. Written by expert respiratory specialists, the articles cover a wide range of topics, including: How air pollution effects airways disease, including asthma, COPD, and cystic fibrosis Risk factors and effects of indoor mold exposure Both medical and non-medical exposures that increase the risk of or cause interstitial lung disease (ILD) also known as diffuse parenchymal lung disease (DPLD) Acute and chronic lung disease associated with recreational inhalants The epidemiologic and molecular mechanisms of air pollution effects on pulmonary hypertension Climate change and weather-related lung health issues Areas in this field that need further evaluation

The Exposome

Gary W. Miller
The Exposome Book PDF

Author : Gary W. Miller
Publisher : Academic Press
Page : 299 pages
File Size : 43,7 Mb
Release : 2020-06-02
Category : Technology & Engineering
ISBN : 9780128140802

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The Exposome by Gary W. Miller Pdf

The Exposome: A New Paradigm for the Environment and Health, Second Edition, is a thoroughly expanded and updated edition of The Exposome: A Primer, the first book dedicated to the topic. This new release outlines the purpose and scope of this emerging field of study, its practical applications, and how it complements a broad range of disciplines. The book contains sections on -omics-based technologies, newer detection methods, managing and integrating exposome data (including maps, models, computation and systems biology), and more. Both students and scientists in toxicology, environmental health, epidemiology and public health will benefit from this rigorous, yet readable, overview. This updated edition includes a more in-depth examination of the exposome, including full references, further reading and thought questions. Addresses an emerging field that connects with other exciting disciplines Written by a single author who is a leader in the field Includes new content that widely expands on the first edition

One Health Meets the Exposome

Mary Ann Ottinger,Cullen Geiselman
One Health Meets the Exposome Book PDF

Author : Mary Ann Ottinger,Cullen Geiselman
Publisher : Elsevier
Page : 338 pages
File Size : 49,7 Mb
Release : 2023-03-26
Category : Science
ISBN : 9780323885973

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One Health Meets the Exposome by Mary Ann Ottinger,Cullen Geiselman Pdf

One Health Meets the Exposome: Human, Wildlife, and Ecosystem Health brings together the two powerful conceptual frameworks of One Health and the Exposome to comprehensively examine the myriad of biological, environmental, social, and cultural challenges impacting the interrelated health of humans, wildlife, and ecosystems. One Health as an encompassing concept and collaborative framework recognizes the interconnections among humans, wildlife, and our shared environment with the goal of optimizing health outcomes for all. The Exposome is more specifically oriented to human health and considers cumulative environmental exposures affecting individuals, communities, and populations. This book will provide the broadened and integrative view that considers a more holistic approach needed to confront the complex issues facing us today. One Health Meets the Exposome: Human, Wildlife, and Ecosystem Health is a valuable and cutting-edge resource for researchers and practitioners in medicine, public health, animal science, wildlife and field biology, and for any reader looking to better understand the relationships among human health and the environment. Examines One Health historical focus on disease transfer from wildlife to humans Analyzes the transition of the One Health concept to a current multi- and trans-disciplinary framework with global programs aimed at optimizing human, and wildlife health Defines the Exposome and current approaches to conceptualize environmental impacts on human health Bridges the concepts of One Health and the Exposome by comparing, contrasting, and visualizing synergistic and integrative conceptual frameworks

Health Impacts of Developmental Exposure to Environmental Chemicals

Reiko Kishi,Philippe Grandjean
Health Impacts of Developmental Exposure to Environmental Chemicals Book PDF

Author : Reiko Kishi,Philippe Grandjean
Publisher : Springer Nature
Page : 554 pages
File Size : 53,6 Mb
Release : 2019-12-13
Category : Medical
ISBN : 9789811505201

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Health Impacts of Developmental Exposure to Environmental Chemicals by Reiko Kishi,Philippe Grandjean Pdf

This book provides concise and cutting-edge studies on threats resulting from exposure to environmental chemicals that can affect human health and development, with a particular emphasis on the DOHaD concept. The book is divided into five main parts, the first of which includes an introduction to the impacts of developmental exposure to environmental chemicals and historical perspectives, while the second focuses on how environmental chemicals can affect human organs, including neurodevelopment, immune functions, etc. In turn, the third part addresses the characteristics of specific chemicals and their effects on human health and development, while the fourth part provides a basis for future studies by highlighting the latest innovations in toxicology, remaining challenges, and promising strategies in children’s environmental health research, as well as ideas on how to bridge the gap between research evidence and practical policymaking. The fifth and last part outlines further research directions and related policymaking aspects. Health Impacts of Developmental Exposure to Environmental Chemicals will appeal to young and veteran researchers, students, and physicians (especially gynecologists and pediatricians) who are seeking comprehensive information on how children’s health can be affected by harmful chemicals and other environmental toxicants.

A New Paradigm for Environmental Chemistry and Toxicology

Guibin Jiang,Xiangdong Li
A New Paradigm for Environmental Chemistry and Toxicology Book PDF

Author : Guibin Jiang,Xiangdong Li
Publisher : Springer
Page : 276 pages
File Size : 50,9 Mb
Release : 2019-08-09
Category : Science
ISBN : 9789811394478

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A New Paradigm for Environmental Chemistry and Toxicology by Guibin Jiang,Xiangdong Li Pdf

This book provides comprehensive coverage of the theoretical developments and technological breakthroughs that have deepened our understanding of environmental pollution and human health, while also promoting a comprehensive strategy to address these problems. The respective chapters highlight groundbreaking concepts fueling the development of environmental chemistry and toxicology; revolutionary analytical and computational approaches providing novel insights into environmental health; and nature-inspired, innovative engineering solutions for tackling complex hazardous exposures. The book also features a forward-looking perspective on emerging environmental issues that call for new research and regulatory paradigms, laying the groundwork for future advances in the broad field of environmental chemistry and toxicology. Written by respected authorities in the field, A New Paradigm for Environmental Chemistry and Toxicology - From Concepts to Insights will offer an invaluable reference guide for concerned researchers and professional practitioners for years to come.

Exposure Science in the 21st Century

National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human and Environmental Exposure Science in the 21st Century
Exposure Science in the 21st Century Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human and Environmental Exposure Science in the 21st Century
Publisher : National Academies Press
Page : 210 pages
File Size : 55,8 Mb
Release : 2012-10-28
Category : Nature
ISBN : 9780309264686

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Exposure Science in the 21st Century by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Human and Environmental Exposure Science in the 21st Century Pdf

From the use of personal products to our consumption of food, water, and air, people are exposed to a wide array of agents each day-many with the potential to affect health. Exposure Science in the 21st Century: A Vision and A Strategy investigates the contact of humans or other organisms with those agents (that is, chemical, physical, and biologic stressors) and their fate in living systems. The concept of exposure science has been instrumental in helping us understand how stressors affect human and ecosystem health, and in efforts to prevent or reduce contact with harmful stressors. In this way exposure science has played an integral role in many areas of environmental health, and can help meet growing needs in environmental regulation, urban and ecosystem planning, and disaster management. Exposure Science in the 21st Century: A Vision and A Strategy explains that there are increasing demands for exposure science information, for example to meet needs for data on the thousands of chemicals introduced into the market each year, and to better understand the health effects of prolonged low-level exposure to stressors. Recent advances in tools and technologies-including sensor systems, analytic methods, molecular technologies, computational tools, and bioinformatics-have provided the potential for more accurate and comprehensive exposure science data than ever before. This report also provides a roadmap to take advantage of the technologic innovations and strategic collaborations to move exposure science into the future.

Environmental Exposures and Human Health Challenges

Papadopoulou, Paraskevi,Marouli, Christina,Misseyanni, Anastasia
Environmental Exposures and Human Health Challenges Book PDF

Author : Papadopoulou, Paraskevi,Marouli, Christina,Misseyanni, Anastasia
Publisher : IGI Global
Page : 449 pages
File Size : 43,9 Mb
Release : 2019-03-15
Category : Medical
ISBN : 9781522576365

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Environmental Exposures and Human Health Challenges by Papadopoulou, Paraskevi,Marouli, Christina,Misseyanni, Anastasia Pdf

Environmental health is an area with significant developments and noteworthy challenges that expand into various disciplines: medicine and public health, sociology and communications, technology, policymaking, and legislation. Due to the massive amount of health-related issues, additional literature involving environmental health is required to improve the wellbeing of citizens worldwide. Environmental Exposures and Human Health Challenges provides interdisciplinary insights into concepts and theories related to environmental exposures and human health impacts via the air, water, soil, heavy metal exposure, and other chemical toxins. The book also addresses inequalities and environmental injustices in relation to environmental exposures and health impacts. Covering topics such as health policies, pollution effects, and heavy metal exposure, this publication is designed for public health professionals, preventive medicine specialists, clinicians, data scientists, environmentalists, academicians, practitioners, researchers, and students.

Breathborne Biomarkers and the Human Volatilome

Jonathan Beauchamp,Cristina Davis,Joachim Pleil
Breathborne Biomarkers and the Human Volatilome Book PDF

Author : Jonathan Beauchamp,Cristina Davis,Joachim Pleil
Publisher : Elsevier
Page : 724 pages
File Size : 46,7 Mb
Release : 2020-06-06
Category : Science
ISBN : 9780128223970

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Breathborne Biomarkers and the Human Volatilome by Jonathan Beauchamp,Cristina Davis,Joachim Pleil Pdf

Breathborne biomarkers carry information on the state of human health, and their role in aiding clinical diagnosis or in therapeutic monitoring has become increasingly important as advances in the field are made. Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a comprehensive update and reworking of the 2013 book Volatile Biomarkers, by Anton Amann and David Smith. The new editing team has expanded this edition beyond volatile organic compounds to cover the broad field of breath analysis, including the many exciting developments that have occurred since the first edition was published. This thoroughly revised volume includes the latest discoveries and applications in breath research from the world's foremost scientists, and offers insights into related future developments. It is an ideal resource for researchers, scientists, and clinicians with an interest in breath analysis. Presents recent advances in the field of breath analysis Includes an extensive overview of established biomarkers, detection tools, disease targets, specific applications, data analytics, and study design Offers a broad treatise of each topic, from basic concepts to a comprehensive review of discoveries, current consensus of understanding, and prospective future developments Acts as both a primer for beginners and a reference for seasoned researchers

Toward Precision Medicine

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Toward Precision Medicine Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Publisher : National Academies Press
Page : 142 pages
File Size : 49,6 Mb
Release : 2012-01-16
Category : Medical
ISBN : 9780309222228

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Toward Precision Medicine by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease Pdf

Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Applying Big Data to Address the Social Determinants of Health in Oncology

National Academies of Sciences, Engineering, and Medicine,Division on Engineering and Physical Sciences,Committee on Applied and Theoretical Statistics,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum
Applying Big Data to Address the Social Determinants of Health in Oncology Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Division on Engineering and Physical Sciences,Committee on Applied and Theoretical Statistics,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum
Publisher : National Academies Press
Page : 83 pages
File Size : 53,9 Mb
Release : 2020-08-14
Category : Medical
ISBN : 9780309679060

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Applying Big Data to Address the Social Determinants of Health in Oncology by National Academies of Sciences, Engineering, and Medicine,Division on Engineering and Physical Sciences,Committee on Applied and Theoretical Statistics,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum Pdf

The National Academies of Sciences, Engineering, and Medicine held the workshop Applying Big Data to Address the Social Determinants of Health in Oncology on October 28â€"29, 2019, in Washington, DC. This workshop examined social determinants of health (SDOH) in the context of cancer, and considered opportunities to effectively leverage big data to improve health equity and reduce disparities. The workshop featured presentations and discussion by experts in technology, oncology, and SDOH, as well as representatives from government, industry, academia, and health care systems. This publication summarizes the presentations and discussions from the workshop.

Count Down

Shanna H. Swan,Stacey Colino
Count Down Book PDF

Author : Shanna H. Swan,Stacey Colino
Publisher : Simon and Schuster
Page : 304 pages
File Size : 48,5 Mb
Release : 2022-02-08
Category : Health & Fitness
ISBN : 9781982113674

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Count Down by Shanna H. Swan,Stacey Colino Pdf

An award-winning scientist, in this urgent, thought-provoking and meticulously researched book, shows how chemicals in the modern environment are changing--and endangering--human sexuality and fertility on the grandest scale.

Methods in Protein Biochemistry

Harald Tschesche
Methods in Protein Biochemistry Book PDF

Author : Harald Tschesche
Publisher : Walter de Gruyter
Page : 379 pages
File Size : 49,7 Mb
Release : 2011-12-23
Category : Science
ISBN : 9783110252361

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Methods in Protein Biochemistry by Harald Tschesche Pdf

This book presents a survey of recent developments in protein biochemistry. Top researchers in the field of protein biochemistry describe modern methods to address the challenges of protein purification by three-phase partitioning, and their folding and degradation by the functions of chaperones. The significance of peptide purity for fibril formation is addressed as well as the use of target oriented peptide arrays in palliative approaches in mucoviszidose. The design and application of protein epitope mimetics just as the structural resolving of the misfolding of various mutant proteins in serpinopathies enlarge our tools in resolving pathophysiological imbalances.